LOCUS       NM_172509               3582 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 7
            (Kctd7), mRNA.
ACCESSION   NM_172509
VERSION     NM_172509.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3582)
  AUTHORS   Liang,J.H., Alevy,J., Akhanov,V., Seo,R., Massey,C.A., Jiang,D.,
            Zhou,J., Sillitoe,R.V., Noebels,J.L. and Samuel,M.A.
  TITLE     Kctd7 deficiency induces myoclonic seizures associated with
            Purkinje cell death and microvascular defects
  JOURNAL   Dis Model Mech 15 (9) (2022)
   PUBMED   35972048
  REMARK    GeneRIF: Kctd7 deficiency induces myoclonic seizures associated
            with Purkinje cell death and microvascular defects.
REFERENCE   3  (bases 1 to 3582)
  AUTHORS   Alevy,J., Burger,C.A., Albrecht,N.E., Jiang,D. and Samuel,M.A.
  TITLE     Progressive myoclonic epilepsy-associated gene Kctd7 regulates
            retinal neurovascular patterning and function
  JOURNAL   Neurochem Int 129, 104486 (2019)
   PUBMED   31175897
  REMARK    GeneRIF: Deletion of Kctd7 induces defective patterning of the
            adult mouse retina vascular network, resulting in increased
            branching, vessel length, and lacunarity. These alterations reflect
            early and specific defects in vessel development, as emergence of
            the superficial and deep vascular layers were delayed. These
            defects are likely due to a role for Kctd7 in inner retina neurons.
REFERENCE   4  (bases 1 to 3582)
  AUTHORS   Albrecht,N.E., Alevy,J., Jiang,D., Burger,C.A., Liu,B.I., Li,F.,
            Wang,J., Kim,S.Y., Hsu,C.W., Kalaga,S., Udensi,U., Asomugha,C.,
            Bohat,R., Gaspero,A., Justice,M.J., Westenskow,P.D., Yamamoto,S.,
            Seavitt,J.R., Beaudet,A.L., Dickinson,M.E. and Samuel,M.A.
  TITLE     Rapid and Integrative Discovery of Retina Regulatory Molecules
  JOURNAL   Cell Rep 24 (9), 2506-2519 (2018)
   PUBMED   30157441
REFERENCE   5  (bases 1 to 3582)
  AUTHORS   Moen,M.N., Fjaer,R., Hamdani,E.H., Laerdahl,J.K., Menchini,R.J.,
            Vigeland,M.D., Sheng,Y., Undlien,D.E., Hassel,B., Salih,M.A., El
            Khashab,H.Y., Selmer,K.K. and Chaudhry,F.A.
  TITLE     Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and
            glutamine transport
  JOURNAL   Brain 139 (Pt 12), 3109-3120 (2016)
   PUBMED   27742667
REFERENCE   6  (bases 1 to 3582)
  AUTHORS   Azizieh,R., Orduz,D., Van Bogaert,P., Bouschet,T., Rodriguez,W.,
            Schiffmann,S.N., Pirson,I. and Abramowicz,M.J.
  TITLE     Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator
            of potassium conductance in neurons
  JOURNAL   Mol Neurobiol 44 (1), 111-121 (2011)
   PUBMED   21710140
  REMARK    GeneRIF: KCTD7 expression hyperpolarizes the cell membrane and
            reduces the excitability of transfected neurons in patch clamp
            experiments.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122339.3.
            
            On May 19, 2018 this sequence version replaced NM_172509.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083583.1, AK162568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AC122339.3         55416-55759         c
            345-514             AC122339.3         52419-52588         c
            515-693             AC122339.3         48793-48971         c
            694-3582            AC122339.3         45523-48411         c
FEATURES             Location/Qualifiers
     source          1..3582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.72 cM"
     gene            1..3582
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /note="potassium channel tetramerisation domain containing
                     7"
                     /db_xref="GeneID:212919"
                     /db_xref="MGI:MGI:2442265"
     exon            1..344
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1070
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD7"
                     /protein_id="NP_766097.1"
                     /db_xref="CCDS:CCDS19707.1"
                     /db_xref="GeneID:212919"
                     /db_xref="MGI:MGI:2442265"
                     /translation="MVVVTGREPDSRHSDGAMSSSEAEDDFLEPATPTATQAGHGLPL
                     LPQEFPEVVPLNIGGAHFTTRLSTLRRYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGT
                     HFGDVLNFLRSGDLPPREHVRAVHKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLM
                     PYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESD
                     GQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYY
                     CKRPIYEFKITWW"
     exon            345..514
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..693
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..3582
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="Kctd7"
                     /gene_synonym="4932409E18; 9430010P06Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaccagcga ctaactgtag gcgcgttggt cgttagactg ttggagggca gcacaggaca
       61 tcctaactgc ttgcaggtcc tcggcgtcta gcgcccgccg gcggcccatc tcgtcatgtc
      121 aggcactgct tggctttagt tcttcaggcc tccgcccacc cgcctacccg aagccgcgcc
      181 caccgcccag agccagaggg atggtggtag tcaccgggcg ggagccagac agccgtcact
      241 cggacggtgc catgtccagc tccgaagccg aagacgactt cctggagccg gccactccta
      301 cggccacgca agcggggcac gggctgcccc tgctgcccca ggagtttcct gaagtcgtcc
      361 ccttgaacat tggaggggct cactttacca cgcgcttgtc tactctgcgg cgctatgaag
      421 acaccatgct ggctgccatg ttcagcgggc ggcattacat ccctacagac tccgagggcc
      481 ggtacttcat cgatcgagat ggcacacact ttggagatgt gctgaacttc ctgcgttcag
      541 gggacctgcc ccccagggag catgtgcgag ctgtgcacaa ggaggcccag tactatgcca
      601 tcgggcccct cctggagcag ctggagaaca tgcagccact gaagggcgag aaggtgcgcc
      661 aggccttcct gggactcatg ccctattaca aagaccactt ggagcggatt gtggagattg
      721 cccggcttcg cgcagtacag cggaaggccc gctttgccaa gctcaaagtc tgtgtcttca
      781 aggaagagat gcccatcacc ccctatgagt gtccgctcct caactccctt cgctttgagc
      841 ggagtgagag tgatggacag ctctttgagc accactgtga agtggacgtg tcttttgggc
      901 cctgggaggc cgtggctgat gtatacgacc tcttgcactg cctggtcact gacctctcag
      961 cccagggcct cacggtggac caccagtgta tcggggtgtg tgacaagcac cttgtcaacc
     1021 attactactg caaacgcccc atctatgagt tcaaaatcac gtggtggtga gttgtcctca
     1081 gaagcaagag taccacgaag gaggatgttc gtcctcttgg gtgactctgg gagtctgatc
     1141 cccacagggg ctgctgactg tcccagaagc cgctgagttg agaggacaga gcgcggaggc
     1201 acagatgcag agagagaggc ccaggcgctt gctgcagtct ccctggctcg tggctcttgg
     1261 ggactcggtc tgctctcacc tgattttctc ttcaaggcct ggcagtcttc actggaagcc
     1321 acaagatcta gcaaggatgt cgctgggagt ccagagagct tttgatacct tcttgatgcc
     1381 ctgcaggaaa gctcctgcct gtccctgacg cagatagcat cactgcctca cattgtttga
     1441 accttcccat gtgtgtccgg cgggataaag agtgagctag gggtttcgcc caaacatctg
     1501 ccctgtatcc ctggccaaag aagaaagcct gtatctcttc ccagtgtgct ccttggtctt
     1561 ccagtgactt gcagtacctt gtcttacgat gtagaaagat atgtcccatg ttcccagaac
     1621 atgcctgtca ccttctcttg gagattaacc atagctgcca aagccgtgta ccatgttggg
     1681 ccttagaaaa accacattgt ttacagccct gccccggggc tttggcttct cccttctttg
     1741 cagggttacc ctttcacagg gctggaatgt taagttctaa aggttctctc tgaagatccc
     1801 ccaagtcagg cagacaagga gcccggaccc tcttgatatg taggatccct ctcagatgtc
     1861 aagaacacag ggccttgctg cggagtctta tgtggggagc cagtgtggta aacctctctg
     1921 gaaggggtgc tctctttctt tgatagtttt tattcagggt ggtggggact tgctctgcag
     1981 tcagggacag gatataacct gtaaccccta aagagagagc tgtttagcgt tcctctgaga
     2041 gcattgcatg tccaggctgc actatggctt ctatgtagtc atgggtgtcc ttgaatgata
     2101 atttttttaa tgaaactttt ttttaaaaaa atgtaaggaa ttgttaagga cagcattgcc
     2161 aagctcagtc ctgtaggatc agagtggtgc agtctgaggg atagaaggcc tggggcttct
     2221 ggctctgagc taaattcctc tgggcagctg gagggcagtg actctcctgg gctctcgtgg
     2281 aaacacgcaa ttttgaacat gtgtctcact ctgagtgtaa cagagaggct gaggtctggc
     2341 agggatggca gggatgaggg gcagtcatta tccaggacac ctgctctctc tgttctcctc
     2401 agcaaacagc cacatcatct gaggtgctga tgtccctgct tgaagcttag tccagcactg
     2461 tggctctggc cttgtttcag caaagatgtt ccttatttca accgattttt tttttaattt
     2521 ttaattttta tttttcggac agggtcttat gtagcccagg ctggcctcat gttagccgta
     2581 gtgctaaggg taaccttata ctcttgccct tcctgctcta cctccgaggc tctgggggac
     2641 acaggcatgt cccgcctccc ctagctctta tgttcactgt ctggagagct agtgaagtac
     2701 actgttcagg atgatgccca cgtgggtaga aagcagacaa ttaagcccgg ggcagttagc
     2761 ctggggctct cgacttcctg ctctagaata ttgcaatgct tggaaaatta gagcccacaa
     2821 atataagaca gaaaattgta tcagctcaaa aaccgggccc agactgcttg ctgaaggttg
     2881 aaagatgctg ggtaaagatg ccatctttgt gacttgctgg agatactgtt tttctgttcc
     2941 cctttttatt ctcaggatga tatagtttgt accattgtgg caagagagag ctctaggctg
     3001 ctggagcagg caggggtggg atacaagata gccagctcag caatcccccc cctttttttt
     3061 agatagttga cttgatattt atggtattag ggatcaaacc atgtactgaa tcttcttgtg
     3121 tggttttgtt tttttttttt ttaaataaca aaaccctttg catttttaag ccagcgactt
     3181 gtccaccgtc ttgcagcaca gaaacttttc tttgtactac aaaatatgtt tattataatt
     3241 ctaattctcc cttgactagt aaaatagaac tatgaaataa agcaatatat attgggatct
     3301 gggatgtggt tccatggtag aatatcaacc tagtgtgcac gaggcgctgg gttccctctt
     3361 cagcaccacc aaaaaccaag tatgtccaag tgtatctttg ctacttggac tctctcctca
     3421 ctagccttct cttccctctt ggaacttctc ttaaatggaa taaaagaatt catagcctgt
     3481 tttggctctc tcacgagaag ccaaggccaa gtctgaaatg cactgttgaa tgtggtggct
     3541 gggggtgact tctgaataaa agggtcatat ctgtgggaag ta
//
