LOCUS       NP_001334150             873 aa            linear   ROD 18-MAR-2025
DEFINITION  lysine-specific histone demethylase 1A isoform 1 [Mus musculus].
ACCESSION   NP_001334150 XP_006539393
VERSION     NP_001334150.1
DBSOURCE    REFSEQ: accession NM_001347221.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 873)
  AUTHORS   Porter,R.S., An,S., Gavilan,M.C., Nagai,M., Murata-Nakamura,Y.,
            Zhou,B., Bonefas,K.M., Dionne,O., Manuel,J.M., St-Germain,J.,
            Gascon,S., Kim,J., Browning,L., Laurent,B., Cho,U.S. and Iwase,S.
  TITLE     Coordinated neuron-specific splicing events restrict nucleosome
            engagement of the LSD1 histone demethylase complex
  JOURNAL   Cell Rep 44 (1), 115213 (2025)
   PUBMED   39817906
REFERENCE   2  (residues 1 to 873)
  AUTHORS   Astleford-Hopper,K., Abrahante Llorens,J.E., Bradley,E.W. and
            Mansky,K.C.
  TITLE     Lysine specific demethylase 1 conditional myeloid cell knockout
            mice have decreased osteoclast differentiation due to increased
            IFN-beta gene expression
  JOURNAL   JBMR Plus 9 (1), ziae142 (2024)
   PUBMED   39664933
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 873)
  AUTHORS   Nagai,M., Porter,R.S., Miyasato,M., Wang,A., Gavilan,C.M.,
            Hughes,E.D., Wu,M.C., Saunders,T.L. and Iwase,S.
  TITLE     Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A,
            prevents excessive synaptogenesis
  JOURNAL   J Biol Chem 300 (11), 107881 (2024)
   PUBMED   39395799
REFERENCE   4  (residues 1 to 873)
  AUTHORS   Gu,T., Vasilatos,S.N., Yin,J., Qin,Y., Zhang,L., Davidson,N.E. and
            Huang,Y.
  TITLE     Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer
  JOURNAL   Cancer Lett 600, 217182 (2024)
   PUBMED   39154703
  REMARK    GeneRIF: Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer.
REFERENCE   5  (residues 1 to 873)
  AUTHORS   Malla,S., Kumari,K., Garcia-Prieto,C.A., Caroli,J., Nordin,A.,
            Phan,T.T.T., Bhattarai,D.P., Martinez-Gamero,C., Dorafshan,E.,
            Stransky,S., Alvarez-Errico,D., Saiki,P.A., Lai,W., Lyu,C.,
            Lizana,L., Gilthorpe,J.D., Wang,H., Sidoli,S., Mateus,A., Lee,D.F.,
            Cantu,C., Esteller,M., Mattevi,A., Roman,A.C. and Aguilo,F.
  TITLE     The scaffolding function of LSD1 controls DNA methylation in mouse
            ESCs
  JOURNAL   Nat Commun 15 (1), 7758 (2024)
   PUBMED   39237615
  REMARK    GeneRIF: The scaffolding function of LSD1 controls DNA methylation
            in mouse ESCs.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 873)
  AUTHORS   Wissmann,M., Yin,N., Muller,J.M., Greschik,H., Fodor,B.D.,
            Jenuwein,T., Vogler,C., Schneider,R., Gunther,T., Buettner,R.,
            Metzger,E. and Schule,R.
  TITLE     Cooperative demethylation by JMJD2C and LSD1 promotes androgen
            receptor-dependent gene expression
  JOURNAL   Nat Cell Biol 9 (3), 347-353 (2007)
   PUBMED   17277772
REFERENCE   7  (residues 1 to 873)
  AUTHORS   Metzger,E., Wissmann,M., Yin,N., Muller,J.M., Schneider,R.,
            Peters,A.H., Gunther,T., Buettner,R. and Schule,R.
  TITLE     LSD1 demethylates repressive histone marks to promote
            androgen-receptor-dependent transcription
  JOURNAL   Nature 437 (7057), 436-439 (2005)
   PUBMED   16079795
  REMARK    GeneRIF: LSD1 interacts with androgen receptor in vitro and in
            vivo, and stimulates androgen-receptor-dependent transcription
            [LSD1]
REFERENCE   8  (residues 1 to 873)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 873)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 873)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671173.12.
            
            On Nov 18, 2016 this sequence version replaced XP_006539393.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.3885816.1,
                                           SRR7974084.22991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.8 cM"
     Protein         1..873
                     /product="lysine-specific histone demethylase 1A isoform
                     1"
                     /EC_number="1.14.99.66"
                     /note="amine oxidase (flavin containing) domain 2;
                     lysine-specific histone demethylase 1A; BRAF35-HDAC
                     complex protein BHC110; flavin-containing amine oxidase
                     domain-containing protein 2; lysine (K)-specific
                     demethylase 1"
                     /calculated_mol_wt=94529
     Region          <39..>99
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          204..846
                     /region_name="PLN02328"
                     /note="lysine-specific histone demethylase 1 homolog"
                     /db_xref="CDD:215187"
     CDS             1..873
                     /gene="Kdm1a"
                     /gene_synonym="1810043O07Rik; Aof2; D4Ertd478e; Kdm1;
                     Lsd1; mKIAA0601"
                     /coded_by="NM_001347221.1:139..2760"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS84806.1"
                     /db_xref="GeneID:99982"
                     /db_xref="MGI:MGI:1196256"
ORIGIN      
        1 mlsgkkaaaa aaaaaaaaaa gteagsgaag gaengsevaa ppagltgptd matgaagert
       61 prkkeppras ppgglaeppg sagpqagpta gpgsatpmet giaetpegrr tsrrkrakve
      121 yremdeslan lsedeyysee ernakaekek klpppppqap peeenesepe epsgqagglq
      181 ddssggygdg qasgvegaaf qsrlphdrmt sqeaacfpdi isgpqqtqkv flfirnrtlq
      241 lwldnpkiql tfeatlqqle apynsdtvlv hrvhsylerh glinfgiykr ikplpikktg
      301 kviiigsgvs glaaarqlqs fgmdvtllea rdrvggrvat frkgnyvadl gamvvtglgg
      361 npmavvskqv nmelakikqk cplyeangqa vpkekdemve qefnrlleat sylshqldfn
      421 vlnnkpvslg qalevviqlq ekhvkdeqie hwkkivktqe elkellnkmv nlkekikelh
      481 qqykeasevk pprditaefl vkskhrdlta lckeydelae tqgkleeklq eleanppsdv
      541 ylssrdrqil dwhfanlefa natplstlsl khwdqdddfe ftgshltvrn gyscvpvala
      601 egldiklnta vrqvrytasg ceviavntrs tsqtfiykcd avlctlplgv lkqqppavqf
      661 vpplpewkts avqrmgfgnl nkvvlcfdrv fwdpsvnlfg hvgsttasrg elflfwnlyk
      721 apillalvag eaagimenis ddvivgrcla ilkgifgssa vpqpketvvs rwradpwarg
      781 sysyvaagss gndydlmaqp itpgpsipga pqpiprlffa gehtirnypa tvhgallsgl
      841 reagriadqf lgamytlprq atpgvpaqqs psm
//
