LOCUS       NM_011419               5471 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus lysine (K)-specific demethylase 5D (Kdm5d), mRNA.
ACCESSION   NM_011419 XM_489864
VERSION     NM_011419.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5471)
  AUTHORS   Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen
            CD, Guo S, Zhang D and Zhao D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5471)
  AUTHORS   Kosugi M, Otani M, Kikkawa Y, Itakura Y, Sakai K, Ito T, Toyoda M,
            Sekita Y and Kimura T.
  TITLE     Mutations of histone demethylase genes encoded by X and Y
            chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy
            in mice
  JOURNAL   Biochem Biophys Res Commun (2020) In press
   PUBMED   32081420
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 5471)
  AUTHORS   Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K,
            Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q,
            Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ,
            Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX and
            Ikawa M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   4  (bases 1 to 5471)
  AUTHORS   Mizukami H, Kim JD, Tabara S, Lu W, Kwon C, Nakashima M and
            Fukamizu A.
  TITLE     KDM5D-mediated H3K4 demethylation is required for sexually
            dimorphic gene expression in mouse embryonic fibroblasts
  JOURNAL   J Biochem 165 (4), 335-342 (2019)
   PUBMED   30541083
  REMARK    GeneRIF: these data not only suggest an importance of
            KDM5D-mediated demethylation of H3K4 involved in the sexually
            dimorphic gene expression in male MEFs, but also may provide
            information regarding sex-dependent changes in gene expression when
            MEFs are used for experiments.
REFERENCE   5  (bases 1 to 5471)
  AUTHORS   Shao GB, Chen JC, Zhang LP, Huang P, Lu HY, Jin J, Gong AH and Sang
            JR.
  TITLE     Dynamic patterns of histone H3 lysine 4 methyltransferases and
            demethylases during mouse preimplantation development
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (7), 603-613 (2014)
   PUBMED   24619213
REFERENCE   6  (bases 1 to 5471)
  AUTHORS   Laval SH, Glenister PH, Rasberry C, Thornton CE, Mahadevaiah SK,
            Cooke HJ, Burgoyne PS and Cattanach BM.
  TITLE     Y chromosome short arm-Sxr recombination in XSxr/Y males causes
            deletion of Rbm and XY female sex reversal
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10403-10407 (1995)
   PUBMED   7479793
REFERENCE   7  (bases 1 to 5471)
  AUTHORS   Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E
            and Mitchell MJ.
  TITLE     Identification of a mouse male-specific transplantation antigen,
            H-Y
  JOURNAL   Nature 376 (6542), 695-698 (1995)
   PUBMED   7544442
REFERENCE   8  (bases 1 to 5471)
  AUTHORS   Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL
            and Bishop CE.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   9  (bases 1 to 5471)
  AUTHORS   Agulnik AI, Mitchell MJ, Lerner JL, Woods DR and Bishop CE.
  TITLE     A mouse Y chromosome gene encoded by a region essential for
            spermatogenesis and expression of male-specific minor
            histocompatibility antigens
  JOURNAL   Hum Mol Genet 3 (6), 873-878 (1994)
   PUBMED   7524912
REFERENCE   10 (bases 1 to 5471)
  AUTHORS   Burgoyne,P.S., Levy,E.R. and McLaren,A.
  TITLE     Spermatogenic failure in male mice lacking H-Y antigen
  JOURNAL   Nature 320 (6058), 170-172 (1986)
   PUBMED   3951555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134433.3, BB647801.1, AB221607.1, CF728912.1, AC145392.2,
            CA316252.1 and BQ921842.1.
            
            [WARNING] On Apr 20, 2023 this sequence was replaced by
            NM_011419.4.
            
            On May 24, 2006 this sequence version replaced NM_011419.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF127244.1, SRR1660811.125559.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC134433.3         91342-91669
            329-529             BB647801.1         327-527
            530-2543            AB221607.1         356-2369
            2544-2788           CF728912.1         268-512
            2789-3147           AC145392.2         92112-92470         c
            3148-3604           CA316252.1         56-512
            3605-4201           AC145392.2         88460-89056         c
            4202-4483           BQ921842.1         184-465
            4484-5471           AC145392.2         86472-87459         c
FEATURES             Location/Qualifiers
     source          1..5471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..5471
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /note="lysine (K)-specific demethylase 5D"
                     /db_xref="GeneID:20592"
                     /db_xref="MGI:MGI:99780"
     exon            1..328
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4825
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /EC_number="1.14.11.67"
                     /note="jumonji, AT rich interactive domain 1D (Rbp2 like);
                     H-Y; protein SmcY; histone demethylase JARID1D;
                     histocompatibility Y antigen; jumonji/ARID
                     domain-containing protein 1D; selected mouse cDNA on the
                     Y; [histone H3]-trimethyl-L-lysine(4) demethylase 5D"
                     /codon_start=1
                     /product="lysine-specific demethylase 5D"
                     /protein_id="NP_035549.1"
                     /db_xref="CCDS:CCDS30541.1"
                     /db_xref="GeneID:20592"
                     /db_xref="MGI:MGI:99780"
                     /translation="MKPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERKILDLYSLNKIVMEEGGYEAICKDRRWARVAQRLNYPSGKNIGSLLRSHYERI
                     IYPYEIFQSGANLVQCNTDPFDSEERDKEYKPHSIPLRQSVQPSKFSCYSRRGKRLQP
                     EPEPTEEDIEKNPELKKLQIYGAGPKMIGLGLKAKEKTLRKKDSKQPDKEEVTCPATI
                     VVKGEASEFGKVTSAFSDKNLNHSFEPCMKMTMQLRNNHSSTQFMNSYVCRICSRGDE
                     VDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPKCILAECKSPPEAFGFEQATQEYT
                     LQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVSSIEEDVTVEYGADIHSKEFGS
                     GFPVNNSKWDLSPEEKEYAACGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFS
                     AFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLTPELFDSQPDLLHQL
                     VTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPV
                     GRQCIEHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKT
                     LLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDSLVCLSHINDLCKCS
                     RNRQYLRYRYTLDELPAMLQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALES
                     EARDRRFPNSELLQRLKKCLTEAEACISQVLGLISNSEDRLQTPQITLTELQLLLKQM
                     GTLPCTMHQIDEVKDVLQQVESYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEA
                     HQLEELLEQAQWLDQVKQALAPSGQRHSLVIMKKLLVMGTKVASSPSVNKARAELQEL
                     LTIAECWEEKAHFCLKASQKHSPATLEVIIREAENIPVYLPNIQSLKEALTKAQAWIA
                     DVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEELRQLENQVLTAHSWKEKASKTFLKK
                     NSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELLGLSAQDLRDPGSVIMAF
                     KEGEEKEKEGILHLRHINSAKPSPMSSSMNASATSICICGQVCAGVESLQCDLCHDWF
                     HGQCVTVPHLLSSVRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRLETILSLLVGLQR
                     LSVRLPEGEALQCLTERAIGWQGRARQALASEDVTALLKQLEKSRQQLQDELRHKKPP
                     TLPSGFAFDCLTENSGKDILKEEEELVLNEERIKSSEKIVPKESSCKGDKELLPSLLS
                     QLTGPVLELPEATRAPLEELMMEGDLLEVTLDENYSIWQLLQAGQNPNLERIHTLLEL
                     EKPENPGNWSEEQTPERRRQRRQKVVLSRKGEDFTQKELESKRVKSSRIKPKEEKFQK
                     PILGDNVLYTHHTEHTNILKEHINSVQGKDPSPSSSFPSLTPLLHLSYFHQQKL"
     exon            329..406
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            407..529
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            530..700
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            701..835
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            836..974
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1138
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1297
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1417
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1576
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1758
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1921
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2041
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2236
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2418
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2543
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2691
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2788
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3147
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3286
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3466
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3604
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..4201
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            4202..4283
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            4284..4483
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..5471
                     /gene="Kdm5d"
                     /gene_synonym="HY; Jarid1d; Smcy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattgtgat ctaaaaatgg tggaaccgaa cgaggaggtg aatatttgta agaatgtgga
       61 attaagcaaa ctctgaaatt tagaagaaaa taaagttcct gggtgccacg cagtgagtag
      121 gcaattccat tcgcccttta atatcgaatc actttttata accgcgtttt gagcgaacat
      181 gaagccagga tctgacgact ttctaccgcc gcctgagtgc cctgtgtttg agcccagttg
      241 ggcggaattc cgcgatcctc ttggctatat agctaaaatc agacccattg cggagaaatc
      301 aggcatttgc aagatacgcc cacctgcgga ttggcaacct ccttttgctg tagaagttga
      361 taacttcaga tttactcctc gaattcagag gctaaatgaa ctggaggccc agaccagagt
      421 aaaactgaac tatttggatc agattgcaaa gttctgggaa attcaaggtt cttccttaaa
      481 gatacctaat gtggagagga agatcttgga cctttacagc cttaataaga ttgtgatgga
      541 ggaaggtgga tatgaagcaa tctgcaagga ccgtcggtgg gcccgtgttg cccaacgcct
      601 taattaccca tcagggaaaa acattggttc cctgcttcgg tcccactacg aacggatcat
      661 ttacccttat gaaatatttc agtctggagc taatcttgtg caatgtaaca cagatccatt
      721 tgacagtgaa gaaagagaca aggaatacaa acctcatagc attcctctta gacagtctgt
      781 tcagccatca aaattcagtt gctacagtag acgaggaaaa aggctacagc ctgagccaga
      841 acccacagaa gaagacattg agaaaaaccc agagctaaag aaactacaga tatatggggc
      901 aggccccaag atgataggct tgggcctcaa ggctaaggag aaaactctga gaaagaaaga
      961 tagcaaacaa ccagataaag aagaagtgac atgccctgca actattgtag tgaaggggga
     1021 agccagtgag tttggaaagg tgacatcagc attttcagac aagaacttaa atcacagttt
     1081 tgaaccttgt atgaagatga ctatgcagct acggaacaat cacagcagta cccagtttat
     1141 gaattcatat gtttgccgaa tatgctctcg tggggatgaa gtcgataagt ttctgctctg
     1201 tgatggctgc agtgataatt accacatctt ttgcctattg ccaccgcttt ctgaagtccc
     1261 caagggagta tggagatgcc cgaagtgtat cttagcagag tgtaagagtc cccctgaagc
     1321 ttttggcttt gagcaggcta cacaggagta tactttgcag agttttggtg agatggctga
     1381 ctccttcaag gctgactact tcaacatgcc tgtgcatatg gtacctacag aagttgtgga
     1441 aaaggaattc tggaggctgg tgagcagcat tgaggaggat gtgacagttg aatatggagc
     1501 agacattcac tccaaagaat ttggcagtgg gtttcctgtc aacaatagca aatgggactt
     1561 atctcctgaa gaaaaggaat atgctgcttg tggttggaat ctcaatgtga tgccagtgct
     1621 ggatcagtct gttctctgcc acatcaatgc agacatctca ggcatgaaag tgccctggtt
     1681 atatgtgggc atggtgtttt cagcattttg ttggcatatt gaggatcact ggagttattc
     1741 cattaactac ctgcactggg gtgaaccaaa gacctggtat ggagtacctt cgctagcagc
     1801 agaacactta gaggatgtaa tgaagagact tacaccagag ttgtttgaca gccaacctga
     1861 cctcctgcac caacttgtca ctctgatgaa tcctaacact ctcatgtcac atggagtgcc
     1921 agttgttcgt acaaaccagt gtgcagggga atttgtcatt acttttcccc gtgcttacca
     1981 cagtggcttt aaccaaggct ataactttgc tgaggcagtg aacttttgca ctgccgattg
     2041 gctacctgtt ggacgccagt gtattgaaca ctaccgccga ctccggcgct attgtgtctt
     2101 ctcccatgaa gaacttatct gcaagatggc tgcatttcca gagaagttgg atctaaatct
     2161 agcagtggca gttcacaagg agatgttcat tatggtacag gaggagcgac gcctacgaaa
     2221 gaccttgttg gagaagggca tcacggaagc tgagcgagag gcttttgagc tactcccaga
     2281 tgatgagcgt cagtgcatca agtgtaagac cacgtgtttc ctatcagcct tggcctgtta
     2341 tgactgtcca gatagtcttg tctgcctttc ccatatcaat gatctgtgca agtgctcaag
     2401 gaatcgacag tacttacggt acaggtacac attggatgaa ctgcctgcta tgctacaaaa
     2461 gctgaagatt cgagctgagt catttgacaa ctgggccaac aaagtacaag cagccctaga
     2521 ggtggaggat ggtcggaaac ggagttttga agagctaaga gcattggaat ctgaggctcg
     2581 tgatagacga tttcctaata gtgagctgct tcagcgattg aagaaatgcc taactgaagc
     2641 agaggcttgt atttcccaag ttcttggact gatcagtaac tcagaggaca ggttacaaac
     2701 accgcaaatc acccttactg aactacagct tcttctcaaa cagatgggca ctctgccctg
     2761 taccatgcat cagattgatg aagttaagga tgttcttcaa caggtggaat cataccaaat
     2821 tgagacccgt gaggctctaa cttcactgcc ttacagttta gaaatacttc agtccctgat
     2881 ggaaaagggt cagcagcttc gtgtggaagt gcctgaagct catcaacttg aagagctgtt
     2941 ggagcaggca caatggctag atcaagtgaa gcaggccctg gctccctcag gccagaggca
     3001 ctctttggtt atcatgaaga agcttttagt tatgggaacc aaggtagcct ccagcccttc
     3061 tgtgaacaaa gctcgagcag agttacaaga actgctgact attgcagaat gttgggagga
     3121 aaaggcccat ttttgcttaa aagctagcca aaagcattct ccagccactt tggaagttat
     3181 aatacgtgag gcagaaaaca tccctgtcta cctacctaac atccagtctc tgaaggaagc
     3241 tctgactaag gcacaggctt ggattgctga tgtgaatgag attcaaaatg gtgatcacta
     3301 cccctgtttg gatgatttgg agggccttgt agctgttggt cgggatttac ctgtggagct
     3361 agaggaattg agacagctgg agaatcaggt actaacagca cattcctgga aagagaaagc
     3421 ttctaagact tttcttaaga agaattcttg ctacacattg ttggaggttc tctgcccatg
     3481 tgcagatgct ggttcagtca gcaccaagcg cagtcggtgg attgaaaagg agatgggatt
     3541 atacaaatat gacacagaat tgctggggct gtctgcacag gacctcaggg acccagggtc
     3601 tgtgatcatg gcctttaagg aaggggaaga gaaagaaaag gaaggtatct tgcacttacg
     3661 tcacatcaac tcagccaagc ccagtccaat gtcctcatcg atgaatgcct ctgcaacctc
     3721 catctgtata tgtgggcagg tctgtgcagg agtggaatct ctgcagtgtg atctttgtca
     3781 tgactggttc catggacaat gtgtgactgt accccaccta ctcagctcag taagggccag
     3841 tcatacctca tctcaactgc tagcttggtg ggaatgggac accaagttcc tgtgcccact
     3901 gtgcatgcga tcaaggcgtc cacgcctgga gaccatcttg tcattgctgg taggactaca
     3961 gagactgtct gtaaggctac ctgagggtga ggccctacag tgcctcacag agagagccat
     4021 tggttggcaa ggccgtgcca ggcaggctct agcttctgag gatgtgactg ctttgttgaa
     4081 acagctggaa aaatcccgcc aacaactaca ggatgaattg agacataaga agccccctac
     4141 cttgccttca ggctttgcct ttgactgtct cacagagaat agtggcaagg atatccttaa
     4201 ggaagaggag gagttggtac taaatgaaga aaggattaaa agttctgaga agattgttcc
     4261 aaaggaaagt tcatgtaaag gagataagga actgctgcct tcacttttat cccaattaac
     4321 tggcccagta ctggaactgc ctgaagccac ccgggcaccc ctagaggagc ttatgatgga
     4381 aggagatcta cttgaagtta ccctagatga gaactacagc atttggcagc tgctgcaggc
     4441 tgggcagaat cccaatctag agcgcattca tacacttctg gagcttgaga agcctgaaaa
     4501 cccaggaaat tggtcagagg aacagacacc agagaggcga cggcagagga ggcaaaaggt
     4561 ggttctgagt agaaagggtg aggattttac tcaaaaagag ctagaatcaa aaagagtcaa
     4621 gagttcaagg attaagccta aggaagaaaa gtttcaaaag ccaatacttg gggataatgt
     4681 gctgtacaca caccatacag aacatacaaa catcttaaaa gagcacataa acagtgtaca
     4741 aggaaaggat ccaagccctt catcttcttt tccttcctta acacctttac tacacctatc
     4801 ttattttcat cagcaaaaat tataacaata gtatgtgatt ataacaatag tatgtgattg
     4861 ttcttttttc ctaccttagt cttttccatt ctccctccct tgttctttct ttccttcttc
     4921 tttttcattt ctttctgttg gtcccttcct ttcctccatt ttactctatt cctacagctt
     4981 cctctgccct taatccctca gataccccca aagtatttgt ttcttatcta gagcttgacc
     5041 acaaattatt ttatccttac tcctaataca tttttatgcc ataattccta agaagtattc
     5101 cctgtatgcg tttcccaaaa ttttaccatc aatattcctg ggactagcat agataaagtg
     5161 atgttcttag ttatctctat tctaatctgg agagacaaaa ataaaatttg agaatgataa
     5221 catttattaa tctttatttt taaatccttc atcaatcaca catcaaaaca agtacttatt
     5281 aaaacaagtg tcttttagtt tataattttc attctatttt tctctttggt ttacattcta
     5341 aaagaacgtt gtatttttaa ttcttaagaa aaaggaatat atacagtaat gcaaacttac
     5401 cataattgtt tatttttaat tttgttcctt ttgattttgt tgttaaaaat aaaacagtat
     5461 ggttagaact g
//
