LOCUS       NM_144787               4271 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript
            variant 1, mRNA.
ACCESSION   NM_144787
VERSION     NM_144787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4271)
  AUTHORS   Wang,M., Hu,Y., Cai,F., Guo,L., Mao,Y. and Zhang,Y.
  TITLE     Jmjd2c maintains the ALDHbri+ cancer stemness with transcription
            factor SOX2 in lung squamous cell carcinoma
  JOURNAL   Cancer Biol Ther 25 (1), 2373447 (2024)
   PUBMED   38975736
  REMARK    GeneRIF: Jmjd2c maintains the ALDH[bri+] cancer stemness with
            transcription factor SOX2 in lung squamous cell carcinoma.
REFERENCE   2  (bases 1 to 4271)
  AUTHORS   Zhu,K., Zhang,H., Luan,Y., Hu,B., Shen,T., Ma,B., Zhang,Z. and
            Zheng,X.
  TITLE     KDM4C promotes mouse hippocampal neural stem cell proliferation
            through modulating ApoE expression
  JOURNAL   FASEB J 38 (5), e23511 (2024)
   PUBMED   38421303
  REMARK    GeneRIF: KDM4C promotes mouse hippocampal neural stem cell
            proliferation through modulating ApoE expression.
REFERENCE   3  (bases 1 to 4271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4271)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   5  (bases 1 to 4271)
  AUTHORS   Pan,H.C., Chen,Y.H., Fang,W.C., Wu,V.C. and Sun,C.Y.
  TITLE     Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury
  JOURNAL   Int J Mol Sci 23 (16), 9318 (2022)
   PUBMED   36012577
  REMARK    GeneRIF: Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4271)
  AUTHORS   Loh,Y.H., Zhang,W., Chen,X., George,J. and Ng,H.H.
  TITLE     Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate
            self-renewal in embryonic stem cells
  JOURNAL   Genes Dev 21 (20), 2545-2557 (2007)
   PUBMED   17938240
  REMARK    GeneRIF: Jmjd2c acts as a positive regulator for Nanog, which
            encodes for a key transcription factor for self-renewal in ES
            cells.
REFERENCE   7  (bases 1 to 4271)
  AUTHORS   Wissmann,M., Yin,N., Muller,J.M., Greschik,H., Fodor,B.D.,
            Jenuwein,T., Vogler,C., Schneider,R., Gunther,T., Buettner,R.,
            Metzger,E. and Schule,R.
  TITLE     Cooperative demethylation by JMJD2C and LSD1 promotes androgen
            receptor-dependent gene expression
  JOURNAL   Nat Cell Biol 9 (3), 347-353 (2007)
   PUBMED   17277772
REFERENCE   8  (bases 1 to 4271)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 4271)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4271)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK173023.1 and BF019842.1.
            
            On Feb 3, 2010 this sequence version replaced NM_144787.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173023.1, AK144103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4254              AK173023.1         1-4254
            4255-4271           BF019842.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 36.06 cM"
     gene            1..4271
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /note="lysine (K)-specific demethylase 4C"
                     /db_xref="GeneID:76804"
                     /db_xref="MGI:MGI:1924054"
     exon            1..208
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            209..369
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3390
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /EC_number="1.14.11.66"
                     /note="isoform 1 is encoded by transcript variant 1; gene
                     amplified in squamous cell carcinoma 1; jumonji domain
                     containing 2C; lysine-specific demethylase 4C; jumonji
                     domain-containing protein 2C; jmjC domain-containing
                     histone demethylation protein 3C; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4C"
                     /codon_start=1
                     /product="lysine-specific demethylase 4C isoform 1"
                     /protein_id="NP_659036.1"
                     /db_xref="CCDS:CCDS18287.1"
                     /db_xref="GeneID:76804"
                     /db_xref="MGI:MGI:1924054"
                     /translation="MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRA
                     GLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQL
                     ANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLD
                     VVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHG
                     KRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYG
                     YHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIW
                     KQGKDIYTIDHTKPTPESTPEVKTWLQRKKKLRKPPKSLQGNKPLCKRPKPEEDEEFA
                     EFSGEEGANPAMGPRHLKVTEKPEKALKLGKLEESSAKEALDTRIQVDQSLLNDTKLS
                     GKGCISSSVTAEIPPEDNRASAVISPSQLKEGADCIPLSHGHQAGKESHLLKILKLES
                     PKIPSPLPESNKVLTEGEENDEEGHGSNLEPGEIPEALSEERNGLNIPKIIEGQPKTT
                     KSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSP
                     NFMAEQEYNATVAKMEPNCAICTLLMPYYKPDSSKEENDSRWETAVNEVVQSGRKTKP
                     IIPEMCFIYSEENVDYSPPNAFLEEDGTSLLISCAKCFVRVHASCYGVPSHEVCDGWL
                     CARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDR
                     IPLQRLKLKCIFCRHRVKKVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVN
                     ITCFRHRVNSNAKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQTFYEVMFDDGS
                     FSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGS
                     QIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKN
                     EYVDDPVYRTFLKSSFQKKCQKRQ"
     exon            370..545
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            546..660
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            661..854
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            855..904
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1008
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1146
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1340
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1576
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1896
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2005
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2187
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2401
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2478
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2534
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2643
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2829
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3000
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3120
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3213
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..4257
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4234..4239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /note="hexamer: ATTAAA"
     polyA_site      4254
                     /gene="Kdm4c"
                     /gene_synonym="2410141F18Rik; Gasc1; Jmjd2c"
                     /note="major polyA site"
ORIGIN      
        1 cgcccgcgcc gcctcccgcc cacctccgag ccgggaggga ggggagcgcg gcggagggat
       61 tccgtggtgg cgccccgtgc gcgtgcgcag cgaacagctg tcacccagtg cggaacaagt
      121 cttccaaaga ttcccaaaac cctcagggga ggccgcactt ttcatccctt tcattcgggt
      181 ggcgtctgga cctccgccag cggcgcagaa acatctgtgg ccatcatgga ggtggtggag
      241 gtggagagtc ccctaaatcc cagctgtaag ataatgacct tcagaccttc catggaggag
      301 tttcgggagt tcaacaaata cctcgcatac atggaatcca aaggagccca tcgagcaggt
      361 cttgccaagg tgattcctcc taaggagtgg aagccaagac agtgctatga tgatattgat
      421 aatttgctca tcccagcacc aattcagcag atggtcacag ggcagtcggg actgttcacg
      481 caatacaaca tccagaagaa agccatgact gtgaaggagt tcaggcagct ggctaacagc
      541 agcaaatact gtactccaag atacttggat tatgaagatt tggaacgcaa atactggaaa
      601 aacttaactt ttgtggcacc tatttatgga gcagatataa atgggagcat ttatgatgag
      661 ggtgtggatg aatggaatat agctcgccta aatacagtct tggatgtggt tgaagaagag
      721 tgtggtattt ctattgaggg ggtaaatacc ccttatctct attttggaat gtggaaaaca
      781 acatttgcgt ggcacacgga ggacatggat ctctacagta ttaattatct ccactttggg
      841 gagcccaagt cttggtatgc tatacctccg gagcatggaa agcgacttga aagactagcc
      901 caaggcttct tccccagtag ctcccaaggc tgtgatgcat ttctccggca caagatgacc
      961 ctcatttccc cctcagtgct gaagaagtat ggcattccct tcgacaagat cacccaggag
     1021 gctggagagt ttatgatcac ttttccttat ggatatcatg ctggttttaa tcatggtttc
     1081 aattgtgctg agtctacaaa ttttgctaca gtcagatgga ttgactacgg caaggttgct
     1141 aagttgtgca cttgtcggaa tgacatggtg aagatatcaa tggatatatt tgtgaagaaa
     1201 tttcagccag atagatacca gatttggaaa caaggaaagg atatatatac tattgaccat
     1261 acaaagccca ctccagaatc tactccagaa gtaaaaacat ggctacagag gaagaaaaaa
     1321 ttaagaaagc ctcccaagag cttacagggc aataagccac tttgtaaaag gcctaaacct
     1381 gaagaagatg aggaatttgc tgaatttagt ggggaagagg gtgcaaaccc tgccatgggc
     1441 cctaggcacc tcaaagtcac tgaaaagcca gaaaaagcat taaagctggg gaaattagaa
     1501 gaatcttcag caaaagaagc tttggatacc aggatacaag tggatcaaag cttactgaac
     1561 gacaccaagc tctcgggaaa aggttgcata agttcatcag taacagctga aattccacca
     1621 gaagacaaca gagccagtgc tgtaatttca ccatctcagc tgaaggaggg cgctgactgc
     1681 ataccacttt ctcatggcca tcaagcaggc aaagagtcac atctacttaa gattctaaag
     1741 cttgaatctc ccaagatacc ttcccccctg ccagaaagta ataaagtatt gacagaggga
     1801 gaagaaaatg atgaagaggg ccatggaagt aaccttgagc ctggggaaat cccagaagct
     1861 cttagtgaag agagaaatgg gctcaacatt cctaagataa ttgaaggaca gccaaaaact
     1921 actaagagtt ggcgccatcc acttggtaag cctccggcca gatccccaat gacacttgtg
     1981 aagcagcagg tagcgagtga tgaagaattg cctgaggttc taagcattga cgaagaagtt
     2041 gaagaaacag agtcttgggc aaagcctctc atccaccttt ggcagacaaa gtctcctaac
     2101 tttatggctg aacaggagta caatgcaact gttgcaaaaa tggagccaaa ctgtgccatc
     2161 tgcactctgc tcatgccgta ctacaagcct gatagcagca aagaagaaaa tgattctaga
     2221 tgggagacag cagtaaatga agtggttcaa tctggaagaa agactaagcc cattattcca
     2281 gagatgtgtt ttatttatag tgaagaaaat gtagactatt cccccccaaa tgccttcctt
     2341 gaagaagatg gaacaagtct tctgatttcc tgtgccaagt gcttcgtgcg ggttcatgca
     2401 agttgttatg gtgtcccttc tcatgaagtc tgtgatggat ggctgtgtgc ccggtgcaag
     2461 agaaatgcat ggactgcaga atgctgtctc tgcaatttga ggggaggtgc tctgaaacag
     2521 actaagaaca atcagtgggc tcatgtcata tgtgctgttg cagttccaga agtgcgattc
     2581 actaatgtcc cagaacggac acaaatagat gtagacagaa tacctttaca gaggttaaaa
     2641 ttgaaatgca tcttctgtag acaccgggtt aaaaaggttt ctggagcctg catccagtgt
     2701 tcttatggcc gctgcccagc ttcattccat gttacgtgtg cccatgctgc tggagtgctc
     2761 atggagcctg atgactggcc ttacgtggta aacatcacat gcttcagaca tagagtcaac
     2821 tcaaacgcga aatccaaaac ttgtgagaaa gccatttctg tgggtcagac agtcatcaca
     2881 aaacatcgaa acactcggta ctacagctgc agagtgatag atgtgacatc tcaaaccttc
     2941 tatgaggtca tgtttgatga tggctccttc agcagagaca catttcctga agatattgtg
     3001 agccgaaact gtgtgaagct gggccctcct gcggagggag aagtcatcca agtcaaatgg
     3061 cctgatggta aactctatgg ggcaaagtat cttggatcaa atgttgccta tatgtatcag
     3121 gttgaatttg aagatggatc gcagattgca atgaagagag aagacatata cactttagat
     3181 gaagagttac ccaagagagt aaaggctcgt ttttccacag cctccgacat gcgatttgaa
     3241 gacacatttt atggagcaga tgtaatccaa ggggagagga agaggcaaag agtgctaagc
     3301 tccaggctca agaatgagta tgtggatgac cctgtgtatc gtactttcct gaagagttct
     3361 ttccagaaga agtgtcagaa gagacagtag ttgataatgt gcagcagcca cagtgcagct
     3421 cagaccagaa gagggaagac aaagggacag ccttggggta cacattggga caggtggctg
     3481 ggtgcttctt tggtattggt aataaaccag gcttctggag tttgattacc aagcaaccaa
     3541 gaagagacat attagttgct tctgtaatct gatcacccct cagtcatttg tttgacccca
     3601 aagaatattc ctaaattaaa ggaaacagca gtgaatggcc cactagataa aacaactgct
     3661 aaagaagcgg ggttccctct ctggctcagg tcccttcctc agggaacaca tttggaggct
     3721 cctttcccac ctccttcagt ggcagcctca tcacccaaca gccggtgggt gtatttatat
     3781 atattttcca cagccaggga aagagtctca ctcacatttg ttttcagtgg cagtttttat
     3841 aaaacatttt taaaacacaa atggcatgta tggtaatagg atttacctgt atgctatctt
     3901 cccttgtaca gaacttttcc attttttata ttattacttt tgattgtgtc tgaaaactga
     3961 gttggccttt ataagaggaa attttttgct cttgaagagg aattcatatg aagtatatgg
     4021 gaattttata tatttacaga ggaaaaatct tggcctgata ttttgaacac ttcataattc
     4081 ctgttctgaa atgatattta taaaatatat atttctttca ttatgtgttt gtaaaaatta
     4141 gagtttaaag aaatatactt aatgcatagt tttaaactaa tgtaacatga tttttctttg
     4201 caaaacagcc tggagatgta ttaatattta aaaattaaaa tctgttttct cctgtccaaa
     4261 aaaaaaaaaa a
//
