LOCUS       NM_001001984            7268 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus lysine (K)-specific demethylase 2A (Kdm2a), mRNA.
ACCESSION   NM_001001984 XM_355123
VERSION     NM_001001984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7268)
  AUTHORS   Nakagawa,R., Llorian,M., Varsani-Brown,S., Chakravarty,P.,
            Camarillo,J.M., Barry,D., George,R., Blackledge,N.P., Duddy,G.,
            Kelleher,N.L., Klose,R.J., Turner,M. and Calado,D.P.
  TITLE     Epi-microRNA mediated metabolic reprogramming counteracts hypoxia
            to preserve affinity maturation
  JOURNAL   Nat Commun 15 (1), 10516 (2024)
   PUBMED   39627218
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7268)
  AUTHORS   Kabeer,S.W., Sharma,S., Sriramdasu,S. and Tikoo,K.
  TITLE     MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated
            epigenetic modulation in diet-induced insulin resistance in
            C57BL/6J mice
  JOURNAL   Biol Res 57 (1), 27 (2024)
   PUBMED   38745315
  REMARK    GeneRIF: MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated
            epigenetic modulation in diet-induced insulin resistance in
            C57BL/6J mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7268)
  AUTHORS   Xiong,X., Yang,M., Hai,Z., Fei,X., Zhu,Y., Pan,B., Yang,Q., Xie,Y.,
            Cheng,Y., Xiong,Y., Lan,D., Fu,W. and Li,J.
  TITLE     Maternal Kdm2a-mediated PI3K/Akt signaling and E-cadherin stimulate
            the morula-to-blastocyst transition revealing crucial roles in
            early embryonic development
  JOURNAL   Theriogenology 209, 60-75 (2023)
   PUBMED   37356280
  REMARK    GeneRIF: Maternal Kdm2a-mediated PI3K/Akt signaling and E-cadherin
            stimulate the morula-to-blastocyst transition revealing crucial
            roles in early embryonic development.
REFERENCE   4  (bases 1 to 7268)
  AUTHORS   Xiong,X., Huang,X., Zhu,Y., Hai,Z., Fei,X., Pan,B., Yang,Q.,
            Xiong,Y., Fu,W., Lan,D., Zhang,X. and Li,J.
  TITLE     Testis-specific knockout of Kdm2a reveals nonessential roles in
            male fertility but partially compromises spermatogenesis
  JOURNAL   Theriogenology 209, 9-20 (2023)
   PUBMED   37354760
  REMARK    GeneRIF: Testis-specific knockout of Kdm2a reveals nonessential
            roles in male fertility but partially compromises spermatogenesis.
REFERENCE   5  (bases 1 to 7268)
  AUTHORS   Martin,M., Motolani,A., Kim,H.G., Collins,A.M., Alipourgivi,F.,
            Jin,J., Wei,H., Wood,B.A., Ma,Y.Y., Dong,X.C., Mirmira,R.G. and
            Lu,T.
  TITLE     KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and
            Potential Liver Damage
  JOURNAL   Biomolecules 13 (10), 1457 (2023)
   PUBMED   37892137
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7268)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 7268)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 7268)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (bases 1 to 7268)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7268)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140073.4, CB246224.1, BC076576.1 and AK173084.1.
            
            On May 24, 2006 this sequence version replaced NM_001001984.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138,
                              SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC140073.4         26333-26691
            360-909             CB246224.1         199-748
            910-3326            BC076576.1         476-2892
            3327-5592           AK173084.1         1145-3410
            5593-7268           AC140073.4         105591-107266
FEATURES             Location/Qualifiers
     source          1..7268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.01 cM"
     gene            1..7268
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="lysine (K)-specific demethylase 2A"
                     /db_xref="GeneID:225876"
                     /db_xref="MGI:MGI:1354736"
     exon            1..767
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            768..868
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     CDS             827..4312
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /EC_number="1.14.11.27"
                     /note="F-box and leucine-rich repeat protein 11; F-box
                     protein containing leucine repeats; F-box/LRR-repeat
                     protein 11; [Histone-H3]-lysine-36 demethylase 1A; jmjC
                     domain-containing histone demethylation protein 1A"
                     /codon_start=1
                     /product="lysine-specific demethylase 2A"
                     /protein_id="NP_001001984.2"
                     /db_xref="CCDS:CCDS37886.1"
                     /db_xref="GeneID:225876"
                     /db_xref="MGI:MGI:1354736"
                     /translation="MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKL
                     QTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCV
                     GSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRP
                     STVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGT
                     SVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTF
                     VIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCW
                     YVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNNKRSVL
                     TSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQ
                     VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLAL
                     TGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARR
                     RRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCG
                     EVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSD
                     KAQKRKIEESDEEAVQAKVLRPLRSCEEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSS
                     PGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSY
                     LTVTLQRPTKELHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGE
                     EEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMR
                     VCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLV
                     NRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTDKPG
                     QDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVG
                     SSTRYSLTELNMAGCNKLTDQTLFFLRRIANVTLIDLRGCKQITRKACEHFISDLSIN
                     SLYCLSDEKLIQKIS"
     exon            869..1007
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1086
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1133
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1312
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1419
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1513
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1667
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1783
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1910
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2305
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2389
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2659
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2791
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2881
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3591
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3755
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3914
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4130
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..7268
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6856..6861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="hexamer: AATAAA"
     polyA_site      6874
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="major polyA site"
     regulatory      7160..7165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="hexamer: AATAAA"
     polyA_site      7185
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
     regulatory      7244..7249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="hexamer: AATAAA"
     polyA_site      7268
                     /gene="Kdm2a"
                     /gene_synonym="100043628; 5530401A10Rik; Cxxc8; Fbl11;
                     Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina"
                     /note="major polyA site"
ORIGIN      
        1 tgagaatctg acgggttcaa aatggcggcg gctgcttcag cggatcctcc tgtgtgaggg
       61 aaacaacacc cctccccggc agcggcggcg gcggcggcgg cgggccgcag agcacctttc
      121 cagttcccgg gcccgtcgcg gttgtttccc tcccgggcag tgggctcttc gcgtggaagg
      181 gcaacgtcag ggggcccatc ccccggagtc cctcctctgc tactggggag tagctggggg
      241 tgtacggggg atcgtcccgc agcgcggagc cccggctcag gggacgacgc aaaggcagcc
      301 gaaggccccc ggtcagggcg cttcgctgct cccgccctct ccgccccccg gggccggggc
      361 ccgcgttccg gggggccggg cggcgcgggg agcgtcggcc gggcgggtct cagctgatcg
      421 gccgcggttc ctgggcttcg gtagcggctg tggccggctg agggtaccga gaggagggtg
      481 tttcccgcgg cccggttgac ccgggtctcg ggctggggct gctgaccgcc agcttggggg
      541 agtagccgag tggtcttgct tccctgacgc ctcggacgcg gagtctgtaa aagccagaag
      601 aggaggtttg attcagtaac tgtttcctct tttccgggtc gctctgaccc ttctctggat
      661 actgggttaa tacacagaaa taccgaagac gacgtttggg attttatttt gtctgtgttt
      721 ggaattttac ttctctcttg gacaagaact caagaacaaa atcctcggaa gaggaaggca
      781 tccctggagt ggtttcttta ctgtacttcc atcagaagag tgagagatgg aacctgaaga
      841 agaaaggatt cggtacagcc agagattgcg tggtaccatg cgtcgtcgct atgaagatga
      901 tggcatttca gatgatgaaa ttgaagggaa aagaactttt gacttggaag agaagctcca
      961 aaccaacaaa tataatgcca attttgttac ttttatggag ggaaaagatt ttaatgtaga
     1021 gtatatccag cggggtggct tgagagaccc tctcattttc aagaattctg atggacttgg
     1081 aataaagatg ccggatccag acttcacagt gaatgatgtc aaaatgtgtg tggggagtcg
     1141 tcggatggtg gatgtcatgg atgtgaacac acagaagggg attgaaatga ccatggcaca
     1201 atggacacga tactatgaga ctccagagga agagcgagaa aaactctata atgttatcag
     1261 cctagagttt agccacacca ggcttgagaa tatggtgcag cggccttcca cggtggattt
     1321 cattgactgg gtagataaca tgtggccaag gcacttgaaa gaaagtcaga cagaatcaac
     1381 aaatgccatc ttagagatgc agtaccctaa agtgcaaaag tactgtctaa tgagtgttcg
     1441 aggctgctat actgacttcc atgtggattt tggaggtact tctgtttggt atcacatcca
     1501 ccaaggtgga aaggtcttct ggctcatccc ccctacagcc cacaacctgg agctgtacga
     1561 gaattggctg ctatcaggga aacagggaga catctttctg ggtgaccggg tgtcagattg
     1621 ccaacgaatt gagctcaagc agggctatac cttcgttatt ccctcaggtt ggattcatgc
     1681 tgtgtatact cctacagaca cattagtgtt tggaggcaat tttttgcata gcttcaacat
     1741 ccccatgcaa ttaaagatat acagcattga agatcgaaca cgggttccaa ataaattccg
     1801 ttacccattt tactatgaaa tgtgttggta tgtgttggag cgctatgtat actgcataac
     1861 caaccgatcc cacctaacta aggattttca gaaagaatcc cttagcatgg atatggagtt
     1921 aaatgagttg gagtctggaa atggtgatga ggaaggggtg gacagagaag cccgacgcat
     1981 gaacaataag cgatctgtgc ttaccagccc tgttgctaat ggagtgaacc tggattacga
     2041 tggacttggc aaagcctgcc gaagtcttcc aagtctgaag aaaactttgt ctggagactc
     2101 atcctcagac tctacccggg gatcccacaa tggccaagtt tgggatcccc aatgtagccc
     2161 taaaaaggat aggcaagtgc atctcaccca ttttgaactt gaaggtcttc gatgtcttgt
     2221 agataagtta gagtcactgc cactgcacaa gaagtgtgtc cccacaggaa tagaagacga
     2281 agatgctctg attgctgatg taaagatttt gctggaagaa cttgccagta gcgatcccaa
     2341 gttagccctc actggagtcc ctatagtaca gtggccaaaa agggataagc ttaaattccc
     2401 taccaggcca aaggtgaggg ttcctacaat tcccatcaca aagcctcaca ccatgaagcc
     2461 agctccacgc ttaacacctg taaggcctgc tgcagcctcc cccattgtgt caggagccag
     2521 gcggagaaga gtgcggtgca ggaaatgcaa agcttgtgtg caaggagaat gtggagtctg
     2581 ccactactgc agggacatga agaaatttgg tggacctgga cgcatgaagc aatcctgtgt
     2641 cctccgacag tgcttagcac ccagactgcc tcattcagtt acgtgttctc tctgtggaga
     2701 agtagatcag aatgaagaga cccaggactt tgaaaagaaa ctcatggaat gctgcatctg
     2761 caacgagata gttcatcctg gctgcctcca gatggatgga gaggggttgc tgaacgagga
     2821 attgccaaat tgctgggagt gtccaaagtg ttaccaggaa gacagctcgg acaaagccca
     2881 gaagcggaaa atagaagaga gtgatgaaga agctgtacaa gccaaagtct tacggcccct
     2941 gaggagctgc gaggagcctc tcacaccccc gcctcactca cctacttcca tgctgcagct
     3001 catccacgac ccggtttctc cccggggtat ggtgactcgg tcatcccctg gggctggccc
     3061 cagcgaccac cacagtgcca gccgtgatga acgcttcaaa cggcggcagt tgctgcggct
     3121 acaagccacc gagcgcacca tggtacggga aaaggagaac aatcccagcg gcaaaaagga
     3181 gctgtctgaa gttgagaaag ccaagatccg gggatcgtac ctcactgtca ctctacagag
     3241 gcccaccaaa gagctccacg ggacatccat tgtgcccaag ctgcaggcca tcacggcctc
     3301 ctctgccaac cttcgcccta acccccgcgt gctaatgcag cactgcccag cccgaaaccc
     3361 ccagcatggg gatgaggagg ggcttggggg agaggaggag gaagaggagg aggaggagga
     3421 agatgacagt gcagaggagg ggggtgcagc caggctgaat ggccggggca gttgggctca
     3481 ggatggagac gaaagctgga tgcagcggga ggtctggatg tctgtcttcc gctacctcag
     3541 ccgcaaagaa ctttgtgaat gtatgcgagt gtgcaagaca tggtataaat ggtgctgtga
     3601 taaacgactt tggacaaaaa ttgacttgag taggtgtaag gccatcgtac cacaagctct
     3661 cagtggtatc atcaagcggc agccagtaag cctcgacctc agctggacta acatctccaa
     3721 aaagcagctg acatggctgg tcaataggct gccaggatta aaagacctcc tcctagcagg
     3781 ctgttcctgg tctgcagtat ctgccctcag cacttccagc tgcccgcttc tcaggaccct
     3841 tgatcttcgg tgggcagtag gaattaaaga ccctcaaatt cgggacttgc tgactccacc
     3901 cacagataag ccaggtcaag acaatcgaag caaactccgg aacatgactg acttccggct
     3961 ggcaggcctt gacatcacag atgctactct ccgactcatc attcgccaca tgcccctttt
     4021 gtctcgactt gacctcagtc actgcagtca ccttacagat cagtcctcca acctactaac
     4081 tgctgtcggg tcttccactc gatactccct tacagagctc aatatggcag gttgcaataa
     4141 attgacagac cagaccctgt tcttcctaag gcgaattgct aatgtcacct tgattgacct
     4201 tcgaggatgc aaacagatca cgagaaaagc ctgtgagcac ttcatctcag acttgtccat
     4261 caacagcctc tactgcctgt ctgatgagaa actgatacag aagattagct aagacatgct
     4321 cagcccagac tgaacaggaa aatcttcccc tgccttccca ccaaggagag tctctccctg
     4381 accctgcgca ggctctgagg ccaacgacac attccctctc tgctctcttt tctctgagcc
     4441 cttctcccac aggtggggca gagaggttgg tggacaccaa ggttattgcc tgctcctctc
     4501 cctcccacgg aaaagaaagg agaggttgat caaggagaaa gcacaggctg tgctatccca
     4561 gttcctgctt gcttgctcgt ctgccagcta ggaagctggg ctctcagttt gggggaattt
     4621 gtgcatcttt cacctgcact gggccaagaa ccctaccttc tcacccatag tccctagcag
     4681 tgcctggttc tgagcatact ctagggagga aggcagcctt gcctccatgg ccagattctc
     4741 ctcatggtgt ccgttgcgtg tctctcctcc gttaaactct cccggcttct gcaggaggag
     4801 ccaacagccc tagaaacacc aggcctggca ggtctcaatg gtgctgtgag ttgtctgaag
     4861 ctttgctcca tgtctgtcat agcccttttt tcttgtccct gagcttgatg ctgtccaaca
     4921 ctcataatac agtccccatt ctgccatcac cccctaaact tttccactag tcacccactt
     4981 gtcctttgtt gcacttactt ggggttatca aaagctcttc agaggagctg gaactctgcc
     5041 cctccccccc ccccccgaaa tgcccatatc attgctaccc aggcatattc taagacaggc
     5101 atcattaata ctccccaccc attgctgccc accaactgcc cttttccatt tgtcctcttt
     5161 ctgcctgagc agggcttttc tagaatttgt gtcctcagaa ggagcagcat gtttctccag
     5221 gtgggggaaa cagaagactg gttgaatccc cacctgcctc tctaagccag gcttttctgg
     5281 gctctggttt agcatggccc tctgagccca ggcctgtgta taacctagca gctcactgac
     5341 ctggtgcctt ttaaggggag tcctgattga aaacctaccc tctgcctgca gccttggaag
     5401 tgtgtgtgca tgtgcctctg tgtgtctggc taagtgtgct gcacatatgt gcagggaagg
     5461 aggggagcat gatggctccc actcctcatc gcccttcttc aagccccatc aagctgcccc
     5521 ctttgacttt gcattgaacg gcctgtccaa agatcctctc tctagggcag cagagagctt
     5581 tttgcacttt agaaaaaaaa aaaaaatgaa agaaagaaaa tggtcggaac tgttctgggt
     5641 caatatttag agtatgagga gatgctcagc agaggcctgt ggccagagtt tgtcagtgat
     5701 acatgcaaat ttgcactctg ctccccatct ataggagatt gataattgat agcacagcct
     5761 tgccccgcct tctcttagcc ccaaacatat cccttcccac ttcccacccc atttcctgga
     5821 atctagcctc agactttcct aaactccatc aagaggggac agagcccggg caccatgagt
     5881 ctgaagtgtg aaccgcccaa ggagagatgc taactgtacc cttgccactg ccaaagcaat
     5941 agaggcagaa gtgtcccctc tgccactcag cccagctttg accctggcaa taaccagact
     6001 ttttccagga aaactgggtt tctggcaagg gatggcattg tttcttccaa tctgctgatt
     6061 tctcttggct gcaccttaaa aacagcagtc tgctcccttg accctctgcc attccattgg
     6121 tcttcaggtc ccagaatcct gggcctgaaa tgttgaggaa acgccagtga cttattccag
     6181 agtgcctcag ttgggggaac ttctgtaaag aaccctgggt gttgagcaaa aaccttatta
     6241 atactattaa tgacctataa ttagaagctt cctgactttt tttctttttg gttgctcctg
     6301 tggaaaatac taaaattact aagttttgtt tgttgtcttt ttatgaaagg ggaggtggag
     6361 agaccctttc agagcaggga ttgtgccggg agagtgcctc tgccctttgg gacagttcat
     6421 ccacagaaat ttctaagctg atggcttgtc tgggttttgg tctttgcatt tgaatttaga
     6481 aaaagcaagc attttaccgc acagaaattt gtcagtggaa aagggagctc agggtggtgg
     6541 cagatggact gacgcccttg ctgggtcttt tctttaggac tatgagggag aatggttttt
     6601 agaggtgaga gttggtcctt gcaaaaagag agaagtgtct ccgaggacgt agaacatgcg
     6661 agttcatagt cctgcatcta ctcttagctg cagtcttgcc agagcctggc ctcagactgc
     6721 aggacctgac ctctgccttc atctttccac atactggggc aaaaaaacac aaaggaaagg
     6781 aagaaaatta tatatatata attatatata tataatataa aatcacttgg tgattaaaaa
     6841 aataactgct caataaataa aactcctaaa gtcactatgt ttaaagggtt tggttttttg
     6901 ggggtgggtg ggaaatattg taaatatata ttttttgttg cttatttaga gtcgatctcc
     6961 aatgttgtgc taagattttt aaattaaatg taagcattaa gggaatgagt cttaggccac
     7021 cagctgacac attggcatta ttttgggtca gggaaggaag aaagctagtt ggactttgtt
     7081 ttctaaaagt ttcccacttg gttttagaaa gagcaaagat gtctttcttc tgacacttgg
     7141 gaatgggaga tatttgtgta ataaaatttt taaaagacaa aaaaagaaat agcctccaat
     7201 gggaaatatt ttgatttggt tttctttttt gtttttgttt ttaaataaaa agactttaaa
     7261 aacaaaaa
//
