LOCUS       NP_001389838             833 aa            linear   ROD 30-APR-2025
DEFINITION  lysine-specific histone demethylase 1B isoform 3 [Mus musculus].
ACCESSION   NP_001389838 XP_006516977
VERSION     NP_001389838.1
DBSOURCE    REFSEQ: accession NM_001402909.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 833)
  AUTHORS   Anvar,Z., Chakchouk,I., Sharif,M., Mahadevan,S., Nasiotis,E.T.,
            Su,L., Liu,Z., Wan,Y.W. and Van den Veyver,I.B.
  TITLE     Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of
            Ovulated Mouse Oocytes and Impacts Expression of Histone
            Demethylase KDM1B
  JOURNAL   Reprod Sci 30 (9), 2780-2793 (2023)
   PUBMED   36976514
  REMARK    GeneRIF: Loss of the Maternal Effect Gene Nlrp2 Alters the
            Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of
            Histone Demethylase KDM1B.
REFERENCE   2  (residues 1 to 833)
  AUTHORS   Liu,S., Tang,S., Yang,G. and Li,Q.
  TITLE     Lysine Demethylase 1B Promotes Tear Secretion Disorder in Sjogren's
            Syndrome by Regulating the PAX6/CLU Axis
  JOURNAL   J Mol Neurosci 73 (1), 28-38 (2023)
   PUBMED   36542318
  REMARK    GeneRIF: Lysine Demethylase 1B Promotes Tear Secretion Disorder in
            Sjogren's Syndrome by Regulating the PAX6/CLU Axis.
REFERENCE   3  (residues 1 to 833)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 833)
  AUTHORS   Takase,R., Hino,S., Nagaoka,K., Anan,K., Kohrogi,K., Araki,H.,
            Hino,Y., Sakamoto,A., Nicholson,T.B., Chen,T. and Nakao,M.
  TITLE     Lysine-specific demethylase-2 is distinctively involved in brown
            and beige adipogenic differentiation
  JOURNAL   FASEB J 33 (4), 5300-5311 (2019)
   PUBMED   30681884
REFERENCE   5  (residues 1 to 833)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 833)
  AUTHORS   Gupta,J., Kumar,S., Li,J., Krishna Murthy Karuturi,R. and Tikoo,K.
  TITLE     Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9
            monomethylation (H3K9me1): distribution and their association in
            regulating gene expression under hyperglycaemic/hyperinsulinemic
            conditions in 3T3 cells
  JOURNAL   Biochimie 94 (12), 2656-2664 (2012)
   PUBMED   22951486
  REMARK    GeneRIF: Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated
            by H3K9me under hyperinsulinemia/hyperglycemia.
REFERENCE   7  (residues 1 to 833)
  AUTHORS   Dey,A., Seshasayee,D., Noubade,R., French,D.M., Liu,J.,
            Chaurushiya,M.S., Kirkpatrick,D.S., Pham,V.C., Lill,J.R.,
            Bakalarski,C.E., Wu,J., Phu,L., Katavolos,P., LaFave,L.M.,
            Abdel-Wahab,O., Modrusan,Z., Seshagiri,S., Dong,K., Lin,Z.,
            Balazs,M., Suriben,R., Newton,K., Hymowitz,S., Garcia-Manero,G.,
            Martin,F., Levine,R.L. and Dixit,V.M.
  TITLE     Loss of the tumor suppressor BAP1 causes myeloid transformation
  JOURNAL   Science 337 (6101), 1541-1546 (2012)
   PUBMED   22878500
REFERENCE   8  (residues 1 to 833)
  AUTHORS   Yang,Z., Jiang,J., Stewart,M.D., Qi,S., Yamane,K., Li,J., Zhang,Y.
            and Wong,J.
  TITLE     AOF1 is a histone H3K4 demethylase possessing demethylase
            activity-independent repression function
  JOURNAL   Cell Res 20 (3), 276-287 (2010)
   PUBMED   20101264
  REMARK    GeneRIF: AOF1 is the second histone demethylase in the family of
            flavin-dependent amine oxidases and reveals a
            demethylase-independent repression function.
            Erratum:[Cell Res. 2010 Jul;20(7):858. Stewart, David M [corrected
            to Stewart, M David]]
REFERENCE   9  (residues 1 to 833)
  AUTHORS   Ciccone,D.N., Su,H., Hevi,S., Gay,F., Lei,H., Bajko,J., Xu,G.,
            Li,E. and Chen,T.
  TITLE     KDM1B is a histone H3K4 demethylase required to establish maternal
            genomic imprints
  JOURNAL   Nature 461 (7262), 415-418 (2009)
   PUBMED   19727073
  REMARK    GeneRIF: oocytes from KDM1B-deficient females showed a substantial
            increase in H3K4 methylation and failed to set up the DNA
            methylation marks at four out of seven imprinted genes examined
REFERENCE   10 (residues 1 to 833)
  AUTHORS   Karytinos,A., Forneris,F., Profumo,A., Ciossani,G., Battaglioli,E.,
            Binda,C. and Mattevi,A.
  TITLE     A novel mammalian flavin-dependent histone demethylase
  JOURNAL   J Biol Chem 284 (26), 17775-17782 (2009)
   PUBMED   19407342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096628.14 and AC154171.5.
            
            On Mar 23, 2022 this sequence version replaced XP_006516977.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.93573.1,
                                           SRR17784644.661533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.5 cM"
     Protein         1..833
                     /product="lysine-specific histone demethylase 1B isoform
                     3"
                     /EC_number="1.14.99.66"
                     /note="amine oxidase, flavin containing 1; lysine-specific
                     histone demethylase 1B; lysine-specific histone
                     demethylase 2; flavin-containing amine oxidase
                     domain-containing protein 1"
                     /calculated_mol_wt=93359
     Region          1..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78; propagated from
                     UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          138..198
                     /region_name="zf-CW"
                     /note="CW-type Zinc Finger; pfam07496"
                     /db_xref="CDD:462181"
     Site            260
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          286..305
                     /region_name="GLYR1-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          <315..830
                     /region_name="PLN02328"
                     /note="lysine-specific histone demethylase 1 homolog"
                     /db_xref="CDD:215187"
     Region          451..480
                     /region_name="Histone H3-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          500..511
                     /region_name="Histone H3-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          551..585
                     /region_name="Histone H3-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          577..579
                     /region_name="GLYR1-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     Region          809..825
                     /region_name="GLYR1-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8NB78"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIG3.1)"
     CDS             1..833
                     /gene="Kdm1b"
                     /gene_synonym="4632428N09Rik; Aof1"
                     /coded_by="NM_001402909.1:146..2647"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:218214"
                     /db_xref="MGI:MGI:2145261"
ORIGIN      
        1 maasrgrskk rsnlelspdn lplrssgrqa kkkaveipde dedgssekky rkcekagcta
       61 aypvcfasas ercakngyts rwyhlscgeh fcnecfdhyy rshkdgydky sawkrvwtsn
      121 gktepspkaf madqqlpywv qctkpecgkw rqltkeiqlt phmartyrcg mkpntitkwd
      181 isellpdtpd hcsfpedlrv levsnhwwyp mliqppllkd svaapllsay ypdcvgmsps
      241 ctsthratvt aattttgsas pgemepskaa psslvlgmnr yfqpfyqpne cgkalcvrpd
      301 vmeldelyef peysrdptmy lalrnlilal wytnckealt pqkciphiiv rglvrircvq
      361 everilyfmt rkglintgvl tvaagqhllp khyhnksvlv vgagpaglaa arqlhnfgmk
      421 vtvleakdri ggrvwddksf kgvvvgrgpq ivngcinnpv almceqlgis mrklgercdl
      481 iqeggritdp tvdkrmdfhf nalldvvsew rkdktllqdv plgekieeiy rafvkesgiq
      541 fselegqvlq fhlsnleyac gsslhqvsar swdhneffaq fagdhtlltp gystiiekla
      601 egldirlksp vqsidytgde vqvtttdgmg hsaqkvlvtv plailqrgai qfnpplsekk
      661 mkainslgag iiekialqfp yrfwdskvqg adffghvpps asqrglfavf ydmdsqqsvl
      721 msvitgeava slrtmddkqv lqqcmgilre lfkeqeipep tkyfvtrwst epwiqmaysf
      781 vktfgsgeay diiaeeiqgt vffageatnr hfpqtvtgay lsgvreaski aaf
//
