LOCUS       NM_177715               6076 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 12
            (Kctd12), mRNA.
ACCESSION   NM_177715
VERSION     NM_177715.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6076)
  AUTHORS   Ren,Y., Liu,Y., Zheng,S. and Luo,M.
  TITLE     KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in
            Habenula Cholinergic Neurons
  JOURNAL   J Neurosci 42 (9), 1648-1665 (2022)
   PUBMED   35017224
  REMARK    GeneRIF: KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB
            Receptors in Habenula Cholinergic Neurons.
REFERENCE   2  (bases 1 to 6076)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6076)
  AUTHORS   Bhandari,P., Vandael,D., Fernandez-Fernandez,D., Fritzius,T.,
            Kleindienst,D., Onal,C., Montanaro,J., Gassmann,M., Jonas,P.,
            Kulik,A., Bettler,B., Shigemoto,R. and Koppensteiner,P.
  TITLE     GABAB receptor auxiliary subunits modulate Cav2.3-mediated release
            from medial habenula terminals
  JOURNAL   Elife 10, e68274 (2021)
   PUBMED   33913808
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6076)
  AUTHORS   Deng,S.L., Hu,Z.L., Mao,L., Gao,B., Yang,Q., Wang,F. and Chen,J.G.
  TITLE     The effects of Kctd12, an auxiliary subunit of GABAB receptor in
            dentate gyrus on behavioral response to chronic social defeat
            stress in mice
  JOURNAL   Pharmacol Res 163, 105355 (2021)
   PUBMED   33285230
  REMARK    GeneRIF: The effects of Kctd12, an auxiliary subunit of GABAB
            receptor in dentate gyrus on behavioral response to chronic social
            defeat stress in mice.
REFERENCE   5  (bases 1 to 6076)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   6  (bases 1 to 6076)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 6076)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 6076)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 6076)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 6076)
  AUTHORS   Resendes,B.L., Kuo,S.F., Robertson,N.G., Giersch,A.B., Honrubia,D.,
            Ohara,O., Adams,J.C. and Morton,C.C.
  TITLE     Isolation from cochlea of a novel human intronless gene with
            predominant fetal expression
  JOURNAL   J Assoc Res Otolaryngol 5 (2), 185-202 (2004)
   PUBMED   15357420
  REMARK    GeneRIF: new gene encoding 327 amino acids in mouse contains a
            voltage-gated potassium (K+) channel tetramerization (T1) domain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087895.1, CF538046.1, AK173260.1 and BP753689.1.
            
            On Jan 20, 2007 this sequence version replaced NM_177715.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AK087895.1         3-290
            289-719             CF538046.1         75-505
            720-809             AK087895.1         722-811
            810-6051            AK173260.1         315-5556
            6052-6076           BP753689.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..6076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 51.55 cM"
     gene            1..6076
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /note="potassium channel tetramerisation domain containing
                     12"
                     /db_xref="GeneID:239217"
                     /db_xref="MGI:MGI:2145823"
     exon            1..6057
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1181
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /note="potassium channel tetramerization domain containing
                     12; predominantly fetal expressed T1 domain"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD12"
                     /protein_id="NP_808383.3"
                     /db_xref="CCDS:CCDS70611.1"
                     /db_xref="GeneID:239217"
                     /db_xref="MGI:MGI:2145823"
                     /translation="MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQV
                     YVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLV
                     LPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLP
                     LGYAEPEPQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRG
                     SYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKF
                     NFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE"
     regulatory      5636..5641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /note="hexamer: ATTAAA"
     polyA_site      5663
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /note="major polyA site"
     regulatory      6032..6037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
                     /note="hexamer: AATAAA"
     polyA_site      6053
                     /gene="Kctd12"
                     /gene_synonym="Pfet1; Pfetin"
ORIGIN      
        1 actcgcctgg agcgcgcggg cgaggcaggc gcagcgcacc ggggctctcg tgggcgcact
       61 gctgcgcgct cgcaccgcgc ggctctcagt ggccggccgc cgcctgagcg cagggctccc
      121 cgataagagc cgctggggct tccgatcgcg accccgctcc ctgccacttg gcccatccgg
      181 gccacctctt tttggccatg gctctggcgg acagcacccg aggattaccc aacgggggcg
      241 gaggcggagg tggcagcggc tcgtcgtcgt cctcggcgga gccgccgctc ttcccggaca
      301 tcgtagagct gaacgtggga gggcaggtgt atgtgacccg gcgctgcacc gtggtgtccg
      361 tgcccgactc gctgctctgg cgtatgttca cgcagcagca gccgcaggag ctggcccggg
      421 acagcaaagg ccgcttcttt ctggaccggg acggcttcct cttccgctac atcctggatt
      481 acctgcggga cttgcagctc gtgctgcccg actacttccc ggagcgcagc cggctgcagc
      541 gcgaggccga gtacttcgag ctgccggagc tcgtgcgtcg cctcggggcg ccccagcaac
      601 ccggtccggg gccaccgccg ccgcactcgc gccgcggggt gcacaaggag ggctctctgg
      661 gcgatgagct gctgccgctg ggctacgcag agcccgagcc gcaggagggc gcctcggccg
      721 gggcgccttc gcccacgctg gagctggcta gccgcagccc gtccgggggc gcggcggggc
      781 ccctgctcac gccgtcccag tctttggacg gcagccggcg ctccggctac atcaccatcg
      841 gctaccgcgg ctcctacacc atcgggcgcg acgctcaggc ggacgccaag ttccggcggg
      901 tggcgcgcat caccgtgtgc ggcaagacgt cgctggccaa ggaggtgttt ggggacaccc
      961 tgaatgagag ccgggacccc gaccggcccc cggagcgcta cacctcccgc tattacctca
     1021 agttcaactt cctagagcag gccttcgata agctgtccga gtcgggcttc cacatggtgg
     1081 cgtgcagctc cacgggcacc tgcgcttttg ctagcagcac cgaccagagc gaggacaaga
     1141 tctggaccag ctacaccgag tacgtcttct gcagggagtg agctccccac gcccgcccct
     1201 cgccactccg gtgcccactt cccttcctcc cctcggggga caggattata gatgccctcg
     1261 cttcctccct gtttcccgat tccttctgcc cccaccccca gatctcctag taggtcaccc
     1321 agacccgtct gcaccccact tgcgaatctg cagccacaaa tcctctgggc gtcttcatca
     1381 tctttggacc ccactagccg agagagtgtt ctgatgtagc ccttcactca tgcttcctct
     1441 actcctggcc tccaaccacc cttcccccag attgtcgtga tctagtggga cagtcaccaa
     1501 gtacctggga atgactgaat tgatcagaat cggattgcac ggtgtccggc gtgcagttcg
     1561 gacgagtcct tgacatctta aaccctttga ctccatagcg gtttcagaga tcagaactga
     1621 gagtgctgtg tggagagagt gctttaaaag gttgttagag atttgaccct cattagaaag
     1681 agagttttag acaattgaat ggtagaccgt atgctggaag accccaagga cgcagttcag
     1741 agactgtaaa taaagagatt tttttgtttg tttttaaagt tacaggtaga agtaaattct
     1801 agtactggca acaggggaga gttctattta cccccaacac attagatctc ctgtggctta
     1861 aaattgtaga aagcaatcct cctgcctgcg gaggcgccct ttctcttcag ctgtttgccg
     1921 agctttaggt tttgttggtt aaggcttcta ggctaggagc aggcagggag cgggaggcag
     1981 cgcttctaga agtcacctgg cagtgaccca gtaacgcagg agtggttagt agggacagtc
     2041 agcccttact taggtctagg actgtgggag ggttggggag ggaggaaaga tgggaggaag
     2101 ggcgggaggg aggaggggga catgctcatt tattatttga aagttggaag tttgtataat
     2161 ccatttgagt atgtgcgcat ttaaaaaaat atgaaacagt acgtgtaaac ttagatttta
     2221 tcaagattag tagaagaccc atcttcagct ggaagtctat cgagctattt tgagtcctaa
     2281 acttagttgc taatacttgt ataacctaac caaagagtta cctagtagag tttttagtga
     2341 tttgaacatt tatttttctt gttgattcta tttcctcact tatagcctat ttacttaagc
     2401 aaaataagtt tgatttttaa ttacttagac ttcagatctc tttattatta ttattattat
     2461 tgttagcagt agtgttttta aattgatgtt ttctgcaagg ccagcaagtg tgggctgctg
     2521 ggctgttctg aaaaccggaa caatgctctt tctttcctgc gtttgtttga cgttgcagtg
     2581 acagattcga aagatcaacg gaagcacggg gggggggggc tgcccatctg tagatagctg
     2641 tcaagtggaa tgtttctaaa tgaaggcaaa taagtacttc agtgtgagcc gagcaataac
     2701 gcggtattta ggtgaatgca acagaaacag gggacctttg ccttattgcc tttcctctca
     2761 cgtggaatga attcccagtg tgtatcctgt gtacaccaca gcagagagga ggtatgcccg
     2821 tatgcttcca caccacagca gagaggaggt atgcccgtat gcttccctct gagagacgtc
     2881 ctttggataa tctgtgatta cagagaagcc tttgtgtatg tgtgtgtgtt tgttttatca
     2941 tcttactctg aaatatgttt ttaaggattt ttgtaagagc catttgaagt gtttaaatta
     3001 gagctatttt ttccttgttt ttaaaaaacg aaccttgtac cgtgtatctc atcatatccg
     3061 aggcagatgt tatgaattgg gacagtttta ttctcagact cctgtgatca aatctgtaca
     3121 taccatatac aaacatttta cacgaatcat ttagtttttt aattcatcta ctgatgctat
     3181 aaaatttcct atatttaccc ctggtaactt gcatttgatg gtgtatatac aaaagcaacg
     3241 cattttggtg agcttctcat atccttgcct gtgaacttgg gtcaggaaaa cagtcacaac
     3301 tacaaggctg ggtttgctcc atactttttt gctgggatgt tagttgtata gtaatcatgt
     3361 gtcagctacc tgtattcaag ctatccatat ttttaatcca atgatgtctt cattttaatt
     3421 gggagatttt tttttccttt agagaagagt tagcttcatg tacaaagtgt gtgattttaa
     3481 agaaagggca gcaggggtcc aggaagctgt gcttactcca gctttgggct tgtttttagg
     3541 cggtggatca ggtaatggct cagaaccttt gtttcaagcc tgaaatgact taggactgtc
     3601 aatcactggc caagtgtgag tctcagactt ctcccatgcc acggaacagt gctagattgc
     3661 ttaagaaaga aatgtatgaa taaaaaccat ctttaggaca gctcaaaata cactgagaga
     3721 tgacaaaacg gaagttctag cttccttgtc aagtctgcat aacactagaa gccatgggaa
     3781 actgctgaag ttttgtctgc attgtttatg aattgaagct tggaaaatta ttcagtttgt
     3841 ctcactaaca cacagacatt tctgtacctt ccaccatact ggctggcctg ttaaagattg
     3901 ggccattagt ataagggaca gtacatggac ctcttcctgg gagtgactgt gccctctgct
     3961 gttaggggca atgcataaaa acttagtgct tttcagccca agttaagtct gagcagtcat
     4021 ctcattatat gataggtaag tatgactgag ccaggctgat gtcgttgggt cctttcctct
     4081 ccatgcactt tgggttgtag aagaaaccct tagggcttat aaaatgttct gaaatctcgg
     4141 tcagcacctg tgaatttgat gactgtacca aacagtggag cctctctcat cagtatcttt
     4201 gaaatgaccc agaagaatat tataaactac tcagatattc acggctgcat taatctatct
     4261 cagagaggca atcatttgca tatgttgatc aaattaccat ttgatgctca taaataatgg
     4321 aatgacatta ggtttaataa gtaatttttt taaaaagtgt tgacagtctc tgtggttgta
     4381 aaaaaacaaa acaaaacagg tcccaggttc catgcttgtc tatcagatgt ttgatatgtc
     4441 tgtttttatt ttaatacgtg tggattacaa accacattcg ttctagattt tcaaacatgt
     4501 aatggaaaat ataccttgca ggtgtgagaa atttcccctt taatactgtt tttattctag
     4561 tgtgtcttat ttgtttttgt tcagttgcta gcaaaatgat aattttagcc ccaattgtct
     4621 tctttttcaa agcagaatca tatgtgtgta tacctgctgc ttctccgggg agatgtatga
     4681 tgtgccaata cccagagaca actggcagtg cttacaacgt ggtctaattt ctatggccgt
     4741 ttccatggaa tgcagttatt acgttaaagc catgtattac gaagctttga taaattttta
     4801 actcttcata ttatgataaa ttccaatcta gcattcaaat aatttttgta ctcctatatg
     4861 taaaatgagc tatacaaata tttagaaaaa tattgagtga aggaagtgaa ttccttaaga
     4921 atttctttta cagtctaaaa ttacaagtac cataaaactg acatgtttta aaaatagtaa
     4981 atttggtatt tttattgtaa aactcttagt tacgtctttg cttaaaattt tattgtgttt
     5041 cctctcacta caaatctttt aaaatctgaa tattttggat aatgtaagtc tctctctctc
     5101 tctctctctc tctctctctc tctctctctc tctctcaagt agtgaataaa acacagtgtt
     5161 ctctgtgtcc acagtacttg gaagaagttt tcacatacct ggaagtaggt tatgttatag
     5221 ctaacttttc ttggtgacag ttttggatag tacacatctc aaaatattaa tactggagga
     5281 tttagattct ttacaaggcc cattaaacaa agatggaaga atcctattag aagacctcca
     5341 ctggagtcag ctgttggatg gtaggagggt tgaccagttg accaagaatg cttgccactt
     5401 tattttataa tatttttcca agccagtttt gtttgtttaa aatgtgtttc aaggtgtgca
     5461 gacatcaatt ttaatgtaaa ctgctataca actgtctttg tgacttgata gccatgtaaa
     5521 ctttgctata actattgaat acaaacgata tatactcatt cattaccact gatcatatcc
     5581 gttggatgat gaaggattga aacattcatc atggttatac actttgaaca tgtaaattaa
     5641 attttctggg tatttgaaaa aaatgctgtt tgtaatactt atttgggttc tgacatgttg
     5701 aaattgttat ttgctaagcg atacctttga gctgtttctt taaaatctaa ggggacatgg
     5761 aaaatataat aatatcacac ttttctaatg aaacataaat ccaagaataa aagctcttct
     5821 atatccaaag ggaaacaaaa acacatggat gaaatctttt cagaggtgct caaactttga
     5881 aattgtcttc atccatctaa atactctcct tcatttcttc tattcacaac cagttgtata
     5941 atggaaacac ccaatactgt tttccctgct gtgtgcgaag taatgaatca ttgattatgt
     6001 gacttgttat gtattctatt aaacactaaa gaataaaaca ttcactcctt taattacaaa
     6061 aaaaaaaaaa aaaaaa
//
