LOCUS       NM_001410506            2813 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus lysine (K)-specific demethylase 4D (Kdm4d), transcript
            variant 2, mRNA.
ACCESSION   NM_001410506 XM_006510271
VERSION     NM_001410506.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Xu,Z., Fujimoto,Y., Sakamoto,M., Ito,D., Ikawa,M. and Ishiuchi,T.
  TITLE     Kdm4d mutant mice show impaired sperm motility and subfertility
  JOURNAL   J Reprod Dev 70 (5), 320-326 (2024)
   PUBMED   39034148
  REMARK    GeneRIF: Kdm4d mutant mice show impaired sperm motility and
            subfertility.
REFERENCE   2  (bases 1 to 2813)
  AUTHORS   Zhang,Y., Li,B., Hong,Y., Luo,P., Hong,Z., Xia,X., Mo,P., Yu,C. and
            Chen,W.
  TITLE     Histone demethylase JMJD2D protects against enteric bacterial
            infection via up-regulating colonic IL-17F to induce beta-defensin
            expression
  JOURNAL   PLoS Pathog 20 (6), e1012316 (2024)
   PUBMED   38905308
  REMARK    GeneRIF: Histone demethylase JMJD2D protects against enteric
            bacterial infection via up-regulating colonic IL-17F to induce
            beta-defensin expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2813)
  AUTHORS   Chen,Q., Zhuang,S., Hong,Y., Yang,L., Guo,P., Mo,P., Peng,K.,
            Li,W., Xiao,N. and Yu,C.
  TITLE     Demethylase JMJD2D induces PD-L1 expression to promote colorectal
            cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling
  JOURNAL   Oncogene 41 (10), 1421-1433 (2022)
   PUBMED   35027670
  REMARK    GeneRIF: Demethylase JMJD2D induces PD-L1 expression to promote
            colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1
            signaling.
REFERENCE   5  (bases 1 to 2813)
  AUTHORS   Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.
  TITLE     TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to
            epigenetically regulate inflammation
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35145029
  REMARK    GeneRIF: TRIM14 inhibits OPTN-mediated autophagic degradation of
            KDM4D to epigenetically regulate inflammation.
REFERENCE   6  (bases 1 to 2813)
  AUTHORS   Iwamori,N., Zhao,M., Meistrich,M.L. and Matzuk,M.M.
  TITLE     The testis-enriched histone demethylase, KDM4D, regulates
            methylation of histone H3 lysine 9 during spermatogenesis in the
            mouse but is dispensable for fertility
  JOURNAL   Biol Reprod 84 (6), 1225-1234 (2011)
   PUBMED   21293030
  REMARK    GeneRIF: These results suggest that demethylation of H3K9 in round
            spermatids is dispensable for spermatogenesis but that possible
            defects in Kdm4d-null elongating spermatids could be rescued by
            functional redundancy of the KDM4B demethylase.
REFERENCE   7  (bases 1 to 2813)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 2813)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   9  (bases 1 to 2813)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   10 (bases 1 to 2813)
  AUTHORS   Nudel,U., Katcoff,D., Zakut,R., Shani,M., Carmon,Y., Finer,M.,
            Czosnek,H., Ginsburg,I. and Yaffe,D.
  TITLE     Isolation and characterization of rat skeletal muscle and
            cytoplasmic actin genes
  JOURNAL   Proc Natl Acad Sci U S A 79 (9), 2763-2767 (1982)
   PUBMED   6953429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485607.8.
            
            On Aug 9, 2022 this sequence version replaced XM_006510271.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               CT485607.8         98307-98633         c
            328-493             CT485607.8         83726-83891         c
            494-2813            CT485607.8         60747-63066         c
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.05 cM"
     gene            1..2813
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /note="lysine (K)-specific demethylase 4D"
                     /db_xref="GeneID:244694"
                     /db_xref="MGI:MGI:3606484"
     exon            1..327
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /inference="alignment:Splign:2.1.0"
     exon            328..493
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /inference="alignment:Splign:2.1.0"
     exon            494..2813
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             801..2333
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /EC_number="1.14.11.66"
                     /note="jumonji domain-containing protein 2D; jmjC
                     domain-containing histone demethylation protein 3D;
                     jumonji domain containing 2D; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4D"
                     /codon_start=1
                     /product="lysine-specific demethylase 4D"
                     /protein_id="NP_001397435.1"
                     /db_xref="GeneID:244694"
                     /db_xref="MGI:MGI:3606484"
                     /translation="MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAG
                     LAKVIPPKEWRARQSYDNISNILIATPLQQVVSGQAGVFTQYHKKKKGMTVGEYRELA
                     NSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDL
                     LEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGR
                     RLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGY
                     HAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYELWK
                     RGQDQAVVDHTETMVSTSQELTTRRVTKAPRKTWGLKRLRLRQVSRSLLPIATVSNVP
                     CNMQVCHTSRQPSDVKGDDVQKSDSARASPHPLSLPSSGHMSTRRCSLGRRPCELGAQ
                     ESSNGAPVKRQLPAGRDDTSPSPELQPQAVSGDLIVDSGLVNPGPQHLMTASEGGLTS
                     DP"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /note="hexamer: AATAAA"
     polyA_site      2813
                     /gene="Kdm4d"
                     /gene_synonym="4932416A15; Jmjd2d"
                     /note="major polyA site"
ORIGIN      
        1 agcttagggg gcgggcgttt gaaaccggtg cttcatagtc gaccccaaat atcatctttt
       61 ttcctttgcg aaccaattac ttaatctctc ttgcgtcttt tcctttcccg accccctccc
      121 agactcgttc gctgcggttc tgcgaggacg gaggcgccag gagccggtcc gcgtctcgca
      181 agagagatgt gaggagagct tgccaactga ccgacccaac ggctcctgct cctcagtaga
      241 ccccgcagcc tagggactag agttgtcact taagtggata tgaagaaggc gcaaataagt
      301 acgggggcag ccacgagctt tccaaagtct cttttcactc tgtcttccct ttttctttgc
      361 cttgtgttgg ttagaacttc cgggacaatg ttgaataaag attctgaccc caggcgtcct
      421 tatttttttc ttgatctgca agataaaact tttaacttac tactgttgag tacagttttg
      481 atggtttgca atgattgtgt cttattcaca tccctgaaga gattctgctg caccccagtc
      541 tgtgcaccca gtagcctaca agaggaaaga accaggttcc aacggaacat attagaccaa
      601 ggctccctga ctgagctgct gccctgagtg ctggctctgg gttagtcagc aagcctaaca
      661 aaagttagtc ccatcacatg cacagaggct gtcaggagat tcggctccat cacagccaca
      721 gcaagtcttc tttatttatt ttttaaatcc ccttcctcaa tcctgtgtgt atattggagt
      781 ttggtgtata cattgaagct atgaagacga agtccacatg tgctcagaat ccaaattgca
      841 gcataatgat atttcgtcca accaaagaag agtttaatga ttttgacaaa tacattgctt
      901 acatggagtc ccaaggggca caccgagctg gactggccaa ggtcatccca ccaaaagaat
      961 ggagggccag gcagtcttat gacaatatca gcaacatctt aatagcaact cccctgcagc
     1021 aagtggtctc tgggcaggca ggcgtgttca cccaatacca taagaagaag aaaggcatga
     1081 cagtggggga gtaccgtgag ctggccaaca gcaaaaagta ccagaccccg ccacacctgg
     1141 attttgaaga tttggagcga aaatactgga agaatcgcct gtatgagtca ccgatttatg
     1201 gtgctgacgt cagcggctcc ctgtttgatg ggaagactca acagtggaat gtgggtcacc
     1261 tgggaacaat tcaagaccta ttggaacagg aatgtggcat agtgattgag ggcgtcaaca
     1321 cgccctacct gtactttggc atgtggaaga ccacctttgc gtggcacacg gaggacatgg
     1381 acctgtacag tatcaactac ctacactttg ggcagcccaa gacctggtat gctgtgcccc
     1441 ctgagcatgg caggcgcctg gagcgcctgg ccagggaact cttccctggc agctcccagg
     1501 gctgccaggc cttcctgagg cacaaggtgg cgctcatctc gcccactgtg cttaaggaga
     1561 atggcatccc ctttggtcgc atcacccagg aggctgggga gttcatggtc acctttccct
     1621 atggctacca cgcgggcttc aaccatggct tcaactgcgc agaggccatc aattttgcca
     1681 ccccaaggtg gattgactat ggcaaggtgg catctcagtg cagctgtggg gaggccaggg
     1741 tgagcttctc catggacgcc tttgtgagga tcttgcagcc tgagcgatat gaactgtgga
     1801 aacgtggcca agatcaggca gttgtggacc acacagagac tatggtgtct accagtcagg
     1861 agctcaccac ccggcgggtg accaaagcac caagaaaaac ttggggcttg aagcgtctcc
     1921 ggcttcgcca ggtctcacga tctcttctgc ctatagccac ggtaagtaac gttccttgca
     1981 acatgcaggt gtgccacacc tccaggcaac catcagatgt gaaaggtgat gatgtccaga
     2041 agtctgactc agccagagcc tcaccacatc ctctgagtct gccttcttct ggtcacatgt
     2101 caactagaag atgtagtctt ggtcgtcgtc cttgtgaact aggagctcag gagtcctcca
     2161 atggagctcc agtcaagagg caacttccag caggcagaga tgacacaagc cccagtccag
     2221 agcttcagcc ccaggctgtg agtggagact taatagtcga ctcaggactt gtgaaccctg
     2281 gcccacagca tcttatgaca gcttctgaag ggggattgac ctccgacccc taaacctatg
     2341 tcctggttta tagggatgct ccctaagtcc attacctcat agttttgact gagtttgcag
     2401 gacattggcc atacctgaga gagctcctgg tcagttctaa ctcctaaaca caccatgcac
     2461 ttccagaact tggcaagcct ctggataact gctaactcct gctcttccag ctgaggttgc
     2521 attggtcact actgttgagt ttctgcaagc taaattcagc tgaggctgct cagcactgat
     2581 ctcccatgct caaggccaac tctagaggaa gcagaacact cacactctcc tccccctctg
     2641 ccatttcttg caaaataaat gtctgactct tgaccgctag attactcctc acaaagaagt
     2701 agtcacaaaa aagattaaag ccacttgaga gtcacagatg acctctcaaa gttgatgtgt
     2761 tacacagtgt ctcacccagc tttcacaaat aaagcaaaac agccaaaagg tta
//
