LOCUS       NM_133707               1745 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus keratinocyte differentiation factor 1 (Kdf1),
            transcript variant 2, mRNA.
ACCESSION   NM_133707
VERSION     NM_133707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Li,Y., Tang,L., Yue,J., Gou,X., Lin,A., Weatherbee,S.D. and Wu,X.
  TITLE     Regulation of epidermal differentiation through KDF1-mediated
            deubiquitination of IKKalpha
  JOURNAL   EMBO Rep 21 (5), e48566 (2020)
   PUBMED   32239614
  REMARK    GeneRIF: Regulation of epidermal differentiation through
            KDF1-mediated deubiquitination of IKKalpha.
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Lee,S., Kong,Y. and Weatherbee,S.D.
  TITLE     Forward genetics identifies Kdf1/1810019J16Rik as an essential
            regulator of the proliferation-differentiation decision in
            epidermal progenitor cells
  JOURNAL   Dev Biol 383 (2), 201-213 (2013)
   PUBMED   24075906
  REMARK    GeneRIF: The Keratinocyte differentiation factor 1 is an essential
            regulator of the proliferation-differentiation balance in epidermal
            progenitor cells.
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY028727.1, BY781417.1, AK007551.1, BG069889.2 and BF318332.1.
            
            On Apr 11, 2007 this sequence version replaced NM_133707.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1 and 2 both encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY028727.1         2-30
            30-360              BY781417.1         1-331
            361-458             AK007551.1         285-382
            459-1233            AK007551.1         384-1158
            1234-1406           BG069889.2         329-501             c
            1407-1745           BF318332.1         1-339               c
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..1745
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /note="keratinocyte differentiation factor 1"
                     /db_xref="GeneID:69073"
                     /db_xref="MGI:MGI:1916323"
     exon            1..90
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            91..1158
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1316
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /codon_start=1
                     /product="keratinocyte differentiation factor 1"
                     /protein_id="NP_598468.2"
                     /db_xref="CCDS:CCDS38905.1"
                     /db_xref="GeneID:69073"
                     /db_xref="MGI:MGI:1916323"
                     /translation="MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRR
                     PDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRC
                     GACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFS
                     YPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYS
                     FHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKIS
                     DLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGH
                     ETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPL
                     LQVYC"
     exon            1159..1233
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1737
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1737
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggtgcgcgg cggcgctcgg cggaggcagg aagtgtgtcc ccagcggcgc cccgtgccgc
       61 gctcccgcga gacgcttacc tgcgacccag gtgcctggct gcagcaagcc atgctctgag
      121 ccatgcccag gccgggacag ccccgcccat catctgggcc tccacgcttg gggccctggg
      181 agaggccatc agagttatgc ctggaaacga acgatgagcg ctcccagccc ccaccgggcc
      241 gtcgcaccag gaggccagac cctaaggacc ctggccacca cgggccagag agtatcacct
      301 tcatttcagg ctctgcagaa ccagccaacg agcccccaac ctgctgcctc ctctggcgcc
      361 cctggggttg ggactggtgt agggctgcct tctgcttccg acgctgcagg gattgcctgc
      421 agcgctgtgg ggcttgtgtg cggggctgca gcccctgctt gtctgccgga gaccccattg
      481 aagggtctgc cgaagccgcc tgggccaagg aacacaatgg tgtgcccccc agcccagacc
      541 gtgcaccccc cagccgccgg gatggccaga ggctcaagac aagcatgggc agcagcttca
      601 gctaccctga tgttaagctc aaaggcatcc ctgtctaccc ctaccgccat gccacctccc
      661 cagtccctga cgtggactcc tgctgcaagg agcccctggc cgagcctcct cccacgcggc
      721 acagcttgcc tagcaccttc accaacagcc cccgcggctc tgaggagtac tactccttcc
      781 atgaatcgga cctggacctg cctgagatgg gcagtggctc catgtcgagc cgggagatcg
      841 acgtgcttat tttcaagaag ctgacagagc tgttcagcgt gcaccagatt gacgagctgg
      901 ccaagtgcac atcggacacc gtgttcctgg agaagaccag caagatctca gacctgatca
      961 gcagcatcac gcaggactac cacctggatg agcaagacgc cgagggccgc ctggtgcggg
     1021 gcatcatccg tattagtacc cgcaaaagcc gctcccgccc acagacctcc gaggggcgct
     1081 cagcccgctc tactgcccct gctgctgccc ccgacagtgg ccatgagacc atgctgggct
     1141 ctggcctcag ccaggacgag ctgacagtcc agatctccca ggagacaacc gcagatgcca
     1201 tcgccaggaa actgaggccg tatggagccc cagggtaccc agccagccaa gactcatcat
     1261 tccagggcac ggacacagac tcttcagggg cacccctgct gcaggtgtac tgctaacccc
     1321 tactggccca gcagtcacgg cctctcctgg aagaagcata gccagcggag gagaggaacc
     1381 aggacctctg tgtggggccg cctctgagcc cagaagcagt gacctctctg gcttctgctt
     1441 ttgttgaatc cccttagacc acatacattt cacagggcca tggtgcccat acccccttcc
     1501 agctggcctg actgctggct gggcctcttc tgcggcctga aagcaaagcc ttggaagtag
     1561 cttcccagtt ccactcccat gacaccctaa gcaattatgg ggactaagta ggttgggttg
     1621 gggacagcat ggcctctgtg attctgtggg cagtgcccac ttgctatatt gataagcagt
     1681 tcatattgat tattggctat tctatactgt taacatgacc ctagttgcaa gcacataaaa
     1741 aaaaa
//
