LOCUS       NM_001289671            1611 bp    mRNA    linear   ROD 24-FEB-2025
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 17
            (Kctd17), transcript variant 1, mRNA.
ACCESSION   NM_001289671
VERSION     NM_001289671.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Shin,M.C., Jung,Y.H., Jeong,Y., Oh,A.R., Lee,S.B. and Kim,K.
  TITLE     Kctd17-mediated Chop degradation promotes adipogenic
            differentiation
  JOURNAL   Biochem Biophys Res Commun 653, 126-132 (2023)
   PUBMED   36868076
  REMARK    GeneRIF: Kctd17-mediated Chop degradation promotes adipogenic
            differentiation.
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Oh,A.R., Jeong,Y., Yu,J., Minh Tam,D.T., Kang,J.K., Jung,Y.H.,
            Im,S.S., Lee,S.B., Ryu,D., Pajvani,U.B. and Kim,K.
  TITLE     Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and
            Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization
  JOURNAL   Gastroenterology 164 (3), 439-453 (2023)
   PUBMED   36402191
  REMARK    GeneRIF: Hepatocyte Kctd17 Inhibition Ameliorates Glucose
            Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp
            Stabilization.
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Kim,K., Ryu,D., Dongiovanni,P., Ozcan,L., Nayak,S., Ueberheide,B.,
            Valenti,L., Auwerx,J. and Pajvani,U.B.
  TITLE     Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway,
            Promotes Hepatic Steatosis
  JOURNAL   Gastroenterology 153 (6), 1568-1580 (2017)
   PUBMED   28859855
  REMARK    GeneRIF: KCTD17, which is up-regulated in liver tissues of obese
            mice and patients with NAFLD, binds to phosphorylated PHLPP2 to
            target it for ubiquitin-mediated degradation; this increases
            expression of genes that regulate lipogenesis to promote hepatic
            steatosis.
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Otto,T., Candido,S.V., Pilarz,M.S., Sicinska,E., Bronson,R.T.,
            Bowden,M., Lachowicz,I.A., Mulry,K., Fassl,A., Han,R.C.,
            Jecrois,E.S. and Sicinski,P.
  TITLE     Cell cycle-targeting microRNAs promote differentiation by enforcing
            cell-cycle exit
  JOURNAL   Proc Natl Acad Sci U S A 114 (40), 10660-10665 (2017)
   PUBMED   28923932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590144.10.
            
            On Mar 25, 2021 this sequence version replaced NM_001289671.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144820.1, SRR1660813.465937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL590144.10        149242-149449       c
            209-317             AL590144.10        147959-148067       c
            318-409             AL590144.10        145033-145124       c
            410-505             AL590144.10        144099-144194       c
            506-631             AL590144.10        142399-142524       c
            632-706             AL590144.10        140877-140951       c
            707-794             AL590144.10        140438-140525       c
            795-1611            AL590144.10        138806-139622       c
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.49 cM"
     gene            1..1611
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /note="potassium channel tetramerisation domain containing
                     17"
                     /db_xref="GeneID:72844"
                     /db_xref="MGI:MGI:1920094"
     exon            1..208
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..751
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD17 isoform
                     1"
                     /protein_id="NP_001276600.2"
                     /db_xref="CCDS:CCDS79384.1"
                     /db_xref="GeneID:72844"
                     /db_xref="MGI:MGI:1920094"
                     /translation="MRMEAGEAAPPVGAGGRPGGGWGKWVRLNVGGTVFLTTRQTLCR
                     EQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL
                     EEAEFYNIGPLIRIIKDRMEEKDYTVAQVPPKHVYRVLQCQEEELTQMVSTMSDGWRF
                     EQLVNIGSSYNYGSEDQAEFLCVVSKELHSSPHGLSSESTRKAKPCHLRIPLTFSPSH
                     HRLLLLRFLLEVPVRTLPDPSLSLQ"
     exon            209..317
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            318..409
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..505
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..631
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..706
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            707..794
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1611
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="Kctd17"
                     /gene_synonym="2900008M13Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagacaacg cggccggcga tgaggatgga ggccggggag gcagcgccac cggtgggggc
       61 gggcggccgc cccgggggcg gctggggcaa gtgggtgcgg ctgaacgtgg ggggcacggt
      121 gttcctgacc acccgccaga cgctgtgtcg ggagcagaag tccttcctca gccgcctgtg
      181 tcagggcgaa gagcttcaat cggacaggga tgagaccggg gcctacctca ttgaccgtga
      241 ccccacctac ttcgggccca tcctgaattt cctcaggcat ggaaaattgg tgctggacaa
      301 ggacatggcc gaggaggggg tcctggagga agcagagttc tacaacattg gtcctctgat
      361 tcgaatcatc aaagacagga tggaggagaa agactacaca gtggcccagg tgccacctaa
      421 gcatgtatac cgagtgctgc agtgccaaga ggaggagctc acacagatgg tatccactat
      481 gtccgacggc tggcgcttcg agcagctggt gaacatcggc tcctcctaca actatgggag
      541 tgaggaccag gccgagttcc tgtgtgtggt gtctaaggag ctccacagct ccccacacgg
      601 cctgagctcc gagtccactc gcaaggccaa gccctgtcat ctcaggatcc cgctaacctt
      661 ttctccctcc caccaccgcc tcctcctcct ccgcttcctg ctggaggtcc ctgtccgcac
      721 cctcccagac ccaagcctga gcttgcagtg agagctcctc ggccccgcgc ccgcccccag
      781 agctgccgcc cctgctatta caagccagag gcacccggat gtgagccccc agatcacctc
      841 cagggacttg gggttccgat ctgaaatcct ttatttttgt accacggggt gggcccctgg
      901 cccgaggagg aagacaagcc ctctaccttg tcagtgctgc ctgcatctgc cgggctgaga
      961 ctcactcctg ccttggggcc caggcctggg gccctctggg accttggaag gcctgacatg
     1021 ggtcctgggg tctccaggca gagacgccaa ggccaaactg tggcactacc tacccatatc
     1081 ttccaggccc ttttgtcccc tcacctgggc gcccttgctg catggcggat acactccctc
     1141 ccagtcccat catagcacct cttagagcct cagtctctat ggcaccatag ggtcatcctc
     1201 tcctcccacc tacctcacag ggttgttgtg agaatcaggg aggatcatgg ggttcctggg
     1261 agccctgagt gtgttggggc tacaatcatt accttcttag gggaagggct ctagccccgc
     1321 ccctgtatgg gacactatgg cctcagatac tggtggggga caatgtgagg actttgccag
     1381 gcaggaagga agttacaggc ttaacagcac cttggccacc acttctctgt gccaccgtgt
     1441 gtttggcagc agagtacagt gtccagggac ttgggatggg gaaggggaca ggtgtaacgg
     1501 gttgagctgt cccgcccgtg tcttgaccac cccgggatgg gcacatgtct gtcagttgtg
     1561 tcccacccgc catgaaataa agctgaacaa acaggcttgg cctggctgcc a
//
