LOCUS       NM_153143               2740 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 11
            (Kctd11), mRNA.
ACCESSION   NM_153143
VERSION     NM_153143.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2740)
  AUTHORS   Zhu,L., Xin,Y.J., He,M., Bian,J., Cheng,X.L., Li,R., Li,J.J.,
            Wang,J., Liu,J.Y. and Yang,L.
  TITLE     Downregulation of miR-337-3p in hypoxia/reoxygenation neuroblastoma
            cells increases KCTD11 expression
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23685 (2024)
   PUBMED   38495002
  REMARK    GeneRIF: Downregulation of miR-337-3p in hypoxia/reoxygenation
            neuroblastoma cells increases KCTD11 expression.
REFERENCE   2  (bases 1 to 2740)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2740)
  AUTHORS   Lospinoso Severini,L., Loricchio,E., Navacci,S., Basili,I.,
            Alfonsi,R., Bernardi,F., Moretti,M., Conenna,M., Cucinotta,A.,
            Coni,S., Petroni,M., De Smaele,E., Giannini,G., Maroder,M.,
            Canettieri,G., Mastronuzzi,A., Guardavaccaro,D., Ayrault,O.,
            Infante,P., Bufalieri,F. and Di Marcotullio,L.
  TITLE     SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic
            Hedgehog-dependent medulloblastoma
  JOURNAL   Cell Death Differ 31 (2), 170-187 (2024)
   PUBMED   38062245
  REMARK    GeneRIF: SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic
            Hedgehog-dependent medulloblastoma.
REFERENCE   4  (bases 1 to 2740)
  AUTHORS   Canettieri,G., Di Marcotullio,L., Greco,A., Coni,S., Antonucci,L.,
            Infante,P., Pietrosanti,L., De Smaele,E., Ferretti,E., Miele,E.,
            Pelloni,M., De Simone,G., Pedone,E.M., Gallinari,P., Giorgi,A.,
            Steinkuhler,C., Vitagliano,L., Pedone,C., Schinin,M.E.,
            Screpanti,I. and Gulino,A.
  TITLE     Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase
            interplay regulates Hedgehog signalling through Gli acetylation
  JOURNAL   Nat Cell Biol 12 (2), 132-142 (2010)
   PUBMED   20081843
  REMARK    GeneRIF: Results show negative regulation of HDAC1 by a Cul3-REN E3
            ubiquitin ligase complex.
REFERENCE   5  (bases 1 to 2740)
  AUTHORS   Argenti,B., Gallo,R., Di Marcotullio,L., Ferretti,E.,
            Napolitano,M., Canterini,S., De Smaele,E., Greco,A., Fiorenza,M.T.,
            Maroder,M., Screpanti,I., Alesse,E. and Gulino,A.
  TITLE     Hedgehog antagonist REN(KCTD11) regulates proliferation and
            apoptosis of developing granule cell progenitors
  JOURNAL   J Neurosci 25 (36), 8338-8346 (2005)
   PUBMED   16148242
  REMARK    GeneRIF: REN protein enhances caspase-3 activation and antagonizes
            the Shh pathway suggesting that this gene may represent a restraint
            of Shh signaling.
REFERENCE   6  (bases 1 to 2740)
  AUTHORS   Di Marcotullio,L., Ferretti,E., De Smaele,E., Argenti,B.,
            Mincione,C., Zazzeroni,F., Gallo,R., Masuelli,L., Napolitano,M.,
            Maroder,M., Modesti,A., Giangaspero,F., Screpanti,I., Alesse,E. and
            Gulino,A.
  TITLE     REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in
            human medulloblastoma
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10833-10838 (2004)
   PUBMED   15249678
REFERENCE   7  (bases 1 to 2740)
  AUTHORS   Gallo,R., Zazzeroni,F., Alesse,E., Mincione,C., Borello,U.,
            Buanne,P., D'Eugenio,R., Mackay,A.R., Argenti,B., Gradini,R.,
            Russo,M.A., Maroder,M., Cossu,G., Frati,L., Screpanti,I. and
            Gulino,A.
  TITLE     REN: a novel, developmentally regulated gene that promotes neural
            cell differentiation
  JOURNAL   J Cell Biol 158 (4), 731-740 (2002)
   PUBMED   12186855
  REMARK    GeneRIF: REN is upregulated by neurogenic signals (retinoic acid,
            EGF, and NGF) in embryonal stem (ES) cells and neural progenitor
            cell lines in association with neurotypic differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY269439.1, AK161602.1 and BC063052.1.
            
            [WARNING] On Jan 27, 2025 this sequence was replaced by
            NM_153143.5.
            
            On Mar 5, 2008 this sequence version replaced NM_153143.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BY269439.1         1-99
            100-2150            AK161602.1         95-2145
            2151-2740           BC063052.1         2102-2691
FEATURES             Location/Qualifiers
     source          1..2740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.91 cM"
     gene            1..2740
                     /gene="Kctd11"
                     /gene_synonym="Ren"
                     /note="potassium channel tetramerisation domain containing
                     11"
                     /db_xref="GeneID:216858"
                     /db_xref="MGI:MGI:2448712"
     exon            1..2722
                     /gene="Kctd11"
                     /gene_synonym="Ren"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..1474
                     /gene="Kctd11"
                     /gene_synonym="Ren"
                     /EC_number="2.3.2.27"
                     /note="retinoic acid, EGF, and NGF upregulated; RING-type
                     E3 ubiquitin transferase KCTD11; KCASH1 protein; RING-type
                     E3 ubiquitin transferase subunit KCTD11; potassium channel
                     tetramerization domain-containing protein 11"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD11"
                     /protein_id="NP_694783.1"
                     /db_xref="CCDS:CCDS24918.1"
                     /db_xref="GeneID:216858"
                     /db_xref="MGI:MGI:2448712"
                     /translation="MLGAMFRADTLMPANLNPQGDGHYFIDRDGKAFRHILNFLRLGR
                     LDLPRGYGETALLKAEADFYQIRPLLDALRELEASRGTPASTAALLHADVDVSPRQVH
                     FSARRGPHHYELSSVQVDTFRANLFCTDPECLAAMRNRFGVAIGDRAEGGPHFRLEWA
                     SRPQELPEVEYQRLGLQPLWTGGPEDRREVANTPTFLEEVLRVALEHGFRLDSVFPDP
                     EDLLNSRSLRFVRH"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd11"
                     /gene_synonym="Ren"
                     /note="hexamer: AATAAA"
     polyA_site      2722
                     /gene="Kctd11"
                     /gene_synonym="Ren"
                     /note="major polyA site"
ORIGIN      
        1 ttaggccact tcctgggggt ggagaggacc tcagtgcctg ctgcgacaac ccaggaaggc
       61 ggtaacgccc gagccctgag acactgttcc caacagagtc ccgggacact ctcagctctg
      121 actgcaagag catcgcctct cccaagccat acagaactgc tggctaccgg ctcctatcag
      181 ttgcgcctcc atcttttggg acacacgccc ctaaccctgg ctgggcctct gaacaggtcc
      241 tcggaacccg acgtggactc tacaactaca aaagctcaga aactcaaact gatcctttca
      301 gcgtccgacc ggtgctcacc accgtcacct gctggttgaa tttcggaaac ccactgtctg
      361 aagagtacag gagggaatcg ctgaccacgc acaatcagaa gcgtctggac caaaagctcc
      421 ctgatcctgt ctggctgccg tctgttcctt tcatcggttc tttcatcctc tcggggattt
      481 ttgtgtcctg aagcccccaa ccaccaccaa agtagcttgg gtgagctaca aactttactg
      541 tcttgttctc caacctctgc ctccaactta gcaagtctga acgttaccac ccaattcttt
      601 ccaaaccccc aaatatctgc tttttccttc tccttgcctg tctcttatat tacccaaaat
      661 ttccccccct cctgtgtcct ctttaccccc ttcctttggg ggtcccgtga ccctaaatgt
      721 ggggggaaca ctatattcca ctacactgga gaccctgact cgcttcccag attccatgct
      781 gggggccatg tttagggctg acaccctaat gccagccaac cttaacccgc aaggagatgg
      841 ccattacttc atcgacaggg atggcaaggc tttccggcac atcctcaatt ttttgcggct
      901 aggccgtctg gacctgcccc gtgggtacgg agaaactgcc cttcttaagg cagaggctga
      961 cttctaccag atccggcccc tcctggatgc cctgcgggaa ttggaagcct ctcggggtac
     1021 acctgcatcc acagccgccc tactccatgc agatgtagat gtcagccccc gccaggtgca
     1081 cttctccgct cgaaggggcc cccaccacta tgagctgagc tctgtccagg tggacacctt
     1141 ccgagccaac ctcttctgca ctgaccctga gtgtctggct gccatgcgca acagatttgg
     1201 tgtggccatt ggggacaggg cagaaggagg tccacatttt cggctagagt gggcctcccg
     1261 cccccaggaa ctccctgaag tagagtatca aagactgggg ctgcagccac tgtggactgg
     1321 ggggccagaa gatcgtcggg aggtagcgaa cacgcctaca ttcctggagg aggtgctacg
     1381 ggtggctctg gaacatggct tccgcctgga ctctgtcttc ccagaccctg aagaccttct
     1441 gaactctaga tccttgcgct ttgtgcgcca ctgagggtgc tgccctccac ttgactgcag
     1501 aggaggggga tgagtcagcc aaggggcctg tggctcttct aaaacctctt tctagtactg
     1561 gtgtggtagc tatgaaagtc agggattcca ccatacctgg ccagagccta gagctggggt
     1621 tcccagatcg agctgccccc ttccacccca caagactcac gaatggtcca gaaggtctac
     1681 gcgggggctt atcctgggaa agcatcgtgg attctctagc ctgtttttgc ttgaggatgg
     1741 gtcctctgta ttcagaagtg tggcaaagta agatagcacc tctttgccca ggctaaacct
     1801 agcagagctc tggcgggttg agcactaggt gggaggactt tgacttatca aatgtaacct
     1861 gctccctaga ctgtggtttc ctttactgga gctgacatct tatcctacag taaccattaa
     1921 gaggccagga ctctctggga ggtttcttta ctatgttcca agccacctat tgtgggacac
     1981 tccatcctag ggtgacatag ggagcaagga gaacctccat caacacgggg gctagagctc
     2041 ccttctggaa ttccagagga tcctgtatgg aagtggggct ggaccatggt gtccagaggc
     2101 ctctttcatg tgtgtgcgcc tgccagtcaa tagatctgat gctgcctggc tccctgctgt
     2161 cttggttccc atcagtgttg ctgactcctg tgcttgtgta ttggtccttc tgtgatcttg
     2221 gcctgtccag gcctgtttgg ggttgcttag aaactctcca ggctcaggta cttctgtggt
     2281 atgtgtaaaa gcagattcag atttagttta atcatagggt gtgtgtgtat gtgtgtgtgt
     2341 gtgtgtgtgt gtgtttgcat gtgtgtttat gcctgcgctg ccacgtaggc aggagggcct
     2401 tgtttgagtt tgagtcacac taggcccttc ctatgagagg taaaagcctc tgggcttagc
     2461 tgggcctctg agacctctgg gagctcttgg ttgctgagac aaccatgagc ctgttgctag
     2521 gaaatagctg ggtaaggaag gcctaaggct gtcctgggca gccaggagct agagttggga
     2581 gagtcgggga gggtgtggga aggatagcat ttctgggttc ctgggcggat gggatacaca
     2641 cataaacatg gtcatcattg ggtggagtca ttcatctatc actgtgactt acaagaagaa
     2701 aaataaattg ctttcagaac caaaaaaaaa aaaaaaaaaa
//
