LOCUS       NM_001301173            3007 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 19
            (Kctd19), transcript variant 2, mRNA.
ACCESSION   NM_001301173 XM_006531073
VERSION     NM_001301173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Zhou,X., Fang,K., Liu,Y., Li,W., Tan,Y., Zhang,J., Yu,X., Wang,G.,
            Zhang,Y., Shang,Y., Zhang,L., Chen,C.D. and Wang,S.
  TITLE     ZFP541 and KCTD19 regulate chromatin organization and transcription
            programs for male meiotic progression
  JOURNAL   Cell Prolif 57 (4), e13567 (2024)
   PUBMED   37921559
  REMARK    GeneRIF: ZFP541 and KCTD19 regulate chromatin organization and
            transcription programs for male meiotic progression.
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Zhang,Y., Huang,X., Xu,Q., Yu,M., Shu,M., Shan,S., Fan,Y., Li,S.,
            Tao,C., Zhao,Y., Ji,J., Qin,Y., Lu,C., Xia,Y. and Zhang,F.
  TITLE     Homozygous nonsense variants of KCTD19 cause male infertility in
            humans and mice
  JOURNAL   J Genet Genomics 50 (8), 615-619 (2023)
   PUBMED   37257643
  REMARK    GeneRIF: Homozygous nonsense variants of KCTD19 cause male
            infertility in humans and mice.
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Wang,W., Su,L., Meng,L., He,J., Tan,C., Yi,D., Cheng,D., Zhang,H.,
            Lu,G., Du,J., Lin,G., Zhang,Q., Tu,C. and Tan,Y.Q.
  TITLE     Biallelic variants in KCTD19 associated with male factor
            infertility and oligoasthenoteratozoospermia
  JOURNAL   Hum Reprod 38 (7), 1399-1411 (2023)
   PUBMED   37192818
  REMARK    GeneRIF: Biallelic variants in KCTD19 associated with male factor
            infertility and oligoasthenoteratozoospermia.
REFERENCE   5  (bases 1 to 3007)
  AUTHORS   Liu,J., Rahim,F., Zhou,J., Fan,S., Jiang,H., Yu,C., Chen,J., Xu,J.,
            Yang,G., Shah,W., Zubair,M., Khan,A., Li,Y., Shah,B., Zhao,D.,
            Iqbal,F., Jiang,X., Guo,T., Xu,P., Xu,B., Wu,L., Ma,H., Zhang,Y.,
            Zhang,H. and Shi,Q.
  TITLE     Loss-of-function variants in KCTD19 cause non-obstructive
            azoospermia in humans
  JOURNAL   iScience 26 (7), 107193 (2023)
   PUBMED   37485353
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3007)
  AUTHORS   Kuribayashi,S., Fukuhara,S., Tsujimura,G., Imanaka,T., Okada,K.,
            Ueda,N., Takezawa,K., Kiuchi,H., Saito,S., Takahashi,Y., Kioka,H.,
            Oura,S., Shimada,K., Ikawa,M. and Nonomura,N.
  TITLE     Evaluation of the efficacy of creatine chemical exchange saturation
            transfer imaging in assessing testicular maturity
  JOURNAL   Reprod Med Biol 22 (1), e12507 (2023)
   PUBMED   36845001
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3007)
  AUTHORS   Li,Y., Meng,R., Li,S., Gu,B., Xu,X., Zhang,H., Tan,X., Shao,T.,
            Wang,J., Xu,D. and Wang,F.
  TITLE     The ZFP541-KCTD19 complex is essential for pachytene progression by
            activating meiotic genes during mouse spermatogenesis
  JOURNAL   J Genet Genomics 49 (11), 1029-1041 (2022)
   PUBMED   35341968
REFERENCE   8  (bases 1 to 3007)
  AUTHORS   Horisawa-Takada,Y., Kodera,C., Takemoto,K., Sakashita,A.,
            Horisawa,K., Maeda,R., Shimada,R., Usuki,S., Fujimura,S., Tani,N.,
            Matsuura,K., Akiyama,T., Suzuki,A., Niwa,H., Tachibana,M., Ohba,T.,
            Katabuchi,H., Namekawa,S.H., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-specific ZFP541 repressor complex promotes developmental
            progression of meiotic prophase towards completion during mouse
            spermatogenesis
  JOURNAL   Nat Commun 12 (1), 3184 (2021)
   PUBMED   34075040
  REMARK    GeneRIF: Meiosis-specific ZFP541 repressor complex promotes
            developmental progression of meiotic prophase towards completion
            during mouse spermatogenesis.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3007)
  AUTHORS   Oura,S., Koyano,T., Kodera,C., Horisawa-Takada,Y., Matsuyama,M.,
            Ishiguro,K.I. and Ikawa,M.
  TITLE     KCTD19 and its associated protein ZFP541 are independently
            essential for meiosis in male mice
  JOURNAL   PLoS Genet 17 (5), e1009412 (2021)
   PUBMED   33961623
  REMARK    GeneRIF: KCTD19 and its associated protein ZFP541 are independently
            essential for meiosis in male mice.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092530.1 and AC124584.5.
            
            On Jul 24, 2014 this sequence version replaced XM_006531073.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2761              BC092530.1         1-2761
            2762-2762           AC124584.5         10455-10455
            2763-3007           BC092530.1         2763-3007
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..3007
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /note="potassium channel tetramerisation domain containing
                     19"
                     /db_xref="GeneID:279499"
                     /db_xref="MGI:MGI:3045294"
     exon            1..49
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2830
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     BTB/POZ domain-containing protein KCTD19"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD19 isoform
                     2"
                     /protein_id="NP_001288102.1"
                     /db_xref="CCDS:CCDS80922.1"
                     /db_xref="GeneID:279499"
                     /db_xref="MGI:MGI:3045294"
                     /translation="MEEPGGLHESAEDLFHFNVGGWHFSVPRSKLAQFPDSLLWKEAS
                     ALTSSENQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTL
                     DNLKEGRHHLRVRPADIPVAERASLNYWRTWKCISKPSDFPIKSPAFTGLHDKAPLGL
                     MDTPLLDTEEEVHYCFLPLDLVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFL
                     RSHKILLPDNFSNIDVLEAEVEILEIPELTEAVRLYRMNMGGCSRTSCPPLSPGKGGR
                     TASVESVKPLYLMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGALFQHVRNWLGT
                     CRLPLTETISEVYELCAFLDKRDITYEPMKVALKTHLEPRTLLPVDVLSEEWTAEVTI
                     YSPQQIIKLYVGSHWYATTLQTLMKYPELLSNTQRVYWIAYGQTLLIHGDGQMFRHIL
                     NFLRLGKLFLPSEFKEWPLFCQEVEEYHIPALSEALAQCEAYKSWTQEKESENEEAFP
                     IRKLHVVTEGTGPMAEFSRDAKETTACMPVDFQECSDRTPWNKAKGNLTRSSQMEEAE
                     QYTRTIQVSLCRNAKRGGNPSTYSHCSGLCANPRHWGGHSESPPKKKCTTINLTQKPD
                     AKDPPVTPMQKLISLVREWDMVNCKQWEFQPLPASRSSSVEEASLHVPSGSEAAPQPG
                     TSAAWKAHSITSEKDAGPQTGPGAGVKDKGPEPTFKPYFPTKRAITLKDWGKQRPKDR
                     ESPAPEQPLPNANGTDNPGAILKVAHPPVVGNDGSCMFFEDSIIYTTQMDNIKHTSLT
                     ASPQLREVTFLSFSLSWEEMFYAQKCHRFLTDIILDSIRQKDPKAITAKVVSLAYRLW
                     TLNISPKQFVVDLLAIAGFKDDRHTQERLYSWVELTLPFARKYGRCVDLLIQRGLSRS
                     VSYSVLGKYLHEG"
     exon            50..346
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..497
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..689
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..821
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1032
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1193
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1297
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1440
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1524
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1639
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..2267
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2459
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2614
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2716
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2979
                     /gene="Kctd19"
                     /gene_synonym="4922504H04Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggaccg gtcacgagtc tgtcgtctgc cacggaattt aggactatgg aggagcctgg
       61 cgggctccat gagtcagcag aggatttgtt tcacttcaat gtcgggggct ggcatttctc
      121 agttcccagg agcaaacttg ctcagttccc agactcgctg ttgtggaaag aggcttcagc
      181 cctgacctct tcagagaacc agcggctctt cattgacaga gacggctcca cgtttaggca
      241 tgtgcactat tacctctaca cgtccaagct ctccttctcc agttgtgcag aactgaactt
      301 gctctatgag caagccctgg gtttgcagct gatgcccttg cttcagaccc tagataacct
      361 gaaggaaggg agacaccacc tccgtgtgcg gcctgccgac attcctgtgg ctgagagagc
      421 atccctgaac tactggcgga catggaagtg tatcagcaag ccctcggatt ttccaataaa
      481 aagccccgcc ttcacaggtc ttcatgacaa ggcccctttg ggactcatgg acacaccgct
      541 gttggacaca gaagaggaag tgcactactg cttcttaccc ctcgacttgg tggccaagta
      601 cccaagccta gtgaccgaag acaatctgct gtggctggct gaaacggtgg ccctgatcga
      661 gtgcgaatgc agcgagttcc gcttcattgt gaattttcta cgctcacaca agattttact
      721 accagataac ttctccaaca tagatgtgtt agaagcagaa gtagaaattc tggaaatccc
      781 tgagcttaca gaagctgtac ggttgtaccg gatgaatatg ggtggctgtt cccggacctc
      841 ctgcccacct ctaagtcctg gaaagggggg tcgtacagcc agtgtggagt ctgtgaaacc
      901 actgtacttg atggccctgg gcctgctggt caagtatcca gactctgcac tgggacagct
      961 gcgcatcgag agcacgctgg acggaagcag actatacatc acagggaacg gggccctttt
     1021 ccagcacgtc aggaactggc tgggcacttg tcggctgccc ctgactgaga ccatctccga
     1081 ggtgtatgag ctctgcgcct tcctggacaa gagggacatc acctacgagc caatgaaagt
     1141 ggctctgaag actcatctgg agccaaggac tttgctgccc gtggatgtgc tcagtgagga
     1201 gtggacagct gaggtcacga tatactcacc acagcagatc atcaagcttt atgttggaag
     1261 ccattggtat gcaacgaccc tgcagaccct gatgaagtac ccagaactgc tatccaacac
     1321 tcagagagtg tactggatcg cctacggaca gaccttgctc attcacgggg acggccaaat
     1381 gttccgacac attctcaact tcctgagact tggaaaactg tttttaccat cagaatttaa
     1441 ggaatggcct ctcttctgcc aggaggtgga ggagtatcat attccagccc tctcagaagc
     1501 cctggcacaa tgcgaagcat acaagtcatg gactcaggag aaagaatctg aaaatgaaga
     1561 agcttttccc attaggaagc tgcatgtggt gaccgaaggg acagggccaa tggcagagtt
     1621 cagcagagat gccaaggaaa ccacagcctg catgcctgtg gacttccagg aatgcagtga
     1681 caggactcca tggaacaagg ccaaagggaa cctgaccagg tccagccaga tggaagaggc
     1741 tgagcagtat acccggacta ttcaggtctc cctctgcaga aatgccaaga ggggaggcaa
     1801 tcccagcaca tactcacact gctctggttt atgtgccaac cccagacatt ggggaggtca
     1861 ctctgagagt ccccccaaga agaagtgcac cactataaac ctcacacaga aacctgatgc
     1921 caaagaccct cctgtcaccc ccatgcaaaa actcatatct ttagtcaggg aatgggacat
     1981 ggtcaactgt aaacagtggg aattccagcc actgccagcc tccaggagca gctctgtgga
     2041 ggaggctagc ctgcatgtcc cctcgggaag tgaggctgct ccgcagcctg gtacctcagc
     2101 tgcttggaaa gctcattcca taacctctga gaaggatgct ggtccccaga ctggacccgg
     2161 agctggagtg aaagacaagg gtccagagcc aacctttaag ccatacttcc ctacaaaaag
     2221 agctattacc ctaaaggact ggggcaagca gaggcccaag gacagagaaa gccctgctcc
     2281 tgagcagcct ctgcctaatg ctaacgggac cgacaatcca ggggccatcc tcaaagtggc
     2341 tcacccccct gtggtgggta atgatggctc ctgcatgttc tttgaagaca gcattatcta
     2401 caccacccaa atggataaca tcaagcatac atcactcaca gccagccccc aacttcgaga
     2461 agtgactttt ctgagcttct ctctgtcctg ggaggagatg ttttatgcac agaaatgtca
     2521 ccgcttcctg accgacatca tcttggattc catcaggcaa aaggatccca aagctatcac
     2581 agccaaggtg gtgtctctgg cctaccgact gtggacactg aacatcagcc ccaagcagtt
     2641 cgtggtggat ctgctggcca tcgctggctt caaggatgac cggcacactc aggagcgtct
     2701 gtacagttgg gtagagctca cactgccttt cgccagaaaa tatggccgtt gcgtggacct
     2761 gctcatccag aggggactgt ccaggtctgt ctcttattca gtcctgggca agtatttaca
     2821 cgagggctag agaacccaga aatgttggtc ccacagacga ccaacacaga ccagttgccc
     2881 aaggctcatt ttctgtggaa acccccagaa tgcatatgcc cagtcaacgg tgcaaatcac
     2941 ttatttttta ttataaacaa ataaaaaagt aaataacaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaa
//
