LOCUS       NM_026145               3095 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 10
            (Kctd10), transcript variant 2, mRNA.
ACCESSION   NM_026145
VERSION     NM_026145.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Cheng,J., Wang,Z., Tang,M., Zhang,W., Li,G., Tan,S., Mu,C., Hu,M.,
            Zhang,D., Jia,X., Wen,Y., Guo,H., Xu,D., Liu,L., Li,J., Xia,K.,
            Li,F., Duan,R., Xu,Z. and Yuan,L.
  TITLE     KCTD10 regulates brain development by destabilizing brain
            disorder-associated protein KCTD13
  JOURNAL   Proc Natl Acad Sci U S A 121 (12), e2315707121 (2024)
   PUBMED   38489388
  REMARK    GeneRIF: KCTD10 regulates brain development by destabilizing brain
            disorder-associated protein KCTD13.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Ye,M.S., Luo,L., Guo,Q., Su,T., Cheng,P. and Huang,Y.
  TITLE     KCTD10 regulates brown adipose tissue thermogenesis and metabolic
            function via Notch signaling
  JOURNAL   J Endocrinol 252 (3), 155-166 (2022)
   PUBMED   34854382
  REMARK    GeneRIF: KCTD10 regulates brown adipose tissue thermogenesis and
            metabolic function via Notch signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Navarro,N. and Maga,A.M.
  TITLE     Does 3D Phenotyping Yield Substantial Insights in the Genetics of
            the Mouse Mandible Shape?
  JOURNAL   G3 (Bethesda) 6 (5), 1153-1163 (2016)
   PUBMED   26921296
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3095)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855690.1, AK161199.1 and AK147714.1.
            
            On May 7, 2009 this sequence version replaced NM_026145.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1, which
            results in a protein (isoform 2) that is one amino acid shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006935.1, AK145295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BB855690.1         1-44
            45-2775             AK161199.1         2-2732
            2776-3095           AK147714.1         2721-3040
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..3095
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /note="potassium channel tetramerisation domain containing
                     10"
                     /db_xref="GeneID:330171"
                     /db_xref="MGI:MGI:2141207"
     exon            1..80
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1025
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     potassium channel tetramerization domain-containing 10;
                     BTB/POZ domain-containing protein KCTD10; BTB/POZ
                     domain-containing adapter for CUL3-mediated RhoA
                     degradation protein 3"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 3 isoform 2"
                     /protein_id="NP_080421.2"
                     /db_xref="CCDS:CCDS19563.1"
                     /db_xref="GeneID:330171"
                     /db_xref="MGI:MGI:2141207"
                     /translation="MEEMSGDSVVSSAVPAAATRTTSFKGASPSSKYVKLNVGGALYY
                     TTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGGVPLPESR
                     REIEELLAEAKYYLVQGLLEECQAALQNKDTYEPFCKVPVITSSKEEQRLIATSNKPA
                     VKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYG
                     QGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATG
                     GAAGRSHHLDEDEERERERIERVRRIHIKRPDDRAHLHQ"
     exon            81..294
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..464
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..551
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..604
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     exon            605..800
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..3095
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="Kctd10"
                     /gene_synonym="mBACURD3"
                     /note="major polyA site"
ORIGIN      
        1 gccccctgca ttgagcgagc tgggtgtttc ctgcctctca gtccggattt ggagactccg
       61 gcgtcctccg acttttcatg gaagagatgt caggagacag cgtggtgagc tcagcggtgc
      121 cagcggctgc cacccgcact acttccttca agggtgccag ccccagctcc aagtacgtga
      181 agctgaacgt ggggggcgct ctctactaca ccaccatgca gacgctcacc aagcaggaca
      241 ccatgctgaa ggccatgttc agtggacgca tggaagtgct cacggacagc gaaggctgga
      301 tcctcattga ccgctgtggg aagcactttg ggacaatcct caactacctg cgagacgggg
      361 gtgtaccctt gcctgagagc cgccgggaga tcgaggagct gctagccgag gccaagtact
      421 acctggtgca gggcctgctg gaagagtgcc aggccgccct acaaaacaaa gatacttacg
      481 agcccttctg caaggtaccc gtcatcacat cctccaagga agaacagagg cttatagcga
      541 cgtcaaataa gcccgccgtg aagctgctct acaacaggag caacaacaag tactcctaca
      601 ccagcaattc tgacgataac atgttgaaaa acatcgaact gttcgataag ctgtccctgc
      661 gcttcaacgg gcgggtcctg ttcattaagg acgtcatcgg ggacgagatc tgctgttggt
      721 cattttacgg ccagggccgg aaaatcgctg aagtctgttg tacctccatc gtctacgcca
      781 ctgagaagaa gcagaccaag gttgagttcc ctgaagcccg catttatgag gagaccctga
      841 atatcttgct gtacgaggcc caggatggcc gaggacctga caatgccctc ctggaggcca
      901 cgggcggggc agctggacgt tctcatcacc tggacgagga cgaggagcgg gagcgggagc
      961 ggatcgagcg cgtgaggagg atccatatca agcgcccaga tgaccgggcc cacctccacc
     1021 agtgagcagg ccgagcaccc tgccttctgc cctccctctg ctcctgcccc gccccctcag
     1081 accctgtgca ggctttgggg cacctcccac ttcccctgga gtctgagaca cttttgtaac
     1141 aagccagatg attattttgt tatttcttga caaagtagat tgcttctgtg ttggcccggg
     1201 tgtgcacccc ttctgaacat gctgtgtctg gggtcccacc tcccgtgaga gcctggagcc
     1261 cagccttctg gggccttgga ggaaaacgta tgaatgagtt tggcgtgtat gtgagaacct
     1321 ttgttgcagt atttattttt atgggtgttg actacctatt agggcctctt aggtgacact
     1381 ccctcaagga cttagtttgg cagttgggag gaactgcgta gttggcagcc ggccaccaag
     1441 gcgtccttga gcagcctggc cctggtgtgt tctgagcagg cagtctttgc tctcctgtga
     1501 gtctgctctg tgtgcggttt tgtacagagc cccttgggca cagtggaagg gggacgaagt
     1561 gtgcttctgg cctctccctg gttctcagca tggcaggcac actccaggct gggagcagac
     1621 cgattcctgg cagttggctg ctctctcggc tcagtccttt tgatgtaccc catccaggaa
     1681 ggggcagcca tcgctgcttt aagggtctac tcctctcttg catggcttcc ttttctcatc
     1741 aagggggtgc cttgcccttt ggttaggaac tggggtgacc gcagacactg gcaccaggtg
     1801 aggacaccac tgagtttgca gcagtttccc tgcagaatag agtgggcatg cagatacctt
     1861 tgggtcttgt tgtgttcagg ggatgtgtgt gtgactgctg gtgggacgtg tgactgtagg
     1921 gcgcaggcgc tcacgacaac agtcagttac ctcgagtctg ctttgcgcag aggagtcgtg
     1981 gctgagtaga ctagtttcaa ggttaggtga gagtgtggga tggatttggc tgcttgataa
     2041 aggaagtgtt ggctattttt tagaccaaag gtattaagtg ggcaatctct gacaggtttt
     2101 aaaatttcta tttagcgacg gtttgtacag ctcgctttgt acatgacagt tgtatacctt
     2161 tctcttgtat ctgacacaaa acctatgata aatactcaaa caatcccgac tggatcgagg
     2221 aaccatgtat ggggtagact tttgtattaa gagccaagaa agggagctta cgaatcatgt
     2281 ttcctacgtt tttatactgt ttgttttaaa cggcagccct gcccagtggg ttcagctttt
     2341 ctaggaagtg aatgtcagta ctggtgtttt ctataggaat ggagaagcca tgtatacact
     2401 gtgtaaatgc tcatgtgaga atgacctagc ggcacaatct gacttgcctt ggcctctggc
     2461 cttccggtta ctgtttttgg cagctctctc taccttcctc tatcctcaaa ccttgtgcct
     2521 gtagctttgt acttcagctc ccagggatag gaacagacct agtgaacatt ccacggtgcc
     2581 tgatctcgct ggcaactgag tccagctagg gcctgaccca gcgtcagtct ccaaagctct
     2641 gcttccggat tccaaacact ggcgtgaggg gcagtagtca gcacttctag atcaccatct
     2701 agtgagtcgc tggtgtagag tgaactttta ctgcacacta agggctcaca attaaaataa
     2761 accagaatag ctttttgctc atggtaacca agttcagtgt ctgtggggcc cacagcctgg
     2821 caggtctggc ccagctctct gtcacctgct gtgggagatg gaccgtttga cctctctgga
     2881 ggctgagacc ccatacctgc tgctcagtgc tggtaatcag ccctccccag agtgcgtgcc
     2941 ggccagaggg ctccacccac agtccctggt catgtacgca catcacactc ttcctgcctc
     3001 tgcactatga aaaccatact gggagtttta gaagtgctca ctcttgtacg agtgtctgcg
     3061 gacatgtgta aaataaacgt taaactctgc ttcta
//
