LOCUS       NM_001403073           10884 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus lysine demethylase 5C (Kdm5c), transcript variant 4,
            mRNA.
ACCESSION   NM_001403073 XM_006528772
VERSION     NM_001403073.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10884)
  AUTHORS   Guak,H., Weiland,M., Ark,A.V., Zhai,L., Lau,K., Corrado,M.,
            Davidson,P., Asiedu,E., Mabvakure,B., Compton,S., DeCamp,L.,
            Scullion,C.A., Jones,R.G., Nowinski,S.M. and Krawczyk,C.M.
  TITLE     Transcriptional programming mediated by the histone demethylase
            KDM5C regulates dendritic cell population heterogeneity and
            function
  JOURNAL   Cell Rep 43 (8), 114506 (2024)
   PUBMED   39052479
  REMARK    GeneRIF: Transcriptional programming mediated by the histone
            demethylase KDM5C regulates dendritic cell population heterogeneity
            and function.
REFERENCE   2  (bases 1 to 10884)
  AUTHORS   Zhang,P., Munier,J.J., Wiese,C.B., Vergnes,L., Link,J.C.,
            Abbasi,F., Ronquillo,E., Scheker,K., Munoz,A., Kuang,Y.L.,
            Theusch,E., Lu,M., Sanchez,G., Oni-Orisan,A., Iribarren,C.,
            McPhaul,M.J., Nomura,D.K., Knowles,J.W., Krauss,R.M., Medina,M.W.
            and Reue,K.
  TITLE     X chromosome dosage drives statin-induced dysglycemia and
            mitochondrial dysfunction
  JOURNAL   Nat Commun 15 (1), 5571 (2024)
   PUBMED   38956041
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10884)
  AUTHORS   Audu,C.O., Wolf,S.J., Joshi,A.D., Moon,J.Y., Melvin,W.J.,
            Sharma,S.B., Davis,F.M., Obi,A.T., Wasikowski,R., Tsoi,L.C.,
            Barrett,E.C., Mangum,K.D., Bauer,T.M., Kunkel,S.L., Moore,B.B. and
            Gallagher,K.A.
  TITLE     Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic cells
  JOURNAL   JCI Insight 9 (12), e172959 (2024)
   PUBMED   38912581
  REMARK    GeneRIF: Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10884)
  AUTHORS   Li,H., Kawatake-Kuno,A., Inaba,H., Miyake,Y., Itoh,Y., Ueki,T.,
            Oishi,N., Murai,T., Suzuki,T. and Uchida,S.
  TITLE     Discrete prefrontal neuronal circuits determine repeated
            stress-induced behavioral phenotypes in male mice
  JOURNAL   Neuron 112 (5), 786-804 (2024)
   PUBMED   38228137
REFERENCE   5  (bases 1 to 10884)
  AUTHORS   Karwacki-Neisius,V., Jang,A., Cukuroglu,E., Tai,A., Jiao,A.,
            Predes,D., Yoon,J., Brookes,E., Chen,J., Iberg,A., Halbritter,F.,
            Ounap,K., Gecz,J., Schlaeger,T.M., Ho Sui,S., Goke,J., He,X.,
            Lehtinen,M.K., Pomeroy,S.L. and Shi,Y.
  TITLE     WNT signalling control by KDM5C during development affects
            cognition
  JOURNAL   Nature 627 (8004), 594-603 (2024)
   PUBMED   38383780
  REMARK    GeneRIF: WNT signalling control by KDM5C during development affects
            cognition.
REFERENCE   6  (bases 1 to 10884)
  AUTHORS   Scott,D.M., Ehrmann,I.E., Ellis,P.S., Bishop,C.E., Agulnik,A.I.,
            Simpson,E. and Mitchell,M.J.
  TITLE     Identification of a mouse male-specific transplantation antigen,
            H-Y
  JOURNAL   Nature 376 (6542), 695-698 (1995)
   PUBMED   7544442
REFERENCE   7  (bases 1 to 10884)
  AUTHORS   Sultana,R., Adler,D.A., Edelhoff,S., Carrel,L., Lee,K.H.,
            Chapman,V.C., Willard,H.F. and Disteche,C.M.
  TITLE     The mouse Sb1.8 gene located at the distal end of the X chromosome
            is subject to X inactivation
  JOURNAL   Hum Mol Genet 4 (2), 257-263 (1995)
   PUBMED   7757076
REFERENCE   8  (bases 1 to 10884)
  AUTHORS   Wu,J., Salido,E.C., Yen,P.H., Mohandas,T.K., Heng,H.H., Tsui,L.C.,
            Park,J., Chapman,V.M. and Shapiro,L.J.
  TITLE     The murine Xe169 gene escapes X-inactivation like its human
            homologue
  JOURNAL   Nat Genet 7 (4), 491-496 (1994)
   PUBMED   7951318
REFERENCE   9  (bases 1 to 10884)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Mattei,M.G., Borsani,G., Avner,P.A.,
            Lerner,J.L. and Bishop,C.E.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   10 (bases 1 to 10884)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Lerner,J.L., Woods,D.R. and
            Bishop,C.E.
  TITLE     A mouse Y chromosome gene encoded by a region essential for
            spermatogenesis and expression of male-specific minor
            histocompatibility antigens
  JOURNAL   Hum Mol Genet 3 (6), 873-878 (1994)
   PUBMED   7524912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083816.21.
            
            On Mar 25, 2022 this sequence version replaced XM_006528772.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.20162.1,
                                           SRR17784651.906295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC083816.21        76764-77236         c
            474-551             AC083816.21        72764-72841         c
            552-722             AC083816.21        70278-70448         c
            723-857             AC083816.21        68303-68437         c
            858-981             AC083816.21        65478-65601         c
            982-1163            AC083816.21        65191-65372         c
            1164-1322           AC083816.21        64061-64219         c
            1323-1442           AC083816.21        61927-62046         c
            1443-1601           AC083816.21        61654-61812         c
            1602-1783           AC083816.21        56869-57050         c
            1784-1946           AC083816.21        56613-56775         c
            1947-2066           AC083816.21        48418-48537         c
            2067-2261           AC083816.21        48117-48311         c
            2262-2443           AC083816.21        43736-43917         c
            2444-2568           AC083816.21        43533-43657         c
            2569-2716           AC083816.21        43244-43391         c
            2717-2822           AC083816.21        42474-42579         c
            2823-3181           AC083816.21        41351-41709         c
            3182-3320           AC083816.21        40621-40759         c
            3321-3500           AC083816.21        39943-40122         c
            3501-3638           AC083816.21        39643-39780         c
            3639-4220           AC083816.21        38881-39462         c
            4221-4290           AC083816.21        38545-38614         c
            4291-4490           AC083816.21        38200-38399         c
            4491-10884          AC083816.21        31372-37765         c
FEATURES             Location/Qualifiers
     source          1..10884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..10884
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:20591"
                     /db_xref="MGI:MGI:99781"
     exon            1..473
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..4856
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /EC_number="1.14.11.67"
                     /note="isoform 4 is encoded by transcript variant 4;
                     jumonji, AT rich interactive domain 1C (Rbp2 like);
                     lysine-specific demethylase 5C; histone demethylase
                     JARID1C; jumonji/ARID domain-containing protein 1C; lysine
                     (K)-specific demethylase 5C; selected mouse cDNA on the X;
                     [histone H3]-trimethyl-L-lysine(4) demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C isoform 4"
                     /protein_id="NP_001390002.1"
                     /db_xref="GeneID:20591"
                     /db_xref="MGI:MGI:99781"
                     /translation="MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEIVVEEGGYETICKDRRWARVAQRLNY
                     PPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSV
                     QPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRK
                     KDKEGPECPPTVVVKEELGGDVKMESTSPKTFLEGKEELSHSPEPCTKMTMRLRRNHS
                     NAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAE
                     CKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE
                     EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHIN
                     ADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVM
                     KKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQ
                     GYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAA
                     VHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYD
                     CPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVAL
                     EVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAG
                     PDRVAGLQMTLAELRDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSS
                     PGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLV
                     AGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIP
                     VHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQL
                     ELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSD
                     TELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTASI
                     CVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLPSSPLLAWWEWDTKFLCP
                     LCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTA
                     LLGRLAELRQRLQAESKPEESLAYPSDGGEGTGNMPKVQGLLENGDSVTSPEKVATEE
                     GSDLELLSSILPQLSGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQP
                     PDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSG
                     PEAEEVQEEEELEEETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGSDTSAPFSTLT
                     SRLLMSCPQQPSLQQL"
     exon            474..551
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            552..722
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            723..857
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            858..981
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1163
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1322
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1442
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1601
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1783
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1946
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2066
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2261
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2443
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2568
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2716
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2822
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3181
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3320
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3500
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3638
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..4220
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4290
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4490
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..10884
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5515..5520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      5539
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="major polyA site"
     regulatory      5573..5578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AACAAA"
     polyA_site      5594
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      6297..6302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATGAA"
     polyA_site      6313
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      10699..10704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      10718
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      10862..10867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      10884
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
ORIGIN      
        1 gagacgctga caaaccaaga tggcggtggc agcggtgaaa cctgccgcga ctgggactta
       61 actgtagtag tgaaggcttc agtagttggg aggcagcggt aaggtgtgga agaaacggaa
      121 caggactaag aacctgtaaa aggaacctca gcctgagact tttagagcac ggcacccgcc
      181 cccctaagcc cttgacgggc ggtggccgtc ctgcttaggg cctagactcc gagaagtacc
      241 tcggtttcag acagcggcgg cgccatgcgt ccttaagggc gacctgagcc ctcccgatct
      301 ctggcccagc cctcgggccc accatggagc tggggtccga cgatttccta ccgccgccgg
      361 agtgtccggt gttcgagcct agctgggccg agttccgaga ccctcttggc tacatcgcga
      421 aaatcagacc catcgccgag aagtccggca tttgcaagat ccgcccaccc gcggactggc
      481 agccaccctt tgccgtggaa gtggataact tcaggtttac tccccgaatc cagaggttga
      541 atgagctgga gattgtggtg gaagaaggtg gttatgaaac tatctgcaag gaccgtcgat
      601 gggcccgtgt ggcccagcgt ctcaactacc cacctggcaa aaacattggt tccttgctac
      661 gctctcacta tgaacgcatt gtttatccct atgaaatgta ccagtctgga gccaaccttg
      721 tgcagtgtaa cacacgccca tttgataatg aggaaaagga caaggaatat aaaccccaca
      781 gcatccccct tcgacagtct gtgcagcctt ccaagttcaa cagttatgga cgacgggcaa
      841 agagactaca gcctgatccg gaacccacag aggaagacat tgaaaagaat ccagaactga
      901 agaaattaca gatatatgga gcaggcccca agatgatggg gctgggccta atggccaaag
      961 ataagactct gcggaaaaaa gataaagaag ggcctgagtg tccccccact gtggtggtaa
     1021 aggaggaatt aggtggggat gtcaagatgg aatcaacctc acccaagacc ttcctagaag
     1081 gcaaggagga actgagtcat agccctgagc cctgcaccaa gatgaccatg aggcttcgaa
     1141 ggaaccacag caatgcccag tttattgagt catacgtatg ccgaatgtgt tcccgaggag
     1201 atgaagatga caaactctta ctgtgtgatg gctgtgatga caattaccac atcttttgcc
     1261 tgctgcctcc tttgcctgaa atcccgaaag gtgtctggag gtgtccaaag tgtgtcatgg
     1321 cggagtgtaa gcggccccct gaagcctttg gctttgagca agctacccgg gaatatactc
     1381 tgcagagctt tggagagatg gctgactcct ttaaagctga ctacttcaac atgcctgtgc
     1441 atatggtacc cacagaactt gtagagaagg agttttggcg gctggtgaat agcatcgagg
     1501 aagacgtaac tgtggagtat ggggctgaca tccattccaa agaatttggc agcggtttcc
     1561 ctgtcagtga cagtaagcgg cacctaaccc cagaggagga ggagtatgct acaagtggtt
     1621 ggaacctgaa tgtgatgcct gtattggagc agtctgtact gtgccacatc aatgcagata
     1681 tatctggcat gaaggtaccg tggctgtatg tgggaatggt cttctcagcc ttttgctggc
     1741 atattgaaga tcactggagt tactctatta actacctcca ctggggtgag ccaaaaacct
     1801 ggtatggagt cccatcgctt gcagcggaac acttggaaga agtgatgaag aagctgacac
     1861 ctgagctttt tgatagccag cctgatctcc ttcaccaact cgtcaccctc atgaatccta
     1921 acacgctcat gtcccatggt gtgccggttg tccgcacaaa ccagtgtgca ggagaatttg
     1981 tcatcacttt tcctcgtgct taccacagtg gtttcaacca aggctacaac tttgctgagg
     2041 cagtcaactt ttgcactgct gactggctgc ctgctgggcg ccaatgcatt gagcactacc
     2101 gccgactacg aagatactgt gtcttttctc atgaggagct catttgcaag atggctgcct
     2161 gccctgagaa actggacctg aacctggcag cagctgtaca taaggagatg ttcattatgg
     2221 tgcaagagga gcggcgtcta cgaaaggctc tgttggaaaa aggtatcacc gaggctgagc
     2281 gagaggcttt tgagctgctt ccagatgatg aacgtcagtg cataaagtgc aagaccacat
     2341 gtttcctatc tgccctggct tgctatgact gcccagatgg ccttgtctgc ctttctcaca
     2401 tcaatgacct ctgcaagtgc tccagtagcc gccagtacct tcggtatcgg tacaccttgg
     2461 atgagctccc tgccatgctg cataaactga aagttagagc tgagtccttt gacacctggg
     2521 ctaacaaagt acgagtggcc ctggaggtgg aagatgggcg gaagcgcagc ctggaagaac
     2581 tgagagcact agaatctgag gctcgtgagc gaaggtttcc taacagtgag cttctacagc
     2641 gactgaaaaa ctgcctgagt gaagcagagg cttgtgtgtc ccgggctctg ggattggtca
     2701 gtggccagga agctggccct gacagggtgg ctggcctaca gatgaccctg gctgagctac
     2761 gggattttct gggccagatg aacaacctgc cctgtgccat gcaccagatt ggggatgtca
     2821 agggtattct ggaacaggtg gaagcctacc agactgaggc ccgtgaggcc ctggtctcac
     2881 agccttccag tccagggctg ctgcagtcct tgttggagag aggacaacag ctgggtgtgg
     2941 aggtacctga agcccagcag ctccaaaggc aggtggaaca ggcgcggtgg ctggatgagg
     3001 taaaacgcac gctggctccc tctgcccgaa ggggtaccct ggccatcatg cggggactgt
     3061 tggttgcggg cgccagtgta gcccctagcc ctgctgtgga taaggcccag gcagagcttc
     3121 aggagctgct gaccatcgct gaacgctggg aagagaaagc ccacctctgc ttagaggcca
     3181 ggcagaagca tccaccagcc acacttgagg ccataatcca tgaagcagaa aacatccctg
     3241 ttcacttgcc caatatccag tctctcaagg aggctcttgc taaggcccgg gcatggattg
     3301 ctgatgtgga tgagatccaa aatggtgacc actacccttg cttggatgac ttggagggcc
     3361 tcgtagctgt gggtcgggac ctccctgtgg ggctggagga actgagacag ctagagctac
     3421 aggtattgac agcacactcc tggagagaaa aggcctccaa gaccttcctc aagaagaact
     3481 cctgctatac attattggag gtgctctgcc cgtgtgcaga cgccggctca gacagcacca
     3541 aacgcagccg gtggatggag aaggagctgg ggttgtacaa atctgacaca gagctgttgg
     3601 ggctgtctgc gcaggacctc agggacccag gctctgtgat cgtggccttc aaagaggggg
     3661 agcagaagga gaaggaaggg atactgcagc ttcgtcgtac caactcagcc aagccaagtc
     3721 cactggcact gttgacaaca gcctcctcta cagcttctat ctgcgtgtgt gggcaagtgc
     3781 cagctggggt gggagctctg cagtgtgacc tgtgtcagga ctggttccat gggcgctgtg
     3841 tgacagtacc ccgcctcctc agctcccaga ggtccagtct tccctcatcc ccactgctgg
     3901 cctggtggga atgggacacc aaattcttgt gccctctgtg tatgcgctca cggcgcccac
     3961 gcttggaaac catcctggca ctgctggtag ccctacagag actgcctgtg cggctgcctg
     4021 agggtgaggc tctacagtgc ctcacagaga gagccatcag ctggcaaggc cgtgccagac
     4081 aggttttggc ctctgaggaa gtgactgctc tgttgggacg gctggctgaa ctgcgccaac
     4141 ggctacaggc tgaatccaag cctgaggagt ccctggctta cccttcagat ggtggagagg
     4201 gcactggcaa tatgccgaag gtccaggggc tgttggagaa tggggacagt gtgaccagtc
     4261 ctgaaaaggt agccacagag gagggctcag atctggagct gctatcctca atattaccac
     4321 agttgtctgg ccctgtgttg gaactgcctg aggcaacccg agccccactg gaggaactta
     4381 tgatggaagg ggatctgctt gaggtgaccc tagatgagaa tcatagcatc tggcagctgc
     4441 tgcaggctgg gcagcctcca gacttgaaga gggtccagac acttctggag ctggagaagg
     4501 cagagcgcca tgggagtcgg acacgaggcc gagccctaga gaggagacga cggaggaagg
     4561 tggatcgggg tggggagccg gatgacccgg cacgagagga gctagagcca aagagggtac
     4621 gaagctcagg accagaagcc gaggaagtcc aggaggaaga ggagctggag gaggagactg
     4681 ggggtgaggt ccctcctgta cccttcccca acagtggcag ccccagcatc caggaggacc
     4741 aggatggctt agaaccagtg ttagaggctg gttctgacac ctcagcccct ttctctactc
     4801 tgacttcccg gctgttgatg tcctgcccac agcagccatc tctgcaacaa ttgtgacagt
     4861 ggctgagcct agcacagacc ccaacaaaga tccttccttg gcctcaagga tcctttctga
     4921 ccatcaagcc tgcttcttgg aggtgggcgg gtaggtggag agacttcccc ctcaccacca
     4981 tccccaagat cgtgactttt atattctgac tccaaggtat tgttcagacc tcagctcctg
     5041 ggggccggcc cctggagtcc tgcgtccctg gtaacctcta accagcattc ccagacacca
     5101 gaggcagata gacaggtggg caggggatct actggggctg ggccagcacc attccagaga
     5161 caaatccagg gcacatgcaa actgggggac ctctccctta tccccagttc tgaccctggg
     5221 tcaggccatg ctacactaac cttccctccc cacttcacac ttttgctccc ccccccctcc
     5281 cagtccattt tacttctttc ctctcccctt catcttttcc cttcccctta ctgttccacc
     5341 caggaggagg aaacttcaca tagctgtcct caccctttta ttttaaatga attttgttgg
     5401 ggttgagcag ggctgcctat ggtctgaagg cttttggtgc ttgtccacac acccacctca
     5461 acccttcctg cccatcctcc cctatctcct ttcctcctcc tgggttcatg ctgtaataaa
     5521 gaagattgtt ggtgtgtaat taatttgttc aaaaggagaa aaaaaaaagc aaaacaaact
     5581 ttgtttcaac taaagcctat tttaatttta ttttattatt ttcctcatta gaaataaaac
     5641 ccttaggaat gttttttttt tttttttttt tggaaacatg tttctgaagt gcatttctct
     5701 tcaaaaagag agcagaacct tcctcgcctg ttagtggagc agctgcagtg ccagttagta
     5761 gtagtgccag ggccagggaa gcagggctct gaattcaaat ctcaccaact tctctctaac
     5821 cttggaaaag atatccttcc tggtcttccc ccaagccatt gcagactggt gggcactggc
     5881 cccctttgat aatttgcacg acagcttccc ctagctttgt gctcttgatt ttctattctc
     5941 tgggggactt tttcttcatg gctttattga ggtagagttt ccatgctata aagttgagct
     6001 gttttaaata tgtaatttgg tgagtcagac catccttggt gtttctccat tagttcttcc
     6061 tgcccctaat gaatgtgtgg ttaatttgta acgtctgtgt cactgttaaa ctgctctgtt
     6121 gagatgaaat gtgcatagat acagttcatc cacttcaagt atacaattca gtgactttta
     6181 gtatatttca gtcattgaat cactgcaaaa agtttagact gtttttacaa ccccagaaga
     6241 cattgcctag gtagtccctc cttcctccca tttgtctctt ctggacattt tatataaatg
     6301 aaatgataca atatgcgctc cttttgtgtc tgccttcttt gacttagcct attaacagtc
     6361 ctacagtagt tgtattttcg cccttctgag cctgaaagaa gggactacgc ttgatcaggg
     6421 actgacctct gaaatacatt tatacatgtt tttgtgggta tctatatgca tttttctcag
     6481 attaagaccc accagattgc atcatattca tgaaggaacc ataaccctct aaagactaag
     6541 aacattctta tggttctgag agttctctgt ccagagttta cctaggagat ataggaggaa
     6601 gcaaaagctt ggaggccctg ttttcactag ctaacttcca ggcatccctg gcttctccaa
     6661 ggtttttcct cttctcaagg ttgtatgagg tgttacaggc taaagtcaag tcttgatccc
     6721 tagctcagga actcagcaca ccagcactct tactttgccc ttcctcattt atatgttcag
     6781 aaggattatt ttgctccatt tctccccttt cccaggattt ccagttgcta gaaatgtagt
     6841 gatatatctc actcaccctc tttgggtggc tttcaggggt gggagcatgg cttagacctc
     6901 cctgccttat gagtctttta gtctatgctg aaaggtaaac accaggaaac agggagtacc
     6961 cctgccccag gtccactttg atactaagtt tcaatcaagg gtcttgcctt tgcccagcca
     7021 ttggtttcca gtgagagttg gaggtagcag aagagacacc caaaggagct tgatcttgat
     7081 actttactac cactctagtc caggaagcta ggcacaggaa gaagcggcca aaggaaaggt
     7141 aaagatggtg cctacaacat ctcctaggct agtgaacttc tcaggccaag taggggtcct
     7201 ttgtggtatg ggcctgtccc ttaccaattt tcaggcagcc gttcgcagca tttccctgac
     7261 atatccctta tacactttct gctcctttca cagtgtccat gtagccattt ttgattcaaa
     7321 actgtcttaa ttaggtttct gttgctgtga taaaacacca cggccaaaaa caacttgggg
     7381 aagaaagggt ttatttcatc ttatagcttg tagtccatcc agggaaggag gcaggagcct
     7441 agaggcagga gttgatgcag aggccatgga ggagtgctgc ttactggctt gctcatcatg
     7501 acttgctcag cctacatact gcacccagga ccaccagccc agggatggca cagccctgtg
     7561 agctaggtcc tgcaatatca gacgtcaata aagaaaatgc accctgggct tgcccaaagg
     7621 ccaatctgaa gggggccatt tttcaattgg gctttccctc ctcctctggg agagcaccga
     7681 gtgggcaagt tttacctcag agtcatttag tttacagaca ccatcttgct gctacatcct
     7741 accagacagt tcactcctgc cagggtagca cctgaggatg caggggtgga aagagatact
     7801 gcttctatta aggacaaatc tctctccctc ctcccctgtt ccccattctc ctctcttact
     7861 gagacagagt cagtatccct ggctgtcctg gaactcacta tgtaggccag gctggcctca
     7921 aactcacagg aggcctgcct ctgcctcctg agtgcttgga ttaaagatgt gccaccacat
     7981 ccagcatcta aattcctctc ttggcccaac tctgcatttc ttcctgtgta gcttttcagt
     8041 gtctccactg tgccttaaat catgtccaaa cactaggttt agtgagtttt tttccccaat
     8101 ctacctgaaa gtacctattc tgagagttcc tggaggagaa aaacaagaac caggtctgag
     8161 tcctctgcta cttcaaggct gggggttggg agggtgggaa tcttgtatgg tcagttcaga
     8221 aagaggcaga tcaagcagca tttccagccc tacactgctt gtgaattctg ttccttatgc
     8281 actgtatgaa gtctgctgat ccaggatgac actctggaag tcatttgggt ctggaccaag
     8341 accaccagag ccctgaaaga gaaacattaa ccatgtgtcc tagacctgaa attagggggt
     8401 gcttaaatcc tgggtgccac actcaagtat gtaagatact tggcaagttc tgagtaagca
     8461 tataaggaat agacccctag gataatacgc tgggcccagc caaaacatga cagggttgta
     8521 ataaccattt tcgatgcaaa ataaagccct atttatttca gaggggggtc taagtatggt
     8581 gtgccaccag gctattgttc ataatggaac tgttagtcaa ctgggacatc agcaatgcca
     8641 gctaggtaga agcttgtatt gctattgttc tgtggcatca ttgccatgcc tgtctgtgtt
     8701 cagtgtgtat tactgtaaag cagtaacatg gttggcacat acctttaaaa ccaaacctat
     8761 ggaagtaaga gcaggtaaga ttgcaaattt gaaactagcc tgagttgtag aatgggaccc
     8821 tgtctcaaac aaaagtcaaa actgccattt agctgacttc aaggtcattc acaggcatcc
     8881 atcaagatgt cagccagtgc agctgtcatc ttctggcata ttgggttagg atgtacttag
     8941 aagttctgta gttggcagga ctcagtttct tacaagttca gtttcttgaa tgtgggtgga
     9001 tttttcacag ggcagctcac aatatggctg attgcttcat gagatcaaga tgggcaagaa
     9061 acagaaatga ctatctcaga aataacattc cattgttttt gcaattgaca atattaatta
     9121 gaagccatta ggaggggaaa ggggggaagg tctagaccat attcagaagg aaggaattaa
     9181 gaggatgggg ttcattgggg gggtcatctt ggaaatgaac tattatggtt tgctctctga
     9241 tacttaattt cattaatgtt ccatccatgt acaaaatata tctactcctt aagttttctt
     9301 aagtcccatc ccattactgc ataacctcaa aggtgctaaa tatgaatgaa ttgccttggg
     9361 cacaatccct acatatggct caagtactgt ttttctctat ggatggaact gtgaaatgta
     9421 aaaatacgca ttatccgtcc ctaccacttc ctaatataca atggtgggaa ggcatataca
     9481 gacattccag ttcaaaaagg gcaaaggata tgtgtgtgcc tgtagcagtt ggaaacagga
     9541 gctgtttcca aactggtccg ttacaagtta aatccatctg ggcatatgaa gttccttgaa
     9601 ttgattccaa aactgaggat ggtttttcat acccctgtct ctgctttctg ggctcttgct
     9661 gtcacctgtg atttttttca tgagaggtag cacatgcttg caaccaagat ttttttttct
     9721 gtttcctgcc agaattttgg agggccagga ctgacttctt gcagtgcatg tgtaatcaat
     9781 tatcatcaag gcaaaggact tctttttggc atgttgagca ttcaacagta aactacaatg
     9841 agattggcct tcagggcaac cctgacttag agcccatgcc tgctatcatg gccactttgt
     9901 tcagaagcct attggcaaag ataacggtga caggatagag attggccaca cccatagaat
     9961 ggaatatctc ttttgagatt ttctatactg gtgcttgttt acgtgggtca tgaaaattct
    10021 cactgtgctc attccaaaat ggacagctat ttgcataggc ctttttcctc agatgtctct
    10081 tcaacatttc agtcttgtta tttccaaatc cttgactgta tgcagacatg aaccagcaag
    10141 ctgtctatgc ttttgactgt ttctgtaata gtaacccaaa gtggagctgt aactctgaaa
    10201 ctagccactt gtagcagagg ctagcatgtc ctgcagaaca tctgtaagcc aagcgtgaat
    10261 attgtatccc tcagttgtct ggtctcaagg aaactcccca tggggtctca aaggaggaaa
    10321 aaaggatgac aatgtagcaa gtgtgagttt ccagacctgc acataatttt agcggacatg
    10381 atggaacagt tgcaaattat tgtttgatgt catggactca gatgttcatt tgagaaaatg
    10441 aaaaagtcca cttttctatt tttatttttc tttgcttctg agatcttgct acttgcagtt
    10501 ttgccctcca tttttgtttg ttttgtctta taaatatgtt gtatcttggg ccagtgagat
    10561 ggcccagtgg gtaaaagtac ttgctacacg agcctggtgg cctgaattca atcccaggga
    10621 tccacgcggt aagagagaat caactcatgc aagttgtcct ggtcaccatt tgtgtgcgtg
    10681 cacacataaa atagatgtaa taaaaataat ttttaaaatg ttgtatctct ttattatttc
    10741 ctgttgaatc ccagaggaga aatgagtctt cctcccctac cagggccctt ctcttcttta
    10801 tgtcatgtat attgtgtata tttacatgat gtatccagaa actggaaaaa tctcctggac
    10861 caataaaatg actcaggaca aaaa
//
