LOCUS       NM_001142731            3456 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus potassium channel tetramerisation domain containing 1
            (Kctd1), transcript variant 1, mRNA.
ACCESSION   NM_001142731
VERSION     NM_001142731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Liao,Y. and Muntean,B.S.
  TITLE     KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2406686121 (2024)
   PUBMED   39413138
  REMARK    GeneRIF: KCTD1 regulation of Adenylyl cyclase type 5 adjusts
            striatal cAMP signaling.
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Ruangchan,C., Ngamphiw,C., Krasaesin,A., Intarak,N., Tongsima,S.,
            Kaewgahya,M., Kawasaki,K., Mahawong,P., Paripurana,K., Sookawat,B.,
            Jatooratthawichot,P., Cox,T.C., Ohazama,A., Ketudat Cairns,J.R.,
            Porntaveetus,T. and Kantaputra,P.
  TITLE     Genetic Variants in KCTD1 Are Associated with Isolated Dental
            Anomalies
  JOURNAL   Int J Mol Sci 25 (10), 5179 (2024)
   PUBMED   38791218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Raymundo,J.R., Zhang,H., Smaldone,G., Zhu,W., Daly,K.E.,
            Glennon,B.J., Pecoraro,G., Salvatore,M., Devine,W.A., Lo,C.W.,
            Vitagliano,L. and Marneros,A.G.
  TITLE     KCTD1/KCTD15 complexes control ectodermal and neural crest cell
            functions, and their impairment causes aplasia cutis
  JOURNAL   J Clin Invest 134 (4), e174138 (2023)
   PUBMED   38113115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Wang,D., Trevillian,P., May,S., Diakumis,P., Wang,Y., Colville,D.,
            Bahlo,M., Greferath,U., Fletcher,E., Young,B., Mack,H.G. and
            Savige,J.
  TITLE     KCTD1 and Scalp-Ear-Nipple ('Finlay-Marks') syndrome may be
            associated with myopia and Thin basement membrane nephropathy
            through an effect on the collagen IV alpha3 and alpha4 chains
  JOURNAL   Ophthalmic Genet 44 (1), 19-27 (2023)
   PUBMED   36579937
  REMARK    GeneRIF: KCTD1 and Scalp-Ear-Nipple ('Finlay-Marks') syndrome may
            be associated with myopia and Thin basement membrane nephropathy
            through an effect on the collagen IV alpha3 and alpha4 chains.
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Marneros,A.G.
  TITLE     Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the
            Distal Nephron
  JOURNAL   Cell Rep 34 (2), 108616 (2021)
   PUBMED   33440155
  REMARK    GeneRIF: Magnesium and Calcium Homeostasis Depend on KCTD1 Function
            in the Distal Nephron.
REFERENCE   7  (bases 1 to 3456)
  AUTHORS   Marneros,A.G.
  TITLE     AP-2beta/KCTD1 Control Distal Nephron Differentiation and Protect
            against Renal Fibrosis
  JOURNAL   Dev Cell 54 (3), 348-366 (2020)
   PUBMED   32553120
REFERENCE   8  (bases 1 to 3456)
  AUTHORS   Pirone,L., Smaldone,G., Spinelli,R., Barberisi,M., Beguinot,F.,
            Vitagliano,L., Miele,C., Di Gaetano,S., Raciti,G.A. and Pedone,E.
  TITLE     KCTD1: A novel modulator of adipogenesis through the interaction
            with the transcription factor AP2alpha
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (12), 158514 (2019)
   PUBMED   31465887
  REMARK    GeneRIF: KCTD1 promotes adipogenesis through the interaction with
            transcription factor AP2 alpha and by removing it from the nucleus.
REFERENCE   9  (bases 1 to 3456)
  AUTHORS   Zhou,J., Wang,R., Zhang,J., Zhu,L., Liu,W., Lu,S., Chen,P., Li,H.,
            Yin,B., Yuan,J., Qiang,B., Shu,P. and Peng,X.
  TITLE     Conserved expression of ultra-conserved noncoding RNA in mammalian
            nervous system
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (12), 1159-1168 (2017)
   PUBMED   29055695
REFERENCE   10 (bases 1 to 3456)
  AUTHORS   Kumar,S., Rathkolb,B., Sabrautzki,S., Krebs,S., Kemter,E.,
            Becker,L., Beckers,J., Bekeredjian,R., Brommage,R.,
            Calzada-Wack,J., Garrett,L., Holter,S.M., Horsch,M.,
            Klingenspor,M., Klopstock,T., Moreth,K., Neff,F., Rozman,J.,
            Fuchs,H., Gailus-Durner,V., Hrabe de Angelis,M., Wolf,E. and
            Aigner,B.
  TITLE     Standardized, systemic phenotypic analysis reveals kidney
            dysfunction as main alteration of Kctd1 I27N mutant mice
  JOURNAL   J Biomed Sci 24 (1), 57 (2017)
   PUBMED   28818080
  REMARK    GeneRIF: The main pathological phenotype of the Kctd1 (I27N)
            heterozygous mutant mice consists of kidney dysfunction and
            secondary effects thereof, without gross additional primary
            alterations in the other phenotypic parameters analyzed.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102409.10 and AC125091.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087623.1, BU522405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1815              AC102409.10        67696-69510
            1816-1994           AC125091.3         31919-32097
            1995-2139           AC125091.3         53313-53457
            2140-2445           AC125091.3         65508-65813
            2446-3456           AC125091.3         70098-71108
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 8.28 cM"
     gene            1..3456
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="potassium channel tetramerisation domain containing
                     1"
                     /db_xref="GeneID:106931"
                     /db_xref="MGI:MGI:1918269"
     exon            1..1815
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2604
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein KCTD1; potassium channel
                     tetramerization domain containing 1"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD1 isoform
                     1"
                     /protein_id="NP_001136203.1"
                     /db_xref="CCDS:CCDS50228.1"
                     /db_xref="GeneID:106931"
                     /db_xref="MGI:MGI:1918269"
                     /translation="MARMPGSGDCNTSAGGSAAAAAENNGDRGEGERGAGGRGRRYGR
                     PHYCSAGEEEEEEEEEDEIQEVQITGDEEEDGGGGLEEDEEEEEEEEMGMDWEEPLEP
                     EDSAGEELEPEPVHMIHMDQSAALEPEAPPRLLAPRARAGPPGDSAELDPDVLQRPER
                     ARLSENTRLATRYAVRIFREYLSEKAQSPDFETMDKGALCRVLRSFYAEARSKSGQLY
                     SKSSLISIRSSLNRYLNEPPYCRTLDLTKDPELRSANLTLAAVIRKLEEQGAGPVVQK
                     QAITRADLRKLYTSSVFSTNTPFGLLNKVWFETCMYFCTRGRENQRELEEDSFGLAMD
                     EDGRKFVYFKSLGPYHKSRSSSWSKKRAESSDEENLPRMYETGTEFCPYASFVKYLSK
                     RNPLCKAFFQRPRDHCSEGDVTWYENKAIGKNLLGTRMQMLSKAAKLSKTYTNHCIGA
                     VSIATLNSIAGIGTKLGSPAPQGCYTDSLNGSARHHSHHAPTHPSHHHRPQPPSLGNT
                     YILPKDSQVGPDVKSEAAPKRTLYESVFGSGEICGPSSPKRLCIRPSSEPVDAVVVVS
                     VKHDPLPLLPEVNGHRSTNSPTIVSPAIVSPAQDSRPNMSRPLITRSPASPLNNQGIP
                     TPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFID
                     RDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRF
                     SRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFP
                     LNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVPSVIRIK
                     QEPLD"
     exon            1816..1994
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2139
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2445
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..3456
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3392
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3456
                     /gene="Kctd1"
                     /gene_synonym="4933402K10Rik"
ORIGIN      
        1 tggcagggag acggcaatat ggcgagaatg cctggcagcg gggactgtaa caccagcgcg
       61 ggcggcagcg ccgctgctgc ggccgagaac aatggggatc ggggtgaggg tgagcgcggg
      121 gccgggggcc gcggccgccg ctacggccgc ccgcattact gcagcgcggg cgaggaggag
      181 gaggaggaag aggaggagga cgagatccag gaggtgcaga taacggggga cgaggaggag
      241 gacggaggtg gggggctgga ggaggacgag gaggaggagg aagaggagga gatggggatg
      301 gactgggaag agcccctgga gccggaggac tcggccgggg aggagctgga gccggagccg
      361 gtccatatga tccatatgga ccagagcgcc gcgctggagc ccgaggcgcc gccacgactg
      421 ttggcgcccc gggcccgcgc ggggccgccg ggggacagcg cggagctgga ccccgacgtg
      481 ctgcagcgcc ccgagcgggc ccggctgagc gagaacacca ggctggccac ccgctacgcc
      541 gtgcgcatct tccgggagta cctgagcgaa aaggctcaga gcccggactt cgagaccatg
      601 gacaaggggg cgctgtgccg cgtgctgcgc tccttctatg ccgaggcccg ttctaagagc
      661 ggccagctct acagcaagtc ctcgctcatc agtatccgca gctccctcaa ccgctacctc
      721 aacgagcccc cttactgtcg cacgctcgac ctcaccaagg accccgagct gcgcagcgcc
      781 aacctgacgc tggccgcagt catccgcaag ctcgaggagc agggcgcggg gcccgtggtg
      841 cagaagcaag ccatcacgcg cgccgacctg cgcaagctct acacctccag cgtcttcagc
      901 accaacacgc cctttgggct gctcaacaag gtctggttcg agacgtgcat gtacttctgc
      961 acgcgaggcc gtgagaacca gcgcgagctg gaggaggact ccttcgggct ggccatggac
     1021 gaggacggtc gcaagttcgt ttacttcaag tcgcttgggc cttaccataa gtcgcgttcc
     1081 tcgtcctgga gtaagaagcg tgcggagagc agcgacgaag agaacttgcc tcgcatgtac
     1141 gagacgggca ctgagttctg tccctacgcc agctttgtca agtacctgtc taagcgcaat
     1201 cccctctgta aggcgttttt ccagcggccc cgggaccact gcagtgaggg cgatgtgaca
     1261 tggtacgaga acaaagccat aggcaagaac ttgctgggca ccaggatgca gatgctgtcc
     1321 aaggcagcca agctgtccaa gacctacact aaccattgca tcggcgcggt gtccatcgcc
     1381 acactcaaca gcatcgcggg tatcgggacc aagctaggct ccccagcccc gcagggctgc
     1441 tataccgact ctctgaacgg gtcagctcgt caccactccc accacgctcc cacccatcct
     1501 tcccaccacc accgccccca gccgccctcg ctgggtaaca cttatatcct ccccaaagac
     1561 agccaggtcg ggcccgacgt gaagtccgag gcggcgccca agcgcacgct gtacgagtca
     1621 gtgttcgggt caggggaaat ctgcggccct tcttccccca aaagactttg tatccgtccc
     1681 tcctcggaac ctgtggatgc ggtggtggtg gtttccgtga aacacgaccc cctgcctctt
     1741 cttccagaag tcaatgggca ccgaagcacc aattctccca ccatagtttc acctgctatt
     1801 gtttcccccg cccaggacag tcggcccaat atgtcaagac ctctgatcac tcgatcccct
     1861 gcatcgccac tgaacaacca aggcattcca actccagctc agctcaccaa atccaacgca
     1921 cccgtccaca tcgacgtggg cggccacatg tacaccagca gcctggccac cctcaccaaa
     1981 taccccgaat ccagaatcgg aagactcttt gatggtacag agcccattgt tctggacagt
     2041 ctcaaacagc actatttcat tgacagagac gggcagatgt tcagatatat cttgaatttt
     2101 ctacgaacat caaaactcct cattcctgat gatttcaagg actatacttt gttatatgaa
     2161 gaggcaaaat actttcaact tcagccaatg ttgttggaga tggagcgatg gaaacaggac
     2221 agggaaactg gccgcttttc acggccctgc gagtgcctcg tggtgcgtgt ggccccggac
     2281 cttggagaaa ggatcaccct cagtggggac aagtccttga tagaggaagt atttcccgag
     2341 atcggcgatg tgatgtgcaa ctcggtcaat gcaggctgga atcacgactc aacacatgtc
     2401 atcaggtttc cactaaacgg ctactgccac ctcaattcag ttcaggtcct tgagcggttg
     2461 cagcaaagag gatttgaaat tgtgggttcc tgtggaggag gagtggactc gtcccagttc
     2521 agtgaatatg tcctccgacg ggaactgagg cggacacccc gagtaccctc agtcatccgg
     2581 ataaaacagg agccactgga ctaaacagac atatttctta tgcaaaaaga aaacatacac
     2641 aaccaataac aatatgagaa aagggacatt tgtgtgcagc tgggacagta aaccaagctc
     2701 tgaacctaaa attgaataaa agacatttat atccactaga aatcacacct gtattcatat
     2761 gggaacaatt ggaatcatga tatcctcaag atgtaaaaaa atatataaat atataaatat
     2821 ctatatgtca aaaggtagga aatgcaagga gagagagaga gagggagaga gagagagaga
     2881 gagagagaga gagagagaga gagagagaac gcagtgggtg ctgtgatgac cgtggtgttc
     2941 tgggcctctg aggtctctgt ccagtaaata agccatgagc agggaggaca gtctccttac
     3001 tgcttcattg ccagcagcca tcaattgttt cttttttctt tattgttctt ttcttttttt
     3061 taaacaaata aacaaaacac ctgggctggt gttcctttgc aagtggaggt tttgtgtctg
     3121 gtcaggtagg gaccagaagg gagttcagag aaccactcaa gagcacacca cacgggacgt
     3181 gcggtagaca ggacatctga ctgcagtctg tacaggactg gcacttttgt ccaccgcaca
     3241 gccgcgacct ttcctttgtt tttatgctga tcgtttggca gaggggccag agttattact
     3301 tgctagagat ctccagtttc agtctgctgc tttcctacaa ttttttcaga ttttataatg
     3361 tattaaatac aataaactct gttttaaaaa aactgagatc tgtgtagaac acacatgttg
     3421 ggatgagaat gaattaaaat gaaatttttc ctttta
//
