LOCUS       NM_029842               2445 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus lysine (K)-specific demethylase 8 (Kdm8), mRNA.
ACCESSION   NM_029842
VERSION     NM_029842.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Sealock,R., Zhang,H., Lucitti,J.L., Moore,S.M. and Faber,J.E.
  TITLE     Congenic fine-mapping identifies a major causal locus for variation
            in the native collateral circulation and ischemic injury in brain
            and lower extremity
  JOURNAL   Circ Res 114 (4), 660-671 (2014)
   PUBMED   24300334
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Oh,S. and Janknecht,R.
  TITLE     Histone demethylase JMJD5 is essential for embryonic development
  JOURNAL   Biochem Biophys Res Commun 420 (1), 61-65 (2012)
   PUBMED   22402282
  REMARK    GeneRIF: Collectively, these data indicate that JMJD5 is essential
            during embryonal development and a repressor of p53 expression. The
            latter suggests that JMJD5 has oncogenic activity and accordingly
            JMJD5 is upregulated in leukemias and breast cancer.
            Erratum:[Biochem Biophys Res Commun. 2015 Sep 11;465(1):166]
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Ishimura,A., Minehata,K., Terashima,M., Kondoh,G., Hara,T. and
            Suzuki,T.
  TITLE     Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell
            proliferation through the regulation of Cdkn1a expression
  JOURNAL   Development 139 (4), 749-759 (2012)
   PUBMED   22241836
  REMARK    GeneRIF: Results suggest that Jmjd5 physiologically moderates
            embryonic cell proliferation through the epigenetic control of
            Cdkn1a expression.
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125187.4 and AK014006.1.
            
            On Mar 23, 2011 this sequence version replaced NM_029842.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024807.1, AK014006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC125187.4         153961-154054
            95-1836             AK014006.1         39-1780
            1837-2445           AC125187.4         171002-171610
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 68.85 cM"
     gene            1..2445
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /note="lysine (K)-specific demethylase 8"
                     /db_xref="GeneID:77035"
                     /db_xref="MGI:MGI:1924285"
     exon            1..173
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            174..674
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1427
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /EC_number="1.14.11.73"
                     /note="lysine-specific demethylase 8; jmjC
                     domain-containing protein 5; jumonji domain-containing
                     protein 5; jumonji domain containing 5; arginyl
                     C3-hydroxylase KDM8; jumonji C domain-containing protein
                     5; L-arginine (3R)-hydroxylase KDM8"
                     /codon_start=1
                     /product="bifunctional peptidase and arginyl-hydroxylase
                     JMJD5"
                     /protein_id="NP_084118.1"
                     /db_xref="CCDS:CCDS21821.1"
                     /db_xref="GeneID:77035"
                     /db_xref="MGI:MGI:1924285"
                     /translation="MSEDTTEPLVGSSTLWKELRTLLPDKEEELKLDLGEKVDRSVAA
                     LLRQAVGLFYAGHWQGCLQASEAVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKALC
                     LCQAPQKATTVVEALRVCDMGLLMGAAILEDILLKVVAVLQTHQLPGKQPARGPHQDQ
                     PATKKAKCDASPAPDVMLERMVPRLRCPPLQYFKQHFLVPGRPVILEGVADHWPCMKK
                     WSLQYIQEIAGCRTVPVEVGSRYTDEDWSQTLMTVDEFIQKFILSEAKDVGYLAQHQL
                     FDQIPELKRDISIPDYCCLGNGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVLGRK
                     YIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFI
                     PAKYWHYVRSLDLSFSVSFWWS"
     exon            675..841
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..974
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1019
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1169
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1262
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2445
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /note="hexamer: AATATA"
     polyA_site      1790
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /note="hexamer: AATAAA"
     polyA_site      2434
                     /gene="Kdm8"
                     /gene_synonym="3110005O21Rik; Jmjd5"
                     /note="major polyA site"
ORIGIN      
        1 ggcctggcat cgattgctcc gcgttcctct aggcacccgt cgcgatcagc cgagtcagaa
       61 gtgatcgatg ctctcggtgt agtcggtgat aaagccagcc gaagaatctt cgcccggacg
      121 gaaccagtcg tcgccagcaa cgagagacac aaacaagtcc aagcgccaga gaggtgctga
      181 tcatgtcaga ggacaccaca gagcccctgg tggggtccag caccctctgg aaggagctca
      241 ggacgctcct gcctgacaaa gaggaggagc tgaagctgga cctcggtgag aaggtggaca
      301 ggagcgtggc tgcgcttttg cggcaggctg tgggtctatt ctacgcgggc cattggcagg
      361 ggtgcctgca ggccagtgag gccgtcctag actactcctg ggaaaagctc aacactggtc
      421 cctggagaga tgtagacaag gagtggcgcc gggtatattc cttcggctgc ctcctgaagg
      481 ccctgtgcct gtgccaggca ccacagaagg ccactactgt ggtggaagca ctgcgggtgt
      541 gtgacatggg cctgttgatg ggggcagcca tcctcgagga cattcttctc aaagttgtcg
      601 cagtcctcca gacacaccag ctcccaggaa agcagcctgc ccgcggcccc caccaggatc
      661 agcctgccac caagaaggca aagtgtgacg ccagcccagc tcctgatgtc atgttagagc
      721 ggatggtacc caggctccgc tgcccacctc tgcagtactt caagcagcat tttctagttc
      781 ctgggaggcc tgtgatcttg gaaggtgtgg ccgaccactg gccgtgcatg aagaagtgga
      841 gtctgcagta catccaggag attgctggct gccgcaccgt ccccgtggaa gtgggctcaa
      901 ggtacacaga tgaagactgg tcccagactc tcatgacagt cgatgagttc atccagaagt
      961 tcatcctgag cgaggcaaag gatgtcgggt accttgctca gcaccagctc ttcgaccaga
     1021 tcccagagtt gaagcgggac atcagcatcc ctgattactg ttgcctgggc aatggagaag
     1081 aggaagagat cactatcaat gcctggtttg gtccacaagg caccatctcc ccactgcatc
     1141 aggaccccca gcagaacttc ctggtccagg tgctaggaag gaagtacatc cgattgtatt
     1201 cgccgcaaga gtctgaggca gtgtaccctc acgagacgca cattcttcat aacaccagcc
     1261 aggttgatgt ggaaaacccc gaccttgaga agtttcccaa gttcactgag gccccattcc
     1321 tgtcctgcat tctgtcccca ggagacaccc tctttatacc tgctaagtac tggcattatg
     1381 tgcgctccct ggacctgagc ttctctgtca gcttctggtg gtcatagcta ggaccagact
     1441 ggaaaggacc tctgggcaga caccttaccc aaaggcagta aaccaagtgt cagtgtgggc
     1501 cctgcatgcc gctagactcc agcagccctg cccccagcca atgtctgttg tgtgacagag
     1561 ctgctatgta cccacgtgtg gcccacctgc tgtgtgtgcc cgcgtgtgta gggcagagct
     1621 gctacatgta cctaagctat ccagattatg ggtgcttttt ttcctttgta actgctgggc
     1681 tgagtatccc ttgctgctag gtgcccaagg gcagctggca agctgctcag agacagaaca
     1741 caacctgtaa taggggtttt cttgggtgga atatagccgg gtctgggaca gctgctgtgg
     1801 tcccagtctt ctgtgtaccc aggcctcact gccagcttac tactaggagt tggaaacaga
     1861 ggtccttggc tccatacttc ccctcggggc acttatgcac caggctggaa gaggagggca
     1921 gcggaactac tttgttgtga atgtggggaa tacagagaag agcgaggtct tcccagaata
     1981 tataggagcg gccttttaca aggaagcccc tgcccccaag cctccttgat gaagagatgg
     2041 ttcttacgtt caaactgttt tagttgatgg cggatgtgca tgcacacacc ttactcaggg
     2101 tgaatcaagg agtaaatacc tcttgtggga aggactgccc aggaagggaa gctcattggc
     2161 tgaacactcg gggcccactt agataccaca ttaccatgga gaactccagg tttttatgtt
     2221 acaagactga ctgtcaccgt cctctcagtg gggtgtcatg ttccagatca ggtagtttgg
     2281 cagggagctg gctctactcc agctgttctc aattctgaga tttccccagt ctgagcctgc
     2341 tcaaccttac cagttcttct gtctggtggc ccggtccact tgccccatat gtaacttaaa
     2401 tattttcaat aacaataaaa tatattttat taattaaaaa acaaa
//
