LOCUS       NM_172747               1654 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 13
            (Kctd13), mRNA.
ACCESSION   NM_172747
VERSION     NM_172747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Cheng,J., Wang,Z., Tang,M., Zhang,W., Li,G., Tan,S., Mu,C., Hu,M.,
            Zhang,D., Jia,X., Wen,Y., Guo,H., Xu,D., Liu,L., Li,J., Xia,K.,
            Li,F., Duan,R., Xu,Z. and Yuan,L.
  TITLE     KCTD10 regulates brain development by destabilizing brain
            disorder-associated protein KCTD13
  JOURNAL   Proc Natl Acad Sci U S A 121 (12), e2315707121 (2024)
   PUBMED   38489388
  REMARK    GeneRIF: KCTD10 regulates brain development by destabilizing brain
            disorder-associated protein KCTD13.
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Seth,A., Rivera,A., Chahdi,A., Choi,I.S., Medina-Martinez,O.,
            Lewis,S., O'Neill,M., Ridgeway,A., Moore,J., Jorgez,C. and
            Lamb,D.J.
  TITLE     Gene dosage changes in KCTD13 result in penile and testicular
            anomalies via diminished androgen receptor function
  JOURNAL   FASEB J 36 (11), e22567 (2022)
   PUBMED   36196997
  REMARK    GeneRIF: Gene dosage changes in KCTD13 result in penile and
            testicular anomalies via diminished androgen receptor function.
REFERENCE   4  (bases 1 to 1654)
  AUTHORS   Matsuki,T., Iio,A., Ueda,M., Tsuneura,Y., Howell,B.W. and
            Nakayama,A.
  TITLE     STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases
            during Cortical Development
  JOURNAL   J Neurosci 41 (43), 8887-8903 (2021)
   PUBMED   34518307
REFERENCE   5  (bases 1 to 1654)
  AUTHORS   Martin Lorenzo,S., Nalesso,V., Chevalier,C., Birling,M.C. and
            Herault,Y.
  TITLE     Targeting the RHOA pathway improves learning and memory in adult
            Kctd13 and 16p11.2 deletion mouse models
  JOURNAL   Mol Autism 12 (1), 1 (2021)
   PUBMED   33436060
  REMARK    GeneRIF: Targeting the RHOA pathway improves learning and memory in
            adult Kctd13 and 16p11.2 deletion mouse models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1654)
  AUTHORS   Escamilla,C.O., Filonova,I., Walker,A.K., Xuan,Z.X., Holehonnur,R.,
            Espinosa,F., Liu,S., Thyme,S.B., Lopez-Garcia,I.A., Mendoza,D.B.,
            Usui,N., Ellegood,J., Eisch,A.J., Konopka,G., Lerch,J.P.,
            Schier,A.F., Speed,H.E. and Powell,C.M.
  TITLE     Kctd13 deletion reduces synaptic transmission via increased RhoA
  JOURNAL   Nature 551 (7679), 227-231 (2017)
   PUBMED   29088697
  REMARK    GeneRIF: Kctd13 deletion reduces synaptic transmission, which
            correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin
            ligase substrate
REFERENCE   7  (bases 1 to 1654)
  AUTHORS   Gladwyn-Ng,I., Huang,L., Ngo,L., Li,S.S., Qu,Z., Vanyai,H.K.,
            Cullen,H.D., Davis,J.M. and Heng,J.I.
  TITLE     Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd
            proteins which influence the long-term positioning and dendritic
            maturation of cerebral cortical neurons
  JOURNAL   Neural Dev 11, 7 (2016)
   PUBMED   26969432
  REMARK    GeneRIF: Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as
            interacting partners to RhoA GTPase proteins which influence the
            development of cortical neurons.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1654)
  AUTHORS   Tomaru,T., Satoh,T., Yoshino,S., Ishizuka,T., Hashimoto,K.,
            Monden,T., Yamada,M. and Mori,M.
  TITLE     Isolation and characterization of a transcriptional cofactor and
            its novel isoform that bind the deoxyribonucleic acid-binding
            domain of peroxisome proliferator-activated receptor-gamma
  JOURNAL   Endocrinology 147 (1), 377-388 (2006)
   PUBMED   16239304
  REMARK    GeneRIF: PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1
            macrophages.
REFERENCE   9  (bases 1 to 1654)
  AUTHORS   Zhou,J., Fan,C., Zhong,Y., Liu,Y., Liu,M., Zhou,A., Ren,K. and
            Zhang,J.
  TITLE     Genomic organization, promoter characterization and roles of Sp1
            and AP-2 in the basal transcription of mouse PDIP1 gene
  JOURNAL   FEBS Lett 579 (7), 1715-1722 (2005)
   PUBMED   15757666
  REMARK    GeneRIF: Promoter of the mouse polymerase delta-interacting protein
            1 gene (PDIP1) was characterized; it is regulated by the AP-2 and
            Sp-1 transcription factors.
REFERENCE   10 (bases 1 to 1654)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK075722.1.
            
            On Apr 5, 2007 this sequence version replaced NM_172747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075722.1, BC079607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1654              AK075722.1         2-1655
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1654
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /note="potassium channel tetramerisation domain containing
                     13"
                     /db_xref="GeneID:233877"
                     /db_xref="MGI:MGI:1923739"
     exon            1..420
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1166
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /note="tumor necrosis factor alpha-inducible protein
                     PDIP1; BTB/POZ domain-containing protein KCTD13;
                     polymerase delta-interacting protein 1"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 1"
                     /protein_id="NP_766335.1"
                     /db_xref="CCDS:CCDS21851.1"
                     /db_xref="GeneID:233877"
                     /db_xref="MGI:MGI:1923739"
                     /translation="MSAEASGPAPAAAECLESPSPSSVEPGSPSYSLKPLTPNSKYVK
                     LNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRD
                     GSVPLPESARELGELLGEARYYLVQGLIEDCQLALQQKREKLSPLCLIPTVTSPREEQ
                     QLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLG
                     DEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENSRGPD
                     LALLEATGGAAGGGGAGRGDDEENREHRVRRIHVRRHITHDERPHGQQIVFKD"
     exon            421..590
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..680
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..733
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..929
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1654
                     /gene="Kctd13"
                     /gene_synonym="1500003N18Rik; Pdip1; PDIP1alpha; Poldip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttccggg tggagagagc gcgcgatggg gcggctggtg gacgtcgcgg agtagctgtg
       61 gagagtgggc gtgtgcgccg agcggccggg cgccggcgct ggagtcgcgg gatctcaggg
      121 aaccggaccg gggcgcagag agggcctccg actgccaccc gcgtccgctc actggcatgt
      181 cggccgaggc ctcgggcccg gcgccggctg cggccgaatg cttggagtcc cctagcccct
      241 cgagtgtgga gcctggctcc ccctcgtaca gtctgaagcc cctcaccccg aacagcaagt
      301 atgtgaagct gaacgtgggc ggctcgctgc attacaccac gctgcgcacc ctcacggggc
      361 aggacaccat gctcaaggcc atgttcagcg gccgcgttga agtgctcaca gacgcgggag
      421 gttgggtgct gattgaccgg agtggccgcc actttggcac aattctcaac tacctgcggg
      481 acgggtcggt gccactgcct gagagtgcca gagaactcgg ggagctgcta ggtgaagccc
      541 gatactacct ggtccagggc ctgattgaag actgtcagct ggcgctgcag caaaaaaggg
      601 agaagctgtc gccactatgc ctcatcccca cagtgacatc accccgggaa gagcagcagc
      661 tcctggccag cacctccaag cctgtggtga agcttctaca caaccgcagt aacaacaagt
      721 actcttacac cagcacttca gatgacaact tactgaagaa catcgagctg tttgacaaac
      781 tagccctgcg cttccatggg cggctgctct tcctcaagga tgtcctagga gatgagattt
      841 gctgctggtc tttctacggg cagggccgaa aaattgccga ggtgtgctgt acctccatag
      901 tctatgctac ggagaagaag cagaccaagg tggaattccc tgaggctcgg atctttgagg
      961 agacactgaa catcttaatt tatgagaatt cccgtggccc agatctcgct ctcctggagg
     1021 ccacaggggg tgcagctgga ggtggtgggg caggccgagg ggacgatgaa gagaaccgag
     1081 agcaccgtgt ccggaggatt cacgtccgcc gccatatcac ccacgatgag cgtccccacg
     1141 gccaacagat tgtcttcaag gactgacctt ggccttcccc cgctgtcctc ttgcttctgg
     1201 gacctagtcc ctctgtctct ttgccccggc tctgctggcc aagtcgtggg tcttccctct
     1261 gtcccctcgt tgcatgctgt tttcagtgag ccctttcctt ccagtcatca ccactcactg
     1321 ctaaccacat ggtacattcc agcatttccc tctggcggcg ctcttcagaa agccagtgac
     1381 cgcccctcct ctacatcctt gttctgccat ctttctctta ccatctgatt ccctttctgt
     1441 tttgttaata cattgaacac acgtgtagaa aggacagtgc tatcagccac actccaagct
     1501 gctttccgcc attgcaacag agtactttgc ccctcctgcc ccaccatccg ccacctccct
     1561 aactttgtac taggctggcc tggacctgtg ccagctctgc tatcgtgatc tgtttcatat
     1621 tatttattat tttaattttc tattaaatta ttgg
//
