LOCUS       NM_001413254            2541 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, delayed-rectifier,
            subfamily S, member 3 (Kcns3), transcript variant 3, mRNA.
ACCESSION   NM_001413254
VERSION     NM_001413254.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Miyamae,T., Hashimoto,T., Abraham,M., Kawabata,R., Koshikizawa,S.,
            Bian,Y., Nishihata,Y., Kikuchi,M., Ermentrout,G.B., Lewis,D.A. and
            Gonzalez-Burgos,G.
  TITLE     Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse
            prefrontal cortex: Implications for the pathophysiology of
            schizophrenia
  JOURNAL   Neurobiol Dis 155, 105382 (2021)
   PUBMED   33940180
  REMARK    GeneRIF: Kcns3 deficiency disrupts Parvalbumin neuron physiology in
            mouse prefrontal cortex: Implications for the pathophysiology of
            schizophrenia.
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Shrestha,B.R., Chia,C., Wu,L., Kujawa,S.G., Liberman,M.C. and
            Goodrich,L.V.
  TITLE     Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity
  JOURNAL   Cell 174 (5), 1229-1246 (2018)
   PUBMED   30078709
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Purcell,M.K., Mu,J.L., Higgins,D.C., Elango,R., Whitmore,H.,
            Harris,S. and Paigen,B.
  TITLE     Fine mapping of Ath6, a quantitative trait locus for
            atherosclerosis in mice
  JOURNAL   Mamm Genome 12 (7), 495-500 (2001)
   PUBMED   11420610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120406.27.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.985882.1,
                                           ERR3363660.194716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC120406.27        19293-19526
            235-334             AC120406.27        41991-42090
            335-524             AC120406.27        50530-50719
            525-2541            AC120406.27        77723-79739
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 5.58 cM"
     gene            1..2541
                     /gene="Kcns3"
                     /note="potassium voltage-gated channel, delayed-rectifier,
                     subfamily S, member 3"
                     /db_xref="GeneID:238076"
                     /db_xref="MGI:MGI:1098804"
     exon            1..234
                     /gene="Kcns3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..334
                     /gene="Kcns3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..524
                     /gene="Kcns3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..2541
                     /gene="Kcns3"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..2059
                     /gene="Kcns3"
                     /note="potassium voltage-gated channel subfamily S member
                     3; voltage-gated potassium channel subunit Kv9.3;
                     delayed-rectifier potassium channel subunit Kv9.3"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS3"
                     /protein_id="NP_001400183.1"
                     /db_xref="GeneID:238076"
                     /db_xref="MGI:MGI:1098804"
                     /translation="MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKL
                     LTCHSEEAILELCDDYSVADKEYYFDRNPFLFRYVLNFYYTGKLHVMEELCVFSFCQE
                     IEYWGINELFIDSCCSSRYQERKEESHDKDWDQKSNDVSTDSSFEESSLFEKELEKFD
                     ELRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD
                     DPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFVSIIPFYATLAVDTKE
                     EESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVG
                     ISIFSVLIYSVEKDEHKSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCII
                     CGILVVALPITIIFNKFSKYYQKQKDMEVDQCSEDPPEKCHELPYFNIRDVYAQQVHA
                     FITSLSSIGIVVSDPDSTDASSVEDNEDAYNTASLENCTGK"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcns3"
                     /note="hexamer: AATAAA"
     polyA_site      2541
                     /gene="Kcns3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggg ctgttggttg tgttttcgct cagtgccagt gcagggaggc caggcgtgtc
       61 ttcaggacta cacgctgccc ttgcataggt ccttggttgt taattcaacc ttagctggag
      121 ccatttctcg gtgactccct ctcccattcc gagctttcca ttcagttcct ttttcctttc
      181 ttcatatgag gtgcatatgc ttggtgcata agtccaacca tctcttcaga cttggtagcc
      241 cttggggtaa agcagtgtcc agtggattaa agcagctcac tattctgtcg ggacccaggg
      301 ggacccagat gaagagtcta tcactggcta gtctgtgaac ttgactttac agcaactgct
      361 ttgacttgga caaccggagg gccacattct tctcttcttt gagcactaaa tgccggtgca
      421 cactccaccc tccagcaagg gaagacagga ggagcttctt ggatgacaat ggaggttcca
      481 ctgtgcagga tgagggcagg ctgtatgaca tcgccaccac gagggttcag cgtgatctcc
      541 tgtgtctccc ttccaggcca gcactctgcc ttctcaatcc atcatggtgt ttggtgagtt
      601 tttccatcgc cctggacaag atgaggaact tgtcaacttg aacgtggggg gctttaagca
      661 gtctgtggat caaagtacac tcctgcggtt ccctcacaca cgactgggaa agctgcttac
      721 ctgccactct gaggaggcca ttctggagct gtgtgatgac tacagcgtgg cagataaaga
      781 gtactacttt gatcggaacc ccttcctgtt cagatacgtc ttgaactttt attacacagg
      841 gaagctgcat gtgatggagg aactgtgtgt cttctccttc tgccaggaga tcgagtactg
      901 gggcatcaat gagctcttca ttgactcctg ctgtagcagt cggtaccagg agcgcaagga
      961 ggagagccac gacaaggact gggaccagaa aagcaacgat gtgagcacag actcctcctt
     1021 tgaagaatcg tctctgtttg agaaagagct ggagaagttt gatgagctga gatttggtca
     1081 gctccgaaag aagatctgga ttcgaatgga aaatccagct tactgcctgt cggccaagct
     1141 cattgccatc tcctccttga gcgtggtgct ggcttccata gtggccatgt gtgtgcacag
     1201 catgtcggaa ttccagaacg aggatggaga agtggatgac cctgtgctgg aaggtgtgga
     1261 gattgcctgc attgcatggt ttactggtga gctagccatc aggctggttg ctgctccatc
     1321 acaaaagaag ttctggaaaa accctctgaa catcattgac tttgtttcta tcattccctt
     1381 ctatgccacg ttggctgtgg acaccaagga agaagagagt gaggacattg agaatatggg
     1441 caaggtggtc cagatccttc ggctcatgag gattttccga attctgaagc ttgcccggca
     1501 ctctgtaggg cttcggtctc ttggggccac actgaggcac agttaccatg aggtggggct
     1561 actgcttctc ttcctttctg tgggcatctc catcttctct gtgcttatct actctgtgga
     1621 gaaagatgaa cacaagtcca gtctcaccag catccccatc tgctggtggt gggccactat
     1681 cagtatgacc acagtgggct atggagacac ccacccagtc accttagctg ggaaaatcat
     1741 tgcaagcaca tgtattatct gtggaatctt agtggtagcc ctccccatta ccatcatctt
     1801 caacaagttt tccaagtact accagaagca gaaagacatg gaagtggacc agtgcagcga
     1861 ggacccacca gagaagtgcc atgagctacc gtactttaac attagggacg tttatgcaca
     1921 gcaagtacat gccttcatca ccagtctgtc ttccattggc atcgtggtca gtgatcctga
     1981 ctccacagat gcttcgagcg ttgaagacaa tgaggatgct tacaacactg catccctgga
     2041 gaactgtact ggaaaatgag caggggcatt tgcacagata tctcgtgtcc cttcctgaca
     2101 ttaggttaac acagctttat aaacctcaat gggtttgttc aaaaaatcat ttaattctca
     2161 gggtgtacct tttagccata gttggacatt cattgctgaa ttctgaaatg atagaattat
     2221 ctttattttt ctcagtgaga tcaattaaaa tgccttgttc tgaaatttat tttttacaag
     2281 agagagttgt aatacggttt tttggggaaa aaagtaaatg atattgggaa ggatttattg
     2341 ctacggctta cgcatcattc tatatttgcc attcactcac attgagctaa ctataaatta
     2401 ctgatgatag agcagaggcc cagctgactg aagatgacga catgcatgta agatctacaa
     2461 catgagacaa tgcatgtaaa tccatgttca tgttccagac atgggaatta ggagcccaat
     2521 aaacttctaa tttggtatgg a
//
