LOCUS       NM_001029985            4905 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kielin/chordin-like protein (Kcp), mRNA.
ACCESSION   NM_001029985 XM_285910
VERSION     NM_001029985.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4905)
  AUTHORS   Xu,Y., Zheng,Z., Pan,H., Zhao,M., Zhang,J., Peng,S., Liu,J.,
            Pan,W., Yin,Z., Xu,S., Wei,C., Qin,J.J., Lin,Y., Wan,J. and Wang,M.
  TITLE     Kielin/chordin-like protein deficiency aggravates pressure
            overload-induced cardiac dysfunction and remodeling via
            P53/P21/CCNB1 signaling in mice
  JOURNAL   FASEB J 38 (5), e23513 (2024)
   PUBMED   38421300
  REMARK    GeneRIF: Kielin/chordin-like protein deficiency aggravates pressure
            overload-induced cardiac dysfunction and remodeling via
            P53/P21/CCNB1 signaling in mice.
REFERENCE   2  (bases 1 to 4905)
  AUTHORS   Ye,D., Feng,Y., Pan,H., Lu,X., Wang,Z., Wang,M., Liu,J., Xu,Y.,
            Zhang,J., Zhao,M., Xu,S., Ye,J. and Wan,J.
  TITLE     Kielin/chordin-like protein deficiency causes cardiac aging in male
            mice
  JOURNAL   J Mol Med (Berl) 101 (6), 731-742 (2023)
   PUBMED   37149518
  REMARK    GeneRIF: Kielin/chordin-like protein deficiency causes cardiac
            aging in male mice.
REFERENCE   3  (bases 1 to 4905)
  AUTHORS   Liu,J., Chanumolu,S.K., White,K.M., Albahrani,M., Otu,H.H. and
            Nawshad,A.
  TITLE     Transcriptional analysis of cleft palate in TGFbeta3 mutant mice
  JOURNAL   Sci Rep 10 (1), 14940 (2020)
   PUBMED   32913205
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4905)
  AUTHORS   Soofi,A., Wolf,K.I., Emont,M.P., Qi,N., Martinez-Santibanez,G.,
            Grimley,E., Ostwani,W. and Dressler,G.R.
  TITLE     The kielin/chordin-like protein (KCP) attenuates high-fat
            diet-induced obesity and metabolic syndrome in mice
  JOURNAL   J Biol Chem 292 (22), 9051-9062 (2017)
   PUBMED   28424263
  REMARK    GeneRIF: Metabolic profiling indicated increased energy expenditure
            in KCP-overexpressing mice and reduced expenditure in the KCP
            mutants with no effect on food intake or activity. These findings
            demonstrate that shifting the TGF-beta superfamily signaling with a
            secreted protein can alter the physiology and thermogenic
            properties of adipose tissue to reduce obesity even when mice are
            fed a high-fat diet.
REFERENCE   5  (bases 1 to 4905)
  AUTHORS   Soofi,A., Wolf,K.I., Ranghini,E.J., Amin,M.A. and Dressler,G.R.
  TITLE     The kielin/chordin-like protein KCP attenuates nonalcoholic fatty
            liver disease in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 311 (4), G587-G598 (2016)
   PUBMED   27514479
REFERENCE   6  (bases 1 to 4905)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   7  (bases 1 to 4905)
  AUTHORS   Soofi,A., Zhang,P. and Dressler,G.R.
  TITLE     Kielin/chordin-like protein attenuates both acute and chronic renal
            injury
  JOURNAL   J Am Soc Nephrol 24 (6), 897-905 (2013)
   PUBMED   23539757
  REMARK    GeneRIF: These data suggest that extracellular regulation of the
            TGF-beta/BMP signaling axis by KCP, and by extension possibly other
            cysteine-rich domain proteins, can attenuate both acute and chronic
            renal injury.
REFERENCE   8  (bases 1 to 4905)
  AUTHORS   Ikeya,M., Kawada,M., Kiyonari,H., Sasai,N., Nakao,K., Furuta,Y. and
            Sasai,Y.
  TITLE     Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis
  JOURNAL   Development 133 (22), 4463-4473 (2006)
   PUBMED   17035289
REFERENCE   9  (bases 1 to 4905)
  AUTHORS   Lin,J., Patel,S.R., Wang,M. and Dressler,G.R.
  TITLE     The cysteine-rich domain protein KCP is a suppressor of
            transforming growth factor beta/activin signaling in renal
            epithelia
  JOURNAL   Mol Cell Biol 26 (12), 4577-4585 (2006)
   PUBMED   16738323
  REMARK    GeneRIF: role for KCP in modulating the responses between these
            anti- and profibrotic cytokines in the initiation and progression
            of renal interstitial fibrosis
REFERENCE   10 (bases 1 to 4905)
  AUTHORS   Lin,J., Patel,S.R., Cheng,X., Cho,E.A., Levitan,I., Ullenbruch,M.,
            Phan,S.H., Park,J.M. and Dressler,G.R.
  TITLE     Kielin/chordin-like protein, a novel enhancer of BMP signaling,
            attenuates renal fibrotic disease
  JOURNAL   Nat Med 11 (4), 387-393 (2005)
   PUBMED   15793581
  REMARK    GeneRIF: The data indicate an important role for KCP in attenuating
            the pathology of renal fibrotic disease.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079276.4 and BC059023.1.
            
            On Mar 29, 2011 this sequence version replaced NM_001029985.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154369.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC079276.4         76231-76326         c
            97-260              AC079276.4         74012-74175         c
            261-429             AC079276.4         72773-72941         c
            430-506             AC079276.4         72607-72683         c
            507-603             AC079276.4         71152-71248         c
            604-686             AC079276.4         70959-71041         c
            687-780             AC079276.4         70664-70757         c
            781-869             AC079276.4         69576-69664         c
            870-963             AC079276.4         67499-67592         c
            964-1043            AC079276.4         67331-67410         c
            1044-1137           AC079276.4         67161-67254         c
            1138-1223           AC079276.4         66803-66888         c
            1224-1305           AC079276.4         66651-66732         c
            1306-1458           AC079276.4         66279-66431         c
            1459-1565           AC079276.4         66096-66202         c
            1566-1659           AC079276.4         65927-66020         c
            1660-1833           AC079276.4         65176-65349         c
            1834-1916           AC079276.4         64994-65076         c
            1917-2010           AC079276.4         64805-64898         c
            2011-2199           AC079276.4         64535-64723         c
            2200-2370           AC079276.4         64132-64302         c
            2371-2547           AC079276.4         61563-61739         c
            2548-2633           AC079276.4         60759-60844         c
            2634-2724           AC079276.4         60429-60519         c
            2725-2807           AC079276.4         60219-60301         c
            2808-2901           AC079276.4         60039-60132         c
            2902-3075           AC079276.4         58769-58942         c
            3076-3158           AC079276.4         58440-58522         c
            3159-3279           AC079276.4         57407-57527         c
            3280-3359           AC079276.4         55871-55950         c
            3360-3459           AC079276.4         55555-55654         c
            3460-3602           AC079276.4         53792-53934         c
            3603-3775           AC079276.4         53377-53549         c
            3776-3887           AC079276.4         53185-53296         c
            3888-3989           AC079276.4         52989-53090         c
            3990-4154           AC079276.4         52304-52468         c
            4155-4461           AC079276.4         51008-51314         c
            4462-4887           AC079276.4         50411-50836         c
            4888-4905           BC059023.1         2674-2691
FEATURES             Location/Qualifiers
     source          1..4905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..4905
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /note="kielin/chordin-like protein"
                     /db_xref="GeneID:333088"
                     /db_xref="MGI:MGI:2141640"
     exon            1..96
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..260
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..429
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..506
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..603
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..686
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..869
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..963
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1043
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1137
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1223
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1305
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1458
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1565
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1659
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1833
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1916
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2010
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2199
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2370
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2547
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2633
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2724
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2807
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2901
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3075
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3158
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3279
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3359
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3459
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3602
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3775
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3887
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..3989
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4154
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4461
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4888
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4865..4870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /note="hexamer: AATAAA"
     polyA_site      4888
                     /gene="Kcp"
                     /gene_synonym="CRIM-2; Crim2; Gm793; KCP-1"
                     /note="major polyA site"
ORIGIN      
        1 cctaaagcga ggcgggtcga gcgagcatgg cgggggctcg ggcggcgttg ctaccactgc
       61 tcctgcacct cgggagcctg gcgctggccg cgcggggtgg agaggtctcc agagagcagc
      121 ctaggcttgc tgatgctatc tctcagcagc aggcaccctc ccactccttg gtccctggtg
      181 agacccacca acagcagtgg tgccccctgg aggagaggct ggaacggctg gaggcagagg
      241 tgactgacct cagaaagcag aacagggagc tgcaagccag ggtggtgcag ctggagtcct
      301 gtgagtgctg ggggccaggt cacacctgtc ccgaaggagc tcgctgggag cctgatgcct
      361 gcacagcctg cgtgtgccgt gatggaacgg cgcactgtgg cccccagccc aacctgcccc
      421 actgccgtgg ctgcagccac aatgggcagt cttatggtca tggggagacc ttctccccag
      481 atgcctgtac cacctgccgc tgtctggcag gaaccgtgca gtgccagggg ccttcatgct
      541 ctgagcttaa ctgtctggag agcttcatcc ctcctggaga atgttgcccc atctgccggc
      601 caggctgtga atatgaaggg cagcttcacc aggaagggtc tagtttcttg tccagttcca
      661 acccatgcct ccagtgctct tgcctgagga gcctggttcg atgtgtgcct gtgaagtgcc
      721 agccaagccc ctgcctcaat ccagtcccga ggcttggaca ctgctgccca gtctgccaag
      781 cctcaggctg cacagaaggg aactctcata gggaccatgg ccaagagtgg accactcctg
      841 gagacccctg ccgcatctgc cagtgcctgg agggccacat ccagtgccgc cagcgggagt
      901 gtgccagcct gtgtccatac cctgccaggc cccttccggg cacctgttgc ccggtgtgtg
      961 acggctgttt cctaaatggg cgggagcaca gcagtgggga gcccgtgggc tcccaggacc
     1021 cctgctctag ctgccgctgt accaatggga gtgtccagtg tgagcctctg ccctgcccgc
     1081 ctgcaccctg cagatacccg ggcaggatcc ctgggcagtg ctgccctgtc tgtgatggct
     1141 gtaaatacca gggacatgaa tatcggagcc aggagacctt caccctccaa gagaatggcc
     1201 gctgccttcg gtgcgtctgc caggctggtg aagtatcctg tgaagaacag gactgcccag
     1261 tcactccctg tgtccgctct gcctccggcc cccagctctg ctccgcctgt gtgctcaatg
     1321 gtgaggagtt tgctgagggg atccagtggg agccagatga ccagccctgt acttcctgtt
     1381 cctgccaaga tggagtgcct gtgtgcaggg ctgtgctttg ctctccagta ccctgccaac
     1441 atcctaccca gccacctggt gcctgctgtc ccagctgtga tagctgcacc taccacagcc
     1501 tggtgtatgc taatgggcag aacttcacag atgtggacag cccttgtcag acctgctact
     1561 gcgaggatgg gactgtgagg tgttcattga tcaactgtcc tttcacaacc tgtgccaagc
     1621 cccagaatgg accaggccag tgctgcccta agtgcccaga ctgcatcttg gaggcacagg
     1681 tgtttgtaga tggggagcgc ttccctcatc caagagaccc ctgccaggag tgctggtgtc
     1741 aggaaggcca agctcactgc cagctccgtg cctgccccag cgccccctgt gttcaccctc
     1801 tgccaggcac ctgctgcaag aatgactgca caggctgtgc ctttggcggg aaagagtacc
     1861 ccaatggagc ggacttccca catcccactg atccgtgtcg cctgtgtcgc tgtctgagcg
     1921 gcaacgtaca gtgcctggcg cgtcgctgtc cgccactgtc ctgtccgcag ccagtcctca
     1981 ctccgggaga ctgctgcccg cagtgcccag atgcccctgc tgactgccca cagtcaggga
     2041 atatggtccc tgtccgccac caggagcact ttttccaacc gggagaccct tgcagccgct
     2101 gcctctgcct ggatggctca gtgtcctgcc agcggctgac ctgccctcct gcgccctgcg
     2161 cccacccacg ccgggacgcc tgttgcccct cttgcgacgg ctgcctgtat caggggaagg
     2221 agtttgccag tggggagcgt tttccatcac caaacgttgc gtgccacgtg tgcctctgct
     2281 gggagggcag cgtcaagtgc gagcccagga cttgtgcccc tgcacagtgc ccctttccca
     2341 ccagggaaga ctgctgccct gcctgtgata gctgtgatta tcttggggtc tcctatctga
     2401 gcagccagga gttcccagac ccccgggaag cctgcaacct atgcacctgc cttggaggct
     2461 tcgtgacttg cacccgccgg ccctgtgagc ctccagcctg cagccatcca ctcatcgtac
     2521 ccgagcactg ctgtccaacc tgccagggat gcctgtacca tgggatcact gctgcccttg
     2581 gagagaccct tcctgacccc cttgacccca cctgctccct ctgcacctgt gaggaaggtt
     2641 ctatgcgctg ccaaaagaag ccatgccctc cggctccctg cgctcacccg tctccaggcc
     2701 cctgcttctg ccctgtttgt cgcagctgcc tctctcaggg ccgggagcac caagatgggg
     2761 aggagtttga gggacccgag ggcagctgtg agcgctgccg ctgtctggcc ggccaggtca
     2821 gctgcacgag gcttcagtgc ccgtccctgc cctgcttgca ccaggtcaca gaaccaggga
     2881 cctgctgtcc tcgatgcaca ggctgcctcg ctcgtgggga ggagcatcct gaagggagta
     2941 gctgggtgcc agcggacagc ccctgttcct cctgcatgtg tcacaagggc atcatcactt
     3001 gtgcccaagt ccagtgtgtc agcgcctgca tctggcccca ggaggggccc agcgactgct
     3061 gtcctcagtg ctctggctgt gagcatgggg gcaggaagta tgagcctggg gagagcttcc
     3121 agcctggggc agacccgtgt gaagtgtgca tctgcaagca gaagcgtgag gggcctccca
     3181 gccttcactg tagtcggcgg cagtgcccca gcctggtggg ctgcccacca agccagcttc
     3241 ttcctcctgg cccccagcac tgctgtccca cctgtgccca ggcactgagt aactgcacag
     3301 aggacctggt ggggtctgag ctggtgccac cagacccctg ctacacctgt cagtgtcagg
     3361 atctgacgtg gctctgtact caccgggcct gtcctgagct cagctgtccc ctgtgggagc
     3421 gtcacacaac ccctggcagc tgctgccccg tgtgtaaaga ccctacccag tcatgcatgc
     3481 atcagggtcg ctgggtggcc tctggagaac agtgggcagt ggatgcctgc accagctgct
     3541 cctgtgtggc tggtactgtg cactgccaga cccagcgctg caggaagctc gcatgtagcc
     3601 gggatgaggt ccctgccctg agtcccggca gctgctgtct ccgctgtttg ccccggccgg
     3661 cttcctgcat ggccttcgga gacccccatt accgcacctt cgatggccgc ctgttgcact
     3721 tccaaggcag ctgcagctac gtgctggcca aggactgcca cggcgaggac ttcagtgtgc
     3781 acgtgactaa tgatgaccgg ggccggaggg gtgtggcctg gacccaagag gtagcagtgc
     3841 tgttgggaac cgtggctgtg aggctgctgc agggcaggac agtcatggtg gaccagcaca
     3901 cagtgacctt gcccttcctc cgggagccac tgctgtacat tgagcttcgt ggtcacactg
     3961 tgatcctgca tgcccagcct gggcttcagg tgctgtggga cgggcaatcc caggtggagg
     4021 tgagagttcc cagctcctac cggggccaga cttgtggtct ctgtgggaac ttcaatggct
     4081 ttgcccagga tgatctgcag ggtccggatg ggaggctcct gcccacagag gcttcgtttg
     4141 ggaacagctg gaaggtcccc aaggggctgg ggcctggccg gccgtgttct gcaggccgag
     4201 aggtggaccc gtgccgggca gcaggctacc gtgccaggcg tgaggccaat gcccggtgcg
     4261 ggatcctgaa gacttcaccg ttcagtcatt gccatgctgt ggtgcccccg gaacccttct
     4321 ttgctgcctg tgtgtacgac ttgtgtgctt gtggtccagg ctcctcctct gacacctgtc
     4381 tctgtgatgc ccttgaagcc tacgctagcc actgtcgcca ggcaggggtg actcctgtct
     4441 ggaggggtcc tacactctgt gtggtgggct gccctgtgga ccgtggcttt gtgtttgatg
     4501 agtgtggacc accttgtccc cgtacctgtt tcaaccggca cataccccta ggggaactgg
     4561 cagcccactg tgtgagaccc tgtgttccag gctgccagtg tcctgcaggc ctggtggaac
     4621 atgaaggcca ttgcatctca cctgaggtct gcccaccagt cctgcttact ggcgactagc
     4681 cagctcacat cctgtccaat cccagtcagg agcagcccct ggttccatgc tgagttaaga
     4741 atacccatat cccgaactta cctggccaga ggttacccct tggtgagcag tagtggagac
     4801 tgccctgctc aggcaatggg atcttatgcc agtcctccag acatccacag tgtgaaaaca
     4861 caagaataaa ctctacactt gcccatgaaa aaaaaaaaaa aaaaa
//
