LOCUS       NM_183285               1746 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 2
            (Kctd2), transcript variant 1, mRNA.
ACCESSION   NM_183285 XM_910173
VERSION     NM_183285.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Kim,E.J., Kim,S.H., Jin,X., Jin,X. and Kim,H.
  TITLE     KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses
            gliomagenesis by destabilizing c-Myc
  JOURNAL   Cell Death Differ 24 (4), 649-659 (2017)
   PUBMED   28060381
  REMARK    GeneRIF: Depletion of KCTD2 using a KCTD2-specific short-hairpin
            RNA in primary Ink4a/Arf-deficient murine astrocytes markedly
            increased self-renewal activity in addition with an increased
            expression of stem cell markers, and mouse in vivo intracranial
            tumor growth.
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627096.9 and AL645470.20.
            
            On Apr 13, 2022 this sequence version replaced NM_183285.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095988.1, AK009318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AL627096.9         12080-12440
            362-470             AL627096.9         13917-14025
            471-562             AL627096.9         16418-16509
            563-658             AL627096.9         19367-19462
            659-784             AL645470.20        195419-195544       c
            785-1746            AL645470.20        193550-194511       c
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..1746
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /note="potassium channel tetramerisation domain containing
                     2"
                     /db_xref="GeneID:70382"
                     /db_xref="MGI:MGI:1917632"
     exon            1..361
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..814
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein KCTD2"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD2 isoform
                     1"
                     /protein_id="NP_899108.3"
                     /db_xref="CCDS:CCDS25634.1"
                     /db_xref="GeneID:70382"
                     /db_xref="MGI:MGI:1917632"
                     /translation="MAELQLDPAVAGLGGGGSSAMGDGGGSGRGPPSPRPAGPTPRGH
                     GRQPAAAAQPLEPGPGPPERTGGGGAARWVRLNVGGTYFVTTRQTLGREPKSFLCRLC
                     CQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLEEAEFYNI
                     ASLVRLVKERIRDNENRTSQGPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLISIGS
                     SYNYGNEDQAEFLCVVSRELNNSTNGIVIEPSEKAKILQERGSRM"
     exon            362..470
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            471..562
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..658
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..784
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1746
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1746
                     /gene="Kctd2"
                     /gene_synonym="2310012I15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggcag cggcggccca agatggcgga gctgcagctg gacccggcag tggcggggct
       61 gggagggggt ggcagcagtg cgatgggcga cggcggcggc tcgggccgcg gaccccccag
      121 ccctcgccct gcgggcccga caccccgcgg acacggccgc cagcccgccg ccgccgcgca
      181 gccgctggag cccgggcccg gacctccgga gcggacggga ggcggcgggg ccgcccgctg
      241 ggtccggctc aacgtgggcg gtacctactt cgtgaccacc agacagaccc taggccggga
      301 gcccaagtcc ttcctctgcc gcctgtgctg ccaggaggac ccggagctgg actccgacaa
      361 ggacgagact ggagcgtatc tgattgacag agaccctacc tactttggtc ctatcctaaa
      421 ctacctccgc catgggaaac tcatcattac caaggagttg gcagaagaag gtgtgctgga
      481 agaagcagag ttttacaata tcgcatctct cgtgcggctg gttaaggaaa ggatacgaga
      541 caatgagaac agaacttcac aaggccccgt gaagcacgtg tacagggtcc tgcagtgtca
      601 agaggaagag ctcacgcaga tggtctccac tatgtctgat ggctggaaat ttgaacagtt
      661 aatcagcatt ggctcttcct ataactatgg aaatgaagac caggcagaat tcctctgtgt
      721 tgtctccaga gaactaaata attctaccaa tggcatcgtc atagagccga gcgaaaaggc
      781 caagattctt caggagagag gctctcgaat gtaagcggac agtctgaagt ttcagaaccc
      841 tgaaggcaag agagcaatcg gcccagcagc tgcgacggag atcctgcacc tgtacagtaa
      901 ccgagctact gcaaagcaaa gctgcgcctg gtcccgagaa gtggtgtccg gccggccaag
      961 ccagaggagc cccaccgcct ggatgaagac agtgcgcctc tggctgcacg gtcccttttc
     1021 agaaacctgc ttttgttttc tagccagtgt tagaacagac cttcacaaca gcatctggga
     1081 tgggtccctg gctggagctt gtggggagtt ggggggaaag gagtaaggtc tagctccctg
     1141 gaacagtcta gatgcttttc taaaagcctg agccgaggaa gaaggcttgt cctgagctgt
     1201 gcctggtctc agcctgcgtg cgccatgatg gacatgagca gctgcttgga ccattcttcc
     1261 ctgggcaggg cattccgtgt tagtgtggtg gacccaagtt ctgggtacag aacaaagttg
     1321 ctgaaggacc cacaatccta tgaacagagc ctcagaggca ggaggataag gtgtcctgta
     1381 gtgtggttgg agcgtgggag ttgctgttcc tggtcccacg agtggatcac ctggtgtctc
     1441 tcagccaggc ccctcgtagc ccatcctcac ccagaggttt gaggctgcgg catcctaagc
     1501 cgtgctagat ggacatcggg actgagcagt tgctgtaact gcttctgcag ccttttccta
     1561 cctggttgac cccgtcttcc tcccccagct tcttgaactg gaccaaagag aaaggacttt
     1621 gtgggcctct gtaatggctt ggggtgagga aggctgttct gtggacgctg ccaaatgtgt
     1681 catattgtca tagctaaaag tggtggtgtg tttgtggttg tctcttgaac atgcgctgat
     1741 aggtga
//
