LOCUS       NM_001033430            9553 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Mus musculus lysine (K)-specific demethylase 7A (Kdm7a), mRNA.
ACCESSION   NM_001033430 XM_145254 XM_914799
VERSION     NM_001033430.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9553)
  AUTHORS   Shan,L., Yang,X., Liao,X., Yang,Z., Zhou,J., Li,X. and Wang,B.
  TITLE     Histone demethylase KDM7A regulates bone homeostasis through
            balancing osteoblast and osteoclast differentiation
  JOURNAL   Cell Death Dis 15 (2), 136 (2024)
   PUBMED   38346941
  REMARK    GeneRIF: Histone demethylase KDM7A regulates bone homeostasis
            through balancing osteoblast and osteoclast differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9553)
  AUTHORS   Wang,Y., Hong,Q., Xia,Y., Zhang,Z. and Wen,B.
  TITLE     The Lysine Demethylase KDM7A Regulates Immediate Early Genes in
            Neurons
  JOURNAL   Adv Sci (Weinh) 10 (28), e2301367 (2023)
   PUBMED   37565374
  REMARK    GeneRIF: The Lysine Demethylase KDM7A Regulates Immediate Early
            Genes in Neurons.
REFERENCE   3  (bases 1 to 9553)
  AUTHORS   Kim,J.H., Nagappan,A., Jung,D.Y., Suh,N. and Jung,M.H.
  TITLE     Histone Demethylase KDM7A Contributes to the Development of Hepatic
            Steatosis by Targeting Diacylglycerol Acyltransferase 2
  JOURNAL   Int J Mol Sci 22 (20), 11085 (2021)
   PUBMED   34681759
  REMARK    GeneRIF: Histone Demethylase KDM7A Contributes to the Development
            of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9553)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9553)
  AUTHORS   Higashijima,Y., Nagai,N., Yamamoto,M., Kitazawa,T., Kawamura,Y.K.,
            Taguchi,A., Nakada,N., Nangaku,M., Furukawa,T., Aburatani,H.,
            Kurihara,H., Wada,Y. and Kanki,Y.
  TITLE     Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster
  JOURNAL   Commun Biol 3 (1), 725 (2020)
   PUBMED   33257809
  REMARK    GeneRIF: Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9553)
  AUTHORS   Huang,C., Chen,J., Zhang,T., Zhu,Q., Xiang,Y., Chen,C.D. and
            Jing,N.
  TITLE     The dual histone demethylase KDM7A promotes neural induction in
            early chick embryos
  JOURNAL   Dev Dyn 239 (12), 3350-3357 (2010)
   PUBMED   20981832
REFERENCE   7  (bases 1 to 9553)
  AUTHORS   Yokoyama,A., Okuno,Y., Chikanishi,T., Hashiba,W., Sekine,H.,
            Fujiki,R. and Kato,S.
  TITLE     KIAA1718 is a histone demethylase that erases repressive histone
            methyl marks
  JOURNAL   Genes Cells 15 (8), 867-873 (2010)
   PUBMED   20629981
  REMARK    GeneRIF: The KIAA1718, a PHF2/PHF8 subfamily member, possesses
            histone demethylase activity specific for H3K9 and H3K27,
            transcriptionally repressive histone marks.
REFERENCE   8  (bases 1 to 9553)
  AUTHORS   Tsukada,Y., Ishitani,T. and Nakayama,K.I.
  TITLE     KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and
            functions in brain development
  JOURNAL   Genes Dev 24 (5), 432-437 (2010)
   PUBMED   20194436
  REMARK    GeneRIF: a JmjC domain-containing protein that catalyzes
            demethylation of both mono- or dimethylated H3K9 and H3K27 [KDM7]
REFERENCE   9  (bases 1 to 9553)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 9553)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042834.1, BC145848.1, AK129429.1, AC153818.5 and AW549902.2.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001033430.5.
            
            On Nov 15, 2007 this sequence version replaced NM_001033430.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.134946.1, BC145848.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-969               AK042834.1         2-970
            970-5540            BC145848.1         860-5430
            5541-6487           AK129429.1         3883-4829
            6488-9065           AC153818.5         62923-65500
            9066-9553           AW549902.2         1-488               c
FEATURES             Location/Qualifiers
     source          1..9553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.87 cM"
     gene            1..9553
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /note="lysine (K)-specific demethylase 7A"
                     /db_xref="GeneID:338523"
                     /db_xref="MGI:MGI:2443388"
     exon            1..333
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2962
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /EC_number="1.14.11.65"
                     /note="jmjC domain-containing histone demethylation
                     protein 1D; lysine-specific demethylase 7; jumonji C
                     domain-containing histone demethylase 1 homolog D;
                     [histone H3]-dimethyl-L-lysine9 demethylase 7A"
                     /codon_start=1
                     /product="lysine-specific demethylase 7A"
                     /protein_id="NP_001028602.2"
                     /db_xref="CCDS:CCDS51753.1"
                     /db_xref="GeneID:338523"
                     /db_xref="MGI:MGI:2443388"
                     /translation="MAGAAAAVAAGAAAGAAAAAGSVSAPGRASAPPPPPPVYCVCRQ
                     PYDVNRFMIECDVCKDWFHGSCVGVEEHHAVDIDLYHCPDCAALHGSSLMKKRRNWHR
                     HDYTEVDDGSKPVQAGTRAFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFDVPI
                     MVPKLDDLGLRLPSPAFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPD
                     RPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQD
                     SYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTNENLALYESWSSSVTQSEVFFGDKVDK
                     CYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPD
                     LFKFPFFEAICWFVAKSLLETLKELKEDGFQPQSYLVQGVKALHTALKLWMKKELVSE
                     HAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRPSNEASPPYHSR
                     RKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDLLSSKLNGKFNKHLQPSST
                     VPEWRAKDNDLRLLLTNGRIIKDERQLFADRSLYTADSENEEDKKPTQNANMKTEQSS
                     GREEAESQGSPKPLNRIFTSVRSELRSRPSEYSDGSDSEDSGPDCTALKINFATEDSE
                     SSGDEKKHEITSHFKEESDIVRNLLQKSQKPSRQEIPVKRECPTSTSTEEEAIQGMLS
                     MAGLHYSSCLQRQIQSTDCSGEKNSLQDPSSCHGSNPEFRQLYRCNKPVEFGYHAKTE
                     DQDLMTSSWNKQFDRTSRFNAQDLSRSQKHIKKESSSEINQKAQSRHCVDSNSSSIQN
                     GKYTLNPSLVSCQISNGSLSPERPIGETSFSMPLHPTKRPASNPPPISNQATKGKRPK
                     KGMATAKQRLGKILKLNRNGHARFFV"
     exon            334..419
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            420..537
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            538..698
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            699..840
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1027
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1190
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1278
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1385
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1477
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1567
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1777
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1902
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2057
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2155
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2304
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2513
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2599
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2867
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..9553
                     /gene="Kdm7a"
                     /gene_synonym="A630082K20Rik; Jhdm1d; mKIAA1718"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgccgcc gctgctgctg ccgccgccgc cgccgccggg gctgctgctc cggctgctgc
       61 aggaggcggc gctggctggc ggctgcgctc gctccagtca gcgagcggag gagcgagcgt
      121 gtgtgtgtgt tttttaaaga tggccggagc ggcggcggcg gtggccgcgg gagcagcagc
      181 tggagccgcc gcggcagcgg ggtcggtgtc cgctccgggt cgggcctcgg cgccccctcc
      241 gcctccgccc gtgtactgtg tatgccggca gccgtacgac gtgaaccgct tcatgatcga
      301 gtgcgatgtc tgcaaggact ggttccacgg cagctgtgtt ggcgtggaag agcatcatgc
      361 tgtggacatt gacctgtacc actgcccgga ctgtgcagct ctacacggct cttccttaat
      421 gaagaagagg aggaactggc acaggcatga ctacacagaa gtggatgatg gctccaaacc
      481 tgttcaagct ggaactaggg cctttgttaa agaactacgt tctcgagtct tcccaagtgc
      541 cgatgaaatc attgtaaaga tgcatggcag tcagctgaca caaagatatc tggagaaaca
      601 tggatttgat gtccctatta tggtccctaa attagatgac cttggactca ggctcccttc
      661 acctgctttt tcagtgatgg atgtggaacg ttatgtaggt ggtgacaaag tgatagatgt
      721 tattgatgtg gcaaggcagg cggacagcaa aatgacactt cacaattatg ttaaatactt
      781 catgaatcct gacagaccaa aagtgctaaa tgtgatcagc cttgaatttt cggatacaaa
      841 aatgtctgaa ttggtggagg ttcctgatat agccagaaaa ctttcatggg tggaaaatta
      901 ctggccagat gattcagtct tccccaagcc ctttgtccag aaatactgct taatgggagt
      961 tcaagatagc tatacagatt tccacattga ctttggtggg acttcagtct ggtaccatgt
     1021 cctttggggt gagaagattt tttatttgat aaagccaaca aatgaaaatt tggcactcta
     1081 tgaatcttgg agttcatctg tgacccagag tgaggtgttc tttggagata aagtagataa
     1141 atgctacaaa tgtgtggtaa agcagggaca tactttgttt gttcctacag ggtggatcca
     1201 tgctgtgctc acttctcagg actgtatggc ttttggaggg aactttctgc acaacctcaa
     1261 cattggcatg cagctcaggt gttatgagat ggaaaaaaga ctaaaaacac cagatctttt
     1321 caaatttcct ttctttgaag ccatatgctg gtttgtagcc aaaagtttgc tggaaacctt
     1381 gaaagaactg aaagaagatg gtttccagcc tcaaagttac ttagtacagg gagtaaaagc
     1441 actgcatact gctttaaaat tatggatgaa aaaagaactt gtatctgaac atgcctttga
     1501 gattccagac aatgttagac ctgggcatct tattaaggaa ctttctaaag taattcgagc
     1561 aatagaggag gaaaatggca aaccagttaa atctcaggga attccttctg tgtgtccagt
     1621 ttcacggcct tcaaatgagg catctccacc atatcattcc cggagaaaga tgaggaaact
     1681 tcgagatcat aatgtccgaa ctccttctaa ccttgacatt cttgagctcc atacaaggga
     1741 agtcctcaaa agattagaga tgtgtccatg ggaggaggac ctactgagct ctaaactgaa
     1801 tggaaaattc aacaaacatc tccagccatc ttccacagta cctgagtgga gagcgaaaga
     1861 taatgatcta cgattactgc tgacaaatgg aagaataatt aaagatgaga gacagctgtt
     1921 tgcagatcga agtctttata cagcagatag tgaaaatgaa gaggacaaga agccaacaca
     1981 gaatgcaaac atgaagacag aacagagctc aggaagagag gaggccgaaa gtcaaggctc
     2041 tcccaaacca ctcaacagaa tctttacaag tgtgagatcg gaactcagga gtagaccgtc
     2101 agaatattct gatggttctg attcagaaga ctctggaccc gactgcactg cactgaaaat
     2161 taactttgcc actgaagatt ctgaaagttc aggtgatgaa aagaaacatg aaataacatc
     2221 acactttaaa gaagagtctg atatagtgag gaacctcctt cagaagagcc agaagccatc
     2281 tagacaggaa atcccagtta aaagggaatg tcctacctcg acgagcacag aggaagaagc
     2341 tattcagggc atgctgtcca tggcagggtt gcactattcc tcgtgtttac aaaggcagat
     2401 acaaagcaca gattgcagtg gtgagaagaa ctctctccag gatcccagca gctgccacgg
     2461 cagtaaccct gagtttaggc agttgtatcg ctgcaataaa ccagtggaat ttggatacca
     2521 tgccaagact gaagatcagg atttgatgac ttcttcctgg aataaacagt ttgatcgaac
     2581 ttccagattt aatgctcagg acttaagtag aagccagaaa cacatcaaaa aggaaagctc
     2641 ttcagaaatc aatcagaagg cacaaagcag gcattgtgtg gacagcaata gctcaagcat
     2701 tcagaatgga aagtacacgc tgaatcccag cttggtttca tgccagataa gtaatggcag
     2761 cctgagccca gaaaggccta ttggtgaaac ttctttttca atgccccttc accccaccaa
     2821 gagacctgca tcaaacccac cacctatcag caaccaggca acaaaaggta aacgtccaaa
     2881 aaaaggaatg gcaacagcca aacaacgtct tgggaagatt ctgaaattga acagaaatgg
     2941 ccatgctcgc ttcttcgtgt gacagagctg ctggtacagt cactcttccc tttggatgcc
     3001 ggtctcgggg cgtggaagcc ggagttcccc ctccccctgc ctggagcagt ttgtgtgtac
     3061 agtatgaata ctgcctgaag aacagaatgg acctgatgct gcattttcac tgtgccacac
     3121 ccactcagca ataacccttg gacctggtgg ggagaggaag gcagagggta gtagaacctt
     3181 aaaaagagac cttgaactgg aaaggggtct cttgtcaggg cttgaattta attttgttgt
     3241 tggtagtgtc ttgattttat ttttcagtag taggataaag aattatcaat aatttattta
     3301 acagattttt ttttaaagtt aacagctttt aatttctttc ttttttttaa agctatttat
     3361 ttggaagatt tctggagaaa tatctcacta atttagattt aagaatgtga aggtttttaa
     3421 attatttttg atagtgtgtg tgttacatgt ggagaagagc cgcagtaaca gtagctagtc
     3481 tggactctta aatttgatat tcaggttaaa gtcttaaaca gggatttgat gcattaatta
     3541 ttttaaatta agatgtatat gaaatcattt tattttatat atttcatgtg tttttataag
     3601 ctattagctt cgcttttgct aacatccaag gtgcatacta taatccaggt tgattccctt
     3661 ataccctacc ttccctctgc agcccagtcc ccaatgtttt gagacaaccc aagactcttc
     3721 tctttgcagg gaaacatgtt catagccaat gttaaagaac cacataaaag agtcctcatt
     3781 tctcatttct tttgacattg tggttttctt ctacaagtaa cgaatctggc ttgttttatt
     3841 ttcatttttc tgggtcccaa agagaacagc tttaatgtct ttttcctgct tatagggaaa
     3901 gtataagttt ggttaaaatg tcatgtttgt tgtctttcca aaaaccttta taattacaga
     3961 gggccttctt caatactgct ggtgttggaa gagccaacat ctatcacagg cttttattat
     4021 ctagacatca tttttttaag aaatacaatt tgatttagga tgttcaaatc tgcataaaag
     4081 ccgtaatata taccatatta agttgtataa tagcaagcat gttggaatag atctttgtgt
     4141 gtgtgtgtgt gtatgctact tttttttttt taattttctg aagaattaat actgatttgg
     4201 agtaaaatgg gtgcttttgc agtttcttcc atatgtcttg gctagtagga tatggaggtt
     4261 aagtgactgg gtgaacttta agataataat ttatctcctt tatgtacaat ttttacttaa
     4321 atgcaatttt tcagtggctt ataatagttt ttagtatctc cattttcccc tcatgacata
     4381 aaaataagtt gatattgggg gtctgatgat accacatttt acaaattcct acaaagacaa
     4441 tataggcaaa taacatgaaa tttattttta tggagaaata tggctatata atggatttgt
     4501 tcttttcaat tcagcaaggc aggtagactt ttacttctgt attaagcatt aagttgaaag
     4561 gaaataatta tgcaccatta tctttcatag ttgcattcaa aatacgtatt tccaaagaga
     4621 aacatttctt attctgtctc ttttacaata tttaatggga taaggaagtt acgaattcac
     4681 cttctggtcc agattgtctg gaccaaagtt tccattgtat tttgagtgtc cggaagaagg
     4741 atttttaagg agttcttcat atctgtagat agcatcccta gcccctgcct acacaatgcc
     4801 ataactagtg gagagaggga tacagtcagc tggttgttgt atttcaacat gcagaaatct
     4861 gaatgtgact gatcactcac ctttccacaa tatatcactg tgatgtctta gtttcctgtc
     4921 ttattgttag atcacatatt tttatttggg ttaaaaaata atagtgatga cttctttttc
     4981 cagttatgat ctagatttgt tttaaacaac tcaaaatatt ttaattattt tgctttttgg
     5041 ccttaaaagt taaaatttat tcttatgaat taaaattatg gccagtatct tccctgtgcc
     5101 cttaggctga tgaacactaa ttttgggttg ccacatatgt agtgttttaa atgacagttt
     5161 tgtggattca ttttaaaaaa tcattttagc ctattaatgg actaaatgac aaaactttta
     5221 gccagttaat atagccacta tgaaagaatc caggtatatt tcttcactga taaaaattca
     5281 gctacacagc caatgatttt tctagtcaaa cttcttctaa agttctccat ctgtggtgtg
     5341 tccttttatc tcatagaaat ggctggactt tgaagtgtga ctactgctag gatctgggct
     5401 cagtaatagg tagtctctgt ctttcccata ttctcacaag tagtataccg cagcttaagt
     5461 cagaagatat tggcgatagc attagttagc tataagcaaa taaaatgtgt aaaattgaga
     5521 aacagcgact tgcacatgca gctttaatag tagtggtgac cctgtcttaa ttcagctaag
     5581 tgacccttaa cctgggatct actgtactgt aattttcaac actatagaat attatgctcc
     5641 ccagtattgg tgaatggtta gcaatacaaa actggcagct tagtagttca ggatctttgg
     5701 aatacattga aattcataaa tgaagttcat ttttgaagca cacaattcaa atcattaact
     5761 cagacgagac aagtccattt atatggctaa atacttagct tgaatactct tctgtatttt
     5821 actaatccta attaattcct tttccatgta ttttactgta cttatccata agagatcagc
     5881 aggtattatc agacactcac tgagtgctca gaaatagtga ggactgtgag gaacctcaag
     5941 ttcagttttg tctgtccgtt tgtctgtccg tgaaggtgtc ttctccagga ggtttgcagt
     6001 gttgttttga cttctaaaca aagttgagca gaaggtggcc catttgtaaa cagaacaaac
     6061 aaaacaaaac ccaacttcat tagtttcaat gagatatacc actgtagaag tggaagtgtt
     6121 taaaaacaaa atactcaagt tctttaacat ttaagaaaaa ttctagccgg gcagtggtgg
     6181 tgcacgcctt taatcccagc acttgggagg cagaggcaag tggacttctg agttcgaggc
     6241 cagcctggtc tacagagtaa attccaggac agccagggct acacagagaa accctgtctc
     6301 aaaaaaaaaa aaaaaaaaag aaagaaaaga aaaattctag cctggcagtg gtggtgctcg
     6361 cctttaatct cagcacttgg gaggcagaca gaggcaggca gatttctgag ttctaggaca
     6421 gcctagtcta cagagtgagt tccaggacag ccagggctac agagaaaccc tctgtgggaa
     6481 aaccaggaaa agaaaagaaa aattctacaa gttagtcatt tctgtatggt atagcttgga
     6541 aggaagcaaa agacctgtat tttagtccat gttctgccag ttatcagcca agcaatgctg
     6601 agtcagtaga ttattctgaa tcttatcttt taagtcccag ttttcttgtt tgtgactgtg
     6661 gattaaaaac tactcaatga agaaacagca ttcttcaggt attatgttat gtcatacttg
     6721 gttaattatt aagttacaac tgatgatgaa tgcacctttc gagagtactt ttaagtaaaa
     6781 atatacaccc aggacatgct atctaaaaat ctgacaaatt cctaacaagg tgctgaatta
     6841 gaatcaggtt ttatccttga agtgaaagaa aaagaaatga gcttcattgt ggacagatga
     6901 gtgagagcat ccatcagcaa gtcatcgatg gttagttagc acagcagagg agctagcttt
     6961 cggtttttct caaagaggaa ttagtatagt actcttctct atatttggcc tactctttgg
     7021 gtactaaaga taaaagaggt ggtaaattta aaatgattta gcagctaccc atggagttag
     7081 gggaaaaata aggtgatgag gaaaaacctt ttcaaaggca gttgtgggct aggtactatg
     7141 acagcccagg gagagagaga agtcagaagt agtatagaaa ggagatgtgt tcagaaatga
     7201 gtgtccactt gcttcagatg tcctgcagtg tgagacagtc cttgggaatc ggtgggaatc
     7261 atgatggcct agtatactgc tgccagagag acaccatagc aaatgtgcat ttttgctatt
     7321 cacatggaaa catgaaactt cataatgcaa atctaaatct ctctcaaaaa ttcatttttc
     7381 ccattataaa actaattgct ccctatgtaa aagagaatgt ctcgcctttc atatgtgcaa
     7441 ggccctggga cttgatccct agcaccacac agagatcaag aggagctgag gcttctagac
     7501 tgttacgggt gtcctagact ttcatctaat acaatctcaa gaattacaca ttacagcttt
     7561 tgtctaggga gagctagcta gtcaataagg gtgaccagtg taacccagag aggatagatt
     7621 tgcctagaga caccagtggc tttaggatct ctggtatctt gttttcttac atggacccca
     7681 ttctttgaca ctgcggcctc tgcttgtctt gtagacactg tccatatatg ttattgaagc
     7741 tagacaaaaa gaattatact ccctgaattg ctgttgtgcg tagttaccct cagccttact
     7801 actaaccctt tccttatttt gctttcatgc tgtaagtgaa aacaaatatt tgataccctt
     7861 tctataaaca tttttttaaa ggtttttaag aagcaaatgt ccatttccaa agcagctggc
     7921 atatcatcag taccacggct ttattcttct atagtaagtc tcccctcttt actggggaga
     7981 aaaaaaattc tcactggaga aacccttagg ttccctgtca cctctggtgc ccttctagtt
     8041 tcttaaggct ttgtcttaac tgtgatatta cacttatgtt taaaacctct taaaggtgta
     8101 ttcgaggatt cttccaacca atgtatctgc tctgcactat tcattaatgg aaccctggct
     8161 accacgtagc ccctgacctc caagtagttt acctatgcaa gacctgtgac actctggatt
     8221 cattttccat tacagaaagc agtcattaat gtgatttaat cataaagatt tgtcttcaag
     8281 ttttttcctt ttttttttca aaatatcagc tatttccctc tgtatttttt accaaaacaa
     8341 ttatcataag tgctagaata tatactattt tgcaggaata aaataaccaa gacataatat
     8401 atttctttgg tggattttgt tttgtaagaa atgccagcac taactatata gagttgattc
     8461 tttgcctaga ataatttttt tcccttttaa gagtcataag taacatttta ttttcacaaa
     8521 gcatgcatat aacttacaca atatagtcag ggacctgagg tgtaacttgc taagtgaacc
     8581 ccaaggttat tttatcttgc aaaagaaacc taaaccaaac taagggcctt acagtttatg
     8641 gttagactga atcaaatgct gtaacctcag tttttccaaa aacagctctt gactgcacaa
     8701 gcaggtcatg cagttgttaa gtatgaaata gcactgatag gaaatgcatg tgcatctttg
     8761 cagactgtat ttcctttgga aaagactttt ctacttttaa tataattaag ccataacagt
     8821 ttcatgctgt ggaaaggatg aaaaggttca ttttaagaga ttatatagta tgaactttca
     8881 catttattgt gaaacatcta actttgccag tgttcagcaa gttttctttt ggggtgttgg
     8941 agggtggtaa tggggagggg tagtgttggt tttaggggtt ttaactatgt gaaatttgaa
     9001 atcaggacag ttgttggcta tggtacttac tagttttgta gtaatgtttt gctagcctga
     9061 ctttccttac tggtttttat gtccatggtc cccggtgact gttactcttg tttggggtgt
     9121 gtgcatagta gtgtctcatc tgtgtgtagg cagtcagtgt atgcacacgg tgtgacagtg
     9181 gaacggggtg tggctgggag tggggtgctg gagctttaag agcatttgtt tttattcaga
     9241 acagtatttc ccatcttttg cctgcaggca gggaaagtgt acagtattta ttttgtttct
     9301 gttttactct gaatttgtaa gtctctaagt agcttatatt attattatag ggaagataag
     9361 tgacttgctt aaagttgtat ttagtattct tactttctaa tttctgtatt ttaaaatatt
     9421 gaaattaaaa ttgtattact tttgttctga tttttttagc actcagtgta ttctttgctc
     9481 attttgtcta aaagtataaa tgttgaaagt tgtataaaaa tgtctgaaag aaaaaaatct
     9541 gaattctata tac
//
