LOCUS       NM_001017426            6830 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus KDM1 lysine (K)-specific demethylase 6B (Kdm6b), mRNA.
ACCESSION   NM_001017426 XM_006532898 XM_126426
VERSION     NM_001017426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6830)
  AUTHORS   He,X.B., Guo,F., Zhang,W., Fan,J., Le,W., Chen,Q., Ma,Y., Zheng,Y.,
            Lee,S.H., Wang,H.J., Wu,Y., Zhou,Q. and Yang,R.
  TITLE     JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and
            aggravates chronic inflammatory pain
  JOURNAL   Acta Neuropathol Commun 12 (1), 201 (2024)
   PUBMED   39716224
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6830)
  AUTHORS   Salman,B., Bon,E., Delers,P., Cottin,S., Pasho,E., Ciura,S.,
            Sapaly,D. and Lefebvre,S.
  TITLE     Understanding the Role of the SMN Complex Component GEMIN5 and Its
            Functional Relationship with Demethylase KDM6B in the
            Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal
            Muscular Atrophy
  JOURNAL   Int J Mol Sci 25 (18), 10039 (2024)
   PUBMED   39337533
  REMARK    GeneRIF: Understanding the Role of the SMN Complex Component GEMIN5
            and Its Functional Relationship with Demethylase KDM6B in the
            Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal
            Muscular Atrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6830)
  AUTHORS   Brauer,B., Ancaten-Gonzalez,C., Ahumada-Marchant,C., Meza,R.C.,
            Merino-Veliz,N., Nardocci,G., Varela-Nallar,L., Arriagada,G.,
            Chavez,A.E. and Bustos,F.J.
  TITLE     Impact of KDM6B mosaic brain knockout on synaptic function and
            behavior
  JOURNAL   Sci Rep 14 (1), 20416 (2024)
   PUBMED   39223259
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6830)
  AUTHORS   Wolf,S.J., Audu,C.O., Moon,J.Y., Joshi,A.D., Melvin,W.J.,
            Barrett,E.C., Mangum,K., de Jimenez,G.S., Rocco,S., Buckley,S.,
            Ahmed,Z., Wasikowski,R., Kahlenberg,J.M., Tsoi,L.C.,
            Gudjonsson,J.E. and Gallagher,K.A.
  TITLE     Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3
            Expression via IL-1R Signaling
  JOURNAL   Diabetes 73 (9), 1462-1472 (2024)
   PUBMED   38869447
  REMARK    GeneRIF: Diabetic Wound Keratinocytes Induce Macrophage
            JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling.
REFERENCE   5  (bases 1 to 6830)
  AUTHORS   Yao,Y., Du,J., Wang,D., Li,N., Tao,Z., Wu,D., Peng,F., Shi,J.,
            Zhou,W., Zhao,T. and Tang,Y.
  TITLE     High-intensity interval training ameliorates postnatal immune
            activation-induced mood disorders through KDM6B-regulated glial
            activation
  JOURNAL   Brain Behav Immun 120, 290-303 (2024)
   PUBMED   38851307
  REMARK    GeneRIF: High-intensity interval training ameliorates postnatal
            immune activation-induced mood disorders through KDM6B-regulated
            glial activation.
REFERENCE   6  (bases 1 to 6830)
  AUTHORS   Hong,S., Cho,Y.W., Yu,L.R., Yu,H., Veenstra,T.D. and Ge,K.
  TITLE     Identification of JmjC domain-containing UTX and JMJD3 as histone
            H3 lysine 27 demethylases
  JOURNAL   Proc Natl Acad Sci U S A 104 (47), 18439-18444 (2007)
   PUBMED   18003914
  REMARK    GeneRIF: UTX and JMJD3 may function as H3K27 demethylases in vivo
            GeneRIF: JMJD3 demethylates di- and trimethylated lysine 27 of
            histone H3 in vitro and in cells.
REFERENCE   7  (bases 1 to 6830)
  AUTHORS   Jepsen,K., Solum,D., Zhou,T., McEvilly,R.J., Kim,H.J., Glass,C.K.,
            Hermanson,O. and Rosenfeld,M.G.
  TITLE     SMRT-mediated repression of an H3K27 demethylase in progression
            from neural stem cell to neuron
  JOURNAL   Nature 450 (7168), 415-419 (2007)
   PUBMED   17928865
  REMARK    GeneRIF: data reveal that SMRT represses expression of JMJD3, a
            direct retinoic-acid-receptor target that functions as a histone H3
            trimethyl K27 demethylase and which is capable of activating
            specific components of the neurogenic program
REFERENCE   8  (bases 1 to 6830)
  AUTHORS   De Santa,F., Totaro,M.G., Prosperini,E., Notarbartolo,S., Testa,G.
            and Natoli,G.
  TITLE     The histone H3 lysine-27 demethylase Jmjd3 links inflammation to
            inhibition of polycomb-mediated gene silencing
  JOURNAL   Cell 130 (6), 1083-1094 (2007)
   PUBMED   17825402
  REMARK    GeneRIF: Jmjd3 binds polycomb group protein target genes and
            regulates their histone H3 lysine 27 trimethylation levels and
            transcriptional activity. Provides a link between inflammation and
            reprogramming of the epigenome.
REFERENCE   9  (bases 1 to 6830)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 6830)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596125.27.
            
            On or before Jun 8, 2018 this sequence version replaced
            XM_006532898.1, NM_001017426.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL596125.27        73356-73533         c
            179-319             AL596125.27        70872-71012         c
            320-437             AL596125.27        66003-66120         c
            438-581             AL596125.27        65597-65740         c
            582-723             AL596125.27        65365-65506         c
            724-822             AL596125.27        65080-65178         c
            823-1042            AL596125.27        64764-64983         c
            1043-1135           AL596125.27        64575-64667         c
            1136-1297           AL596125.27        64323-64484         c
            1298-1501           AL596125.27        64036-64239         c
            1502-1852           AL596125.27        63598-63948         c
            1853-4020           AL596125.27        61345-63512         c
            4021-4147           AL596125.27        61129-61255         c
            4148-4253           AL596125.27        60917-61022         c
            4254-4459           AL596125.27        59415-59620         c
            4460-4524           AL596125.27        59256-59320         c
            4525-4596           AL596125.27        59098-59169         c
            4597-4745           AL596125.27        58854-59002         c
            4746-4860           AL596125.27        58602-58716         c
            4861-5048           AL596125.27        58332-58519         c
            5049-5190           AL596125.27        58046-58187         c
            5191-5317           AL596125.27        57535-57661         c
            5318-5488           AL596125.27        57279-57449         c
            5489-6830           AL596125.27        55847-57188         c
FEATURES             Location/Qualifiers
     source          1..6830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.6 cM"
     gene            1..6830
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /note="KDM1 lysine (K)-specific demethylase 6B"
                     /db_xref="GeneID:216850"
                     /db_xref="MGI:MGI:2448492"
     exon            1..178
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..319
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..437
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..581
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..723
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..5512
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /EC_number="1.14.11.68"
                     /note="jumonji domain containing 3; jmjC domain-containing
                     protein 3; jumonji domain-containing protein 3; [histone
                     H3]-trimethyl-L-lysine(27) demethylase 6B"
                     /codon_start=1
                     /product="lysine-specific demethylase 6B"
                     /protein_id="NP_001017426.1"
                     /db_xref="CCDS:CCDS24895.1"
                     /db_xref="GeneID:216850"
                     /db_xref="MGI:MGI:2448492"
                     /translation="MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRSSWLPG
                     GRCSASVGQPPLSAPLPPSHGSSSGHPNKPYYAPGTPTPRPLHGKLESLHGCVQALLR
                     EPAQPGLWEQLGQLYESEHDSEEAVCCYHRALRYGGSFAELGPRIGRLQQAQLWNFHA
                     GSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPS
                     GEEGLSPGGKRRRGCSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPPPLPGLAISPPF
                     QLTKPGLWNTLHGDAWGPERKGSAPPERQEQRHSMPHSYPYPAPAYSAHPPSHRLVPN
                     TPLGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRP
                     PGLPGTSSSSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEISPHQARLGPSAHSSR
                     KPFLTAPAATPHLSLPPGTPSSPPPPCPRLLRPPPPPAWMKGSACRAAREDGEILGEL
                     FFGAEGPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHNPPIPPTTTSSSSSSNSHSSS
                     PTGPVPFPPPSYLARSIDPLPRPSSPTLSPQDPPLPPLTLALPPAPPSSCHQNTSGSF
                     RRSESPRPRVSFPKTPEVGQGPPPGPVSKAPQPVPPGVGELPARGPRLFDFPPTPLED
                     QFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQQEAGVAPPPPLKEPFASLQPPFP
                     SDTAPATTTAAPTTATTTTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPQPPPPP
                     PASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVA
                     PSAQGSPKPSVSSSSQFSTSGGPWAREHRAGEEPAPGPVTPAQLPPPLPLPPARSESE
                     VLEEISRACETLVERVGRSAINPVDTADPVDSGTEPQPPPAQAKEESGGVAVAAAGPG
                     SGKRRQKEHRRHRRACRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGRE
                     KARPDVGGVSKVKTPTAPAPPPAPAPAAQPTPPSAPVPGKKTREEAPGPPGVSRADML
                     KLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKN
                     AKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
                     DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQ
                     IWPCESSRSHTTIAKYAQYQASSFQESLQEERESEDEESEEPDSTTGTSPSSAPDPKN
                     HHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYM
                     KVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWW
                     PILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLA
                     LERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESL
                     VRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAG
                     LQGVVVLEQYRTEELAQAYDAFTLAPASTSR"
     exon            724..822
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1042
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1135
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1297
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1501
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1852
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..4020
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4147
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4253
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4459
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4524
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4596
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4745
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4746..4860
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4861..5048
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5190
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5317
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5488
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5489..6830
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6451..6456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /note="hexamer: AATAAA"
     regulatory      6456..6461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /note="hexamer: AATAAA"
     polyA_site      6471
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /note="major polyA site"
     polyA_site      6486
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /note="major polyA site"
ORIGIN      
        1 ccgggactca gggacgggga ggaggaggga gggaggcaga ggctgcaagc gccggggcag
       61 gcccaggagg cagaggaggg accgtctccc ccgcccccca gcccccactc ccccccctgc
      121 tgcttccccc tccctacccg gactctgggg gcaccgccgg gggacagaca cccagcaggt
      181 tcccccaggc accatgtcag cctcatagca ggacccaccc cacgacttct gctgtagccc
      241 ataggaccca ccccacttct gctgtaaccc actgctggag tgcttgttcc atgagacagt
      301 ccacttccaa ctccatctgg ctgttactga ggcggagaca agggtgatga ttggctttct
      361 gtggatagag aagtcttgtg attggctaaa tttctgaagc tcttgaagct gtgagaggac
      421 gctcccacgg aggctggaat tggttgcaga aggccagaga ctgtcacctg gaaacagtgg
      481 gcactattgt taagggcagt tggagctgga ccatcgtgcc agagagctgg ggcagggggc
      541 cgtgccccat ctccagggct cctggggcca ctgctgacct ggctggatgc atcgggcagt
      601 ggaccctcca ggggcccgct ctgcacggga agcctttgcc cttgggggct tgagctgtgc
      661 tggggcttgg agctcctgcc caccccatcc tcctccccga agctcatggc tgcccggagg
      721 cagatgctct gccagcgttg ggcagccccc actctcagct cctttacccc catctcatgg
      781 cagtagctcc gggcacccta acaaacccta ttatgctcct gggacaccca ccccaagacc
      841 ccttcacggg aagttggaat ccctacatgg ctgtgtccag gcattgctcc gggagccagc
      901 gcagccaggg ttgtgggaac agcttggaca gttgtatgaa tcagagcacg acagtgagga
      961 agccgtatgc tgctaccata gggcccttcg ctatggagga agcttcgccg agctgggacc
     1021 ccggattggc cgcttgcagc aggcccagct ctggaacttt catgccggtt cctgtcagca
     1081 cagagccaag gtcctgcctc ccctggagca agtctggaat ttgctgcacc ttgagcacaa
     1141 acggaactat ggggctaagc gagggggccc tccagtgaag agatctgctg aaccccccgt
     1201 ggtccagcct atgcctcctg cagccctctc aggcccctca ggagaggagg gccttagccc
     1261 tggaggcaag cgcaggagag gctgcagctc tgaacaggct ggccttcccc caggtctgcc
     1321 actccctcca ccacccccac ccccaccgcc tccaccacca ccaccacccc ctccaccacc
     1381 accgctgcct ggcctggcta ttagcccccc atttcagctg actaagccag ggctgtggaa
     1441 taccctgcat ggagatgctt ggggccccga gcgcaagggt tcagcgccgc cagagcgcca
     1501 ggagcagcgg cactcgatgc ctcattcata tccataccca gctcccgcct actccgctca
     1561 tccgcccagc catcggctgg tccccaacac accccttggt ccaggtcccc gacccccagg
     1621 agcagagagc catggctgcc tgcctgccac ccgtcccccc ggaagtgacc ttagagagag
     1681 cagagttcag aggtcgcgga tggactccag cgtttcacca gcagcatcta ccgcctgcgt
     1741 gccttacgcc ccttcccggc cccctggcct ccccggcacc agcagcagca gcagcagcag
     1801 cagtagcagt aacaacactg gtcttcgggg tgtggagcca agcccaggca ttcctggcgc
     1861 tgaccattac caaaaccctg cgctggagat atcccctcac caggcccgcc tgggtccctc
     1921 cgcacacagc agtcggaaac catttttgac ggcccctgct gccacgcccc acttatccct
     1981 accccctggg accccatcat cccctccacc cccatgtcct cgcctcttgc gccctccacc
     2041 gccccctgct tggatgaagg gctcagcctg ccgtgcagcc cgagaggatg gagagatctt
     2101 aggggagctc ttctttggtg ctgagggacc tccccgtcct cctcccccac cccttcccca
     2161 ccgtgatggc ttcttggggc ctccaaaccc ccgcttttct gtgggcactc aggattcgca
     2221 taaccctccc attcccccaa ccaccaccag cagcagcagc agcagcaaca gccacagcag
     2281 tagtcctact gggccggtgc cctttccacc accctcctat ctggccagaa gtatagaccc
     2341 cctccccagg ccatccagcc caaccttgag cccccaggac ccacctcttc caccactgac
     2401 tcttgccctg cctccagccc ctccctcctc ctgccaccaa aatacctcag gaagcttcag
     2461 gcgctcggag agcccccggc ccagggtctc cttcccaaag acccccgagg tggggcaggg
     2521 gccaccccca ggccctgtga gtaaagcccc ccagcctgtg ccacctgggg ttggagagct
     2581 gcctgcccga ggcccgaggc tctttgattt cccacccact ccgctggagg accagtttga
     2641 agagccagcc gaattcaaga tcctacctga tgggctggca aacatcatga agatgctgga
     2701 tgaatccatt cggaaggagg aggagcagca gcagcagcag gaggcaggcg tggctccccc
     2761 acccccactc aaagagccct ttgcatctct acagcctcca tttcccagtg acacagcccc
     2821 agccaccacc actgctgccc ccaccaccgc caccaccacc acaaccacca ccaccaccac
     2881 cacccaagaa gaggagaaga agccaccacc agccctacca ccaccaccgc ctctagccaa
     2941 gtttcctcca cctccccagc cacagccccc accacctcca ccagccagcc cagccagcct
     3001 gctcaaatcg ttggcctctg ttcttgaggg acaaaagtac tgttaccggg ggactggagc
     3061 agccgtctca accaggcccg ggtccgtgcc cgccactcag tattccccta gtcctgcatc
     3121 aggtgctacc gccccaccac ccacttcagt ggcccctagt gcccagggct cccccaagcc
     3181 ctcggtttcc tcgtcatctc agttctctac ctcaggcggg ccttgggccc gggagcacag
     3241 ggcgggtgaa gagccagcac caggccccgt gacccctgcc cagttgcccc cacctctgcc
     3301 gctgccccct gctcgttctg agtctgaggt gctagaagaa atcagtcggg cttgtgagac
     3361 ccttgtagag cgggtgggcc ggagtgccat caacccagtg gacacggcag acccagtgga
     3421 cagtgggact gagccacagc cgccgcctgc gcaggccaag gaggagagtg ggggggtggc
     3481 ggtagcagca gcaggtccag gtagtggcaa gcgtcgtcaa aaggagcatc ggcggcacag
     3541 gcgggcctgt agggacagtg tgggtcgacg accccgcgag gggagggcca aggccaaggc
     3601 caaggctccc aaagaaaaaa gccgaagggt gctggggaac ctcgacttgc agagtgagga
     3661 gatccagggc cgggagaagg cccggcccga tgtcggtggg gtttccaaag tcaagacacc
     3721 cacagctcca gcacccccgc ctgctcctgc acccgctgct cagccaacac ccccatcagc
     3781 tcctgtccct gggaagaaga ctcgtgagga ggctccgggg cctccaggtg tgagccgggc
     3841 agatatgctg aagctccggt cacttagtga ggggcctccc aaggagctga agatcaggct
     3901 catcaaggtg gaaagtgggg acaaggagac ctttatcgcc tctgaggtgg aagagcggcg
     3961 gctgcgcatg gcagacctca ccatcagcca ctgtgccgcc gatgtcatgc gtgccagcaa
     4021 gaatgccaag gtgaaaggga aattccgaga gtcctacctg tcccctgccc agtctgtgaa
     4081 acccaagatc aacactgagg agaagctgcc ccgggaaaaa ctcaaccccc ctacccccag
     4141 catctatttg gagagcaaac gagatgcctt ctcgccggtc ctgctacagt tctgtacaga
     4201 cccccggaac cccatcaccg tcatcagggg cctggctggt tcacttcggc tcaacttagg
     4261 ccttttctcc accaagactc tggtggaggc gagcggtgaa catacggtgg aggtccgtac
     4321 ccaagtacag cagccctcag acgagaactg ggacctgaca ggtaccagac aaatctggcc
     4381 ctgtgagagc tcccgttccc acaccaccat cgctaaatac gcacagtacc aggcctcgtc
     4441 cttccaggag tcactgcagg aggagaggga gagtgaggat gaggaatccg aggaaccaga
     4501 cagcactaca ggaacctctc ccagcagtgc accggacccc aagaaccatc acatcatcaa
     4561 gtttggcact aacatcgacc tgtctgatgc caagaggtgg aagccacagc tacaggagct
     4621 gctgaaactg cccgccttca tgcgggtaac atccacaggc aacatgctca gccacgtggg
     4681 ccacaccatc ctgggcatga acaccgtgca gctatacatg aaggtccctg gcagccgaac
     4741 gccaggccac caagagaata acaatttctg ctcagtcaac atcaacattg gccctgggga
     4801 ctgcgagtgg ttcgcggtac atgagcacta ttgggagacc atcagcgcct tctgcgaccg
     4861 gcatggtgtg gactacttga ctggttcctg gtggccaatc ttggatgacc tctatgcgtc
     4921 caatattcct gtttaccgct tcgtgcagcg ccctggagac cttgtgtgga ttaatgcagg
     4981 gactgtacat tgggtgcagg ctaccggctg gtgcaacaac attgcctgga acgtggggcc
     5041 cctcaccgcc tatcagtacc agctggccct ggagcgatat gagtggaacg aggtgaagaa
     5101 cgtcaagtcc attgtgccca tgattcatgt gtcctggaac gtcgctcgaa cggtcaagat
     5161 cagcgatcct gacttgttca agatgatcaa gttctgcctc ctgcagtcaa tgaagcactg
     5221 tcaggtacag cgggagagcc tggtgcgggc agggaagaag atcgcttacc aaggccgtgt
     5281 caaagacgag cctgcctact actgcaacga atgcgacgtg gaggtgttca acatcctgtt
     5341 cgttacaagt gagaatggca gccgaaacac gtacctggtg cactgcgagg gctgtgcgcg
     5401 ccgtcgcagc gcgggcctac agggcgtggt ggtgctagag cagtaccgca cggaggagct
     5461 ggcgcaggcc tacgatgcct tcacactggc tcccgccagc acgtctcgat gaggccggac
     5521 gccccgctcg cccgcccacg ctgggcgcgg cggggccacc agcacacgcc tgggctggac
     5581 ctaggtcccg cctctggccg ggaagggggt cgggcccagc ccttccaccc tattggcagc
     5641 tcccctcact taatttatta agaaaaaaaa aatgtttttt ttttaacaaa tacgaggaaa
     5701 aaaaaaggaa aaaaaatggg agacggggag ggggctggca gcctctcgcc caccagcgcc
     5761 tcccctcacc gactttggcc tttctagcaa cagacacaag gaccaggctc cggcggcggc
     5821 gggggtcaca tacgggttcc ctcaagcctg cccgccgcgc gcccgcccgc cgcccgccgg
     5881 cgcagacgtt cgcggctcgt tgtgtacata gacgttcggc agccgaggtt tttaatgaga
     5941 ttctctctat gggctttacc cctacccctg gacctccttt tttttttttt tttttttttt
     6001 ttttttactt ccaatgctag ctgtgatccc tgtatatgtc tcttgtttat tcacttggtt
     6061 atgattcgta tttttgttct ttttgttttt tggtttttaa tttataacag tcccactcac
     6121 ctctatttat tcattttttt tttctctttt tttgggaaaa cccgacctct tacatcccca
     6181 agccatccct cctgcctctt tgggaggccc actcctgggc cttccctgcg ccccagtatg
     6241 tccgggcttg gcccgtctgt ctccgcccgc ccgcggctcc agccgggctc tcatggtgct
     6301 caaacctgct cccctcccct acgtcctgca ctttcttgga ccagtacccc cactcccgac
     6361 ccaaccccga ccccacctga gggtgagcga ctcctgtact gtaggggaag aagtgggaac
     6421 tgaaatggta ttttgtaaaa aaaataaata aataaaataa aaagttttaa agaactatga
     6481 ggaaaagaaa ccctgtcctc cccagcctcg gccattttaa aaacattgga cacacacaca
     6541 cacacacaca cacacacctt ttttaaggcg tgaaacatcc cagggcaggg cctctctggg
     6601 gcagggacac cctggggtga ttttctctgg ggctttattt tcattttctt agttcggttt
     6661 ttttcccccc cgctggggct gcggaggggt gggggggttt acagtcccgc cccctcgcac
     6721 tgcactgtct ctctgcccca ggggcagagg ggggcttccc attcctaccc tattttcggt
     6781 gatttttgtg tgagaatatt attaaaaata aaagcaggaa aaaaaaaaaa
//
