LOCUS       NM_146188               4536 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 15
            (Kctd15), transcript variant 3, mRNA.
ACCESSION   NM_146188
VERSION     NM_146188.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   Raymundo,J.R., Zhang,H., Smaldone,G., Zhu,W., Daly,K.E.,
            Glennon,B.J., Pecoraro,G., Salvatore,M., Devine,W.A., Lo,C.W.,
            Vitagliano,L. and Marneros,A.G.
  TITLE     KCTD1/KCTD15 complexes control ectodermal and neural crest cell
            functions, and their impairment causes aplasia cutis
  JOURNAL   J Clin Invest 134 (4), e174138 (2023)
   PUBMED   38113115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Smaldone,G., Pirone,L., Capolupo,A., Vitagliano,L., Monti,M.C., Di
            Gaetano,S. and Pedone,E.
  TITLE     The essential player in adipogenesis GRP78 is a novel KCTD15
            interactor
  JOURNAL   Int J Biol Macromol 115, 469-475 (2018)
   PUBMED   29665387
  REMARK    GeneRIF: the physiological role played by the complex KCTD15-GRP78
            in the adipogenesis
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Williams,M.J., Goergen,P., Rajendran,J., Zheleznyakova,G.,
            Hagglund,M.G., Perland,E., Bagchi,S., Kalogeropoulou,A., Khan,Z.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     Obesity-linked homologues TfAP-2 and Twz establish meal frequency
            in Drosophila melanogaster
  JOURNAL   PLoS Genet 10 (9), e1004499 (2014)
   PUBMED   25187989
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4536)
  AUTHORS   Zarelli,V.E. and Dawid,I.B.
  TITLE     The BTB-containing protein Kctd15 is SUMOylated in vivo
  JOURNAL   PLoS One 8 (9), e75016 (2013)
   PUBMED   24086424
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4536)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 4536)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649462.9, BC031749.1 and AW124009.1.
            
            On Feb 15, 2018 this sequence version replaced NM_146188.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031749.1, SRR1660813.81623.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                BX649462.9         121854-121944       c
            92-2504             BC031749.1         1-2413
            2505-4352           BX649462.9         106179-108026       c
            4353-4536           AW124009.1         1-184               c
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 20.41 cM"
     gene            1..4536
                     /gene="Kctd15"
                     /note="potassium channel tetramerisation domain containing
                     15"
                     /db_xref="GeneID:233107"
                     /db_xref="MGI:MGI:2385276"
     exon            1..349
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     exon            350..442
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1228
                     /gene="Kctd15"
                     /note="potassium channel tetramerization domain-containing
                     protein 15"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD15"
                     /protein_id="NP_666300.1"
                     /db_xref="CCDS:CCDS21141.1"
                     /db_xref="GeneID:233107"
                     /db_xref="MGI:MGI:2385276"
                     /translation="MPHRKERPSGSSLNAHGSSGTAEGGNMSRLSLTRSPVSPLAAQG
                     IPLPAQLTKANAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYF
                     IDRDGEIFRYILSFLRTSKLLLPDDFKDFNLLYEEARYYQLQPMVRELERWQQDQEQR
                     RRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIR
                     FPLNGYCRLNSVQVLERLFQRGFSVAASCGGGVDSSQFSEYVLCREERRPQPTPTAVR
                     IKQEPLD"
     exon            443..618
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     exon            619..763
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1069
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..4520
                     /gene="Kctd15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd15"
                     /note="hexamer: TATAAA"
     polyA_site      2504
                     /gene="Kctd15"
                     /note="major polyA site"
     regulatory      4498..4503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd15"
                     /note="hexamer: AATAAA"
     polyA_site      4520
                     /gene="Kctd15"
ORIGIN      
        1 tgtgtaaatg agcgtggcat tctgctcact tccctctgct cgggcgggcg gggctcggct
       61 gcgggtgggc gcgggaccgg ggtctcccac cacagcttgg agaagcgggt caatgctggg
      121 ccagtttgca aacccgctga ggtccctgca acaggcggct tggccaagcc tcagccgcgt
      181 ctgggtcctg gtgtttggtg cagggaactt gtgtctctta tcaattgcac gtctatgttt
      241 gtgatctcag cagtgttctg ggaagaaggg tcgtggtcca ccacagatgc gtttggcaga
      301 gggagcagtg gagattcggg tcaaggctta aggcctgggg cttccaatga tactctgggc
      361 agggatggaa gcctagatgc ctcaccgcaa ggagcggccg agcgggtcct cgcttaacgc
      421 acacggcagc agcggcacgg cggagggagg aaatatgtcc cggctgtcac tcacccggtc
      481 gcctgtgtct cccctggctg cccaggggat cccactgcca gctcagctca ccaaagccaa
      541 cgcacccgtg cacatcgatg tgggaggtca catgtatacg agcagcctgg ccacactcac
      601 caagtaccct gactccagaa taagccgtct cttcaacggc acggagccca ttgtcctaga
      661 cagtctcaag caacattatt tcatcgaccg cgatggggag attttccgct acatactgag
      721 tttcctgcgg acgtcaaaac tgctgcttcc agatgacttc aaggacttca acctgctgta
      781 tgaggaggca aggtactacc agctgcagcc catggtgcgt gagctggagc gctggcagca
      841 agaccaagag caaagacgtc gcagccgggc ctgcgactgc ctggtggtac gggtcacccc
      901 tgacttgggt gaacggatcg cactcagtgg tgagaaggcc ctcattgagg aggtcttccc
      961 ggagactgga gacgtcatgt gcaactctgt caatgctggc tggaaccagg accccacaca
     1021 cgtcatccgt ttccctctca acggctactg tagactcaac tcagtgcagg tcctagaaag
     1081 gctgtttcag agagggttca gcgtggccgc atcctgcggg ggtggtgtgg actcttccca
     1141 gttcagcgaa tatgttcttt gccgggaaga gcggcgacca cagcctaccc caactgctgt
     1201 ccggataaag caggagcccc tggactaggc gctgcctcgg tgcccaccta agacccctca
     1261 gtcctggggc aaccccaggg acatggaaat agcgctgagg agttctgcct gtttgtgctt
     1321 cacagtgggc acaagactgg gggcgggatc ggagggtctg cactcacccc tgggaatgcc
     1381 aggtgcggag gcgtgtccac ggaaggactg ttgatgtgac ctggggttga tgtgacctgg
     1441 ttgatgtgac ctgctgctcc tgctgcaact gtgctgccag cctcccagcc ctcctgctcc
     1501 tcggcctggt atagcgtcct ctgctgggcc agtcactcca gagcagctgt ttctcctcca
     1561 cacttggcag acatattttt ctacagtatt taaaacagta ctaactgtct cgctgcacag
     1621 gtcggcaagg ctaaggagga ccatccatcg ctgcttttac ctggtgctca gttctcagtc
     1681 caactgttca gcaagccttg caaaggatgg gctgccggca ttcggggccc aggtgcctgc
     1741 tgagctgggt ctgtggggac agatgtgagg tggcgggtgc tacaggacgt ggaacagagt
     1801 cctctagggg cagggcagtg gggaagaggg caatgggggc tttgtgactc tgtgactttt
     1861 atctgagata ctctgctgcc acctgtgtcc cagactgcac ttggtgcaca cctgacctgt
     1921 taatgcccag gggcttccaa tcccgactga ctgtgctcac atctgggggt tcttggagaa
     1981 gtctccgccc acccagtcag catgggggcc acagcttatc tcaggaatgg gcccttctac
     2041 caagggaccc atctgtcagc atcactctct gggtccccag ctcagggaac caccctccac
     2101 cctagcgcca gtttccccat tcatatgcac accaagtgtt aatgaaatgt cctaaactag
     2161 cctgtctgta agacccagac ccaagcttac ctagtgctct taaccccaga tttccaacaa
     2221 ggactggtcc tgagaggtcc tcacagatct gctcttctcc cagacgacag ggccaaaaga
     2281 tggataccct ggccttgtca catctccctt agctcctccc aagtggagga accgcaaaga
     2341 actgacagat ggggtgccct ggccggcacc cccttgtgta taacgcctgt agacttgtat
     2401 atgactcctt taatattgta aagatgctga tgtacaattg ttctgtgttt gtgtgaacac
     2461 accgcgttcc cggttcatgc cataaagaac gctataaagc aaaagactga ggctccgtcc
     2521 tgtgcagaag ctgcagccag attcccgcac ttgacttctg gcagagaggg ttggggggca
     2581 gtttccttcc ttggttcttg tgggtcaaat cgaggaagga gcatccgtcc gtgggaggca
     2641 cagggtcaca atcctgctct tattacagca tttgggtgtt ttcattactt ctgcacatcc
     2701 tccctgggct acagggattc agaattctta ttcttagccc ctaaccagat gcaaaactga
     2761 gaggtaagca cgtttcttct ggtttcagac caggcacaag tgtcttggat tttcacatgt
     2821 attttagctg gaactgaggt gatgttcctc ctcctcctcc tcctcctcct cttcctcctc
     2881 ttcctcctcc tccttttcct cctcctgctc ctgctcctcc tgctcctcct cctcctcttc
     2941 ttcctcctcc tccttttcct cctcctcctc ctcctcctcc tgctcctgct cctcctcctc
     3001 ttcctcctcc tcctcttcct cctcctcctc ttcctcctcc tcctcttcct cctcctcttc
     3061 ctcctcctcc tcctcctctt cctccttctc cttgacatct gtttttcttg agaacttact
     3121 gtgaatccag gctggcctgg aactcactgt gtactcctga ttgacctgag actcccaagt
     3181 cctgggattt ccatctgttt gccatatcta acttgctccc tttaaacccc gacacacgta
     3241 cacaatggta tgagaagctc gggccagcca agagacagag gctgtgcagc cagcgtgcaa
     3301 actgaattgc gtgatgtccc cttccaggga aggagttagg acatgtcaga gaggccccgg
     3361 gttttaatga gcgttttaat tttttttttt tctcaaagtc ctgtatgttt gagtcctcgt
     3421 gggctcaatc attcaggact ttgagttaaa aaaaaaaaaa aaaaattaca tgcctgtcaa
     3481 gggccaccag ccacagagct tgggagtaca ggccagcacc ctacatggcc acagagctgc
     3541 catcccagtg tagaatctaa tttgctggtc aaacttgtta ggcttctctg cttagcagca
     3601 tgcccacagc tggcacatct gcattttggc atcaggcagg tatctgagag gaggaaaagg
     3661 gttgtgtttg ttagcaggga aaccttgtgg aaacacctaa tgctgtgtgt gtctggattt
     3721 ttttttcccc ctggcataac agctagcgtg agtcctgagg ggtggagatt ctgtagttct
     3781 ttcaagccat ctttttgtac aagaagttgc agcagggtgt ggtgggtact cctgaaatcc
     3841 cagcaggtgg gaggggaatg caggaaaatc aggagttcaa ggccatcctc agctacctag
     3901 ccaagaagca taatttcaca caggtttgga gctctaccta ggagacttgg gacaggagga
     3961 tcacaagttg aaggtcagcc tagggaactt agagcttgtc ttaaaaggta aaagggggct
     4021 gggtgtgccc aaggacgtag gttcaactct actatccctc ctcactcccc aaacaaagta
     4081 acaaaaacag acaagcaaac acgatttttt ttacaacaac caaagcgtct gaatttccag
     4141 ggaaatgctg tgctcctgcg gtgatcctgt caaaataccc ttctaaatga tctatgtact
     4201 ctccttaaag catagagact gaacatttcg ccagagtctc tccatgaaat accagcatta
     4261 ctctcacagc tcccttgtaa acctcagaac taattattct ctataagcaa ctggacggag
     4321 agctgggatc gcacggcctc ccaccagacc tctgcagtcc agaaccaggg aaagatacag
     4381 caggtggccc caccactgcc ccgtgcatga actcaaagcc agttcacaac attagtaata
     4441 ccttttggaa agtgagtttt ttaaaaaagc tatgacttga ttgtgttcct tagaaacaat
     4501 aaaagatatt ttataaatga aaaaaaaaaa aaaaaa
//
