LOCUS       NM_001081256            7112 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus KDM3B lysine (K)-specific demethylase 3B (Kdm3b),
            mRNA.
ACCESSION   NM_001081256 XM_619530
VERSION     NM_001081256.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7112)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7112)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 7112)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7112)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7112)
  AUTHORS   Kim,Y.G., Bak,M.S., Kim,A., Kim,Y., Chae,Y.C., Kim,Y.L., Chun,Y.S.,
            An,J.Y., Seo,S.B., Kim,S.J. and Lee,Y.S.
  TITLE     Kdm3b haploinsufficiency impairs the consolidation of
            cerebellum-dependent motor memory in mice
  JOURNAL   Mol Brain 14 (1), 106 (2021)
   PUBMED   34217333
  REMARK    GeneRIF: Kdm3b haploinsufficiency impairs the consolidation of
            cerebellum-dependent motor memory in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7112)
  AUTHORS   Kim,S., Zhang,S., Choi,K.H., Reister,R., Do,C., Baykiz,A.F. and
            Gershenfeld,H.K.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
REFERENCE   7  (bases 1 to 7112)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 7112)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 7112)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 7112)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114820.4.
            
            On Feb 6, 2007 this sequence version replaced XM_619530.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC114820.4         169954-170271       c
            319-486             AC114820.4         154108-154275       c
            487-600             AC114820.4         152716-152829       c
            601-706             AC114820.4         151499-151604       c
            707-831             AC114820.4         150367-150491       c
            832-906             AC114820.4         147920-147994       c
            907-1506            AC114820.4         143230-143829       c
            1507-2755           AC114820.4         137790-139038       c
            2756-2957           AC114820.4         136819-137020       c
            2958-3172           AC114820.4         134693-134907       c
            3173-3325           AC114820.4         133718-133870       c
            3326-3433           AC114820.4         127391-127498       c
            3434-3561           AC114820.4         124780-124907       c
            3562-3841           AC114820.4         123568-123847       c
            3842-4098           AC114820.4         122321-122577       c
            4099-4365           AC114820.4         119674-119940       c
            4366-4537           AC114820.4         118694-118865       c
            4538-4628           AC114820.4         118250-118340       c
            4629-4759           AC114820.4         117981-118111       c
            4760-4879           AC114820.4         117031-117150       c
            4880-5019           AC114820.4         115716-115855       c
            5020-5196           AC114820.4         113792-113968       c
            5197-5331           AC114820.4         112928-113062       c
            5332-7112           AC114820.4         107909-109689       c
FEATURES             Location/Qualifiers
     source          1..7112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.73 cM"
     gene            1..7112
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /note="KDM3B lysine (K)-specific demethylase 3B"
                     /db_xref="GeneID:277250"
                     /db_xref="MGI:MGI:1923356"
     exon            1..318
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..5412
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /EC_number="1.14.11.65"
                     /note="jumonji domain containing 1B; jumonji
                     domain-containing protein 1B; jmjC domain-containing
                     histone demethylation protein 2B; [histone
                     H3]-dimethyl-L-lysine(9) demethylase 3B"
                     /codon_start=1
                     /product="lysine-specific demethylase 3B"
                     /protein_id="NP_001074725.1"
                     /db_xref="CCDS:CCDS37761.1"
                     /db_xref="GeneID:277250"
                     /db_xref="MGI:MGI:1923356"
                     /translation="MADAAASPVGKRLLLLFADPTASASASAPTAAAVVSGDPGPALR
                     TRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHSWVKVHAEDVLALLLEGSLVWAPR
                     KDPVLLQGTRVPVAQWPALTFTPLVDKLGLGSVVPVEYLVDRELRFLSDANGMHLFQM
                     GTDVQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKVYQPEGEEVWLCG
                     VVSRQDSVTRLMEVSITETGEVKSVDPRLTHVMLMDSSTPQSEGGTIKAVKSSKGKKK
                     RESIEGRDGRRRKSASDSGCDPATKKLKGDRGEVDSNGSDGGEASRGPWKGGNASGEP
                     GLEQRAKQPPSTFVPQINRNIRFATYTKENGRTLVVQDEPVGGDTPVPFTPYASATGQ
                     TPLAPEVGGAENKEAGKTLEQVSQGMVASAAVVTTASSTPTTVRISDTGLASGTGPEK
                     QKGSWSQASGENSRNSSLASSGFGVSLSSLSQPLTFGSGRSQSNGVLATDNKPLGFSF
                     SCSSASESQKDSDLSKNLFFQCMSQNVPSTNYLSRVSESVADDSSSRDSFTQSLESLT
                     SGLCKGRSVLGADTQPGPKAGSSVDRKVPAESMPTLTPAFPRSLLNTRTPENHENLFL
                     QPPKLSREEPSNPFLAFVEKVEHSPFSSFVSQASGSSSSATSVTSKATASWPESHSSA
                     ESAPLAKKKPLFITTDSSKLVSGVLGSALSTGSPSLSAVGNGRSSSPTNSLTQPIEMP
                     TLSSSPTEERPTVGPGQQDNPLLKTFSTVFGRHSGSFLSAPAEFAQENKAPFEAVKRF
                     SLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKSGLKGIPEHLMGKLGPNGERSAEL
                     LLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVRKLKQSGEPFLQDGSCINVAPHLHK
                     CRECRLERYRKFKEQEQDDSTVACRFFHFRRLVFTRKGVLRVEGFLSPQQSDPDAMNL
                     WIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVRE
                     MCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQS
                     HEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQSKSVLRPAVTNGISQ
                     LPSVTPSASSGNETTFSSGGGAAAVTNPEPDQVPKGAGTDGRSEEPLKAEGSASNSNS
                     ELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKDAGSLRSVLNKESHSPFGLDSFN
                     STAKVSPLTPKLFNSLLLGPTASNSKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVF
                     SSSSAVAKSKASLPDFLDHIIASVVENKKTSDPSKRSCNLTDTQKEVKEMAMGLNVLD
                     PHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFS
                     QEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGED
                     FRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAED
                     RRVGTTNLHLDVSDAVNVMVYVGIPVGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEK
                     PGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQILRKRLFEEYG
                     VQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSN
                     THTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS"
     exon            319..486
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            487..600
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            601..706
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            707..831
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            832..906
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1506
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2755
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2957
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3172
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3325
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3433
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3561
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3841
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..4098
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4365
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4537
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4628
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4759
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4760..4879
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            4880..5019
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5196
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5331
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..7112
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6632..6637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /note="hexamer: AATAAA"
     polyA_site      6656
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
     regulatory      6720..6725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /note="hexamer: ATTAAA"
     polyA_site      6733
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
     polyA_site      6737
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /note="major polyA site"
ORIGIN      
        1 gggggtgggg gggagcggcg gccgcgggtg gtgcggaggg aggccttgcg ggtggatcgg
       61 gcgcttggcg gcggaggtgg tgggaggcgg cgggcgggag cgcgggtccg tccggccctg
      121 gcgatggcgg acgcggcggc ctccccggtg ggcaagcggc tgttgcttct gttcgcggac
      181 cctacggcct cagcttcggc ctcggccccc acggcggcgg cggtagtgag cggagatcct
      241 gggcctgcgc tgcgcactcg ggcctggagg gccggcacgg tgcgggccat gagcggggcg
      301 gtgccccagg acctagcgat ctttgtggag tttgacggct gtaactggaa gcagcactcc
      361 tgggttaagg ttcacgctga agacgtgctt gcgcttctgc tggaaggctc acttgtttgg
      421 gctccccgga aggaccccgt ccttctgcag ggcacccgag tcccagttgc ccagtggcca
      481 gccctgactt tcacccccct agtagataag ctggggttgg ggtctgtggt gccagttgaa
      541 taccttgtgg atcgagagct tcgtttcctg tcggatgcta atgggatgca tctgttccag
      601 atgggaacag atgttcaaaa tcagattctt ttagaacatg ctgcattaag agagacagtt
      661 aatgctttga tcagtgacca aaagctacaa gagattttca gccgaggtcc ctatagtgtc
      721 cagggccaca gagtcaaggt ctaccaaccc gaaggagagg aagtatggct ctgtggtgtt
      781 gtgagccgtc aggactcagt cacccgtctt atggaagtgt ctataactga gactggtgag
      841 gtcaagtcag tagatcccag actcacccac gtgatgctga tggacagctc gacaccacag
      901 agtgaggggg gtaccataaa agcagtaaaa tcttccaaag gaaagaagaa gagagagagc
      961 atagagggga gagatggccg gaggaggaaa agtgcttcgg actctgggtg tgaccctgct
     1021 acaaagaaat taaaaggaga caggggtgaa gtagacagta atgggagtga tggaggtgag
     1081 gcaagccgag ggccctggaa aggaggtaat gccagtggag agccagggct ggagcagaga
     1141 gccaagcagc caccgtctac atttgttccc cagattaacc gcaacattcg ctttgccact
     1201 tacaccaaag aaaacggcag aactctggtg gtacaggatg agcctgtagg tggggatacg
     1261 cccgtccctt tcactccgta tgcttcagcc acaggtcaga cacctttggc cccagaggta
     1321 ggtggagctg aaaacaaaga ggcgggaaaa acgctggaac aagttagcca gggcatggtg
     1381 gcttcagcag ctgtagtcac taccgccagc tccaccccaa ccacggtgag gatctcagac
     1441 actggccttg catcagggac tgggccggaa aaacagaaag gcagctggtc gcaggcctca
     1501 ggagagaatt caagaaattc tagtctggcc tcttctggat ttggagtgtc tctctcaagt
     1561 ttgtcacaac cattgacttt tggaagtgga cggagccagt ccaatggagt tttagccaca
     1621 gataacaagc ctttgggctt ctctttcagc tgcagctctg catcagagtc tcagaaggac
     1681 tccgatctct ccaagaactt gttttttcaa tgcatgtccc aaaatgtacc cagcactaac
     1741 tacctgagca gggtttcaga gagcgtggcc gatgactcct cgagcaggga ttccttcaca
     1801 caaagcctcg agagcctgac ttcaggcctg tgtaaaggca gatctgttct cggagcagat
     1861 actcagccag gtcccaaggc cggcagctct gtggaccgaa aagtgcctgc agagtccatg
     1921 cccaccctta ctccagcctt cccacggagt ctcctaaata cccgcacccc agagaatcat
     1981 gaaaatctat ttttacagcc cccgaaactg tcccgagaag aaccttctaa ccctttcctg
     2041 gcgtttgtgg agaaagtgga acacagccct ttcagcagct ttgtgtctca ggcatcaggt
     2101 agctcttcct ctgctacctc tgtcacctca aaggcaacag ccagctggcc tgagtctcac
     2161 tcctctgcag agtctgcacc tttagcaaag aaaaagcccc tctttattac aactgactcc
     2221 tccaagctgg tatctggtgt tctgggctcc gctctcagca ctgggagtcc gagtctctct
     2281 gcagtgggga atggccgctc cagctcgccc accaacagcc tcacccaacc tattgagatg
     2341 cctactctct cctccagtcc cacagaagag aggccaactg tggggcctgg ccagcaggac
     2401 aatccgctcc tcaaaacctt cagtaccgtc tttggcaggc actcaggcag ctttctctcc
     2461 gccccagcag agtttgcaca ggagaacaaa gcaccttttg aagctgtaaa aaggttctca
     2521 ttggatgagc gaagcttggc ttgcagacag gattcggact ccagcaccaa cagtgacctg
     2581 tcagatctga gcgactcaga ggagcagctg caggccaaga gtggcctgaa ggggattcca
     2641 gagcacctga tggggaagct aggccccaac ggggagcgta gtgctgagct gctactgggc
     2701 aagggcaaag ggaagcaggc cccaaagggc cggccccgga ctgctcccct gaaagttggc
     2761 cagtcggtgc tgaaggacgt gagtaaagta aggaagctga agcagtctgg agagcccttc
     2821 ctgcaggacg gctcctgcat caacgtggcg cctcacttgc acaagtgccg agagtgccgc
     2881 ctggagaggt accgcaagtt taaggaacag gagcaagatg attctactgt agcctgccgc
     2941 ttctttcact tccggaggtt ggtcttcact cgaaaggggg tgctccgtgt ggagggattt
     3001 ctgagccccc agcagagtga cccggatgcc atgaacctgt ggatcccctc ttcctcccta
     3061 gcagaaggaa tagacctaga aacctcaaaa tacatcttgg ccaatgttgg ggaccagttc
     3121 tgtcagcttg taatgtctga gaaggaggcc atgatgatgg tggagccaca ccagaaagtg
     3181 gcgtggaagc gagcagtgcg tggagttcgg gagatgtgtg atgtgtgtga gacaaccctc
     3241 ttcaatatcc actgggtctg tcggaaatgt ggatttgggg tctgccttga ctgttaccgg
     3301 ctcaggaaaa gccgtccaag gagtgagaca gaagaaatgg gggatgagga agttttctcc
     3361 tggctgaagt gtgcaaaggg gcagtcccac gaaccagaaa acctcatgcc cacccagatc
     3421 atccctggca cagcgcttta caatattgga gacatggtac acgctgcccg gggaaagtgg
     3481 gggattaaag ctaactgccc ttgtataagt cggcaaagca aatctgtttt gagacctgct
     3541 gtcaccaatg ggatatcaca gcttcccagt gtaaccccta gtgcctcttc tggaaacgaa
     3601 actaccttct caagcggagg cggagctgca gcggtcacaa atccagagcc agaccaagtt
     3661 cccaaaggtg ctggcactga cggcagatct gaggagcccc taaaagcaga aggttctgcg
     3721 tcaaatagca atagtgaact aaaagccatc aggcccccgt gcccggacac agcccctcct
     3781 tcctctgctc tgcattggtt ggccgactta gcaactcaga aggcgaaaga agaaacgaaa
     3841 gatgcagggt ccctgcggtc ggtgctcaat aaggagtctc attcaccctt tgggctggac
     3901 tcattcaact ctactgcaaa agtctctcca ttgactccaa agctttttaa cagcctgtta
     3961 ctgggtccca ctgcctccaa cagcaaaact gagggttcta gtcttcgaga cctccttcac
     4021 tctgggcccg gaaagcttcc tcaaaccccc ctggatacag gcataccctt cccccctgtt
     4081 ttctcttcat cctcagcagt agcgaagagc aaagccagcc tacccgactt cctcgaccac
     4141 atcatcgcct cagtggtaga aaacaagaaa acctcagatc cctcaaagcg gtcctgcaac
     4201 ctgaccgaca cccagaagga ggtgaaggag atggcgatgg ggctgaatgt gctcgacccc
     4261 cacacgtctc actcctggct ctgcgacggg cgccttctgt gtctccatga ccccagcaac
     4321 aaaaataact ggaagatctt ccgagagtgt tggaaacaag gccagccagt gctagtttca
     4381 ggggtgcata aaaagctcaa gtctgaactc tggaagccgg aagccttcag ccaggagttt
     4441 ggagaccagg acgtggactt ggtgaactgc aggaattgtg ctatcatttc cgatgttaaa
     4501 gttcgagatt tctgggatgg ctttgagatc atatgcaaga gactacggtc agaagatggg
     4561 cagccaatgg tgctcaaact caaagactgg ccccctgggg aagatttccg ggacatgatg
     4621 cctacaaggt ttgaagatct gatggagaat cttcctcttc cagaatatac caaacgagat
     4681 ggcaggctca atctggcttc taggctaccc agctactttg taaggcctga tctgggcccc
     4741 aagatgtaca acgcctatgg tttgataaca gcagaagaca gaagagttgg tacaacaaat
     4801 cttcatttag atgtgtcaga cgctgttaat gtgatggtgt atgttgggat ccctgtcggg
     4861 gagggtgctc acgatgaaga agtactcaaa actattgatg agggagatgc tgatgaggtg
     4921 accaagcaga ggattcatga tggcaaagag aagccaggag ctttatggca catttatgca
     4981 gcgaaggatg cagagaagat ccgagagctg ctccggaagg ttggagaaga gcaaggccaa
     5041 gagaatcctc cagatcatga cccaattcat gaccaaagtt ggtatctgga ccagatcctc
     5101 cgaaagcgac tctttgaaga gtatggtgtg caaggctggg ccattgtgca gttcctgggt
     5161 gacgctgtct tcatccctgc tggagccccg caccaggttc acaatctgta cagttgcata
     5221 aaggtcgcag aagattttgt atctccagag cacgtgaagc actgtttccg cctgactcag
     5281 gaattcaggc atctctccaa cactcacacc aatcatgagg ataagctaca ggtgaagaac
     5341 atcatatacc acgcagtgaa agacgctgtc ggcactctca aggcccacga atccaagctc
     5401 gcaaggtcct aaaacctggg gtacttcagc tctcctgtca agcaggcctt tcacaacact
     5461 taccagggaa cggcagggtt ctctgcagga gcagaggccc ttccccaagc cagtgtggtc
     5521 agtattacaa actccagccg ctctttctgt gctgcctcaa cactgaaggg tgacacaagc
     5581 aagtcgcact gttgacacac agtgtcagac tcaagccgag ggtgccacat tcccatccag
     5641 tggccttttg ggaatccagg ttgcttgaac attgctgggc tctcctgcac attctcctgg
     5701 tttgagacca tggaaaccag gaatgtgggc acaccttcct ttcctgttcc tcttgtgcct
     5761 ggctaactag ggatgtgttt ggaggcagag gaagtcataa ctggcaacat aaggtgatga
     5821 cttactgtgc ctggtgagag cctggcagtg tctccacacg tgacctctga cctggcccat
     5881 cctaggagat gggggtgcag cccttcccgt actctccatg aacaccggag tcttcaggac
     5941 ccagggagag cccactgctt ttcccaggag gctccaggat taggaaacgt gtatttagtg
     6001 aaaaataggt ttgtagtgaa atagttacta tttcatgaaa gtagatattt ttagaacttt
     6061 tgaaataaca gttgttttcc tggactatga ggaaaggcac attacagtta gtcttccttt
     6121 cgataaaact ctttgaaaag aaatatgatt tttagaaatc agctgcccct tatagcacaa
     6181 aatcagccaa agcgtgattt aaaagaattg gctttttatt aggagttttt tagtttctcc
     6241 gcgtccttct cagtcttatc ttgagggagc agtcatctga gaaagaactg catcatgtct
     6301 gagcttcgga gtgttccctg cacgtgaact gctgacccca ggagctgtgt caccaattac
     6361 cagcgttccc ttgggactcc tcatgtgtgt ccaaacgggg tggaaagttt gatctccaat
     6421 ataaagaagt tttgcttttg ttttttggag ttttgtctag aatattttca gcaaagcttt
     6481 ccaactcagt ggagttttta ttaaggattt acttggaaat gatagaattc attggcccat
     6541 aggtgcattg ggaaatgtgt ctctttccag gtgtactacc ctgcagcctt gtttatatgt
     6601 tcacagttac tttctttttt tttttttttt aaataaaagt catttattgt agaatacttt
     6661 taatttcact ttctgtattt taattttatt gaagggctga ttgggatttc catgttctta
     6721 ttaaaaaatc taacaaatct ctttggagta gacaaaattc tttctctacc aacctttcta
     6781 aagtcaagaa agtctctcac attgggtgtg agagatggag ttgatttcag ggtttcctac
     6841 tgccctgcct gcatctggtc attgcacttt gctgtttgaa ttgtgcttag ttgggaggaa
     6901 gacagacagt ggggatggag ccatgtgagc tgggaagtgg agagagggtt cccagtttgt
     6961 gctcattgaa cagaatggag tacgtgcaat cctgctagga gccgtgcaat cctgctagga
     7021 gccggatgag agacgcctgc cctgacgtgc agcctggaca gagctgcagg ccaggctgtg
     7081 aggctgcagt cgcctgcctg ccttaacctg tg
//
