LOCUS       NM_010612               5921 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus kinase insert domain protein receptor (Kdr),
            transcript variant 1, mRNA.
ACCESSION   NM_010612 XM_984991
VERSION     NM_010612.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5921)
  AUTHORS   Vitali,H.E., Kuschel,B., Sherpa,C., Jones,B.W., Jacob,N.,
            Madiha,S.A., Elliott,S., Dziennik,E., Kreun,L., Conatser,C.,
            Bhetwal,B.P. and Sharma,B.
  TITLE     Hypoxia regulate developmental coronary angiogenesis potentially
            through VEGF-R2- and SOX17-mediated signaling
  JOURNAL   Dev Dyn 254 (2), 174-188 (2025)
   PUBMED   39360476
REFERENCE   2  (bases 1 to 5921)
  AUTHORS   Raudales,A., Schager,B., Hancock,D., Narayana,K., Sharma,S.,
            Reeson,P., Oshanyk,A., Cheema,M., Korbelin,J. and Brown,C.E.
  TITLE     Angiogenesis in the mature mouse cortex is governed in a regional-
            and Notch1-dependent manner
  JOURNAL   Cell Rep 43 (12), 115029 (2024)
   PUBMED   39612246
REFERENCE   3  (bases 1 to 5921)
  AUTHORS   Canu,G., Correra,R., Diez-Pinel,G., Castellan,R.F.P., Denti,L.,
            Fantin,A. and Ruhrberg,C.
  TITLE     A Pax3 lineage gives rise to transient haematopoietic progenitors
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629666
REFERENCE   4  (bases 1 to 5921)
  AUTHORS   Sekimoto,A., Takaso,Y., Saruyama,H., Ookawa,M., Yamamoto,M.,
            Toyohara,T., Saigusa,D., Fukuuchi,T., Otsuka,M., Fushiki,Y.,
            Yamakoshi,S., Tanaka,K., Ikeda,T., Tanaka,T., Takahashi,N.,
            Mishima,E. and Sato,E.
  TITLE     Impacts of low birthweight on kidney development and
            intergenerational growth of the offspring
  JOURNAL   iScience 27 (11), 111159 (2024)
   PUBMED   39524353
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5921)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   6  (bases 1 to 5921)
  AUTHORS   Chakraborty,I., Das,S.K. and Dey,S.K.
  TITLE     Differential expression of vascular endothelial growth factor and
            its receptor mRNAs in the mouse uterus around the time of
            implantation
  JOURNAL   J Endocrinol 147 (2), 339-352 (1995)
   PUBMED   7490564
REFERENCE   7  (bases 1 to 5921)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   8  (bases 1 to 5921)
  AUTHORS   Duttlinger,R., Manova,K., Berrozpe,G., Chu,T.Y., DeLeon,V.,
            Timokhina,I., Chaganti,R.S., Zelenetz,A.D., Bachvarova,R.F. and
            Besmer,P.
  TITLE     The Wsh and Ph mutations affect the c-kit expression profile: c-kit
            misexpression in embryogenesis impairs melanogenesis in Wsh and Ph
            mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 3754-3758 (1995)
   PUBMED   7537375
REFERENCE   9  (bases 1 to 5921)
  AUTHORS   Brunkow,M.E., Nagle,D.L., Bernstein,A. and Bucan,M.
  TITLE     A 1.8-Mb YAC contig spanning three members of the receptor tyrosine
            kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5
  JOURNAL   Genomics 25 (2), 421-432 (1995)
   PUBMED   7540588
REFERENCE   10 (bases 1 to 5921)
  AUTHORS   Matthews,W., Jordan,C.T., Gavin,M., Jenkins,N.A., Copeland,N.G. and
            Lemischka,I.R.
  TITLE     A receptor tyrosine kinase cDNA isolated from a population of
            enriched primitive hematopoietic cells and exhibiting close genetic
            linkage to c-kit
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9026-9030 (1991)
   PUBMED   1717995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124615.11, AC160723.2 and AC134903.4.
            
            On May 11, 2018 this sequence version replaced NM_010612.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020530.1, X70842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AC124615.11        24808-25161         c
            355-448             AC124615.11        21108-21201         c
            449-651             AC124615.11        18959-19161         c
            652-782             AC124615.11        15437-15567         c
            783-951             AC124615.11        15027-15195         c
            952-1091            AC124615.11        14378-14517         c
            1092-1269           AC160723.2         309-486
            1270-1384           AC160723.2         1894-2008
            1385-1548           AC160723.2         2095-2258
            1549-1705           AC160723.2         3967-4123
            1706-1817           AC160723.2         4988-5099
            1818-1926           AC160723.2         6015-6123
            1927-2268           AC160723.2         7375-7716
            2269-2415           AC160723.2         9723-9869
            2416-2547           AC160723.2         10548-10679
            2548-2654           AC160723.2         13887-13993
            2655-2790           AC160723.2         14426-14561
            2791-2895           AC160723.2         14915-15019
            2896-3009           AC160723.2         16611-16724
            3010-3098           AC160723.2         17230-17318
            3099-3252           AC160723.2         17929-18082
            3253-3350           AC160723.2         19917-20014
            3351-3473           AC160723.2         22188-22310
            3474-3585           AC160723.2         22451-22562
            3586-3685           AC160723.2         22809-22908
            3686-3791           AC160723.2         23293-23398
            3792-3943           AC160723.2         24872-25023
            3944-4043           AC134903.4         197444-197543       c
            4044-4129           AC134903.4         196900-196985       c
            4130-5921           AC134903.4         193432-195223       c
FEATURES             Location/Qualifiers
     source          1..5921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 40.23 cM"
     gene            1..5921
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /note="kinase insert domain protein receptor"
                     /db_xref="GeneID:16542"
                     /db_xref="MGI:MGI:96683"
     exon            1..354
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..4325
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; soluble vascular endothelial growth factor
                     receptor 2; kinase NYK; fetal liver kinase 1;
                     protein-tyrosine kinase receptor flk-1; vascular
                     endothelial growth factor receptor-3; VEGF receptor-2"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_034742.2"
                     /db_xref="CCDS:CCDS39114.1"
                     /db_xref="GeneID:16542"
                     /db_xref="MGI:MGI:96683"
                     /translation="MESKALLAVALWFCVETRAASVGLPGDFLHPPKLSTQKDILTIL
                     ANTTLQITCRGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGA
                     YKCSYRDVDIASTVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLN
                     VSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIV
                     VVVGYRIYDVILSPPHEIELSAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVN
                     RDVKPFPGTVAKMFLSTLTIESVTKSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAF
                     GSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTE
                     RDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVY
                     ANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGK
                     NKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQPAAQPTEQESVS
                     LLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILI
                     VAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILERMAPMITGNLENQTTTIGETI
                     EVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNV
                     LGCARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLLVIVLRTVKRANEGELKTG
                     YLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDK
                     TATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV
                     EFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSAS
                     SGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAAR
                     NILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWS
                     FGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPN
                     QRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCMEEEE
                     VCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGMVL
                     ASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSD
                     EAGLLKMVDAAVHADSGTTLRSPPV"
     exon            355..448
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..651
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..782
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..951
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1091
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1269
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1384
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1548
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1705
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1817
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1926
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2268
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2415
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2547
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2654
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2790
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2895
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3009
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3098
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3252
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3350
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3473
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3585
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3685
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3791
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3943
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4043
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4129
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..5921
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5897..5902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      5921
                     /gene="Kdr"
                     /gene_synonym="6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv;
                     sVEGFR-2; VEGFR-2; VEGFR2"
                     /note="major polyA site"
ORIGIN      
        1 gagtcctcag gaccccaaga gagtaagctg tgtttcctta gatcgcgcgg accgctaccc
       61 ggcaggactg aaagcccaga ctgtgtcccg cagccgggat aacctggctg acccgattcc
      121 gcggacaccg ctgcagccgc ggctggagcc agggcgccgg tgccccgcgc tctccccggt
      181 cttgcgctgc gggggcgcat accgcctctg tgacttcttt gcgggccagg gacggagaag
      241 gagtctgtgc ctgagaactg ggctctgtgc ccagcgcgag gtgcaggatg gagagcaagg
      301 cgctgctagc tgtcgctctg tggttctgcg tggagacccg agccgcctct gtgggtttgc
      361 ctggcgattt tctccatccc cccaagctca gcacacagaa agacatactg acaattttgg
      421 caaatacaac ccttcagatt acttgcaggg gacagcggga cctggactgg ctttggccca
      481 atgctcagcg tgattctgag gaaagggtat tggtgactga atgcggcggt ggtgacagta
      541 tcttctgcaa aacactcacc attcccaggg tggttggaaa tgatactgga gcctacaagt
      601 gctcgtaccg ggacgtcgac atagcctcca ctgtttatgt ctatgttcga gattacagat
      661 caccattcat cgcctctgtc agtgaccagc atggcatcgt gtacatcacc gagaacaaga
      721 acaaaactgt ggtgatcccc tgccgagggt cgatttcaaa cctcaatgtg tctctttgcg
      781 ctaggtatcc agaaaagaga tttgttccgg atggaaacag aatttcctgg gacagcgaga
      841 taggctttac tctccccagt tacatgatca gctatgccgg catggtcttc tgtgaggcaa
      901 agatcaatga tgaaacctat cagtctatca tgtacatagt tgtggttgta ggatatagga
      961 tttatgatgt gattctgagc cccccgcatg aaattgagct atctgccgga gaaaaacttg
     1021 tcttaaattg tacagcgaga acagagctca atgtggggct tgatttcacc tggcactctc
     1081 caccttcaaa gtctcatcat aagaagattg taaaccggga tgtgaaaccc tttcctggga
     1141 ctgtggcgaa gatgtttttg agcaccttga caatagaaag tgtgaccaag agtgaccaag
     1201 gggaatacac ctgtgtagcg tccagtggac ggatgatcaa gagaaataga acatttgtcc
     1261 gagttcacac aaagcctttt attgctttcg gtagtgggat gaaatctttg gtggaagcca
     1321 cagtgggcag tcaagtccga atccctgtga agtatctcag ttacccagct cctgatatca
     1381 aatggtacag aaatggaagg cccattgagt ccaactacac aatgattgtt ggcgatgaac
     1441 tcaccatcat ggaagtgact gaaagagatg caggaaacta cacggtcatc ctcaccaacc
     1501 ccatttcaat ggagaaacag agccacatgg tctctctggt tgtgaatgtc ccaccccaga
     1561 tcggtgagaa agccttgatc tcgcctatgg attcctacca gtatgggacc atgcagacat
     1621 tgacatgcac agtctacgcc aaccctcccc tgcaccacat ccagtggtac tggcagctag
     1681 aagaagcctg ctcctacaga cccggccaaa caagcccgta tgcttgtaaa gaatggagac
     1741 acgtggagga tttccagggg ggaaacaaga tcgaagtcac caaaaaccaa tatgccctga
     1801 ttgaaggaaa aaacaaaact gtaagtacgc tggtcatcca agctgccaac gtgtcagcgt
     1861 tgtacaaatg tgaagccatc aacaaagcgg gacgaggaga gagggtcatc tccttccatg
     1921 tgatcagggg tcctgaaatt actgtgcaac ctgctgccca gccaactgag caggagagtg
     1981 tgtccctgtt gtgcactgca gacagaaata cgtttgagaa cctcacgtgg tacaagcttg
     2041 gctcacaggc aacatcggtc cacatgggcg aatcactcac accagtttgc aagaacttgg
     2101 atgctctttg gaaactgaat ggcaccatgt tttctaacag cacaaatgac atcttgattg
     2161 tggcatttca gaatgcctct ctgcaggacc aaggcgacta tgtttgctct gctcaagata
     2221 agaagaccaa gaaaagacat tgcctggtca aacagctcat catcctagag cgcatggcac
     2281 ccatgatcac cggaaatctg gagaatcaga caacaaccat tggcgagacc attgaagtga
     2341 cttgcccagc atctggaaat cctaccccac acattacatg gttcaaagac aacgagaccc
     2401 tggtagaaga ttcaggcatt gtactgagag atgggaaccg gaacctgact atccgcaggg
     2461 tgaggaagga ggatggaggc ctctacacct gccaggcctg caatgtcctt ggctgtgcaa
     2521 gagcggagac gctcttcata atagaaggtg cccaggaaaa gaccaacttg gaagtcatta
     2581 tcctcgtcgg cactgcagtg attgccatgt tcttctggct ccttcttgtc attgtcctac
     2641 ggaccgttaa gcgggccaat gaaggggaac tgaagacagg ctacttgtct attgtcatgg
     2701 atccagatga attgcccttg gatgagcgct gtgaacgctt gccttatgat gccagcaagt
     2761 gggaattccc cagggaccgg ctgaaactag gaaaacctct tggccgcggt gccttcggcc
     2821 aagtgattga ggcagacgct tttggaattg acaagacagc gacttgcaaa acagtagccg
     2881 tcaagatgtt gaaagaagga gcaacacaca gcgagcatcg agccctcatg tctgaactca
     2941 agatcctcat ccacattggt caccatctca atgtggtgaa cctcctaggc gcctgcacca
     3001 agccgggagg gcctctcatg gtgattgtgg aattctgcaa gtttggaaac ctatcaactt
     3061 acttacgggg caagagaaat gaatttgttc cctataagag caaaggggca cgcttccgcc
     3121 agggcaagga ctacgttggg gagctctccg tggatctgaa aagacgcttg gacagcatca
     3181 ccagcagcca gagctctgcc agctcaggct ttgttgagga gaaatcgctc agtgatgtag
     3241 aggaagaaga agcttctgaa gaactgtaca aggacttcct gaccttggag catctcatct
     3301 gttacagctt ccaagtggct aagggcatgg agttcttggc atcaaggaag tgtatccaca
     3361 gggacctggc agcacgaaac attctcctat cggagaagaa tgtggttaag atctgtgact
     3421 tcggcttggc ccgggacatt tataaagacc cggattatgt cagaaaagga gatgcccgac
     3481 tccctttgaa gtggatggcc ccggaaacca tttttgacag agtatacaca attcagagcg
     3541 atgtgtggtc tttcggtgtg ttgctctggg aaatattttc cttaggtgcc tccccatacc
     3601 ctggggtcaa gattgatgaa gaattttgta ggagattgaa agaaggaact agaatgcggg
     3661 ctcctgacta cactacccca gaaatgtacc agaccatgct ggactgctgg catgaggacc
     3721 ccaaccagag accctcgttt tcagagttgg tggagcattt gggaaacctc ctgcaagcaa
     3781 atgcgcagca ggatggcaaa gactatattg ttcttccaat gtcagagaca ctgagcatgg
     3841 aagaggattc tggactctcc ctgcctacct cacctgtttc ctgtatggag gaagaggaag
     3901 tgtgcgaccc caaattccat tatgacaaca cagcaggaat cagtcattat ctccagaaca
     3961 gtaagcgaaa gagccggcca gtgagtgtaa aaacatttga agatatccca ttggaggaac
     4021 cagaagtaaa agtgatccca gatgacagcc agacagacag tgggatggtc cttgcatcag
     4081 aagagctgaa aactctggaa gacaggaaca aattatctcc atcttttggt ggaatgatgc
     4141 ccagtaaaag cagggagtct gtggcctcgg aaggctccaa ccagaccagt ggctaccagt
     4201 ctgggtatca ctcagatgac acagacacca ccgtgtactc cagcgacgag gcaggacttt
     4261 taaagatggt ggatgctgca gttcacgctg actcagggac cacactgcgc tcacctcctg
     4321 tttaaatgga agtggtcctg tcccggctcc gcccccaact cctggaaatc acgagagagg
     4381 tgctgcttag attttcaagt gttgttcttt ccaccacccg gaagtagcca catttgattt
     4441 tcatttttgg aggagggacc tcagactgca aggagcttgt cctcagggca tttccagaga
     4501 agatgcccat gacccaagaa tgtgttgact ctactctctt ttccattcat ttaaaagtcc
     4561 tatataatgt gccctgctgt ggtctcacta ccagttaaag caaaagactt tcaaacagtg
     4621 gctctgtcct ccaagaagtg gcaacggcac ctctgtgaaa ctggatcgaa tgggcaatgc
     4681 tttgtgtgtt gaggatgggt gagatgtccc agggccgagt ctgtctacct tggaggcttt
     4741 gtggaggatg cgggctatga gccaagtgtt aagtgtggga tgtggactgg gaggaaggaa
     4801 ggcgcaagct cgctcggaga gcggttggag cctgcagatg cattgtgctg gctctggtgg
     4861 aggtgggctt gtggcctgtc aggaaacgca aaggcggccg gcagggtttg gttttggaag
     4921 gtttgcgtgc tcttcacagt cgggttacag gcgagttccc tgtggcgttt cctactccta
     4981 atgagagttc cttccggact cttacgtgtc tcctggcctg gccccaggaa ggaaatgatg
     5041 cagcttgctc cttcctcatc tctcaggctg tgccttaatt cagaacacca aaagagagga
     5101 acgtcggcag aggctcctga cggggccgaa gaattgtgag aacagaacag aaactcaggg
     5161 tttctgctgg gtggagaccc acgtggctgc cctggtggca gtgtctgagg gttctctgtc
     5221 aagtggcggt aaaggctcag gctggtgttc ttcctctatc tccactcctg tcaggccccc
     5281 aagtcctcag tattttagct ttgtggcttc ctgatggcag aaaaatctta attggttggt
     5341 ttgctctcca gataatcact agccagattt cgaaattact ttttagccga ggttatgata
     5401 acatctactg tatcctttag aattttaacc tataaaacta tgtctactgg tttctgcctg
     5461 tgtgcttatg ttaaaaaaaa aaagaaagaa agaaactgtt cttttcattt ggtaccatag
     5521 tgtgaagagc tgggagcaat gactgttaaa catgctatgg cacatctatt tatagtctgt
     5581 tatgtagaac aaatgtaata tattaaaacg ttatattata tataatgaac tttgtactac
     5641 ccaccttttg tatcagtatt atgtaccact agagagatta caaggctttc agcagccgct
     5701 gttgttttgt taaagacttt gagaaactcg aaggaatcct ttcatggaat atgcagctat
     5761 ataccctacc gtctctctca tctcaaacgg aggaggagga ggaggagtca ggtataatgt
     5821 gagtgtgttc tacgtgtcct tgttctctgt tcttaggagg aatgatttca tcaaatgttt
     5881 atatgcttta taaaccaata aacgtattct gagtaaagag a
//
