LOCUS       NM_172132               5529 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus lysine (K)-specific demethylase 4B (Kdm4b), transcript
            variant 1, mRNA.
ACCESSION   NM_172132
VERSION     NM_172132.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Ma,X., Mei,S., Wuyun,Q., Zhou,L., Cai,Z., Ding,H. and Yan,J.
  TITLE     Super-enhancer-driven LncRNA PPARalpha-seRNA exacerbates glucolipid
            metabolism and diabetic cardiomyopathy via recruiting KDM4B
  JOURNAL   Mol Metab 86, 101978 (2024)
   PUBMED   38950776
  REMARK    GeneRIF: Super-enhancer-driven LncRNA PPARalpha-seRNA exacerbates
            glucolipid metabolism and diabetic cardiomyopathy via recruiting
            KDM4B.
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5529)
  AUTHORS   Wang,Z., Li,M., Liu,Y., Qiao,Z., Zu,X., Cao,T. and Bai,T.
  TITLE     Novel insights into the angiogenic function of JMJD2B in diabetic
            hind limb ischemia: involvement of activating Wnt/beta-catenin
            pathway
  JOURNAL   Hum Cell 36 (3), 1011-1023 (2023)
   PUBMED   36773117
  REMARK    GeneRIF: Novel insights into the angiogenic function of JMJD2B in
            diabetic hind limb ischemia: involvement of activating
            Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 5529)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   5  (bases 1 to 5529)
  AUTHORS   Udugama,M., Vinod,B., Chan,F.L., Hii,L., Garvie,A., Collas,P.,
            Kalitsis,P., Steer,D., Das,P.P., Tripathi,P., Mann,J.R.,
            Voon,H.P.J. and Wong,L.H.
  TITLE     Histone H3.3 phosphorylation promotes heterochromatin formation by
            inhibiting H3K9/K36 histone demethylase
  JOURNAL   Nucleic Acids Res 50 (8), 4500-4514 (2022)
   PUBMED   35451487
  REMARK    GeneRIF: Histone H3.3 phosphorylation promotes heterochromatin
            formation by inhibiting H3K9/K36 histone demethylase.
REFERENCE   6  (bases 1 to 5529)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   7  (bases 1 to 5529)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
  REMARK    GeneRIF: A subgroup of murine Jmjd2 proteins antagonize H3K9me3 at
            pericentric heterochromatin.
REFERENCE   8  (bases 1 to 5529)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 5529)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5529)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA324771.1, AK141879.1, CJ093438.1, CT009637.4 and BP762845.1.
            
            On Nov 10, 2017 this sequence version replaced NM_172132.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007145.1, AK141879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CA324771.1         1-24
            25-321              AK141879.1         2-298
            322-480             CJ093438.1         293-451
            481-4601            AK141879.1         458-4578
            4602-5454           CT009637.4         117205-118057
            5455-5529           BP762845.1         27-101              c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.27 cM"
     gene            1..5529
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /note="lysine (K)-specific demethylase 4B"
                     /db_xref="GeneID:193796"
                     /db_xref="MGI:MGI:2442355"
     exon            1..180
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            181..345
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..3465
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /EC_number="1.14.11.66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific demethylase 4B; jumonji domain-containing
                     protein 2B; jmjC domain-containing histone demethylation
                     protein 3B; [histone H3]-trimethyl-L-lysine(9) demethylase
                     4B"
                     /codon_start=1
                     /product="lysine-specific demethylase 4B isoform 1"
                     /protein_id="NP_742144.1"
                     /db_xref="CCDS:CCDS28904.1"
                     /db_xref="GeneID:193796"
                     /db_xref="MGI:MGI:2442355"
                     /translation="MGSEDHSAQNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAG
                     LAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLA
                     NSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGNLRTILDM
                     VERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGK
                     RLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGY
                     HAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYEQWK
                     QGRDLTVLDHTRPTALSSPELSSWSASRTSIKAKLLRRQISVKESRPWRKAEEERRRE
                     PTRRPGPASHRRRSQPKKSKPEESRSPGEATAGVSTLDEARGCSRGEAMPEDEEEEEL
                     LPSQGHEAEGVEEDGRGKPRPTKARNKKKTPSPSSPPLLSAPPALFPTEEVLRPPPQP
                     KSPGPAMGPMAAEGGPPPTPLNVVPPGAPVEEAEVRPRPIIPMLYVLPRTSSTDGDRE
                     HSAHAQLAPMELGPEEENQAQAGDSQGTTPFSKLKVEIKKSRRHPLGRPPTRSPLSVV
                     KQEASSDEEAFLFSGEDDVTDPEALRSLLSLQWKNKAASFQAERKFNAAAALSEPYCA
                     ICTLFYPYSQSVQTERDSAVQPPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGED
                     GTSPLISCAHCCLQVHASCYGVRPELAKEGWTCSRCAAHAWTAECCLCNLRGGALQRT
                     TEHRWIHVICAIAVPEVRFLNVIERNPVDVSAIPEQRWKLKCIYCRKRMKRVSGACIQ
                     CSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHRASGAGGQLLRTVSLGQIVI
                     TKNRNGLYYRCRVIGTTAQTFYEVNFDDGSYSDNLYPESITSRDCLRLGPPPEGELVE
                     LRWTDGNLYRARFISMATSLIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLST
                     GTPQEPSFSGDDVKAAKRPRVASVLATTTEDTGRSPEYLSFMESLLQAQGRPGAPF"
     exon            346..521
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            522..636
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            637..830
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            831..880
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            881..984
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1122
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1319
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1403
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1591
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1980
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2101
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2280
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2476
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2553
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2609
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2718
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2904
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3069
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3189
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3282
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..5511
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4569..4574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /note="hexamer: ATTAAA"
     polyA_site      4603
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /note="major polyA site"
     regulatory      5489..5494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
                     /note="hexamer: AATAAA"
     polyA_site      5511
                     /gene="Kdm4b"
                     /gene_synonym="4732474L06Rik; Jmjd2b"
ORIGIN      
        1 cgggctcttg ctgagggctc ggccgcgagc gagcgaacca tcgaaggagc aaagagaccg
       61 ggcgaagctc ggagcccagt ggccggggcg agcgagtgag ggccggcggg ggcgacgcga
      121 gacggccggg cacgcgccgc tcagcctgct gtctgcggcc cgggccgcgc gttgcgccag
      181 gtgtagctcc actttgctgc aaccatgggg tccgaggacc acagcgccca gaaccccagc
      241 tgtaagatca tgactttccg ccccaccatg gatgaattca gggacttcaa cagatatgtg
      301 gcgtacattg agtcgcaggg tgcccaccgt gctggcctgg ccaagatcat tccacccaag
      361 gagtggaagc cacggcagac gtatgatgac atcgacgatg tggtcatccc agcgcctatt
      421 cagcaggtgg tgacgggcca gtcggggctt ttcacacagt acaacatcca gaagaaggcc
      481 atgactgtgg gggagtaccg ccgcctagcc aatagtgaaa agtactgtac cccacgccat
      541 caggacttcg atgacttgga gcgcaagtac tggaagaacc tgacctttgt ctcacccatc
      601 tatggagctg acatcagtgg ctccctgtac gacgatgacg tggcgcagtg gaacatcggc
      661 aatctgagga ccatcctaga catggtggag cgcgaatgcg ggaccatcat tgagggcgtg
      721 aatacaccct acttgtactt tggcatgtgg aagaccacgt ttgcctggca cacagaggac
      781 atggacctct acagcatcaa ctacctgcac ttcggcgagc ctaagtcctg gtacgccata
      841 ccaccggagc acggcaagcg cctggagcgc ctggccatag gcttcttccc tgggagctca
      901 cagggctgtg atgccttcct aaggcacaag atgacactca tctcgcccat catcctgaag
      961 aagtacggca tccccttcag ccggattaca caggaagctg gggagttcat gatcacgttc
     1021 ccctatggtt accatgcggg cttcaaccat ggctttaact gcgctgagtc cactaacttc
     1081 gccacactgc gctggatcga ctatggcaaa gtggccacac agtgtacatg tcgaaaggac
     1141 atggtcaaga tctccatgga cgtgtttgta cgcatcctgc agcccgaacg ctatgagcaa
     1201 tggaagcaag gccgtgacct cacagtgctg gaccacacga ggcccacagc cctgagcagt
     1261 cctgagctca gctcctggag tgcctcgcgc acctccatca aggccaagct cctgcgcaga
     1321 caaattagtg tgaaggagag cagaccctgg agaaaggctg aggaggagag gaggcgggag
     1381 ccgaccagga ggccagggcc ggcgtcacac cggagacgga gccagcccaa gaagtcaaaa
     1441 cctgaagagt ccaggtctcc aggggaagcc acggctgggg tatctactct ggatgaggcc
     1501 aggggctgct cccgaggaga ggccatgcct gaggacgagg aggaggagga gctgctacct
     1561 tcacagggcc atgaggccga gggtgtggaa gaggatggca gaggcaagcc tcggcctact
     1621 aaggccagaa ataagaagaa gactcccagc ccgtcgtcac ccccgttgct gtctgcccca
     1681 ccagccctat tccccaccga ggaggtcctg aggccaccac cccaacccaa gtctccaggg
     1741 ccagctatgg gccccatggc tgcagagggg ggtcctccac caacacccct caatgtcgtg
     1801 cctcctgggg cgccagttga ggaagcagag gtgcggccac ggcccattat cccaatgctg
     1861 tacgtgttgc cccgcaccag cagcaccgat ggggacaggg agcactctgc ccacgcacag
     1921 ttggcaccca tggagctggg gccagaagag gaaaaccagg cccaggctgg tgactcacag
     1981 ggaacaaccc ctttctctaa gctgaaggtg gagatcaaaa agagccggcg tcaccccttg
     2041 ggtcggccac ccactcgatc cccgctgtct gtggtcaagc aggaggcctc aagtgatgaa
     2101 gaagccttcc tgttctcagg agaggatgat gtcactgatc ctgaggcctt gagatcgctg
     2161 ctgtccctgc agtggaagaa caaggcggcc agcttccaag ccgagaggaa gttcaatgcg
     2221 gcagccgccc tcagtgagcc ctactgtgcc atctgtaccc tcttctaccc ctacagccag
     2281 tcagtacaga cagagcggga cagtgctgtc cagccgccct ccaaaagtgg ccagaggaca
     2341 cggccactga tccctgagat gtgcttcact tcaagtgggg agaacacaga gccgctgcct
     2401 gctaactcct acgtcggtga ggacggcacc agtccactca tctcctgtgc ccactgctgc
     2461 ctgcaggtcc atgccagttg ctatggtgtc cggcctgagt tggccaaaga gggctggaca
     2521 tgttcccggt gtgcggccca cgcttggact gcggaatgct gtttgtgcaa cctgcggggg
     2581 ggagcgctac agaggaccac agagcacagg tggattcacg tgatctgcgc cattgcagtc
     2641 cctgaggtac gattcctcaa tgtgattgaa cgcaacccag tggacgtcag tgccatccct
     2701 gagcagcgat ggaaactgaa atgcatttac tgccgcaagc gtatgaagag agtgtcgggt
     2761 gcctgcatcc agtgctccta tgagcactgc tccacatcct tccatgtgac ctgtgcgcat
     2821 gctgctggtg tcctcatgga acccgatgac tggccctatg tggtgtccat cacctgcctc
     2881 aagcaccggg ccagcggagc agggggccag ctcctgcgca cagtgtccct gggccagatc
     2941 gtcatcacca agaaccgcaa tgggctctac tatcgctgcc gggtcattgg caccactgcg
     3001 cagacattct acgaggtcaa ctttgacgat ggctcctaca gtgacaacct gtacccagag
     3061 agcatcacga gcagagactg cctacggcta gggccacctc ctgagggcga gctggtggag
     3121 cttcggtgga cagacggtaa tctgtacaga gccaggttta tctccatggc caccagcctc
     3181 atctaccagg tagagtttga ggatgggtct cagctgactg tgaagcgtgg ggacatcttc
     3241 acactggaag aggagctgcc caagagggtg cgttcccggc tgtcactgag cactggcaca
     3301 ccacaggagc ccagcttctc tggagacgat gtgaaggctg ccaagcgccc acgggtggcc
     3361 tcagtgctgg ccaccaccac tgaggacaca gggcgtagcc cagaatacct gtccttcatg
     3421 gagagcctgc tgcaggcaca gggccggcct ggagcaccct tctagatcct gcccactcct
     3481 gtcccactgt aggtaactgg taacaggacc agcaggatcc aacttggcca gactcaggga
     3541 gtggggccag cacccctgga ctacagtgac tccatggggc ctggcctggc tctgctcttc
     3601 tcctaaaggt gctaaggggc atcctagagc ctcctgtgac agatgctagc caaggacact
     3661 ggggcacagc cccaacctgt tttctagatt tgtggcttta aaaactgaca gcaggcacat
     3721 tctttttcct ctaaaccagg atgtgaggag ataaaagttt catctgtgtt tgacacctgc
     3781 agatgtttgt ctactgatca ggtcgaaagg cacttttgta tccctggaag ggacagcagt
     3841 ccagtgtgca gtgacctgtg tgatggccgc ttgtgattcc tcatgcttcc tgctctggga
     3901 ggtgggcctg caggagtggc ccctgccatg cccccaccat gtccctgctc tgtgcagagt
     3961 ctgcttcact ctgcctctgc tgcctggggt cccatgagcc ttcacacttg gaccagggcc
     4021 tctgtgtggc tgagggcagg agaaagcagg tgacaccttc acttgaagcc ctggtcaagt
     4081 gacacaggac gcagacttca caggcccagt ctgcactatc cgccaccgcc cacgggttgg
     4141 ctatgggctc tgtctcttta gaagctatgg ccaccctagg gcatcaggcc caggatagac
     4201 agctgatctt aaatgacaaa ggactggact gagggccctg ggcctgtgga ccagctggaa
     4261 acttagggac tgggcctctg ctgagtgccc gatggcggcc gtgcccatgt gtacttggaa
     4321 attctattta tattgtaaag agaataaaaa aggacctaac cttgggcctg gagggagagg
     4381 ccagaccaca ggagtctcag gctgtgcccc ttgtgggctc tgcagtggct gcaggtggcc
     4441 ccacacatgc cccacacaga gaggtccggg tttttgtgca aaagcaaaac catgccctcc
     4501 tcctctcccc accccagatg aaggacttca tatttttgcc tcattctctg gcctccagtt
     4561 cagtatcaat taaagcccgt gagctgagcg cttcctattc ccacctggtc atggctgtgt
     4621 cttcatttct ggccaggaca agatcggctc cggatggggt gtccttggca ggcatgatgg
     4681 gtgcagtgtg tcctggtctg gatgtagggg ctgccaagga ggtgggatac catccccaag
     4741 acttttagtc tcaccccagt ggcatggagc tgaggcagca tgtctcccct ggatgtctgt
     4801 gttctctgac tctctgcttg tcagctgccc agcctcggcc tacttctaca ctaggtgggg
     4861 ccacagatga gcagaggccc tggggttggg cagatcatgg cctggtgcag tagagggagg
     4921 actggaggaa gggaagccct gccctgcctg atgggccaaa gggaagactt gggttttccc
     4981 tggaggaggg aggagagtgg aagctacaga aggctatggg cagaagaggg aggagcctac
     5041 caggtactta cagcaggagg tcagtggcag gcccctgggt ggcgcagggg cctttttttc
     5101 tattcctctt tctgttccct cataagatga tgggacaggc caggcgtggt ggtgcatgcc
     5161 tttaatccca gcactgggga ggcagaggca ggcggatttc tgagttcgag gccagcctgg
     5221 tctacaaagt gagttccttg acagccagag ctataaagag aaaccctgtc tcgaaaaacc
     5281 aaaaaaaaaa aaaaagttgg gacagatgtt tcctctagga agggaaggga aggcggccct
     5341 gccagaggca tggccaggac cctgtgggag tggagcactg tgctaggaag gggcattgaa
     5401 ctagctctga acctgcctgg cacatcctgc caagctcaca tatgcagcct gcagccctgg
     5461 gccacatcca gcggtggacc tgtttatcaa taaagtttta cttgcacatg gaaaaaaaaa
     5521 aaaaaaaaa
//
