LOCUS       NM_001111028            3324 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 9
            (Kctd9), transcript variant 1, mRNA.
ACCESSION   NM_001111028
VERSION     NM_001111028.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Zhang,X., Wang,P., Chen,T., Yan,W., Guan,X., Shen,G., Luo,X.,
            Wan,X. and Ning,Q.
  TITLE     Kctd9 Deficiency Impairs Natural Killer Cell Development and
            Effector Function
  JOURNAL   Front Immunol 10, 744 (2019)
   PUBMED   31024568
  REMARK    GeneRIF: Kctd9 Deficiency Impairs Natural Killer Cell Development
            and Effector Function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Zhang,X., Zhu,L., Zhou,Y., Shi,A., Wang,H., Han,M., Wan,X.,
            Kilonzo,S.B., Luo,X., Chen,T. and Ning,Q.
  TITLE     Interference with KCTD9 inhibits NK cell activation and ameliorates
            fulminant liver failure in mice
  JOURNAL   BMC Immunol 19 (1), 20 (2018)
   PUBMED   29940856
  REMARK    GeneRIF: Interference with potassium channel tetramerisation domain
            containing 9 (KCTD9) expression exert beneficial effect in viral
            fulminant hepatitis therapy, which may be mediated by impairment of
            NK cell activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Zhou,Y.Y., Zou,Y., Chen,T., Wang,H.W., Han,M.F., Pi,B., Yan,W.M.,
            Xi,D., Huang,J.Q., Luo,X.P. and Ning,Q.
  TITLE     [KCTD9, a novel potassium channel related gene, was highly
            expressed in hepatic NK cells and T cells of fulminant hepatitis
            mice induced by MHV-3]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 19 (11), 833-837 (2011)
   PUBMED   22433305
  REMARK    GeneRIF: A novel potassium channel gene KCTD9 was highly expressed
            in hepatic NK cells and T cells of fulminant hepatitis mice induced
            by MHV-3.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158922.1, AK087312.1 and AI854539.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-902               AK158922.1         3-904
            903-1052            AK087312.1         777-926
            1053-3154           AK158922.1         905-3006
            3155-3324           AI854539.1         1-170               c
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.66 cM"
     gene            1..3324
                     /gene="Kctd9"
                     /note="potassium channel tetramerisation domain containing
                     9"
                     /db_xref="GeneID:105440"
                     /db_xref="MGI:MGI:2145579"
     exon            1..287
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1409
                     /gene="Kctd9"
                     /note="isoform a is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein KCTD9"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD9 isoform
                     a"
                     /protein_id="NP_001104498.1"
                     /db_xref="CCDS:CCDS49531.1"
                     /db_xref="GeneID:105440"
                     /db_xref="MGI:MGI:2145579"
                     /translation="MRRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYN
                     GKGGLIDDIALIRDDDVLFVCEGEPFIDPQTDARPPGGLLGSHTDWLTLNVGGRYFTT
                     TRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVN
                     DGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSEL
                     RCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQ
                     GVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAK
                     LKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR"
     exon            288..409
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            410..453
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            454..550
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            551..609
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            610..738
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            739..806
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            807..902
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1052
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1158
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1292
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..3307
                     /gene="Kctd9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd9"
                     /note="hexamer: AATAAA"
     polyA_site      3157
                     /gene="Kctd9"
                     /note="major polyA site"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd9"
                     /note="hexamer: ATTAAA"
     polyA_site      3307
                     /gene="Kctd9"
ORIGIN      
        1 ggggggaagg gccgctagca ggctgaggag cctaggggcg gggtgggaag gaggatcggc
       61 caaccccggg gtgtgggact gagggtgcgt gcgtgaggag tgtggggccg accaggaagg
      121 tggcgaaggg cggagagtcc gggtgggagg cgggaggggt ctcgcgggcg cggagcgcgg
      181 cgggtggcgg gccgggagcg agggtggcgg ctccctcagg acccggcgcg ggcggcgcga
      241 tgcggcgggt cacgctgttc ttgaacggca gcccgagcaa cggcaaggtg gttgctgtat
      301 acggaacttt gtctgacttg ctctcagtgg ccagcagtaa actcggcata aaagccacca
      361 gtgtatataa tgggaaaggc ggactgattg atgatattgc tttgatcagg gatgatgatg
      421 tgctgtttgt gtgtgaagga gagccgttta ttgatcctca gacagatgct agaccacctg
      481 gaggattgct aggatcccac acagactggc tcacattaaa tgtaggagga cgatacttca
      541 caacaacaag gagcacttta gtgaataaag agcctgacag tatgctggcg cacatgttca
      601 aggacaaagg tgtctgggga aataagcaag atcatagagg agcattctta attgaccgaa
      661 gtcctgagta ctttgaacct attttgaact acttacgtca tggacagctc attgtaaatg
      721 atggcattaa cttattgggt gtgctagaag aagccaggtt ttttggtatt gactcactga
      781 ttgaacacct agaagtggcc ataaagaatt cccaaccacc agaggatcat tcaccaatat
      841 cccgaaagga atttgttcga tttctgctgg ccactccaac caagtcagag ctgcgctgcc
      901 agggtttaaa cttcagtggt gctgatcttt cccgtttgga ccttcgatac attaacttca
      961 aaatggccaa tttaagccgc tgcaacctcg cacatgcaaa tctctgctgt gctaatcttg
     1021 aacgagctga tctttctgga tcagtgctcg actgtgcaaa tctccaggga gtcaagatgc
     1081 tctgctcaaa cgcagaaggc gcatccctga ggctctgtaa ttttgaggat ccttcgggtc
     1141 ttaaagccaa cttagagggt gctaatctga aaggtgtgga catggaagga agccagatga
     1201 cagggattaa cctcagagtt gccaccttaa aaaatgcaaa actgaagaac tgtaatctca
     1261 gaggagcaac tctggcagga accgatttag aaaactgtga tttgtcgggg tgtgacctcc
     1321 aggaagccaa cctgagaggc tccaatgtga agggtgccat atttgaagag atgctgacac
     1381 cattacatat gtcccagagt gtcagatgag agtggcagga gctggaggaa gatgtcccag
     1441 atggaagcgt ttccttattt tatttctcca tccatccatc gagttgtgta gtggagataa
     1501 aattgtaagg gaatttaagg catatgcttg ttcccagagg tgcataaggg gaagtaattg
     1561 gctttcccct cattgggact gtaacagaag gacactctgt tcatagatgt aggggcagta
     1621 gatgatgctg ctgcattttg agtggagttg gggcatttgt ctggtctctg accaggagta
     1681 gtagctatta tatttgcttt tatttaggca ttgtgtggaa gtgccatctt ggttcaagat
     1741 gcatttgaaa ttttaattta tgaaaagcac aacatatgca aatatattta ttgaatacct
     1801 agatgcagta aggatgttta agttgttaaa tgtcttgaag actctgaaga gttgttcagg
     1861 tttataaata gctttagtga tgccttcctc ttcacacacc tatctatcac atgagggtgg
     1921 ttagtttaag actccctgtg gctcttttga gattcatttc tataatgttt acttttaaag
     1981 aagaaaacag ctaaatttga gtcataatct gctctcacat tttgagacac agtggacgga
     2041 aagctcttgt gtatccttgt gcaggagaag gaagggctca ccagtactgc agctgtctag
     2101 tgagcatgct tctgcttcat tggaggcaag tcccattctg cacgagacta ggctactctt
     2161 tcccttcact cgtccagttc tcatgctcag ttgtcacaag cacaggaaga aacgtcagaa
     2221 ccaaaataca agctttagcc tgatcacagt tcatgtaatg ccaattagtt tatacacaac
     2281 cagcttagaa tagactttca atctgaatct actgcaggtg gagtatgaat aaatcctgca
     2341 gtcgcctaca agaaggcaac atcagataat tatagctgaa accctgcaga ggggactaag
     2401 aaattctaaa ctgatggctt gattatagcc accaggaaag gttgatgaac aaaggaagca
     2461 tttggctagg acacgatgct ctatgtcagt acctgtggct cgctcttttt tttttttctt
     2521 aaatagtttt tgttgtttgt cttgtttttc aatgaaattt tagtccagtt ttcttgagtc
     2581 attatctgtg aacacagtag tagggccttt accttcctcg taggtgtccc agtgtcctta
     2641 tttgttgccc aaaagcaggg aagaagctgt gtccaaatgg gttctaaatc ctacaggctg
     2701 gtcggcttga ggcagtgaat cattacagac tccctagtct ccttcaggag agtggcatgt
     2761 cttcattatt ctgtagcgta ttcttatatc tacatatgca aagctttcct tcacagtaaa
     2821 gggcttacat ggggaggaga gcactccttt acagggaaag gaaagcaatt tcaaaaatga
     2881 attattttct ttgtgttatt atttttacca agacagagaa gtattgtatt gagagatacc
     2941 tattttcata atcaatatgt gcctaaattc tatttaactc atttcactgc actctatttt
     3001 caataattat agactgtatt cattcactga atggtcctct gcagacatat ctgaggctgc
     3061 agaaggagct gaaagatgga aacacagtgt gtgtgggaac tgcggggttc agagctgatg
     3121 gaaaccacat taataaatga ccagtgtgga acgctgacgg cctgtttctg ctcttgcttt
     3181 tctaagacag cactttctgc atttcccaca gttcttcatg atggtgccat gtaggagcgg
     3241 accacacagg ccgcgctctt aatggattag gtttcttgaa aaagccatta aagcacattt
     3301 acttgttaaa aaaaaaaaaa aaaa
//
