LOCUS       NM_027534               5582 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus 3-ketodihydrosphingosine reductase (Kdsr), transcript
            variant 1, mRNA.
ACCESSION   NM_027534 XM_203753 XM_900177 XM_900183 XM_910823 XM_921787
            XM_921793 XM_985103
VERSION     NM_027534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5582)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 5582)
  AUTHORS   Alatibi,K.I., Wehbe,Z., Spiekerkoetter,U. and Tucci,S.
  TITLE     Sex-specific perturbation of complex lipids in response to
            medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase
            deficiency
  JOURNAL   FEBS J 287 (16), 3511-3525 (2020)
   PUBMED   31971349
REFERENCE   3  (bases 1 to 5582)
  AUTHORS   Li,S., Teegarden,A., Bauer,E.M., Choi,J., Messaddeq,N.,
            Hendrix,D.A., Ganguli-Indra,G., Leid,M. and Indra,A.K.
  TITLE     Transcription Factor CTIP1/ BCL11A Regulates Epidermal
            Differentiation and Lipid Metabolism During Skin Development
  JOURNAL   Sci Rep 7 (1), 13427 (2017)
   PUBMED   29044125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5582)
  AUTHORS   Wang,Z., Kirkwood,J.S., Taylor,A.W., Stevens,J.F., Leid,M.,
            Ganguli-Indra,G. and Indra,A.K.
  TITLE     Transcription factor Ctip2 controls epidermal lipid metabolism and
            regulates expression of genes involved in sphingolipid biosynthesis
            during skin development
  JOURNAL   J Invest Dermatol 133 (3), 668-676 (2013)
   PUBMED   23096701
REFERENCE   5  (bases 1 to 5582)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
REFERENCE   6  (bases 1 to 5582)
  AUTHORS   Fukatsu,K., Bannai,H., Zhang,S., Nakamura,H., Inoue,T. and
            Mikoshiba,K.
  TITLE     Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1
            is regulated by actin filaments and 4.1N in neuronal dendrites
  JOURNAL   J Biol Chem 279 (47), 48976-48982 (2004)
   PUBMED   15364918
REFERENCE   7  (bases 1 to 5582)
  AUTHORS   Kihara,A. and Igarashi,Y.
  TITLE     FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an
            active site that faces the cytosolic side of the endoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 279 (47), 49243-49250 (2004)
   PUBMED   15328338
  REMARK    GeneRIF: FVT-1 is a mammalian 3-ketodihydrosphingosine reductase
            with an active site that faces the cytosolic side of the
            endoplasmic reticulum membrane
REFERENCE   8  (bases 1 to 5582)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122842.3.
            
            On Mar 1, 2008 this sequence version replaced NM_027534.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023820.1, AK018155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC122842.3         167569-167767       c
            200-289             AC122842.3         163469-163558       c
            290-346             AC122842.3         161237-161293       c
            347-412             AC122842.3         155796-155861       c
            413-508             AC122842.3         155513-155608       c
            509-700             AC122842.3         151694-151885       c
            701-784             AC122842.3         147356-147439       c
            785-868             AC122842.3         142572-142655       c
            869-970             AC122842.3         135654-135755       c
            971-5582            AC122842.3         128435-133046       c
FEATURES             Location/Qualifiers
     source          1..5582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 49.99 cM"
     gene            1..5582
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /note="3-ketodihydrosphingosine reductase"
                     /db_xref="GeneID:70750"
                     /db_xref="MGI:MGI:1918000"
     exon            1..199
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1090
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /EC_number="1.1.1.102"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; follicular lymphoma variant translocation 1;
                     KDS reductase; 3-dehydrosphinganine reductase; follicular
                     variant translocation protein 1 homolog"
                     /codon_start=1
                     /product="3-ketodihydrosphingosine reductase isoform 1
                     precursor"
                     /protein_id="NP_081810.1"
                     /db_xref="CCDS:CCDS15210.1"
                     /db_xref="GeneID:70750"
                     /db_xref="MGI:MGI:1918000"
                     /translation="MLLLAAAGLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGI
                     GKCIAIECYKQGAFITLVARNEDKLLQAKKDIEKHSINDKQVVLCISVDVSQDYNQVE
                     NVIKQAQEKLGPVDMLVNCAGTSMSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTM
                     KERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYPPD
                     TDTPGLAEENKTKPLETRLISETTAICKPEQVAKQIVKDAIQGNFNSSIGSDGYMLSS
                     LTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDNIVRRCMVQKAKPEVVDKTA"
     exon            200..289
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..346
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..412
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..508
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..700
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..784
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..868
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..970
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..5582
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2074..2079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /note="major polyA site"
     polyA_site      4489
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
     regulatory      5054..5059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /note="hexamer: AATAAA"
     polyA_site      5075
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
                     /note="hexamer: TATAAA"
     polyA_site      5517
                     /gene="Kdsr"
                     /gene_synonym="6330410P18Rik; 9430079B08Rik; Fvt1"
ORIGIN      
        1 tcttcccttc gccgccgtcc cgccctcgct cgcaaaccca aacactcccg gctgctggtg
       61 catgtgatct cccagtagtc gctcggcaga gatgttgctg ttggccgctg ccggcctcgt
      121 ggccttcgtg ctgctcctct acatggtgtc gccgctcatc agtcccaagc ccctcgcgct
      181 gcccggcgcg cacgtagtgg tcacaggagg ctccagtggc attgggaagt gcattgctat
      241 tgagtgctac aaacaaggag catttataac tctggttgca cgaaatgagg acaagctact
      301 gcaggcgaag aaagacattg aaaagcactc tattaatgac aaacaggtgg tgctgtgtat
      361 ctcagttgat gtgtctcaag actataacca agtggagaat gtcataaagc aggcacaaga
      421 gaagctgggt cctgtggaca tgctggtcaa ctgtgcaggc acctctatgt caggaaagtt
      481 tgaagagctt gaagttagta gttttgagaa attaatgagc ataaattacc tgggcagcgt
      541 gtaccccagc agggcagtaa tcactaccat gaaggagcga cgggtgggca ggatcgtgtt
      601 tgtgtcctct caggcaggac agctgggact gtttggtttc acggcctact cttcatccaa
      661 gtttgccata agaggattgg cagaagctct gcagatggag gtgaagccgt acaatgtgta
      721 cgtcactgtg gcctacccac cagacaccga cacgccgggg ctggctgagg aaaacaaaac
      781 gaagcccctg gagacccggc ttatctcaga gaccacagct atttgcaaac cagagcaggt
      841 ggccaaacaa attgtcaaag atgccataca aggaaatttt aacagttcta ttggctcaga
      901 tgggtacatg ctgtcctccc tgacctgtgg gatggccccg gtgacttcca tcactgaagg
      961 actccagcag gtggtcacca tgggcctttt ccgaacaatt gccttgtttt accttggaag
     1021 tttcgataat atagttcgcc gctgcatggt gcagaaagca aaacctgaag ttgtagacaa
     1081 aactgcctaa accttgcccc ttggatgaaa gactgaatcc agtgatttga acagtgtgct
     1141 gctaatggaa cacaagtttt ggcctccaga cttttgtatc ttgtttttga atgtgtgaga
     1201 ttggaccccg tgctcttcag aaatctggct gtaagcagag ggacatgagg ccatctctac
     1261 aactgttaaa cactatgcaa atatgggcca ggacaccttt gattttctgg gctgtagggg
     1321 tgatagtgtg agaactaata acaggaaagc agggtaaaga atagcattcc agaacagtaa
     1381 attcagcttt tcggtcattc tcccatccta cccatagaga tcaagaaatg tcctctgtgg
     1441 cgtttctgag gttttgtttt gtttgttttt tgtttttgtt ttgttttgct tttttttttt
     1501 ttttttttga ttttgggttt taacttttta tgaaagatgg tccggatttt tattagtctt
     1561 tttttctttt ttgtaatttt tttagtgtat gttattcaag gtgtgtcttc cgagtagccc
     1621 atgagtctga ctctcagcat gccttgctgc gcctgggact cgcttctgct agtgaagctg
     1681 gtttctctct ctttgatccc ataaaattcg agggggatga gagagcagca cagagggcaa
     1741 ggggtgagtc ctttgtgacg gcaagcgggg ctttcttgtc ttcttagact gatgcttaca
     1801 acgttttcat ttttattcaa ggggaaaggc agcctcttta cgtgtttcgt gaagagaaat
     1861 aaaatctcct agcagcttaa gttacagttt cttcaggagc catgatgacc tgaagttcac
     1921 attccatttc agctcagttc ctagtgctta tcgctcttcc tagttttgct tatgctactg
     1981 taatattttt gtagaagaaa ggaaggaaga aaaaaaagat ggagatcagt gcaaatgttt
     2041 ttgacttttt taattaatcc atgaattaat taaaataaaa aaatgaaaag catgaccttc
     2101 ttactctcag agcatacaat ggagcttcag ggaaggcagc tggttgtgta cttctactat
     2161 taaaagaggg tcaggtttgg aggttgggtg ttgagcggct ctgtctcgcg cactggcacc
     2221 cagcagtatc ttcagcatgg taaggagccc tctgatggca gcctgtgcgc gtgcacatgc
     2281 gcaagactgc ggttccatgg gcgagcctgc aacaagtgcc tcagatgagt cctgcctgta
     2341 tcccactcat cctgtttatt gttccccagg ctctaggaca gtgttctatg tcctgatatt
     2401 ttaccctgtt ctccttgtat acaaaataca gcatttcagt tcactccacc aggagaatac
     2461 tactttgaaa gaaaaaactt tattgttaaa aaacagaaaa cagccgggca tggtgacgca
     2521 cgcctttaat cccagcactc aggaggcaga ggcaggcgga cttctgagtt cgaggccagc
     2581 ctggtcttca aagtgagttc caggacagcc agggctacac agagaaaccc tgtataggaa
     2641 aaaaaccaaa acccaaaaaa aaaaaaaaaa aaaaaaaaga acaaacaaaa aaaaccccaa
     2701 caaacaacaa aagggtttga aaattattta gagattattg ccatggtaaa cattttcttt
     2761 ttgcttttct ttttcctttt tttttttttt ttaaagatga gtttttgctg tgtggtcttt
     2821 tgcctcaggc acctgagtcc tggcagtaca gttttactcc atcatggtca atgagccaac
     2881 cagtttttgc tctttgagtt tttttaatct cttgacttta tagtggctta gtttttattt
     2941 aataagatat ttaatggatc catttttatc aaggtcagaa aacattttaa atattgttat
     3001 agaagacatt ttttattata tgcattactg tttacaggag cgggttgaca aggccaaaac
     3061 agttccagca ccccttcagt ccagcctagc caaagtctac gacttgtggc atattggaca
     3121 gctgctgagg tgggacagca gggaccactt cccaattcag agggaacaac tggacagttt
     3181 ccaattttat tttcttttaa gtgtccccag acagctggca ctttctactc ttacctgtta
     3241 agatctaatc ccagatgaca tctgacagta caattaactt ttctcattat actattttca
     3301 aacattcctc ggccagagga tggctgtcta gataatgcct gacatacagt gaaaagcctt
     3361 gtttcatggt gggcgatgct ggctctaacc cactttaaac tcaggtttgc agagaccgtg
     3421 atgccatggc attagaggcc tcaacaccct gattcacaaa agtttggagt aagctttcct
     3481 tttcttctga agtagatacc atagtcccag atgaacttga tgtgagaata ctgtttttat
     3541 tcatgtcaca tcagcacagc gtgcctgtgt gttaacttta ccagactccc tgcaagcatc
     3601 ttgcctctca gtatgtgttc cacattacct ttgacagagg aactcttgag actcctgctt
     3661 ggaatgcagc attgaagcaa tacccctgaa agtcaccgtt catcccagtt gaggtagaaa
     3721 actacagttg gggccggggg aggcggtgtg gacagcccca ttgttaggga aattatcagc
     3781 tttccccccc agagagctaa acactttcca tcctttgcca cgtgctaagg ctgagttgga
     3841 tgctgaggct tgcagttcct ctgtgccatt ccctctgtgt gaccaagggc ttctggggtt
     3901 tcagtgctga gtgcctgctc tgatagtcag atcgtattac tttattttaa tatatccctg
     3961 tgttcatttg aaaattaata ttctgctata taaagttaag gacgcttcat aactgagaaa
     4021 gaataggagg caatcattta tttatttaaa gaagaaaaag ataatgtcac gggctgggga
     4081 agtgtttcat tggagaatgc ttgcctagca tgcttgggac cctgggtttg attccttacc
     4141 ccaatccaaa aacattcttt attaaaattg tcctatcatt tcagacttta gtaatttata
     4201 cagtttagac tgttgttgtg gtctctctct gtataatgta gtggtgtgta tttatctaga
     4261 tctgttaaat catataattg attcctgaaa gcagaatctt taagatgact ttctgttaga
     4321 tgatgagaac atttctatac catttgctct actcaaagaa tcctatgcat ttgtccttgt
     4381 agaaggctgt acaatgaatt atgttgtggt acataagttt attatattgt attctaattg
     4441 aaatgtgtct tgctgaagac cacagttaat attcatactt ttgctagaag atgctttgtg
     4501 tctttcttat cacccttagt ccttaggacc ccagctcaga aggcccctgc tgactgttac
     4561 cctctagttc cggactgggt cttgctgttc tgatctttct gggttaatgg aggcctatgg
     4621 gtttgatttt cgaaaatgag agagttgcca ttatatttta tacttatttg tggtgtgaac
     4681 tcttaaggcg ttttgacaca tgttaggaca gggtttctac cttagaagct tttgtggcgg
     4741 tactgtatgg tagcactgct gtaatgtgat tttcatatct tgtatttctg aattacacat
     4801 acagactagg gaacaagctt tactgatctg aaaatttatt tttctagata tttgtcattt
     4861 taaagatact taatcaagct acaaaagtct tttatagcat tgtctctatt tggcttccta
     4921 gacatttcat aaggcctgat ttttattatt tttaggaagt aatattttta caatatatac
     4981 ttaggaatct gaacattcat ttcaagtatg ctctgtctgt atgagtaaaa gaagcctaag
     5041 aaatatagaa tataataaag ctttttgaac agttacattt catatgcaaa tagattttct
     5101 gacccttatt cctgcttatt ttgtgagctg tgtctacatt ttgataacaa gaagtaggtg
     5161 agagaacacc ttggtttctt gtaagcagaa atgtttgctc atcctgagga gatgtttctt
     5221 aaaacacatt tttcaccata ggtcttcctt tgctgcttgt ctgcactctt aggggaaatg
     5281 ctcggacatc tcactacaac atagacggct acttgtaagg ttttcataga gctcatttct
     5341 taggttgaca atttctcatt tcctgtttgc tgagagtttt ttattaatag gtctctgtta
     5401 aattttattg tatgttttct gcagctctat gttgattata tgattttgtt tataccttta
     5461 aattgctttt attcattgta ctcaatggtg agttttataa agacatttca ttaagtagat
     5521 cattttggaa gcatcttgaa ttgcaagcca aacttttctt taaatttgaa aattttatat
     5581 tc
//
