LOCUS       NM_133950               1525 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein
            retention receptor 1 (Kdelr1), mRNA.
ACCESSION   NM_133950
VERSION     NM_133950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Gatius,A., Tarabal,O., Cayuela,P., Casanovas,A., Piedrafita,L.,
            Salvany,S., Hernandez,S., Soler,R.M., Esquerda,J.E. and Caldero,J.
  TITLE     The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of
            the Postsynaptic Compartment of C-Type Cholinergic Afferent
            Synapses on Motoneurons
  JOURNAL   Front Cell Neurosci 13, 582 (2020)
   PUBMED   32038174
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Hou,W. and Jerome-Majewska,L.A.
  TITLE     TMED2/emp24 is required in both the chorion and the allantois for
            placental labyrinth layer development
  JOURNAL   Dev Biol 444 (1), 20-32 (2018)
   PUBMED   30236446
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Kamimura,D., Arima,Y., Tsuruoka,M., Jiang,J.J., Bando,H., Meng,J.,
            Sabharwal,L., Stofkova,A., Nishikawa,N., Higuchi,K., Ogura,H.,
            Atsumi,T. and Murakami,M.
  TITLE     Strong TCR-mediated signals suppress integrated stress responses
            induced by KDELR1 deficiency in naive T cells
  JOURNAL   Int Immunol 28 (3), 117-126 (2016)
   PUBMED   26489882
  REMARK    GeneRIF: In a mouse line having nonfunctional KDELR1, polyclonal
            naive T cells show excessive integrated stress responses, which are
            rescued by strong TCR-mediated signaling
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Siggs,O.M., Popkin,D.L., Krebs,P., Li,X., Tang,M., Zhan,X.,
            Zeng,M., Lin,P., Xia,Y., Oldstone,M.B., Cornall,R.J. and Beutler,B.
  TITLE     Mutation of the ER retention receptor KDELR1 leads to
            cell-intrinsic lymphopenia and a failure to control chronic viral
            infection
  JOURNAL   Proc Natl Acad Sci U S A 112 (42), E5706-E5714 (2015)
   PUBMED   26438836
  REMARK    GeneRIF: present a recessive mouse missense allele of the
            prototypical mammalian KDEL receptor, KDEL ER protein retention
            receptor 1 (KDELR1). Kdelr1 homozygous mutants were mildly
            lymphopenic, as were mice with a CRISPR/Cas9-engineered frameshift
            allele
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Kamimura,D., Katsunuma,K., Arima,Y., Atsumi,T., Jiang,J.J.,
            Bando,H., Meng,J., Sabharwal,L., Stofkova,A., Nishikawa,N.,
            Suzuki,H., Ogura,H., Ueda,N., Tsuruoka,M., Harada,M., Kobayashi,J.,
            Hasegawa,T., Yoshida,H., Koseki,H., Miura,I., Wakana,S.,
            Nishida,K., Kitamura,H., Fukada,T., Hirano,T. and Murakami,M.
  TITLE     KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key
            phosphatase for ISR
  JOURNAL   Nat Commun 6, 7474 (2015)
   PUBMED   26081938
  REMARK    GeneRIF: regulates naive T-cell homeostasis by controlling
            integrated stress responses
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Rezvani,K., Teng,Y., Pan,Y., Dani,J.A., Lindstrom,J., Garcia
            Gras,E.A., McIntosh,J.M. and De Biasi,M.
  TITLE     UBXD4, a UBX-containing protein, regulates the cell surface number
            and stability of alpha3-containing nicotinic acetylcholine
            receptors
  JOURNAL   J Neurosci 29 (21), 6883-6896 (2009)
   PUBMED   19474315
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Hamada,H., Suzuki,M., Yuasa,S., Mimura,N., Shinozuka,N., Takada,Y.,
            Suzuki,M., Nishino,T., Nakaya,H., Koseki,H. and Aoe,T.
  TITLE     Dilated cardiomyopathy caused by aberrant endoplasmic reticulum
            quality control in mutant KDEL receptor transgenic mice
  JOURNAL   Mol Cell Biol 24 (18), 8007-8017 (2004)
   PUBMED   15340063
  REMARK    GeneRIF: dilated cardiomyopathy found in the mutant KDEL receptor
            transgenic mice is associated with ER stress
REFERENCE   9  (bases 1 to 1525)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1525)
  AUTHORS   Butkevich,E., Hulsmann,S., Wenzel,D., Shirao,T., Duden,R. and
            Majoul,I.
  TITLE     Drebrin is a novel connexin-43 binding partner that links gap
            junctions to the submembrane cytoskeleton
  JOURNAL   Curr Biol 14 (8), 650-658 (2004)
   PUBMED   15084279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149053.3.
            
            On Nov 17, 2006 this sequence version replaced NM_133950.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278132.1, BC011370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC149053.3         88605-88866         c
            263-363             AC149053.3         87847-87947         c
            364-522             AC149053.3         87505-87663         c
            523-775             AC149053.3         79954-80206         c
            776-1525            AC149053.3         77980-78729         c
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.57 cM"
     gene            1..1525
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /note="KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum
                     protein retention receptor 1"
                     /db_xref="GeneID:68137"
                     /db_xref="MGI:MGI:1915387"
     exon            1..262
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..810
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /note="KDEL endoplasmic reticulum protein retention
                     receptor 1; KDEL receptor 1"
                     /codon_start=1
                     /product="ER lumen protein-retaining receptor 1"
                     /protein_id="NP_598711.1"
                     /db_xref="CCDS:CCDS21268.1"
                     /db_xref="GeneID:68137"
                     /db_xref="MGI:MGI:1915387"
                     /translation="MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVF
                     TARYLDLFTNYISLYNTCMKVVYIACSFTTVWMIYSKFKATYDGNHDTFRVEFLVVPT
                     AILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRT
                     LYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA"
     exon            263..363
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..522
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..775
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1525
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1506..1511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /note="hexamer: AATAAA"
     polyA_site      1525
                     /gene="Kdelr1"
                     /gene_synonym="8030486F04Rik; Erd2.1"
                     /note="major polyA site"
ORIGIN      
        1 agctttacca ccagctccgg cctcggctca ccttccagag ccccttcccc ggagctgagc
       61 taccgaaggg cttctctccc gccctcaacc cagcagcacc gcagctccgg ggcagcccgg
      121 ccggccagcc tcccccccca cccagctcag ccctgcccga gtcccccagt catgaacctc
      181 ttccgattcc tgggagacct ctcccacctc ctagctatca tcttgttact gctcaaaatc
      241 tggaagtccc gatcgtgtgc gggcatttca gggaagagcc aagtcctgtt tgctgtggtg
      301 ttcactgccc gatatctgga cctgttcacc aactacattt cactctacaa cacctgcatg
      361 aaggtggtct acatagcttg ttcctttacc acggtgtgga tgatctacag caagttcaaa
      421 gctacttatg atggcaacca cgacactttc cgggtggagt tcctcgtcgt tcctactgct
      481 attttggctt tcctggtcaa ccatgacttc acccctctgg agatcctctg gaccttctcc
      541 atctacctgg agtcagtggc tatcttgcca cagttgttca tggtgagcaa gacgggtgag
      601 gcggagacca tcaccagcca ttacctgttt gcactgggtg tctaccgtac actctatctc
      661 ttcaattgga tctggcgcta ccacttcgag ggcttttttg acctcatcgc catcgttgct
      721 ggcctggtcc agacagtcct ctactgcgat ttcttctacc tctatatcac caaagtcctg
      781 aaggggaaga agctgagctt gccggcataa ccctggcctc accagccttc tctgaggcag
      841 ggcaggaggc agaggaaggc tgctggagcc cgagagcctt ccatccagag ctgactttgt
      901 aaagagctcg cctctcctgg ctccccaccc ctccagctgg gttttggggt ctatggacga
      961 ccctgctcct ggggagctca ggacctgagc tgtttgtagc cttttgcctt ttagagaaga
     1021 aaaacaaaaa acaaatcttt ccactattta gtttttgatt ctgatgactt ttttctcttc
     1081 tacctggccc tgatttttta taaactgtgt tttgagtgtt ctctggatca gggccagggg
     1141 aggtcgaccc ccttctccaa aatcccaccc cagccccatg gttgccaaac actacgtctg
     1201 ccaatatctg cctgcccacc ttggctgtga caacgatgct ccttacatgt tcctggattg
     1261 gtggtaagaa ggaggaaagt taaggagggt ctcctaattt ttcatgattt tttttcttcc
     1321 ccagaatttg ttagcttttt gtgtgtgggg tgggggaggg gagggttgtc ctgtttttga
     1381 taaattaggg gaagctatgg gcttaggcaa gggaaagagg ctggctgacc caggtggtga
     1441 cccagactac actctaacac catgtttttg tacagaattt gatggctgat tctttgttct
     1501 cttgaaataa accaagaaac ctgtc
//
