LOCUS       NM_001403071           11016 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus lysine demethylase 5C (Kdm5c), transcript variant 2,
            mRNA.
ACCESSION   NM_001403071 XM_006528769
VERSION     NM_001403071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11016)
  AUTHORS   Guak,H., Weiland,M., Ark,A.V., Zhai,L., Lau,K., Corrado,M.,
            Davidson,P., Asiedu,E., Mabvakure,B., Compton,S., DeCamp,L.,
            Scullion,C.A., Jones,R.G., Nowinski,S.M. and Krawczyk,C.M.
  TITLE     Transcriptional programming mediated by the histone demethylase
            KDM5C regulates dendritic cell population heterogeneity and
            function
  JOURNAL   Cell Rep 43 (8), 114506 (2024)
   PUBMED   39052479
  REMARK    GeneRIF: Transcriptional programming mediated by the histone
            demethylase KDM5C regulates dendritic cell population heterogeneity
            and function.
REFERENCE   2  (bases 1 to 11016)
  AUTHORS   Zhang,P., Munier,J.J., Wiese,C.B., Vergnes,L., Link,J.C.,
            Abbasi,F., Ronquillo,E., Scheker,K., Munoz,A., Kuang,Y.L.,
            Theusch,E., Lu,M., Sanchez,G., Oni-Orisan,A., Iribarren,C.,
            McPhaul,M.J., Nomura,D.K., Knowles,J.W., Krauss,R.M., Medina,M.W.
            and Reue,K.
  TITLE     X chromosome dosage drives statin-induced dysglycemia and
            mitochondrial dysfunction
  JOURNAL   Nat Commun 15 (1), 5571 (2024)
   PUBMED   38956041
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11016)
  AUTHORS   Audu,C.O., Wolf,S.J., Joshi,A.D., Moon,J.Y., Melvin,W.J.,
            Sharma,S.B., Davis,F.M., Obi,A.T., Wasikowski,R., Tsoi,L.C.,
            Barrett,E.C., Mangum,K.D., Bauer,T.M., Kunkel,S.L., Moore,B.B. and
            Gallagher,K.A.
  TITLE     Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic cells
  JOURNAL   JCI Insight 9 (12), e172959 (2024)
   PUBMED   38912581
  REMARK    GeneRIF: Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11016)
  AUTHORS   Li,H., Kawatake-Kuno,A., Inaba,H., Miyake,Y., Itoh,Y., Ueki,T.,
            Oishi,N., Murai,T., Suzuki,T. and Uchida,S.
  TITLE     Discrete prefrontal neuronal circuits determine repeated
            stress-induced behavioral phenotypes in male mice
  JOURNAL   Neuron 112 (5), 786-804 (2024)
   PUBMED   38228137
REFERENCE   5  (bases 1 to 11016)
  AUTHORS   Karwacki-Neisius,V., Jang,A., Cukuroglu,E., Tai,A., Jiao,A.,
            Predes,D., Yoon,J., Brookes,E., Chen,J., Iberg,A., Halbritter,F.,
            Ounap,K., Gecz,J., Schlaeger,T.M., Ho Sui,S., Goke,J., He,X.,
            Lehtinen,M.K., Pomeroy,S.L. and Shi,Y.
  TITLE     WNT signalling control by KDM5C during development affects
            cognition
  JOURNAL   Nature 627 (8004), 594-603 (2024)
   PUBMED   38383780
  REMARK    GeneRIF: WNT signalling control by KDM5C during development affects
            cognition.
REFERENCE   6  (bases 1 to 11016)
  AUTHORS   Scott,D.M., Ehrmann,I.E., Ellis,P.S., Bishop,C.E., Agulnik,A.I.,
            Simpson,E. and Mitchell,M.J.
  TITLE     Identification of a mouse male-specific transplantation antigen,
            H-Y
  JOURNAL   Nature 376 (6542), 695-698 (1995)
   PUBMED   7544442
REFERENCE   7  (bases 1 to 11016)
  AUTHORS   Sultana,R., Adler,D.A., Edelhoff,S., Carrel,L., Lee,K.H.,
            Chapman,V.C., Willard,H.F. and Disteche,C.M.
  TITLE     The mouse Sb1.8 gene located at the distal end of the X chromosome
            is subject to X inactivation
  JOURNAL   Hum Mol Genet 4 (2), 257-263 (1995)
   PUBMED   7757076
REFERENCE   8  (bases 1 to 11016)
  AUTHORS   Wu,J., Salido,E.C., Yen,P.H., Mohandas,T.K., Heng,H.H., Tsui,L.C.,
            Park,J., Chapman,V.M. and Shapiro,L.J.
  TITLE     The murine Xe169 gene escapes X-inactivation like its human
            homologue
  JOURNAL   Nat Genet 7 (4), 491-496 (1994)
   PUBMED   7951318
REFERENCE   9  (bases 1 to 11016)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Mattei,M.G., Borsani,G., Avner,P.A.,
            Lerner,J.L. and Bishop,C.E.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   10 (bases 1 to 11016)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Lerner,J.L., Woods,D.R. and
            Bishop,C.E.
  TITLE     A mouse Y chromosome gene encoded by a region essential for
            spermatogenesis and expression of male-specific minor
            histocompatibility antigens
  JOURNAL   Hum Mol Genet 3 (6), 873-878 (1994)
   PUBMED   7524912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083816.21.
            
            On Mar 25, 2022 this sequence version replaced XM_006528769.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.19020.1,
                                           SRR10223969.20169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC083816.21        76764-77236         c
            474-551             AC083816.21        72764-72841         c
            552-674             AC083816.21        70722-70844         c
            675-845             AC083816.21        70278-70448         c
            846-980             AC083816.21        68303-68437         c
            981-1104            AC083816.21        65478-65601         c
            1105-1286           AC083816.21        65191-65372         c
            1287-1445           AC083816.21        64061-64219         c
            1446-1565           AC083816.21        61927-62046         c
            1566-1724           AC083816.21        61654-61812         c
            1725-1906           AC083816.21        56869-57050         c
            1907-2069           AC083816.21        56613-56775         c
            2070-2189           AC083816.21        48418-48537         c
            2190-2384           AC083816.21        48117-48311         c
            2385-2566           AC083816.21        43736-43917         c
            2567-2691           AC083816.21        43533-43657         c
            2692-2839           AC083816.21        43244-43391         c
            2840-2945           AC083816.21        42474-42579         c
            2946-3304           AC083816.21        41351-41709         c
            3305-3443           AC083816.21        40621-40759         c
            3444-3623           AC083816.21        39943-40122         c
            3624-3761           AC083816.21        39643-39780         c
            3762-4343           AC083816.21        38881-39462         c
            4344-4422           AC083816.21        38536-38614         c
            4423-4622           AC083816.21        38200-38399         c
            4623-11016          AC083816.21        31372-37765         c
FEATURES             Location/Qualifiers
     source          1..11016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..11016
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:20591"
                     /db_xref="MGI:MGI:99781"
     exon            1..473
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..4988
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /EC_number="1.14.11.67"
                     /note="isoform 2 is encoded by transcript variant 2;
                     jumonji, AT rich interactive domain 1C (Rbp2 like);
                     lysine-specific demethylase 5C; histone demethylase
                     JARID1C; jumonji/ARID domain-containing protein 1C; lysine
                     (K)-specific demethylase 5C; selected mouse cDNA on the X;
                     [histone H3]-trimethyl-L-lysine(4) demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C isoform 2"
                     /protein_id="NP_001390000.1"
                     /db_xref="GeneID:20591"
                     /db_xref="MGI:MGI:99781"
                     /translation="MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERRILDLYSLSKIVVEEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERI
                     VYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQP
                     DPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEE
                     LGGDVKMESTSPKTFLEGKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGD
                     EDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREY
                     TLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFG
                     SGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVF
                     SAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQ
                     LVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLP
                     AGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRK
                     ALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKC
                     SSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALE
                     SEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAGPDRVAGLQMTLAELRDF
                     LGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVE
                     VPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLVAGASVAPSPAVDKAQAE
                     LQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIPVHLPNIQSLKEALAKAR
                     AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKT
                     FLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSV
                     IVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTASICVCGQVPAGVGALQCDL
                     CQDWFHGRCVTVPRLLSSQRSSLPSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALL
                     VALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESK
                     PEESLAYPSDGGEGTGNMPKVQGLLENGDSVTSPEKVATEEGSGKRDLELLSSILPQL
                     SGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLKRVQTLLELEK
                     AERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEE
                     ETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGSDTSAPFSTLTSRLLMSCPQQPSLQ
                     QL"
     exon            474..551
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            552..674
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            675..845
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            846..980
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1104
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1286
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1445
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1565
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1724
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1906
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2069
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2189
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2384
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2566
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2691
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2839
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2945
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3304
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3443
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3623
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3761
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..4343
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4422
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4622
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..11016
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5647..5652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      5671
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="major polyA site"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AACAAA"
     polyA_site      5726
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      6429..6434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATGAA"
     polyA_site      6445
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      10831..10836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      10850
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
     regulatory      10994..10999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
                     /note="hexamer: AATAAA"
     polyA_site      11016
                     /gene="Kdm5c"
                     /gene_synonym="D930009K15Rik; Jarid1c; mKIAA0234; Smcx"
ORIGIN      
        1 gagacgctga caaaccaaga tggcggtggc agcggtgaaa cctgccgcga ctgggactta
       61 actgtagtag tgaaggcttc agtagttggg aggcagcggt aaggtgtgga agaaacggaa
      121 caggactaag aacctgtaaa aggaacctca gcctgagact tttagagcac ggcacccgcc
      181 cccctaagcc cttgacgggc ggtggccgtc ctgcttaggg cctagactcc gagaagtacc
      241 tcggtttcag acagcggcgg cgccatgcgt ccttaagggc gacctgagcc ctcccgatct
      301 ctggcccagc cctcgggccc accatggagc tggggtccga cgatttccta ccgccgccgg
      361 agtgtccggt gttcgagcct agctgggccg agttccgaga ccctcttggc tacatcgcga
      421 aaatcagacc catcgccgag aagtccggca tttgcaagat ccgcccaccc gcggactggc
      481 agccaccctt tgccgtggaa gtggataact tcaggtttac tccccgaatc cagaggttga
      541 atgagctgga ggcccagaca agagtgaaac tgaactattt ggaccagatt gccaaattct
      601 gggagatcca gggctcatcc ttaaagattc ccaatgtaga acggcggatc ttggacctct
      661 atagcctcag caaaattgtg gtggaagaag gtggttatga aactatctgc aaggaccgtc
      721 gatgggcccg tgtggcccag cgtctcaact acccacctgg caaaaacatt ggttccttgc
      781 tacgctctca ctatgaacgc attgtttatc cctatgaaat gtaccagtct ggagccaacc
      841 ttgtgcagtg taacacacgc ccatttgata atgaggaaaa ggacaaggaa tataaacccc
      901 acagcatccc ccttcgacag tctgtgcagc cttccaagtt caacagttat ggacgacggg
      961 caaagagact acagcctgat ccggaaccca cagaggaaga cattgaaaag aatccagaac
     1021 tgaagaaatt acagatatat ggagcaggcc ccaagatgat ggggctgggc ctaatggcca
     1081 aagataagac tctgcggaaa aaagataaag aagggcctga gtgtcccccc actgtggtgg
     1141 taaaggagga attaggtggg gatgtcaaga tggaatcaac ctcacccaag accttcctag
     1201 aaggcaagga ggaactgagt catagccctg agccctgcac caagatgacc atgaggcttc
     1261 gaaggaacca cagcaatgcc cagtttattg agtcatacgt atgccgaatg tgttcccgag
     1321 gagatgaaga tgacaaactc ttactgtgtg atggctgtga tgacaattac cacatctttt
     1381 gcctgctgcc tcctttgcct gaaatcccga aaggtgtctg gaggtgtcca aagtgtgtca
     1441 tggcggagtg taagcggccc cctgaagcct ttggctttga gcaagctacc cgggaatata
     1501 ctctgcagag ctttggagag atggctgact cctttaaagc tgactacttc aacatgcctg
     1561 tgcatatggt acccacagaa cttgtagaga aggagttttg gcggctggtg aatagcatcg
     1621 aggaagacgt aactgtggag tatggggctg acatccattc caaagaattt ggcagcggtt
     1681 tccctgtcag tgacagtaag cggcacctaa ccccagagga ggaggagtat gctacaagtg
     1741 gttggaacct gaatgtgatg cctgtattgg agcagtctgt actgtgccac atcaatgcag
     1801 atatatctgg catgaaggta ccgtggctgt atgtgggaat ggtcttctca gccttttgct
     1861 ggcatattga agatcactgg agttactcta ttaactacct ccactggggt gagccaaaaa
     1921 cctggtatgg agtcccatcg cttgcagcgg aacacttgga agaagtgatg aagaagctga
     1981 cacctgagct ttttgatagc cagcctgatc tccttcacca actcgtcacc ctcatgaatc
     2041 ctaacacgct catgtcccat ggtgtgccgg ttgtccgcac aaaccagtgt gcaggagaat
     2101 ttgtcatcac ttttcctcgt gcttaccaca gtggtttcaa ccaaggctac aactttgctg
     2161 aggcagtcaa cttttgcact gctgactggc tgcctgctgg gcgccaatgc attgagcact
     2221 accgccgact acgaagatac tgtgtctttt ctcatgagga gctcatttgc aagatggctg
     2281 cctgccctga gaaactggac ctgaacctgg cagcagctgt acataaggag atgttcatta
     2341 tggtgcaaga ggagcggcgt ctacgaaagg ctctgttgga aaaaggtatc accgaggctg
     2401 agcgagaggc ttttgagctg cttccagatg atgaacgtca gtgcataaag tgcaagacca
     2461 catgtttcct atctgccctg gcttgctatg actgcccaga tggccttgtc tgcctttctc
     2521 acatcaatga cctctgcaag tgctccagta gccgccagta ccttcggtat cggtacacct
     2581 tggatgagct ccctgccatg ctgcataaac tgaaagttag agctgagtcc tttgacacct
     2641 gggctaacaa agtacgagtg gccctggagg tggaagatgg gcggaagcgc agcctggaag
     2701 aactgagagc actagaatct gaggctcgtg agcgaaggtt tcctaacagt gagcttctac
     2761 agcgactgaa aaactgcctg agtgaagcag aggcttgtgt gtcccgggct ctgggattgg
     2821 tcagtggcca ggaagctggc cctgacaggg tggctggcct acagatgacc ctggctgagc
     2881 tacgggattt tctgggccag atgaacaacc tgccctgtgc catgcaccag attggggatg
     2941 tcaagggtat tctggaacag gtggaagcct accagactga ggcccgtgag gccctggtct
     3001 cacagccttc cagtccaggg ctgctgcagt ccttgttgga gagaggacaa cagctgggtg
     3061 tggaggtacc tgaagcccag cagctccaaa ggcaggtgga acaggcgcgg tggctggatg
     3121 aggtaaaacg cacgctggct ccctctgccc gaaggggtac cctggccatc atgcggggac
     3181 tgttggttgc gggcgccagt gtagccccta gccctgctgt ggataaggcc caggcagagc
     3241 ttcaggagct gctgaccatc gctgaacgct gggaagagaa agcccacctc tgcttagagg
     3301 ccaggcagaa gcatccacca gccacacttg aggccataat ccatgaagca gaaaacatcc
     3361 ctgttcactt gcccaatatc cagtctctca aggaggctct tgctaaggcc cgggcatgga
     3421 ttgctgatgt ggatgagatc caaaatggtg accactaccc ttgcttggat gacttggagg
     3481 gcctcgtagc tgtgggtcgg gacctccctg tggggctgga ggaactgaga cagctagagc
     3541 tacaggtatt gacagcacac tcctggagag aaaaggcctc caagaccttc ctcaagaaga
     3601 actcctgcta tacattattg gaggtgctct gcccgtgtgc agacgccggc tcagacagca
     3661 ccaaacgcag ccggtggatg gagaaggagc tggggttgta caaatctgac acagagctgt
     3721 tggggctgtc tgcgcaggac ctcagggacc caggctctgt gatcgtggcc ttcaaagagg
     3781 gggagcagaa ggagaaggaa gggatactgc agcttcgtcg taccaactca gccaagccaa
     3841 gtccactggc actgttgaca acagcctcct ctacagcttc tatctgcgtg tgtgggcaag
     3901 tgccagctgg ggtgggagct ctgcagtgtg acctgtgtca ggactggttc catgggcgct
     3961 gtgtgacagt accccgcctc ctcagctccc agaggtccag tcttccctca tccccactgc
     4021 tggcctggtg ggaatgggac accaaattct tgtgccctct gtgtatgcgc tcacggcgcc
     4081 cacgcttgga aaccatcctg gcactgctgg tagccctaca gagactgcct gtgcggctgc
     4141 ctgagggtga ggctctacag tgcctcacag agagagccat cagctggcaa ggccgtgcca
     4201 gacaggtttt ggcctctgag gaagtgactg ctctgttggg acggctggct gaactgcgcc
     4261 aacggctaca ggctgaatcc aagcctgagg agtccctggc ttacccttca gatggtggag
     4321 agggcactgg caatatgccg aaggtccagg ggctgttgga gaatggggac agtgtgacca
     4381 gtcctgaaaa ggtagccaca gaggagggct caggtaagag agatctggag ctgctatcct
     4441 caatattacc acagttgtct ggccctgtgt tggaactgcc tgaggcaacc cgagccccac
     4501 tggaggaact tatgatggaa ggggatctgc ttgaggtgac cctagatgag aatcatagca
     4561 tctggcagct gctgcaggct gggcagcctc cagacttgaa gagggtccag acacttctgg
     4621 agctggagaa ggcagagcgc catgggagtc ggacacgagg ccgagcccta gagaggagac
     4681 gacggaggaa ggtggatcgg ggtggggagc cggatgaccc ggcacgagag gagctagagc
     4741 caaagagggt acgaagctca ggaccagaag ccgaggaagt ccaggaggaa gaggagctgg
     4801 aggaggagac tgggggtgag gtccctcctg tacccttccc caacagtggc agccccagca
     4861 tccaggagga ccaggatggc ttagaaccag tgttagaggc tggttctgac acctcagccc
     4921 ctttctctac tctgacttcc cggctgttga tgtcctgccc acagcagcca tctctgcaac
     4981 aattgtgaca gtggctgagc ctagcacaga ccccaacaaa gatccttcct tggcctcaag
     5041 gatcctttct gaccatcaag cctgcttctt ggaggtgggc gggtaggtgg agagacttcc
     5101 ccctcaccac catccccaag atcgtgactt ttatattctg actccaaggt attgttcaga
     5161 cctcagctcc tgggggccgg cccctggagt cctgcgtccc tggtaacctc taaccagcat
     5221 tcccagacac cagaggcaga tagacaggtg ggcaggggat ctactggggc tgggccagca
     5281 ccattccaga gacaaatcca gggcacatgc aaactggggg acctctccct tatccccagt
     5341 tctgaccctg ggtcaggcca tgctacacta accttccctc cccacttcac acttttgctc
     5401 ccccccccct cccagtccat tttacttctt tcctctcccc ttcatctttt cccttcccct
     5461 tactgttcca cccaggagga ggaaacttca catagctgtc ctcacccttt tattttaaat
     5521 gaattttgtt ggggttgagc agggctgcct atggtctgaa ggcttttggt gcttgtccac
     5581 acacccacct caacccttcc tgcccatcct cccctatctc ctttcctcct cctgggttca
     5641 tgctgtaata aagaagattg ttggtgtgta attaatttgt tcaaaaggag aaaaaaaaaa
     5701 gcaaaacaaa ctttgtttca actaaagcct attttaattt tattttatta ttttcctcat
     5761 tagaaataaa acccttagga atgttttttt tttttttttt tttggaaaca tgtttctgaa
     5821 gtgcatttct cttcaaaaag agagcagaac cttcctcgcc tgttagtgga gcagctgcag
     5881 tgccagttag tagtagtgcc agggccaggg aagcagggct ctgaattcaa atctcaccaa
     5941 cttctctcta accttggaaa agatatcctt cctggtcttc ccccaagcca ttgcagactg
     6001 gtgggcactg gccccctttg ataatttgca cgacagcttc ccctagcttt gtgctcttga
     6061 ttttctattc tctgggggac tttttcttca tggctttatt gaggtagagt ttccatgcta
     6121 taaagttgag ctgttttaaa tatgtaattt ggtgagtcag accatccttg gtgtttctcc
     6181 attagttctt cctgccccta atgaatgtgt ggttaatttg taacgtctgt gtcactgtta
     6241 aactgctctg ttgagatgaa atgtgcatag atacagttca tccacttcaa gtatacaatt
     6301 cagtgacttt tagtatattt cagtcattga atcactgcaa aaagtttaga ctgtttttac
     6361 aaccccagaa gacattgcct aggtagtccc tccttcctcc catttgtctc ttctggacat
     6421 tttatataaa tgaaatgata caatatgcgc tccttttgtg tctgccttct ttgacttagc
     6481 ctattaacag tcctacagta gttgtatttt cgcccttctg agcctgaaag aagggactac
     6541 gcttgatcag ggactgacct ctgaaataca tttatacatg tttttgtggg tatctatatg
     6601 catttttctc agattaagac ccaccagatt gcatcatatt catgaaggaa ccataaccct
     6661 ctaaagacta agaacattct tatggttctg agagttctct gtccagagtt tacctaggag
     6721 atataggagg aagcaaaagc ttggaggccc tgttttcact agctaacttc caggcatccc
     6781 tggcttctcc aaggtttttc ctcttctcaa ggttgtatga ggtgttacag gctaaagtca
     6841 agtcttgatc cctagctcag gaactcagca caccagcact cttactttgc ccttcctcat
     6901 ttatatgttc agaaggatta ttttgctcca tttctcccct ttcccaggat ttccagttgc
     6961 tagaaatgta gtgatatatc tcactcaccc tctttgggtg gctttcaggg gtgggagcat
     7021 ggcttagacc tccctgcctt atgagtcttt tagtctatgc tgaaaggtaa acaccaggaa
     7081 acagggagta cccctgcccc aggtccactt tgatactaag tttcaatcaa gggtcttgcc
     7141 tttgcccagc cattggtttc cagtgagagt tggaggtagc agaagagaca cccaaaggag
     7201 cttgatcttg atactttact accactctag tccaggaagc taggcacagg aagaagcggc
     7261 caaaggaaag gtaaagatgg tgcctacaac atctcctagg ctagtgaact tctcaggcca
     7321 agtaggggtc ctttgtggta tgggcctgtc ccttaccaat tttcaggcag ccgttcgcag
     7381 catttccctg acatatccct tatacacttt ctgctccttt cacagtgtcc atgtagccat
     7441 ttttgattca aaactgtctt aattaggttt ctgttgctgt gataaaacac cacggccaaa
     7501 aacaacttgg ggaagaaagg gtttatttca tcttatagct tgtagtccat ccagggaagg
     7561 aggcaggagc ctagaggcag gagttgatgc agaggccatg gaggagtgct gcttactggc
     7621 ttgctcatca tgacttgctc agcctacata ctgcacccag gaccaccagc ccagggatgg
     7681 cacagccctg tgagctaggt cctgcaatat cagacgtcaa taaagaaaat gcaccctggg
     7741 cttgcccaaa ggccaatctg aagggggcca tttttcaatt gggctttccc tcctcctctg
     7801 ggagagcacc gagtgggcaa gttttacctc agagtcattt agtttacaga caccatcttg
     7861 ctgctacatc ctaccagaca gttcactcct gccagggtag cacctgagga tgcaggggtg
     7921 gaaagagata ctgcttctat taaggacaaa tctctctccc tcctcccctg ttccccattc
     7981 tcctctctta ctgagacaga gtcagtatcc ctggctgtcc tggaactcac tatgtaggcc
     8041 aggctggcct caaactcaca ggaggcctgc ctctgcctcc tgagtgcttg gattaaagat
     8101 gtgccaccac atccagcatc taaattcctc tcttggccca actctgcatt tcttcctgtg
     8161 tagcttttca gtgtctccac tgtgccttaa atcatgtcca aacactaggt ttagtgagtt
     8221 tttttcccca atctacctga aagtacctat tctgagagtt cctggaggag aaaaacaaga
     8281 accaggtctg agtcctctgc tacttcaagg ctgggggttg ggagggtggg aatcttgtat
     8341 ggtcagttca gaaagaggca gatcaagcag catttccagc cctacactgc ttgtgaattc
     8401 tgttccttat gcactgtatg aagtctgctg atccaggatg acactctgga agtcatttgg
     8461 gtctggacca agaccaccag agccctgaaa gagaaacatt aaccatgtgt cctagacctg
     8521 aaattagggg gtgcttaaat cctgggtgcc acactcaagt atgtaagata cttggcaagt
     8581 tctgagtaag catataagga atagacccct aggataatac gctgggccca gccaaaacat
     8641 gacagggttg taataaccat tttcgatgca aaataaagcc ctatttattt cagagggggg
     8701 tctaagtatg gtgtgccacc aggctattgt tcataatgga actgttagtc aactgggaca
     8761 tcagcaatgc cagctaggta gaagcttgta ttgctattgt tctgtggcat cattgccatg
     8821 cctgtctgtg ttcagtgtgt attactgtaa agcagtaaca tggttggcac atacctttaa
     8881 aaccaaacct atggaagtaa gagcaggtaa gattgcaaat ttgaaactag cctgagttgt
     8941 agaatgggac cctgtctcaa acaaaagtca aaactgccat ttagctgact tcaaggtcat
     9001 tcacaggcat ccatcaagat gtcagccagt gcagctgtca tcttctggca tattgggtta
     9061 ggatgtactt agaagttctg tagttggcag gactcagttt cttacaagtt cagtttcttg
     9121 aatgtgggtg gatttttcac agggcagctc acaatatggc tgattgcttc atgagatcaa
     9181 gatgggcaag aaacagaaat gactatctca gaaataacat tccattgttt ttgcaattga
     9241 caatattaat tagaagccat taggagggga aaggggggaa ggtctagacc atattcagaa
     9301 ggaaggaatt aagaggatgg ggttcattgg gggggtcatc ttggaaatga actattatgg
     9361 tttgctctct gatacttaat ttcattaatg ttccatccat gtacaaaata tatctactcc
     9421 ttaagttttc ttaagtccca tcccattact gcataacctc aaaggtgcta aatatgaatg
     9481 aattgccttg ggcacaatcc ctacatatgg ctcaagtact gtttttctct atggatggaa
     9541 ctgtgaaatg taaaaatacg cattatccgt ccctaccact tcctaatata caatggtggg
     9601 aaggcatata cagacattcc agttcaaaaa gggcaaagga tatgtgtgtg cctgtagcag
     9661 ttggaaacag gagctgtttc caaactggtc cgttacaagt taaatccatc tgggcatatg
     9721 aagttccttg aattgattcc aaaactgagg atggtttttc atacccctgt ctctgctttc
     9781 tgggctcttg ctgtcacctg tgattttttt catgagaggt agcacatgct tgcaaccaag
     9841 attttttttt ctgtttcctg ccagaatttt ggagggccag gactgacttc ttgcagtgca
     9901 tgtgtaatca attatcatca aggcaaagga cttctttttg gcatgttgag cattcaacag
     9961 taaactacaa tgagattggc cttcagggca accctgactt agagcccatg cctgctatca
    10021 tggccacttt gttcagaagc ctattggcaa agataacggt gacaggatag agattggcca
    10081 cacccataga atggaatatc tcttttgaga ttttctatac tggtgcttgt ttacgtgggt
    10141 catgaaaatt ctcactgtgc tcattccaaa atggacagct atttgcatag gcctttttcc
    10201 tcagatgtct cttcaacatt tcagtcttgt tatttccaaa tccttgactg tatgcagaca
    10261 tgaaccagca agctgtctat gcttttgact gtttctgtaa tagtaaccca aagtggagct
    10321 gtaactctga aactagccac ttgtagcaga ggctagcatg tcctgcagaa catctgtaag
    10381 ccaagcgtga atattgtatc cctcagttgt ctggtctcaa ggaaactccc catggggtct
    10441 caaaggagga aaaaaggatg acaatgtagc aagtgtgagt ttccagacct gcacataatt
    10501 ttagcggaca tgatggaaca gttgcaaatt attgtttgat gtcatggact cagatgttca
    10561 tttgagaaaa tgaaaaagtc cacttttcta tttttatttt tctttgcttc tgagatcttg
    10621 ctacttgcag ttttgccctc catttttgtt tgttttgtct tataaatatg ttgtatcttg
    10681 ggccagtgag atggcccagt gggtaaaagt acttgctaca cgagcctggt ggcctgaatt
    10741 caatcccagg gatccacgcg gtaagagaga atcaactcat gcaagttgtc ctggtcacca
    10801 tttgtgtgcg tgcacacata aaatagatgt aataaaaata atttttaaaa tgttgtatct
    10861 ctttattatt tcctgttgaa tcccagagga gaaatgagtc ttcctcccct accagggccc
    10921 ttctcttctt tatgtcatgt atattgtgta tatttacatg atgtatccag aaactggaaa
    10981 aatctcctgg accaataaaa tgactcagga caaaaa
//
