LOCUS       NM_145997              10969 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lysine demethylase 5A (Kdm5a), mRNA.
ACCESSION   NM_145997 XM_359326 XM_925213 XM_979596
VERSION     NM_145997.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10969)
  AUTHORS   El Hayek,L., DeVries,D., Gogate,A., Aiken,A., Kaur,K. and
            Chahrour,M.H.
  TITLE     Disruption of the autism gene and chromatin regulator KDM5A alters
            hippocampal cell identity
  JOURNAL   Sci Adv 9 (47), eadi0074 (2023)
   PUBMED   37992166
REFERENCE   2  (bases 1 to 10969)
  AUTHORS   Kim,D.K., Jeong,H., Bae,J., Cha,M.Y., Kang,M., Shin,D., Ha,S.,
            Hyeon,S.J., Kim,H., Suh,K., Choi,M.S., Ryu,H., Yu,S.W., Kim,J.I.,
            Kim,Y.S., Lee,S.W., Hwang,D. and Mook-Jung,I.
  TITLE     Abeta-induced mitochondrial dysfunction in neural progenitors
            controls KDM5A to influence neuronal differentiation
  JOURNAL   Exp Mol Med 54 (9), 1461-1471 (2022)
   PUBMED   36056186
  REMARK    GeneRIF: Abeta-induced mitochondrial dysfunction in neural
            progenitors controls KDM5A to influence neuronal differentiation.
REFERENCE   3  (bases 1 to 10969)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10969)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10969)
  AUTHORS   El Hayek,L., Tuncay,I.O., Nijem,N., Russell,J., Ludwig,S., Kaur,K.,
            Li,X., Anderton,P., Tang,M., Gerard,A., Heinze,A., Zacher,P.,
            Alsaif,H.S., Rad,A., Hassanpour,K., Abbaszadegan,M.R.,
            Washington,C., DuPont,B.R., Louie,R.J., Couse,M., Faden,M.,
            Rogers,R.C., Abou Jamra,R., Elias,E.R., Maroofian,R., Houlden,H.,
            Lehman,A., Beutler,B. and Chahrour,M.H.
  CONSRTM   CAUSES Study
  TITLE     KDM5A mutations identified in autism spectrum disorder using
            forward genetics
  JOURNAL   Elife 9, e56883 (2020)
   PUBMED   33350388
  REMARK    GeneRIF: KDM5A mutations identified in autism spectrum disorder
            using forward genetics.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10969)
  AUTHORS   Klose,R.J., Yan,Q., Tothova,Z., Yamane,K., Erdjument-Bromage,H.,
            Tempst,P., Gilliland,D.G., Zhang,Y. and Kaelin,W.G. Jr.
  TITLE     The retinoblastoma binding protein RBP2 is an H3K4 demethylase
  JOURNAL   Cell 128 (5), 889-900 (2007)
   PUBMED   17320163
  REMARK    GeneRIF: Study reports that RBP2 is a demethylase that specifically
            catalyzes demethylation on histone H3 lysine 4, whose methylation
            is normally associated with transcriptionally active genes.
REFERENCE   7  (bases 1 to 10969)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   8  (bases 1 to 10969)
  AUTHORS   Ohno,T., Nakajima,K., Kojima,M., Toyoda,M. and Takeuchi,T.
  TITLE     Modifiers of the jumonji mutation downregulate cyclin D1 expression
            and cardiac cell proliferation
  JOURNAL   Biochem Biophys Res Commun 317 (3), 925-929 (2004)
   PUBMED   15081428
  REMARK    GeneRIF: mutation can downregulate cardiac cell proliferation by
            repressing cyclin D1 expression in the same way as jumonji
REFERENCE   9  (bases 1 to 10969)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 10969)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155720.7 and AC078896.23.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_925213.3, XM_979596.2, XM_359326.6, NM_145997.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.7173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-680               AC155720.7         136014-136693
            681-758             AC155720.7         138485-138562
            759-881             AC155720.7         140847-140969
            882-1052            AC155720.7         146732-146902
            1053-1187           AC155720.7         153450-153584
            1188-1293           AC155720.7         154832-154937
            1294-1385           AC155720.7         157537-157628
            1386-1544           AC155720.7         159925-160083
            1545-1664           AC155720.7         160845-160964
            1665-1823           AC155720.7         161468-161626
            1824-2005           AC155720.7         162569-162750
            2006-2168           AC155720.7         166002-166164
            2169-2288           AC155720.7         170853-170972
            2289-2483           AC155720.7         174421-174615
            2484-2665           AC155720.7         176880-177061
            2666-2790           AC155720.7         177775-177899
            2791-2941           AC155720.7         178490-178640
            2942-3056           AC155720.7         180160-180274
            3057-3412           AC155720.7         184070-184425
            3413-3551           AC155720.7         187131-187269
            3552-3731           AC155720.7         190474-190653
            3732-3893           AC155720.7         191315-191476
            3894-4445           AC155720.7         198729-199280
            4446-4589           AC155720.7         199644-199787
            4590-4749           AC155720.7         200133-200292
            4750-4970           AC155720.7         201975-202195
            4971-5381           AC155720.7         203728-204138
            5382-10969          AC078896.23        55751-61338
FEATURES             Location/Qualifiers
     source          1..10969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.95 cM"
     gene            1..10969
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="lysine demethylase 5A"
                     /db_xref="GeneID:214899"
                     /db_xref="MGI:MGI:2136980"
     exon            1..680
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..758
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..881
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1052
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1187
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1293
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1385
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1544
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1664
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1823
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2005
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2168
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2288
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2483
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2665
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2790
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2941
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3056
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3412
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3551
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3731
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3893
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4445
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4589
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4749
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..4970
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4971..5381
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5382..10969
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6661..6666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="hexamer: AGTAAA"
     polyA_site      6684
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="major polyA site"
     regulatory      8135..8140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="hexamer: AATATA"
     polyA_site      8152
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="major polyA site"
     regulatory      8618..8623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      8646
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="major polyA site"
     regulatory      10943..10948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
                     /note="hexamer: AATAAA"
     polyA_site      10969
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a; Rbbp2; RBP2"
ORIGIN      
        1 ggcattacac attcctccgc gcgccggaag cgcgcgttcc accttgcggg gtagcttttc
       61 cctcgcctct cctcgagaga ggtcgcggcg ccttgagggg ccgcgcaccc ggggtggacg
      121 gagggcgcag aactttgaca ggcaagctgt gagaaaacaa aaaaccaaaa taaaacaaaa
      181 aagctccgcc ggccgtcatg gaagggagcg aggagagaag acccgactag acgtggcggc
      241 ggtgggattt tgtttcctgc ggtggcggac tgatttagca gcacgttaac ttccgggagc
      301 gtcctgcccc tgagaggaaa agccctgaag gaaacaataa caaacgagcg gagggagagc
      361 ggctggcgct cctgtgagga ctcgttctcg tcctaagaag atgcgctgcg gccccagtgc
      421 ggggacgtga gagggctttg gtggccgtca gccaagcctt tcctcgcttg tgcacctcag
      481 gcccccctgg ctttttattt tattttttgg tgaccatggc gtccgtgggc ccggggggct
      541 acgcggcgga gttcgtgcca ccgcccgagt gcccggtctt tgagcccagt tgggaggagt
      601 tcacagaccc gctgagtttt atcgggcgca tccggccctt tgcggagaaa acgggcatct
      661 gcaaaatccg gccacccaag gattggcaac ctccatttgc ctgtgaagta aaaaccttcc
      721 gtttcactcc tagagtccag cgcctgaatg aacttgaggc aatgactaga gtaagattgg
      781 acttcttgga tcaactggca aaattttggg aacttcaagg atctacattg aagatccctg
      841 tggtggagag aaaaatcctg gatttgtatg ctttaagcaa gattgttgcc agcaaaggag
      901 gttttgaaat agtcaccaaa gagaagaaat ggtctaaagt gggtagccgc ttgggatatc
      961 tgccaggaaa aggaactggg tctcttttga agtcacacta tgaaagaatt ctctacccat
     1021 atgaactttt ccaatctggt gtcagcctta tgggtgtaca aatgcctgat ttagatctta
     1081 aagaaaaagt tgaggctgag gttctcagca ctgacatcca gccttcccca gagcggggaa
     1141 caagaatgaa tattccacca aagagaacaa gacgagttaa gtctcagtca gactctggag
     1201 aagtaaatag aaacacagaa ctgaagaaac ttcagatttt tggggctgga cccaaagttg
     1261 tgggcctggc agtaggagca aaagataaag aagatgaagt cacccgaaga agaaaagtta
     1321 ccaacaggtc agatgcattt aacatgcaaa tgagacaacg gaaaggaact ctctctgtta
     1381 actttgttga tctctatgtt tgcatgtttt gtggtcgagg aaataatgag gataaactgc
     1441 ttttgtgtga tgggtgcgat gacagctatc atacattttg tctacttcca ccactacctg
     1501 atgtccccaa aggagactgg aggtgtccta aatgtgttgc tgaggaatgt aacaaacctc
     1561 gagaagcctt tggatttgag caagctgtaa gagaatatac acttcaaagc tttggagaga
     1621 tggcagataa ttttaaatct gattatttca atatgccagt ccatatggtt cctacagagc
     1681 tagtagaaaa agaattctgg cggctagtaa gtagcattga agaagatgtt attgtagagt
     1741 atggagctga tatctcttca aaagattttg gaagtggatt tcctaaaaag gatggtcaaa
     1801 gaaagatgtt gccagaagaa gaggaatatg cactttctgg ttggaatttg aataacatgc
     1861 ctgttctgga gcagtccgtt cttgcacata ttaatgtgga catttctggt atgaaggtgc
     1921 catggctcta tgtgggaatg tgcttttctt ctttttgctg gcatattgaa gatcactgga
     1981 gttattccat taactacttg cattggggcg agccaaagac atggtatggt gtaccatctc
     2041 atgctgcaga acaactggag gaggtgatga gggagctggc ccctgagtta tttgaatccc
     2101 agcctgatct cctacatcag ttagtaacca tcatgaaccc aaatgtgctc atggagcatg
     2161 gtgtgcctgt gtacaggact aatcagtgtg ctggagagtt tgtggtgacg tttcctcgtg
     2221 cctatcactc tggatttaac cagggataca actttgccga agcggtgaac ttctgtactg
     2281 ctgactggtt gcccattgga cgtcagtgtg taaatcacta tcgacggctc aggcgccatt
     2341 gtgtcttttc acatgaggaa ctcattttca agatggcagc agatccagaa tgcttagatg
     2401 tggggctggc tgccatggta tgcaaagagt tgactctcat gactgaagaa gaaacacgat
     2461 tgagagaatc agttgttcaa atgggtgtcg tgatgtcaga agaagaagtc tttgaacttg
     2521 ttcctgatga tgagcggcag tgttcagcat gcagaactac atgttttctc tcagctctca
     2581 catgctcctg taatccggag cgacttgtat gtctgtatca tccaactgat ttgtgctctt
     2641 gccccatgca gaacaaatgt cttaggtacc gctatccact agaagacctt ccatctctgc
     2701 tttatggtgt caaagtgaga gcacaatcct atgacacttg ggtcaatcgt gttacagaag
     2761 cattgtcagc tagcttcaac cataagaaag atttgattga attgagagta atgctggaag
     2821 atgctgagga taggaaatac ccagagaatg atctctttcg aaagctcagg gacgcggtga
     2881 aagaagctga gacctgtggt tctgtggctc agctgcttct gagcaaaaag caaaaacaca
     2941 ggcagagctc agatagtggg aagactcgga ccaaactgac agtagaagaa ttgaaggcct
     3001 ttgtccaaca acttgttagt cttccgtgtg tcatcagcca aactcgacaa gtaaagaatc
     3061 tgctggatga tgtagaagaa tttcatgaac gtgcccagga ggccatgatg gatgaaaccc
     3121 cagattcttc caaactccaa atgttaatag acatgggctc tagtctctat gtggagctac
     3181 ctgaattgcc ccgactaaag caagagctcc agcaggctcg atggctggat gaagtaaggc
     3241 taactctatc agatccacaa caagtcactt tggatgtcat gaagaaattg attgactctg
     3301 gcgtaggctt ggcacctcac catgctgtag aaaaagcaat ggccgaacta caggaactcc
     3361 ttacagtctc tgaacgatgg gaagagaagg ctaaggtctg cctgcaagca agacctcggc
     3421 acagtatggc aaatttagaa aatattgtga atgaagccaa gaacattcca gcctttctac
     3481 ccaatgtgtt gtccttaaaa gaagccttac aaaaggctcg tgaatggaca gctaaagtgg
     3541 aagctattca gagtggcaac aactatgctt acttggaaca gcttgagagc ctatctgcta
     3601 aaggacgccc tatccctgtg cgtcttgatg ccttgcctca agtggagtca caggtagcag
     3661 cagcacgggc ctggagagaa cgtactgggc ggaccttcct taaaaagaat tccagccata
     3721 cattgttaca ggtgctaagt ccacgaactg acattggtgt atatgggagt ggtaaaaaca
     3781 ggaggaaaaa ggtaaaagaa ataatagaaa aagaaaagga gaaggacctc gaccttgagc
     3841 ctttgagtga cttagaggaa ggactggagg agtcaagaga tacagccatg gtggtggcag
     3901 ttttcaaaga acgagagcaa aaggagattg aagccatgca ttccctcaga gcagccaacc
     3961 tagccaagat gacaattgtg gagcgcatag aagaagtgaa attttgtatt tgccgcaaga
     4021 cagccagtgg gtttatgcta cagtgtgagc tctgcaaaga ctggttccat aacagctgtg
     4081 ttccccttcc taaatcaagt tcccagaaaa agggatccag ctggcaggct aaagatgtaa
     4141 aattcctttg ccctctttgc atgagatctc ggaggccaag gctagagact attctgtcac
     4201 tcctggtatc ccttcagaag ttgcctgtac ggttgccgga aggagaagca ctgcagtgtt
     4261 tgacagaacg tgccatgagt tggcaagata aagcacgcca agctttagcc acagatgaac
     4321 tgtcctctgc cctggccaag ctctctgtgc taagccagcg tatggtggaa caagcagcta
     4381 gagaaaaaac tgaaaagatt atcagtgcag aactccaaaa agcagctgcc aatccagatt
     4441 tacagggaca cttacctagt ttccagcagt ctgcttttaa ccgggtggtg agcagtgtat
     4501 catcttcccc ccaccaaaca atggactatg atgatgaaga aacagattct gatgaagata
     4561 ttcgggagac atacggctat gacatgaagg atacagccag cgtgaagtcc tctagtagtc
     4621 tggaacccaa tctcttttgt gatgaagaga ttcccatcaa gtctgaggaa gtggtgactc
     4681 acatgtggac ggcaccgtca ttctgtgcag agcatgcata ttcttctgct tcaaagagtt
     4741 gttctcaagg ttctagcact ccaagaaagc agcctcggaa gagccctttg gttcccagaa
     4801 gtttggagcc tccagtattg gaattgtctc ctggagcaaa agcccagttg gaagaactca
     4861 tgatggttgg agacctccta gaagtgtctc tggatgagac acaacacatt tggcggattt
     4921 tgcaggccac acatccaccc tcagaggaca gattcttaca tatcatggag gatgatagca
     4981 tagaagagaa accattaaaa atgaaaggaa aggactcttc agagaagaaa cggaaacgga
     5041 agctagaaaa ggtagaacag ctttttggag aaggaaaaca gaagaccaag gagctaaaga
     5101 aaatagataa acctaaaaag aagaaattaa aattaaatgt ggacaaatca aaagagctga
     5161 ataaattggc caagaagtta gctaaagaag aagagcgaaa gaaaaagaaa gaaaaggctg
     5221 ctgccgccaa agtggagctt gtgaaagaga gcacggagaa gaaacgggag aggaaggtgt
     5281 tggatatccc ctcaaagtat gactggtcgg gggcagagga gtctgatgat gagaatgctg
     5341 tgtgtgcagc ccaaaactgc caaaggccgt gtaaggacaa ggtagactgg gtacagtgtg
     5401 atggtggctg tgatgagtgg tttcatcaag tttgtgttgg tgtatccgca gaaatggctg
     5461 aaaatgaaga ttacatctgt ataaactgtg caaagaagca ggggccagat agcccaggcc
     5521 aagcaccacc tcctcccttc ctaatgagct acaaactacc aatggaggat cttaaagaga
     5581 ccagttagca gatgtctggt tagcttgcaa catgggggga agtggaccac attgagacct
     5641 tactcatcaa gcagagtggt tccgaccact cagaatgttg tttccaaaga tgaatggact
     5701 tcagaaaaag tcctcttagt gctggcttcc tctctgcatg gattgtgtgg gctccattct
     5761 cttatcatct gtgcagagga tgtcttcttt ggtgcagcag ccaagtattt caactcttga
     5821 ttcgttgagt gtggtttgct gaattaaggt caggttctaa tggaactctc aggaggctgt
     5881 ttggcattaa tacattgatg tgcttagtgg ggcatataag aagtggcttt cgaccaactg
     5941 atacttgttg tagacggtta caacctacag gtggtgccat tggaaggccc tgaccgttta
     6001 aatatcctta gttaggataa ttggacagga gtcagagcac aactttgtaa ttactgacat
     6061 ttatgcccta ctgatccagt taagagaagc aggccaaagt tatcccttct agaagtcttg
     6121 gagtggcagt gcagtctatg acctcagctg cttgtgttta tttagaccaa taagaaaatc
     6181 ctccaaaaga tcccctcact ttcctcagga ggatgtcaag caggttagaa tatctgatta
     6241 gactggattc tgggaagaag gggttttttt tttgtttgtt tgtttggttt ggtttggttt
     6301 tttcttactt caaggcaagt aggccattgg tttgagaagt ccatctgggt ctgtgtttta
     6361 gaaaagaaag gtaggtacac agatccaggt ttctggaggg agtagggatg actaatgaga
     6421 atgttttact gagcctcggt gatgcatgct tatctgggaa accctcattc acaagtattc
     6481 cagactccac catgcttcac gcatggccat gagcaagact ggcagataac agcttttgcc
     6541 ttgcagccct aaccccaatg cctgtagttt ccaacatggc ctcagcagat atttgtgaat
     6601 aacaccatgg cttcatcaga ggatgtgggg ctgtaggtcc tctgggtgtg aagctgttct
     6661 agtaaaccca tttttaaaaa gaaagacttg tttttacttt tttctaaatg tctctgacta
     6721 ctgactgttc tatagattat ttttcctttt ttgatataca tatatgaata tagatatata
     6781 tatatatatt tactgttacc agcagcgtat gatagagttt gagcatcaga aatccatttg
     6841 gaagcttgca ttttctttct gctttttgat aaagaaatcc cattccttcc ttgtagtaca
     6901 aggagttagc acttccttct tcattctcac ctaaacatat cttccacttt tcttctattc
     6961 aaatagataa tatatttcct ccatgttggg acttgtccct gtctgttggg cagcttggtc
     7021 ttattctagt cagtgctgaa tgttttgtat gtctgaaact atggtgctgt gccccccccc
     7081 cctgccccta ttgggttctg tgttcttaca aaggtcttag gtggactctg taaactcctg
     7141 ctagaaggag aataatatat tttaaaggac aaaaaggttt tctaaaaatg gtgtttatct
     7201 tcactatcct ttgttcttta ttttggttta agaatctgca atttaactta aactcatcac
     7261 ttgtcctgtt aaaggggcat tgagcaaacc taggaagttt gtagcctctg ttccccttta
     7321 ctccagtctc ttaaataaat gtcttctagt aactagaagt gagatgtact gtccagttac
     7381 agactgtgtg ggtatgaggg ctacctcaaa aggcatctta ggaaaagaaa aggttttctt
     7441 acaaaaccct ttatcccaag tgctaaccag gcttggccct gcttagcttc caaggtcaga
     7501 ggagacatac acgtgcaggt ggtacggcta taggtacaac atccaatttc tgaaaatact
     7561 ttctctggtt tatactacct actttttggt ctcttcactt aatgttaagt aacatatctt
     7621 gaccagttat gttgtttgaa tgtgttgctg tgcttgtatc ttgaatttcc atctcaatgt
     7681 gagtgtgagc taagatttca gtaatggtta caaggttaat taagtaaata gttaatttca
     7741 cacattttca ttttgccaaa catgaagatt atcacgtaag aattttattt ggttattgtt
     7801 ataatgaaaa aaagcacaat atttcttaac ttttagtctt tgtaaaagac ttgagatact
     7861 tgtggtttaa aattgagtgt acaccaaccc ttcagaaatt tacaatgtaa gtgatagaat
     7921 cccagaatac attttacaat tttgattttc cttccagtta actacttttc attaactgtg
     7981 ttatcaatag taaggagtca tgaggatact gaaaggtgac tgttttgagt aatttgtgtt
     8041 ctttgtacag tgtttgtctg ttggagacct cagacatagg cagtctgtac ctgtgaatag
     8101 ctgcctgtca tcttctgatg ttttgaaact tttaaatata taatttaatt gattcattcg
     8161 gctcttctgt acttatttga agactttgat atcttaacca tagatttaga caaaaactca
     8221 aaagaccata agggaggggg tggaaagatg actcaacggt taagaatcct ggctgctctt
     8281 ccagaggacc caggttcagt tctcagcact acatggtggc tcacagccat ctgtaatgtc
     8341 ctcttctgga cgttactgca ctgtacacat gtggcataca gacatctatt ctggaaaata
     8401 ctcaaaacac aaatacaagt aattaaaatc tttttttaaa aaattaagga tataagagaa
     8461 actagcactc tacccacaaa ttaaaaaccc tatagtttgt gagttaatga aataaagagt
     8521 catctattta aggaaaagta gatgttctaa tgtaaagctt tgtttcacaa gaattgcaag
     8581 taactccatt cttctgtact gtttgtttac attttgtatt aaaacttgat ttatgtttct
     8641 ttctgactcc tcaaagttgc acttcttcgt tattaagtgt ttaatatttt ttaagctatt
     8701 tctcactgcc ttcattatac tttaacaaag gtaacggaat gaaaaaagtt ggaagtctgc
     8761 ctggtgtttt ggcacacaca ctaagtccta gcacttggga gtcagaggca gaagatttaa
     8821 gtccagtgag ttctacacta gccagggcta cataataaga aagaaaagaa aaggtagtag
     8881 gtcatttaga actctacaga aatacaaggt agcagtcgtt acaggtccct agttgttgga
     8941 gaagaggcag atgtttgttt cacctcctgt tattgctgca gaaaccatga gcagtggctg
     9001 ctgtgaacca gctctgcctg gctgactctg acttgagccg cagtgagatt atgaattaca
     9061 gtgtggcata cttagaagaa ctgggaggca aacattcaat ctgtgattgc ccatgacctg
     9121 aggaacatgg cagacactgc cagatctgag agatggatgt gatttcacaa gtccttccct
     9181 tcctttccag ctccgccttt ggtcctcaac agggtccaag aaatgtcaat ttgtttttct
     9241 tagtttgctg gacacagttc agtgaatata aagaaactgc ttgtcagctg ggcatggtag
     9301 tatatactta atcctggcac tcgggagaca taggcagatt ggtctatata gtgtgttcta
     9361 agacagccag agctgcataa tagaacttgt caccaaaaaa aaaaaaaaaa aaggaaaaga
     9421 aactgcctgt cagccattaa aatagaaata atggaaaaat aaagcctgcc ttttgccaag
     9481 cagttatgaa gcacaccttt atttccagca ctcaggagcc agaggcagga ggatctttct
     9541 tgagttcgag gcctgtctgg tatacagaac ttgttcaaga gcagccaaag ctacagagag
     9601 accctgcctt tcaaaaggtt acatcagaat acttttggga gaaagtaaca atttggagtg
     9661 ggttttgaaa attgcaaggt gtaaagattt taagttgttt aagtcccaaa taaccctaaa
     9721 ccaagtccaa tgaagtttca tttatgaagt ttcaaatgtg aattcgcttt atgtgtgtag
     9781 aatgttgctt ttagcgtagg tccttgagca cagtaccttt cagacatcct gtccctttaa
     9841 atcaaaccac accgttactt tgaatatgga tttactacgt ggtatttata gcacaagagg
     9901 gaaagaatgg actttgatgt ctgagactgg agtattctct tggccgggat ccactcaccg
     9961 ctgtgcggca taggatgtgc accgggaagg gacacaacat cttatacaat gatatgtctg
    10021 tctaaacagg aatatatttt aagaacttga acctcccccg gttgatgatt cccttacatg
    10081 ttcattaaat tttaccaggg tttttggttg tgtgtaagag taacttttag tcgtctggct
    10141 taattgttct caggcttact gcctccctct gctaacctaa gcttagaata tattcacctc
    10201 cgagactttg tgcttgccct ttctagctct ttgtgaactc tggctttact ctctgctctg
    10261 cttgaattgc tctgctaact ctagcaatct gttccaaact tctggctcct tttcattctc
    10321 tggctcattc tgtcttcacc tgtctctgta aaattaactc tcccagtaaa ctgcctctga
    10381 attccacgaa ctcagctcca ctgcctgcct ttgaactgac tcaaccgaaa tgactaaaga
    10441 gaactaacta gcactgagaa atctgcatgc ctctctctcc tgagggctgg gattaagagt
    10501 gtgtaccccc acgtctggac ttgagcttct tgttacctga agtttgctgt gtaccaggct
    10561 ggccttgaat ccagagatct gtttgtctat gtctctggga ttaaaggcat gtctgtattc
    10621 cagccagatc acagagacct agaaggtctt tggatgtgat ctcttggcag agcagccatg
    10681 ttctgaatta aaattactcc acagttgtgc cttacagaaa ttgtaacttg atttcatgat
    10741 gtttgagcat ctggtttttt gttttttgtt tttgtctgaa ctgtagctaa ttttactaca
    10801 ttgtttgcca ttatgtctgt gctcaagatt ccccacccaa ctctcagcca atcccattat
    10861 ttgtattggt ggtgatttca aatggttacc aagtaaatgt aaattctaga atgagtactg
    10921 aaaatcctga ggaaaaatag ccaataaaca ggagccactt ttaaccagg
//
