LOCUS       NM_001161823            4616 bp    mRNA    linear   ROD 15-MAR-2023
DEFINITION  Mus musculus lysine (K)-specific demethylase 4A (Kdm4a), transcript
            variant 1, mRNA.
ACCESSION   NM_001161823
VERSION     NM_001161823.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4616)
  AUTHORS   Cai J, Yang Y, Han J, Gao Y, Li X and Ge X.
  TITLE     KDM4A, involved in the inflammatory and oxidative stress caused by
            traumatic brain injury-hemorrhagic shock, partly through the
            regulation of the microglia M1 polarization
  JOURNAL   BMC Neurosci 24 (1), 17 (2023)
   PUBMED   36869312
  REMARK    GeneRIF: KDM4A, involved in the inflammatory and oxidative stress
            caused by traumatic brain injury-hemorrhagic shock, partly through
            the regulation of the microglia M1 polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4616)
  AUTHORS   Wang K, Zhou M, Zhang Y, Du Y, Li P, Guan C and Huang Z.
  TITLE     IRX2 activated by jumonji domain-containing protein 2A is crucial
            for cardiac hypertrophy and dysfunction in response to the
            hypertrophic stimuli
  JOURNAL   Int J Cardiol 371, 332-344 (2023)
   PUBMED   36181956
  REMARK    GeneRIF: IRX2 activated by jumonji domain-containing protein 2A is
            crucial for cardiac hypertrophy and dysfunction in response to the
            hypertrophic stimuli.
REFERENCE   3  (bases 1 to 4616)
  AUTHORS   Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen
            CD, Guo S, Zhang D and Zhao D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4616)
  AUTHORS   Zhang W, Liu W, Jia L, Chen D, Chang I, Lake M, Bentolila LA and
            Wang CY.
  TITLE     Targeting KDM4A epigenetically activates tumor-cell-intrinsic
            immunity by inducing DNA replication stress
  JOURNAL   Mol Cell 81 (10), 2148-2165 (2021)
   PUBMED   33743195
  REMARK    GeneRIF: Targeting KDM4A epigenetically activates
            tumor-cell-intrinsic immunity by inducing DNA replication stress.
REFERENCE   5  (bases 1 to 4616)
  AUTHORS   Zhu Q, Liang F, Cai S, Luo X, Duo T, Liang Z, He Z, Chen Y and Mo
            D.
  TITLE     KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic
            regulatory factors
  JOURNAL   Cell Death Dis 12 (6), 514 (2021)
   PUBMED   34011940
  REMARK    GeneRIF: KDM4A regulates myogenesis by demethylating H3K9me3 of
            myogenic regulatory factors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4616)
  AUTHORS   Zhang D, Yoon HG and Wong J.
  TITLE     JMJD2A is a novel N-CoR-interacting protein and is involved in
            repression of the human transcription factor achaete scute-like
            homologue 2 (ASCL2/Hash2)
  JOURNAL   Mol Cell Biol 25 (15), 6404-6414 (2005)
   PUBMED   16024779
REFERENCE   7  (bases 1 to 4616)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 4616)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 4616)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4616)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY308642.1, AK054095.1 and AL626764.6.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by
            NM_001161823.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145066.1, AK054095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY308642.1         2-38
            38-3304             AK054095.1         2-3268
            3305-4616           AL626764.6         107247-108558       c
FEATURES             Location/Qualifiers
     source          1..4616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.31 cM"
     gene            1..4616
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /note="lysine (K)-specific demethylase 4A"
                     /db_xref="GeneID:230674"
                     /db_xref="MGI:MGI:2446210"
     exon            1..151
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            152..333
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            334..509
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            510..624
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            625..818
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            819..868
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            869..972
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1110
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1358
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1558
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1929
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2050
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2232
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2437
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2514
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2570
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2679
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2865
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3036
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3156
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3249
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..4616
                     /gene="Kdm4a"
                     /gene_synonym="D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a;
                     mKIAA0677"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttggttg actatgggct ctgtgaggct gcgcagagtc agactttaaa ggaggcggag
       61 ctctgtcttt cgccctcaag aaagacagtg ggatcggcga gtggcgacaa cagcaatcgg
      121 gcctgagccc tgctagggct ttaggctcca ggtttttatc ctagcaaaat cggcctcaaa
      181 aacagagaag acaagatggc ttctgaatca gaaactttga accccagtgc tcggatcatg
      241 accttttacc ccaccatgga agagttccgg aacttcagcc gctacattgc ctacattgaa
      301 tcccaaggag ctcatcgggc tgggctagcc aaggtcgttc ctcccaaaga gtggaagcct
      361 cgaacatcct acgacgatat tgatgatcta gtcatccctg cgcccatcca gcagctggtg
      421 actggccagt ctggcctctt cactcagtac aacatacaga agaaagccat gaccgttcgt
      481 gagttccgca agatcgccaa tagcgacaag tactgcaccc cgcgatacag tgaatttgaa
      541 gaacttgagc gtaaatactg gaaaaacctc acattcaatc ctcccatcta tggagcagac
      601 gtgaatggta ctctctatga acagcacgtt gatgagtgga atatcggccg gctgaagacc
      661 atcctggacc tggtggagaa ggagagcggg atcaccattg agggggtgaa caccccctac
      721 ctttacttcg gcatgtggaa gacgtccttc gcctggcaca cggaagacat ggatctatac
      781 agcatcaact atctgcactt cggagagcca aagtcttggt actctgttcc acctgagcat
      841 gggaaacgcc tggagcgtct tgccaaaggc tttttcccag gaagtgctca aagctgtgag
      901 gcttttctcc gccacaagat gaccctgatc tccccattaa tgctgaagaa gtatggcatt
      961 ccctttgaca aggtgaccca agaagctggc gagtttatga tcacttttcc gtatggttac
     1021 catgctggct tcaaccatgg cttcaactgt gcagagtcaa ccaattttgc tacccgtcgg
     1081 tggattgagt atggcaagca ggctgtgctg tgctcctgca gaaaagatat ggtgaagatc
     1141 tccatggacg tgttcgtgag gaggttccag ccggaacgct acaaactttg gaaagctggg
     1201 aaggacagca tggttattga ccacactctg cccacaccgg aagcagccga gttcctgaag
     1261 gacagcggcg gactaacccc gagagcaggg agtgaggagt gcccagagga ggacgtggaa
     1321 gcagcggatc agggagagga gggggatgtg aagagaagcc tggccaagca tcggatcggg
     1381 acaaagagac acagagtctg tctggaaata ccccaggagg tcagtcagag cgagctcttc
     1441 cccaaggaag agctaagttc tggacagtat gagatgacag agtgcccggc caccctcgcc
     1501 ccagtgaggc ccacccacag ctccgtgcgg caagttgagg acagtcttcc cttcccagat
     1561 tactctgacc ccactgaagt caaatttgaa gagctgaaga atgtcaaact agaagaggaa
     1621 gatgaggagg atgagcccga agcagccgca ctggaccttt ctgtgaatcc tgcgtctgta
     1681 ggaggacgcc tcgtcttctc gggttccaaa aagaaatcat cttccagcct gggctccact
     1741 tcatctcagg attcagtttc ttcagattct gaaaccgccg agtctgtctc ttgccagggc
     1801 caagagaaaa cgggagttct caccgtgcac agctatgcca gaggggacgg caaggctgcc
     1861 acaggagagc cgagtgtgaa gaagaagcgc agtgctcccc gcagcatcag cgagcaggag
     1921 ctggcagagg ttgcagatga gtacatgctt tccctggagg agaataagaa gaccaagggt
     1981 cgccgccagc ccttgagcaa gctcccacgc caccacccac tcgtgctgca ggagtgcggc
     2041 agcgatgacg agacttctga gcagctgacc cccgaggagg aggctgagga gacagaggct
     2101 tgggccaagc ctctgagcca gctgtggcag aaccgacccc cgaactttga ggctgaaaag
     2161 gaattcaatg agatcatggc ccaacaggcc cctcactgtg ctgtgtgtat gatcttccag
     2221 acctaccatc aggtggaatt tggagccttc agtcagagct gtggggatgc ttcagagccg
     2281 gctgcccaga ctcagaggac caagccactg atccccgaaa tgtgctttac caccactggc
     2341 tgcagcacag acatcaatct gtccaccccg tacctagagg aggatggcac cagcatgcta
     2401 gtgtcctgca agaagtgcag tgtccgggtc cacgccagtt gctatggcgt ccctcctgcc
     2461 aaggcttctg aagaatggat gtgctctcga tgttcagcca atgccctgga ggaagactgc
     2521 tgcttatgct cgttgcgtgg aggggccctg cagagagcca atgacgacag atgggttcat
     2581 gtttcatgtg cagtggcaat tctagaagca aggtttgtca acattgctga aagaagtcca
     2641 gtggatgtga gcaaaatccc tctgccccgc ttcaaactga agtgtgtttt ttgtaagaag
     2701 cggagaaaac ggaatgctgg ctgctgtgtg cagtgctccc atggccgctg ccccactgcc
     2761 ttccatgtga gctgtgccca ggctgctggg gtgatgatgc aacccgacga ctggcccttt
     2821 gttgtcttca tcacgtgctt ccgtcacaag attcccaatc tggagcgtgc taagggagcc
     2881 ttgctgagca tcacggcggg ccagaaggtt atcagcaaac acaagaacgg gcgcttctac
     2941 cagtgtgagg tggtcagact caccaccgag accttctacg aagtcaactt tgacgacggc
     3001 tccttcagtg acaaccttta tcctgaggac atagtgagtc aggactgtct ccaactgggg
     3061 cctcctgctg aaggtgaagt ggttcaagtc agatggacag atggccaagt ctatggggct
     3121 aagtttgtgg cctcccaccc catccagatg taccaggtgg agtttgagga tggctcgcag
     3181 ctggtggtta agagagatga tgtatacaca ctcgatgaag agcttcccaa gagagtcaag
     3241 tctagactgt cggtggcttc agacatgcgc ttcaatgaga ttttcacaga gaaggaagtg
     3301 aagcaagaaa agaagaggca acgggtcatc aactcgcggt accgggagga ttacatcgag
     3361 ccagcgctgt accgggccat catggagtag atgcttccag gatctgagag gttcccagcc
     3421 atcaaggcga gagcactcta gggttccaca gcacagcaga cacttggaac tcgaacttgg
     3481 aacttcactt cgaaagtgaa gctgtacaca gaaaaggaat gacgtgtccg acctttcacc
     3541 ttctcactcc accctcgatg cattctgccg ggaaaagaca agcctattgt gggtgcttgg
     3601 cagcagctgt ccgtcctcag ctgacgggcc gacactggga tgctgtgatt gcatcagccc
     3661 ccagtccaat cgggtcagct gttcctgctg ggcggattgt tctttcttag tggcttgctt
     3721 cctacccgcc caccggcacc agcaaggcag agaggtgctg gtgctgaccc aatccccttt
     3781 tgtatttatg tatgcgtgtg tgagcgtgca cacgtgcaag tgtgtacctg tgtgtaagcg
     3841 tgagaacgtg tgagtgtaca cctgtgtgtg tgtgtgtgtg tgtgcttgag aatgtgtgtg
     3901 tgggtgtgca agtacgtatg tggttgcact cgtgtacgtg agtgcgtgtg tgtgcttggt
     3961 caggactagc ttctgccagc ccctgggctt cactttcttc tttgcctctg cagggcaaac
     4021 aaaatgtgaa attctgccct cagccaagct gagtaagggc cccgggggat gggtagaggt
     4081 ggggtgccat ctgtcccttc ctggaccgat ctcaagagag cgccggcaaa gctgcagtat
     4141 tgggatgcta aggagctggc tgccacctct gtccaccctt gaagtagaac tcagaggtta
     4201 tatactatga gcccacaaat gtcaggcacg gaagcccctg cctgcggcca cagtgttaga
     4261 gggtgtgggt ggggaccacc ttgaagggat aattttaatg atggaaacag gcagagcctg
     4321 gtgggtgatt tttgtgcagt tatgcagggg ctaactatgg gttaggatga actggggcca
     4381 ctggaggcca agggctggta tagctacgcc cttggtcagg ggtggggtgg ggctggttga
     4441 gggtgggggt gggatgggac tagagggcaa cattgaaggg gttaaacagg ttcctgaatt
     4501 tgtttgcctg ggcccaatat ggagggcttc ataccttgct ctgtatacag gagtcagatt
     4561 tataatactt cccctttttt gttacgtatg aactctataa accaaattat tttgaa
//
