LOCUS       NP_001074725            1762 aa            linear   ROD 27-APR-2025
DEFINITION  lysine-specific demethylase 3B [Mus musculus].
ACCESSION   NP_001074725 XP_619530
VERSION     NP_001074725.1
DBSOURCE    REFSEQ: accession NM_001081256.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1762)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (residues 1 to 1762)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1762)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1762)
  AUTHORS   Kim,Y.G., Bak,M.S., Kim,A., Kim,Y., Chae,Y.C., Kim,Y.L., Chun,Y.S.,
            An,J.Y., Seo,S.B., Kim,S.J. and Lee,Y.S.
  TITLE     Kdm3b haploinsufficiency impairs the consolidation of
            cerebellum-dependent motor memory in mice
  JOURNAL   Mol Brain 14 (1), 106 (2021)
   PUBMED   34217333
  REMARK    GeneRIF: Kdm3b haploinsufficiency impairs the consolidation of
            cerebellum-dependent motor memory in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1762)
  AUTHORS   Kim,S., Zhang,S., Choi,K.H., Reister,R., Do,C., Baykiz,A.F. and
            Gershenfeld,H.K.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
REFERENCE   7  (residues 1 to 1762)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (residues 1 to 1762)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 1762)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 1762)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114820.4.
            
            On Feb 6, 2007 this sequence version replaced XP_619530.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.73 cM"
     Protein         1..1762
                     /product="lysine-specific demethylase 3B"
                     /EC_number="1.14.11.65"
                     /note="jumonji domain containing 1B; jumonji
                     domain-containing protein 1B; jmjC domain-containing
                     histone demethylation protein 2B; [histone
                     H3]-dimethyl-L-lysine(9) demethylase 3B"
                     /calculated_mol_wt=191329
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          253..350
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          426..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            547
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            557
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            561
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          574..613
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            615
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          713..763
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            767
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            774
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            779
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            799
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          806..853
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          1146..1217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            1254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Site            1260
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7LBC6; propagated from
                     UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          1285..1306
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          1294..1298
                     /region_name="LXXLL motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZPY7.3)"
     Region          1503..1575
                     /region_name="JmjC"
                     /note="A domain family that is part of the cupin
                     metalloenzyme superfamily; smart00558"
                     /db_xref="CDD:214721"
     Region          1600..1705
                     /region_name="cupin_RmlC-like"
                     /note="RmlC-like cupin superfamily; cl40423"
                     /db_xref="CDD:477354"
     CDS             1..1762
                     /gene="Kdm3b"
                     /gene_synonym="5830462I21Rik; JHDM2B; Jmjd1b; mKIAA1082"
                     /coded_by="NM_001081256.1:124..5412"
                     /db_xref="CCDS:CCDS37761.1"
                     /db_xref="GeneID:277250"
                     /db_xref="MGI:MGI:1923356"
ORIGIN      
        1 madaaaspvg krllllfadp tasasasapt aaavvsgdpg palrtrawra gtvramsgav
       61 pqdlaifvef dgcnwkqhsw vkvhaedvla lllegslvwa prkdpvllqg trvpvaqwpa
      121 ltftplvdkl glgsvvpvey lvdrelrfls dangmhlfqm gtdvqnqill ehaalretvn
      181 alisdqklqe ifsrgpysvq ghrvkvyqpe geevwlcgvv srqdsvtrlm evsitetgev
      241 ksvdprlthv mlmdsstpqs eggtikavks skgkkkresi egrdgrrrks asdsgcdpat
      301 kklkgdrgev dsngsdggea srgpwkggna sgepgleqra kqppstfvpq inrnirfaty
      361 tkengrtlvv qdepvggdtp vpftpyasat gqtplapevg gaenkeagkt leqvsqgmva
      421 saavvttass tpttvrisdt glasgtgpek qkgswsqasg ensrnsslas sgfgvslssl
      481 sqpltfgsgr sqsngvlatd nkplgfsfsc ssasesqkds dlsknlffqc msqnvpstny
      541 lsrvsesvad dsssrdsftq slesltsglc kgrsvlgadt qpgpkagssv drkvpaesmp
      601 tltpafprsl lntrtpenhe nlflqppkls reepsnpfla fvekvehspf ssfvsqasgs
      661 sssatsvtsk ataswpeshs saesaplakk kplfittdss klvsgvlgsa lstgspslsa
      721 vgngrssspt nsltqpiemp tlssspteer ptvgpgqqdn pllktfstvf grhsgsflsa
      781 paefaqenka pfeavkrfsl derslacrqd sdsstnsdls dlsdseeqlq aksglkgipe
      841 hlmgklgpng ersaelllgk gkgkqapkgr prtaplkvgq svlkdvskvr klkqsgepfl
      901 qdgscinvap hlhkcrecrl eryrkfkeqe qddstvacrf fhfrrlvftr kgvlrvegfl
      961 spqqsdpdam nlwipsssla egidletsky ilanvgdqfc qlvmsekeam mmvephqkva
     1021 wkravrgvre mcdvcettlf nihwvcrkcg fgvcldcyrl rksrprsete emgdeevfsw
     1081 lkcakgqshe penlmptqii pgtalynigd mvhaargkwg ikancpcisr qsksvlrpav
     1141 tngisqlpsv tpsassgnet tfssgggaaa vtnpepdqvp kgagtdgrse eplkaegsas
     1201 nsnselkair ppcpdtapps salhwladla tqkakeetkd agslrsvlnk eshspfglds
     1261 fnstakvspl tpklfnslll gptasnskte gsslrdllhs gpgklpqtpl dtgipfppvf
     1321 ssssavaksk aslpdfldhi iasvvenkkt sdpskrscnl tdtqkevkem amglnvldph
     1381 tshswlcdgr llclhdpsnk nnwkifrecw kqgqpvlvsg vhkklkselw kpeafsqefg
     1441 dqdvdlvncr ncaiisdvkv rdfwdgfeii ckrlrsedgq pmvlklkdwp pgedfrdmmp
     1501 trfedlmenl plpeytkrdg rlnlasrlps yfvrpdlgpk mynayglita edrrvgttnl
     1561 hldvsdavnv mvyvgipvge gahdeevlkt idegdadevt kqrihdgkek pgalwhiyaa
     1621 kdaekirell rkvgeeqgqe nppdhdpihd qswyldqilr krlfeeygvq gwaivqflgd
     1681 avfipagaph qvhnlyscik vaedfvspeh vkhcfrltqe frhlsnthtn hedklqvkni
     1741 iyhavkdavg tlkaheskla rs
//
