LOCUS       NM_001003953            5191 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus lysine (K)-specific demethylase 2B (Kdm2b), transcript
            variant 1, mRNA.
ACCESSION   NM_001003953 XM_144523
VERSION     NM_001003953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5191)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   2  (bases 1 to 5191)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    GeneRIF: KDM2B regulates hippocampal morphogenesis by
            transcriptionally silencing Wnt signaling in neural progenitors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5191)
  AUTHORS   Iwagawa,T., Fukushima,M., Takeuchi,S., Kawamura,Y., Aihara,Y.,
            Ozawa,M., Yakushiji-Kaminatsui,N., Aihara,M., Koseki,H., Suzuki,Y.
            and Watanabe,S.
  TITLE     The histone H3K36 demethylase Fbxl11 plays pivotal roles in the
            development of retinal late-born cell types
  JOURNAL   Genes Cells 28 (7), 482-495 (2023)
   PUBMED   37073980
REFERENCE   4  (bases 1 to 5191)
  AUTHORS   Blackledge,N.P., Farcas,A.M., Kondo,T., King,H.W., McGouran,J.F.,
            Hanssen,L.L.P., Ito,S., Cooper,S., Kondo,K., Koseki,Y.,
            Ishikura,T., Long,H.K., Sheahan,T.W., Brockdorff,N., Kessler,B.M.,
            Koseki,H. and Klose,R.J.
  TITLE     Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2
            recruitment and polycomb domain formation
  JOURNAL   Cell 157 (6), 1445-1459 (2014)
   PUBMED   24856970
  REMARK    GeneRIF: Genetic ablation in embryonic stem cells reveal that
            deletion of PRC1 has genome-wide effects on PRC2 occupancy and
            H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the
            PCGF1/PRC1 variant complex, is important for deposition of
            H2AK119ub1 and recruitment of PRC2 to a subset of CpG island
            targets and that this activity is essential for normal mouse
            development.
REFERENCE   5  (bases 1 to 5191)
  AUTHORS   He,J., Shen,L., Wan,M., Taranova,O., Wu,H. and Zhang,Y.
  TITLE     Kdm2b maintains murine embryonic stem cell status by recruiting
            PRC1 complex to CpG islands of developmental genes
  JOURNAL   Nat Cell Biol 15 (4), 373-384 (2013)
   PUBMED   23502314
REFERENCE   6  (bases 1 to 5191)
  AUTHORS   Fukuda,T., Tokunaga,A., Sakamoto,R. and Yoshida,N.
  TITLE     Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death
            and leads to exencephaly
  JOURNAL   Mol Cell Neurosci 46 (3), 614-624 (2011)
   PUBMED   21220025
  REMARK    GeneRIF: Results suggest that the Fbxl10 gene makes important
            contributions to embryonic neural development by regulating cell
            proliferation and cell death in mice.
REFERENCE   7  (bases 1 to 5191)
  AUTHORS   He,J., Kallin,E.M., Tsukada,Y. and Zhang,Y.
  TITLE     The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and
            senescence through p15(Ink4b)
  JOURNAL   Nat Struct Mol Biol 15 (11), 1169-1175 (2008)
   PUBMED   18836456
  REMARK    GeneRIF: Results indicate that Jhdm1b is an H3K36 demethylase that
            regulates cell proliferation and senescence through p15(Ink4b).
REFERENCE   8  (bases 1 to 5191)
  AUTHORS   Sanchez,C., Sanchez,I., Demmers,J.A., Rodriguez,P., Strouboulis,J.
            and Vidal,M.
  TITLE     Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel
            complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6
            interacting corepressor
  JOURNAL   Mol Cell Proteomics 6 (5), 820-834 (2007)
   PUBMED   17296600
  REMARK    GeneRIF: Study using a high throughput proteomics approach
            identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein
            kinase subunits, and the BcoR corepressor
REFERENCE   9  (bases 1 to 5191)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 5191)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK136625.1 and BC065090.1.
            
            On Oct 31, 2014 this sequence version replaced NM_001003953.1.
            
            Summary: The protein encoded by this gene is a H3K36-specific
            histone demethylase, which contains an N-terminal jumonji C domain,
            a CxxC zinc finger domain, a plant homeodomain finger, an F-box,
            and eight leucine-rich repeats. Amongst its demonstrated functions,
            this protein plays roles in the suppression of premature cellular
            senescence, leukemia maintenance and development, maintenance of
            mouse embryonic stem cell pluripotency, and induced pluripotent
            stem cell generation. Mice homozygous for a targeted deletion of
            the zinc finger domain display embryonic lethality with development
            ceasing at approximately 7 to 8 days post coitum, demonstrating an
            essential role in early development. A pseudogene of this gene is
            found on chromosome 4. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065090.1, AK129479.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK136625.1         2-15
            15-5191             BC065090.1         1-5177
FEATURES             Location/Qualifiers
     source          1..5191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.63 cM"
     gene            1..5191
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /note="lysine (K)-specific demethylase 2B"
                     /db_xref="GeneID:30841"
                     /db_xref="MGI:MGI:1354737"
     exon            1..232
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..4129
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /EC_number="1.14.11.27"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and leucine-rich repeat protein 10; F-box protein
                     containing leucine repeats 10; lysine-specific demethylase
                     2B; F-box protein FBL10; F-box/LRR-repeat protein 10;
                     [Histone-H3]-lysine-36 demethylase 1B; jmjC
                     domain-containing histone demethylation protein 1B"
                     /codon_start=1
                     /product="lysine-specific demethylase 2B isoform 1"
                     /protein_id="NP_001003953.1"
                     /db_xref="CCDS:CCDS39259.1"
                     /db_xref="GeneID:30841"
                     /db_xref="MGI:MGI:1354737"
                     /translation="MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLR
                     SQLYQGDFVHAMEGKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVG
                     SRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPT
                     VVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTS
                     VWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFF
                     IPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWY
                     VLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEE
                     EEEEDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNES
                     EESVKSTSMPTDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVP
                     EGIEDPQALLEGVKNVLKEHVDDDPTLAITGVPVVSWPKKTAKNRVVGRPKGKLGPAS
                     AVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC
                     IAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVV
                     NDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRR
                     SECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRKRASSLQTSP
                     GSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRLSLAN
                     KPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL
                     VNKELSKELSKELNHEIQKTESTLAHESQQPIKSEPESENDEPKRPLSHCERPHRFSK
                     GLNGTPRELRHSLGPGLRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDSLPL
                     DDGAAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKRLWTRIDLNRCKSITP
                     LMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCP
                     LLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLR
                     LIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDSLTEVNLSDCNKVTDLCLSFF
                     KRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS"
     exon            233..377
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..456
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..503
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..682
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..789
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..883
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1037
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1153
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1280
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1765
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1852
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2077
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2221
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2308
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2569
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2683
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2722
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..3402
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3566
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3728
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3947
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..5177
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5177
                     /gene="Kdm2b"
                     /gene_synonym="Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2"
ORIGIN      
        1 aactgctgaa aatggtttcc taggactttg caaacggatc tgcttaagtg ttggtgcaaa
       61 actttgtaga tatcggctct ggcttgctct atttatttat ttttttgctt tcttttcttt
      121 ggtcttccct cctttccccc tccgccaaaa tgcagggggc aggagtgttg acaattaatt
      181 ggtgaactct cctaaaaaaa tggaggcaga gaaagactct ggaagaagat tgcgtgcgat
      241 tgaccgccag agatacgacg agaacgaaga cttgtcggac gtggaggaaa ttgtcagcgt
      301 ccgtggcttc agcctggagg agaagctacg tagccagtta taccaggggg acttcgtgca
      361 tgctatggaa ggcaaagatt ttaactatga gtacgtacag agagaagctc tcagggtccc
      421 cctggttttt cgggacaagg atggactagg gatcaagatg ccagaccctg atttcacagt
      481 ccgagacgtc aaactcctgg tggggagccg ccgtttggtg gatgtcatgg acgtcaacac
      541 ccagaagggt accgagatga gcatgtccca gtttgtgcgc tactacgaga caccagaggc
      601 acagcgggat aaactgtaca acgtcatcag cctcgagttc agccatacga agctggagca
      661 tctggtcaag cgtcccactg tggtggacct ggtcgactgg gtggacaaca tgtggcctca
      721 gcatctaaag gaaaagcaga cagaagccac caatgccctt gcagagatga agtaccccaa
      781 agtgaaaaag tactgtctga tgagcgtgaa gggctgtttc actgacttcc acattgactt
      841 tggaggcacc tccgtgtggt accatgtgtt ccgtggtggc aagatctttt ggctgatccc
      901 tccaaccctg cacaacttgg ctttgtacga ggagtgggtg ctgtctggca aacagagcga
      961 catctttctg ggagaccgcg tggaacgctg ccaaagaatt gagctgaagc aaggctacac
     1021 ctttttcatc ccttccggtt ggatccatgc ggtttatacg cctgtggact ctctggtgtt
     1081 cggcgggaac atcctgcata gcttcaacgt gcccatgcag ctgcggatct acgagatcga
     1141 ggacaggacc cgggttcagc ccaagttccg ttaccccttc tactatgaga tgtgctggta
     1201 tgtcttggag agatatgtgt actgtgtgac ccagcgctcc tacctcactc aggaatacca
     1261 gagagaatta atgcttattg atgccccaag aaaaaccagt gtagacggct tttcatccga
     1321 ctcctggctg gacatggagg aggagtcctg cgagcagcag ccacaggagg aagaggagga
     1381 ggaggaggac aaggaggagg aaggagatgg tgcagataaa acacccaagc cacccaccga
     1441 tgaccccacc tcacccacca gcaccccgcc cgaagaccag gacagcacag ggaagaagcc
     1501 taaagcccct gccatacggt tcctcaagag gacgttgtcc aatgagtcag aggaaagtgt
     1561 caagtcgacc tcgatgccca cggacgatcc caagacgccc acgggctccc cggccaccga
     1621 ggtttctacc aagtggactc accttaccga atttgaactg aagggcttga aagccctggt
     1681 tgaaaagcta gagtcccttc cggagaataa gaagtgtgtc cctgagggaa tcgaggaccc
     1741 ccaggccctc ctggaaggtg taaagaatgt actgaaagag cacgtggatg acgaccccac
     1801 cctggccatc accggggtcc ctgtggtcag ctggccaaag aaaactgcaa agaaccgggt
     1861 ggtgggtcgg cctaagggca agttgggccc ggcctcagcg gtgaagttgg ctgccaaccg
     1921 aacaacagca ggagctcgca ggcgccggac gcgatgccgc aagtgcgagg cctgcctgcg
     1981 gacggagtgt ggagagtgcc acttttgcaa ggacatgaag aagtttggag gtcctgggcg
     2041 catgaagcag agctgcatca tgcggcagtg catcgcgcca gtgctgcccc acaccgccgt
     2101 gtgccttgtg tgtggcgagg cagggaagga ggacacagtg gaagaggaag aaggcaagtt
     2161 taacctcatg ctcatggaat gctccatctg caacgagatc atccaccctg gatgccttaa
     2221 gattaaggaa tcggagggtg tggtcaacga tgagcttccc aactgctggg agtgtccgaa
     2281 gtgtaaccat gccggcaaga ccgggaaaca aaagcgtggc cctggcttta agtatgcctc
     2341 caacctgcct ggctccttgc tcaaggagca gaagatgaac cgggacaaca aggaagggca
     2401 agagcctgcc aagcggagaa gtgagtgtga agaggctccc cgtcggaggt cagacgagca
     2461 ccccaaaaag gtgcctgcag atggcatcct ccgccgaaag tctgatgatg tgcacctgag
     2521 gaggaagcgg aaatacgaga agccccaaga gctgagtgga cgcaagcgag cctcgtcgct
     2581 tcaaacgtcc cccggttcct cctctcacct ctcgccgagg ccccctctag gcagcagtct
     2641 cagcccttgg tggagatcca gtctcactta cttccagcag cagctaaaac ctggcaaaga
     2701 agataagctt ttcaggaaaa agcggcggtc ctggaagaac gctgaggatc gtctgtcact
     2761 ggccaacaag ccccttcggc gctttaagca ggaaccggag gacgatctgc ctgaggcacc
     2821 tcctaagacc cgggagagtg atcagtcacg ttccagctca cccactgctg gtcccagcac
     2881 tgagggagct gaaggcccag aagagaagaa aaaggtgaag atgcgccgga agcggcgact
     2941 tgttaacaag gagctgagca aagagctaag caaggagctc aaccatgaga tccaaaagac
     3001 ggagagcacc ctggctcacg agagccagca gcccatcaag tcagagcctg agagcgagaa
     3061 cgacgagccc aagaggccct taagccactg cgagcgcccc caccgcttca gcaaagggct
     3121 caacggcaca cctcgggagc tgcggcactc gctgggacct ggcctgcgta gtccacctcg
     3181 tgttatgtcc cggcccccgc cctctgcatc cccacccaag tgcatccaga tggagcgtca
     3241 cgtgatccgg ccaccgccca tcagcccccc acctgactcg ctgcccctgg atgatggagc
     3301 agcccacgtc atgcataggg aggtgtggat ggcagtcttc agctacctca gccaccgaga
     3361 cctgtgtgtc tgcatgcggg tctgcaggac ctggaaccgc tggtgctgcg ataagcggtt
     3421 gtggacccgc atcgacctga accgctgcaa gtccatcaca cccctgatgc tgagcggtat
     3481 catccggcga cagcctgtct cccttgacct cagttggacc aacatctcca agaagcagct
     3541 gagttggctc atcaaccggt tgcctgggct ccgagacttg gtgctgtcag gctgctcatg
     3601 gatcgctgtc tcagccctct gtagctccag ttgtccattg ctccggaccc tggatgtcca
     3661 gtgggtagaa ggactaaagg atgcccagat gagggatctc ctgtctccac ccacagacaa
     3721 caggccaggt cagatggaca atcggagcaa gctccggaac attgtagagc tgcgcctagc
     3781 tggcctggac atcacagatg tctccctgcg gctcattatt cgccatatgc ccctgctctc
     3841 gaagctccaa ctcagttact gtaaccacat caatgaccag tccatcaacc tgctcactgc
     3901 cgtcggcacc accacccgag actcgctgac agaggtcaac ctatcagact gtaataaggt
     3961 aactgacctg tgcctgtcct tcttcaaacg ctgtggaaat atctgtcata ttgacctgag
     4021 gtactgcaag caagtcacca aggaaggctg tgagcaattc atagctgaaa tgtctgtgag
     4081 tgtccaattt gggcaagtgg aagagaaact cctgcaaaaa ctaagttagt tccaggacaa
     4141 gtatgtaaat atggagggtt ggggggaata caaccaggaa gggtgaaaga ctgcaaaatc
     4201 aagtgggcct attatttccc tttggaattt gaaacaagag actacaggac acagttctgt
     4261 tttgcaaatc ttgccaaggg ggaagccatt caaccaccca ttttgggatg agtgagccag
     4321 atgttttcct ttgctctttc tgcatcgtaa ctgcactgct ttctggacca tttctaaggc
     4381 ggcctttaga agacattcca attggaaagg aagatgagct ttggagaaat cctcttagaa
     4441 gcctaagctt ggtgttttta tcagtagttt ttgtttgggg cacttgttcc ttgcaatgct
     4501 gaggcttctg gcgtcaacat ggagtggacc acacacacac catctgcagc cgtcgttgat
     4561 acattttgtt tagttggttt tgttacatct tacattatgc agaactattt ttgtataaat
     4621 tgtttaaaaa ttatttatgg gagatttgaa tgcataccag tgtttttatt atttagattg
     4681 ccaactgtcc ttcaggtagg agagttaacc tgtactatgt cagcataaaa agcccatctc
     4741 cagatgtgcc caggtgtgac agggggctat gaccttccac ttaaaaagca tgtttaactg
     4801 gatgctgaga gcctactgtg tatgtcaaga agctacacaa gcatgttgtg gatatgtgta
     4861 aagtatagtc caggtaaaac actttgccaa gtttcaatag acttcacctc tccctcagac
     4921 ttgagccttt acactcagga gggtttgctc caagcatgag ctcttgtatt ctacttacat
     4981 aggtctaatt tataccaaga atcaggtaga ataaatgtgc ccacaccctc tcctttgtcc
     5041 tcctcctctc aagtgttcag ttctcacttt agttggtaag ttctgcatcc cttgttgttt
     5101 ggtggtgttt cctaaccttt ccctgatgca gtttgacctt tgttggattt atataaacaa
     5161 ttgtacaaaa aaaaaaaaaa aaaaaaaaaa a
//
