LOCUS       NM_001347221            3075 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript
            variant 1, mRNA.
ACCESSION   NM_001347221 XM_006539330
VERSION     NM_001347221.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Porter,R.S., An,S., Gavilan,M.C., Nagai,M., Murata-Nakamura,Y.,
            Zhou,B., Bonefas,K.M., Dionne,O., Manuel,J.M., St-Germain,J.,
            Gascon,S., Kim,J., Browning,L., Laurent,B., Cho,U.S. and Iwase,S.
  TITLE     Coordinated neuron-specific splicing events restrict nucleosome
            engagement of the LSD1 histone demethylase complex
  JOURNAL   Cell Rep 44 (1), 115213 (2025)
   PUBMED   39817906
REFERENCE   2  (bases 1 to 3075)
  AUTHORS   Astleford-Hopper,K., Abrahante Llorens,J.E., Bradley,E.W. and
            Mansky,K.C.
  TITLE     Lysine specific demethylase 1 conditional myeloid cell knockout
            mice have decreased osteoclast differentiation due to increased
            IFN-beta gene expression
  JOURNAL   JBMR Plus 9 (1), ziae142 (2024)
   PUBMED   39664933
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3075)
  AUTHORS   Nagai,M., Porter,R.S., Miyasato,M., Wang,A., Gavilan,C.M.,
            Hughes,E.D., Wu,M.C., Saunders,T.L. and Iwase,S.
  TITLE     Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A,
            prevents excessive synaptogenesis
  JOURNAL   J Biol Chem 300 (11), 107881 (2024)
   PUBMED   39395799
REFERENCE   4  (bases 1 to 3075)
  AUTHORS   Gu,T., Vasilatos,S.N., Yin,J., Qin,Y., Zhang,L., Davidson,N.E. and
            Huang,Y.
  TITLE     Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer
  JOURNAL   Cancer Lett 600, 217182 (2024)
   PUBMED   39154703
  REMARK    GeneRIF: Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer.
REFERENCE   5  (bases 1 to 3075)
  AUTHORS   Malla,S., Kumari,K., Garcia-Prieto,C.A., Caroli,J., Nordin,A.,
            Phan,T.T.T., Bhattarai,D.P., Martinez-Gamero,C., Dorafshan,E.,
            Stransky,S., Alvarez-Errico,D., Saiki,P.A., Lai,W., Lyu,C.,
            Lizana,L., Gilthorpe,J.D., Wang,H., Sidoli,S., Mateus,A., Lee,D.F.,
            Cantu,C., Esteller,M., Mattevi,A., Roman,A.C. and Aguilo,F.
  TITLE     The scaffolding function of LSD1 controls DNA methylation in mouse
            ESCs
  JOURNAL   Nat Commun 15 (1), 7758 (2024)
   PUBMED   39237615
  REMARK    GeneRIF: The scaffolding function of LSD1 controls DNA methylation
            in mouse ESCs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3075)
  AUTHORS   Wissmann,M., Yin,N., Muller,J.M., Greschik,H., Fodor,B.D.,
            Jenuwein,T., Vogler,C., Schneider,R., Gunther,T., Buettner,R.,
            Metzger,E. and Schule,R.
  TITLE     Cooperative demethylation by JMJD2C and LSD1 promotes androgen
            receptor-dependent gene expression
  JOURNAL   Nat Cell Biol 9 (3), 347-353 (2007)
   PUBMED   17277772
REFERENCE   7  (bases 1 to 3075)
  AUTHORS   Metzger,E., Wissmann,M., Yin,N., Muller,J.M., Schneider,R.,
            Peters,A.H., Gunther,T., Buettner,R. and Schule,R.
  TITLE     LSD1 demethylates repressive histone marks to promote
            androgen-receptor-dependent transcription
  JOURNAL   Nature 437 (7057), 436-439 (2005)
   PUBMED   16079795
  REMARK    GeneRIF: LSD1 interacts with androgen receptor in vitro and in
            vivo, and stimulates androgen-receptor-dependent transcription
            [LSD1]
REFERENCE   8  (bases 1 to 3075)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3075)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3075)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671173.12.
            
            On Nov 18, 2016 this sequence version replaced XM_006539330.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.3885816.1,
                                           SRR7974084.22991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               AL671173.12        64981-65472         c
            493-658             AL671173.12        55714-55879         c
            659-718             AL671173.12        44789-44848         c
            719-852             AL671173.12        39820-39953         c
            853-931             AL671173.12        36774-36852         c
            932-1024            AL671173.12        35822-35914         c
            1025-1131           AL671173.12        34967-35073         c
            1132-1213           AL671173.12        33207-33288         c
            1214-1308           AL671173.12        31322-31416         c
            1309-1451           AL671173.12        23767-23909         c
            1452-1542           AL671173.12        23072-23162         c
            1543-1677           AL671173.12        21922-22056         c
            1678-1751           AL671173.12        21247-21320         c
            1752-1863           AL671173.12        20391-20502         c
            1864-1996           AL671173.12        17922-18054         c
            1997-2184           AL671173.12        16962-17149         c
            2185-2299           AL671173.12        16545-16659         c
            2300-2427           AL671173.12        15210-15337         c
            2428-2574           AL671173.12        14621-14767         c
            2575-3075           AL671173.12        13282-13782         c
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.8 cM"
     gene            1..3075
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /note="lysine (K)-specific demethylase 1A"
                     /db_xref="GeneID:99982"
                     /db_xref="MGI:MGI:1196256"
     exon            1..492
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2760
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /EC_number="1.14.99.66"
                     /note="isoform 1 is encoded by transcript variant 1; amine
                     oxidase (flavin containing) domain 2; lysine-specific
                     histone demethylase 1A; BRAF35-HDAC complex protein
                     BHC110; flavin-containing amine oxidase domain-containing
                     protein 2; lysine (K)-specific demethylase 1"
                     /codon_start=1
                     /product="lysine-specific histone demethylase 1A isoform
                     1"
                     /protein_id="NP_001334150.1"
                     /db_xref="CCDS:CCDS84806.1"
                     /db_xref="GeneID:99982"
                     /db_xref="MGI:MGI:1196256"
                     /translation="MLSGKKAAAAAAAAAAAAAAGTEAGSGAAGGAENGSEVAAPPAG
                     LTGPTDMATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGI
                     AETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAP
                     PEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFP
                     DIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSY
                     LERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRV
                     GGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVP
                     KEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIE
                     HWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDL
                     TALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLS
                     TLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVI
                     AVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNK
                     VVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENIS
                     DDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMA
                     QPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYT
                     LPRQATPGVPAQQSPSM"
     exon            493..658
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            659..718
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            719..852
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            853..931
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1024
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1131
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1213
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1308
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1451
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1542
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1677
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1751
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1863
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1996
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2184
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2299
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2427
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2574
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..3075
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /note="hexamer: AATAAA"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /note="hexamer: AATAAT"
     polyA_site      3051
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /note="major polyA site"
     polyA_site      3064
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
ORIGIN      
        1 gggcgcgtgc gcacgcgggg gtgtttggct tcgcacggag cgtgagaggt gcggggcgga
       61 gaggcgcgag gcggctgcgg acccacggag cggcagaccg atcggcccct gcggcccgcg
      121 gcggccaggc ggcccgagat gttgtctggg aagaaggcgg cggcggcggc agcggcagcg
      181 gcggcggcgg cggctgctgg gaccgaggcc gggtccgggg cggcgggcgg tgccgagaac
      241 ggctctgagg tggccgcgcc gcccgcgggc ctgacgggcc ccaccgacat ggctacgggg
      301 gcggcgggcg agcgcactcc ccgaaagaag gagcctccgc gggcctcgcc gcccgggggc
      361 ctagccgagc cgccggggtc tgctgggccc caggcggggc ccacagccgg gcccggctcc
      421 gcgacgccca tggagaccgg aatagccgag accccggagg gccgacggac cagccggcgc
      481 aagcgggcca aggtagaata cagagaaatg gatgaaagct tggccaacct ctcagaagat
      541 gaatattatt cggaagaaga aagaaatgct aaagcagaga aggaaaagaa gcttccccca
      601 ccacctcctc aagccccacc tgaggaagaa aatgaaagtg agccggaaga gccgtctggg
      661 caagcaggag gacttcaaga cgacagttct ggagggtatg gagacggcca agcatcaggt
      721 gtggagggtg cagcttttca aagccgactt ccccatgacc gaatgacctc tcaggaagca
      781 gcctgtttcc cagacatcat cagtgggcct cagcagacac agaaggtttt tctgttcatc
      841 aggaatcgca cattgcagtt atggctggac aacccaaaga tccagctgac gtttgaagcc
      901 actctccagc agctggaagc gccttacaac agcgatactg tgcttgtcca ccgagttcac
      961 agttacttag agcgccatgg tcttatcaac ttcggcatct acaagaggat aaaaccctta
     1021 ccaattaaaa agacaggaaa ggtgattatt ataggttcag gtgtttctgg cttggcagca
     1081 gctcgacagc tacagagttt tgggatggat gtcacacttc tggaagccag ggatcgagta
     1141 ggtggacgag ttgctacatt tcgaaaagga aactatgtag ctgatcttgg cgccatggtt
     1201 gtaacaggtc ttggagggaa tcccatggct gtcgtcagca aacaagtaaa tatggaactg
     1261 gccaagatca agcaaaaatg cccactttat gaagccaatg gacaagctgt tccaaaagaa
     1321 aaagatgaaa tggtagaaca agaatttaac cggttgctag aagccacttc ttaccttagt
     1381 caccagttag acttcaacgt cctcaataat aaacctgtat cccttggcca ggcattggag
     1441 gttgtcattc agctgcaaga aaagcatgtc aaagatgagc agattgaaca ttggaagaag
     1501 atagtgaaaa ctcaggagga gttgaaagag cttcttaata agatggtaaa tttgaaggag
     1561 aaaattaaag agctccatca gcaatacaaa gaagcttcag aagtgaagcc gcccagagat
     1621 atcacagccg agttcctggt gaagagcaag cacagggacc tgactgccct ctgcaaggaa
     1681 tatgatgaat tagctgaaac acaaggaaag ctagaagaaa aacttcaaga attggaagcc
     1741 aatcccccaa gtgatgtata cctctcatca agagacagac aaatacttga ctggcatttt
     1801 gcaaatcttg aatttgccaa cgccacacct ctctctaccc tctctcttaa acattgggat
     1861 caggatgatg actttgagtt tactggaagc cacctgacag taaggaatgg ctactcatgt
     1921 gtgcctgtgg ctttagctga aggcttggac attaaactga acacagcagt gcggcaggtt
     1981 cgctacacag cctcaggatg tgaagtgatt gctgtgaaca cacgttccac aagtcaaacc
     2041 tttatttata agtgtgatgc agttctctgt acacttcctt tgggagtgtt gaagcagcag
     2101 ccaccagctg ttcagtttgt gccacctctt cctgagtgga aaacatctgc agtccaaagg
     2161 atgggatttg gcaaccttaa caaggtggtg ttatgctttg accgtgtgtt ctgggaccca
     2221 agtgtcaatt tgtttgggca cgttggcagt acaactgcta gcaggggtga gctcttcctc
     2281 ttctggaacc tatataaagc tccaatacta ttggccctgg tagcaggaga agctgctggc
     2341 attatggaga acattagtga tgatgtgatt gtcggccggt gcctggccat tctcaaaggg
     2401 atttttggca gcagtgcagt cccacagccc aaggaaactg tggtatctcg ttggcgtgct
     2461 gatccgtggg cccggggctc ctattcttat gtggctgcag gatcctctgg aaatgactat
     2521 gatttaatgg ctcagccgat cactcctggc ccctcaattc caggtgcccc acagccaatc
     2581 ccaagactct tctttgctgg agaacacaca atccggaact acccagctac agtccatggt
     2641 gctctgttga gtgggcttcg agaagcagga aggattgccg accagttttt gggagccatg
     2701 tacactttgc ctcgtcaggc cacaccaggt gtccctgcac agcagtcccc aagtatgtga
     2761 gacagatggt tctgaacaga gagatccaac ggcatgtcat ctgccacgta agcaagctct
     2821 tctagcaata ctagatccta ctgagaaact ccatgtcatc agctactggg actcctagtt
     2881 tgacagcaga ggctggctcc tttggctgac agcaacttac ccattgattt ggaagtacag
     2941 ctccataaag actgctcgag aagcaagtgg tgtgagataa cctcttagtc tatggtgttt
     3001 gtttgttttt gttttttttt aatatatttt gagaataaaa ctttaaaata attttatatg
     3061 aaaatttatt tttaa
//
