LOCUS       NP_598468                397 aa            linear   ROD 02-JUN-2024
DEFINITION  keratinocyte differentiation factor 1 [Mus musculus].
ACCESSION   NP_598468
VERSION     NP_598468.2
DBSOURCE    REFSEQ: accession NM_133707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Li,Y., Tang,L., Yue,J., Gou,X., Lin,A., Weatherbee,S.D. and Wu,X.
  TITLE     Regulation of epidermal differentiation through KDF1-mediated
            deubiquitination of IKKalpha
  JOURNAL   EMBO Rep 21 (5), e48566 (2020)
   PUBMED   32239614
  REMARK    GeneRIF: Regulation of epidermal differentiation through
            KDF1-mediated deubiquitination of IKKalpha.
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Lee,S., Kong,Y. and Weatherbee,S.D.
  TITLE     Forward genetics identifies Kdf1/1810019J16Rik as an essential
            regulator of the proliferation-differentiation decision in
            epidermal progenitor cells
  JOURNAL   Dev Biol 383 (2), 201-213 (2013)
   PUBMED   24075906
  REMARK    GeneRIF: The Keratinocyte differentiation factor 1 is an essential
            regulator of the proliferation-differentiation balance in epidermal
            progenitor cells.
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY028727.1, BY781417.1, AK007551.1, BG069889.2 and BF318332.1.
            
            On Apr 11, 2007 this sequence version replaced NP_598468.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1 and 2 both encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     Protein         1..397
                     /product="keratinocyte differentiation factor 1"
                     /calculated_mol_wt=43366
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9F4.1)"
     Region          48..397
                     /region_name="DUF4656"
                     /note="Domain of unknown function (DUF4656); pfam15551"
                     /db_xref="CDD:464761"
     Region          130..158
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9F4.1)"
     Region          192..214
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9F4.1)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A9F4.1)"
     Region          304..339
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9F4.1)"
     Region          361..392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9F4.1)"
     CDS             1..397
                     /gene="Kdf1"
                     /gene_synonym="1810019J16Rik"
                     /coded_by="NM_133707.2:123..1316"
                     /db_xref="CCDS:CCDS38905.1"
                     /db_xref="GeneID:69073"
                     /db_xref="MGI:MGI:1916323"
ORIGIN      
        1 mprpgqprps sgpprlgpwe rpselcletn dersqpppgr rtrrpdpkdp ghhgpesitf
       61 isgsaepane pptccllwrp wgwdwcraaf cfrrcrdclq rcgacvrgcs pclsagdpie
      121 gsaeaawake hngvppspdr appsrrdgqr lktsmgssfs ypdvklkgip vypyrhatsp
      181 vpdvdsccke plaeppptrh slpstftnsp rgseeyysfh esdldlpemg sgsmssreid
      241 vlifkkltel fsvhqidela kctsdtvfle ktskisdlis sitqdyhlde qdaegrlvrg
      301 iiristrksr srpqtsegrs arstapaaap dsghetmlgs glsqdeltvq isqettadai
      361 arklrpygap gypasqdssf qgtdtdssga pllqvyc
//
