LOCUS       NM_181317               5473 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus K+ voltage-gated channel, subfamily S, 2 (Kcns2),
            transcript variant 1, mRNA.
ACCESSION   NM_181317
VERSION     NM_181317.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5473)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5473)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   3  (bases 1 to 5473)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK173110.1, AK050926.1 and BE954026.1.
            
            On Nov 9, 2012 this sequence version replaced NM_181317.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173110.1, AK048819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4386              AK173110.1         1-4386
            4387-5446           AK050926.1         474-1533
            5447-5473           BE954026.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..5473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.34 cM"
     gene            1..5473
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /note="K+ voltage-gated channel, subfamily S, 2"
                     /db_xref="GeneID:16539"
                     /db_xref="MGI:MGI:1197011"
     exon            1..498
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..5456
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1975
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /note="potassium voltage-gated channel subfamily S member
                     2; voltage-gated potassium channel subunit Kv9.2;
                     delayed-rectifier K(+) channel alpha subunit 2;
                     delayed-rectifier potassium channel subunit Kv9.2"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS2"
                     /protein_id="NP_851834.1"
                     /db_xref="CCDS:CCDS27421.1"
                     /db_xref="GeneID:16539"
                     /db_xref="MGI:MGI:1197011"
                     /translation="MTRQSLWDVSDTDVEDGEIRINVGGFKRRLRSHTLLRFPETRLG
                     RLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFS
                     QEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASK
                     FDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQ
                     GNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLV
                     VNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLL
                     YLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTAS
                     ACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAH
                     KVKSLMASLTNMSRSSPSELSLDDSLH"
     polyA_site      5337
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /note="major polyA site"
     regulatory      5429..5434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
                     /note="hexamer: ATTAAA"
     polyA_site      5447
                     /gene="Kcns2"
                     /gene_synonym="E130006J24Rik; Kv9.2"
ORIGIN      
        1 aagctggggg gcgcccgaag aacagaatga tgctccggaa cgtctcaaga gtctgggcgg
       61 cgactgtgcc ccgggctggc gcgctcggag ctgtccgttc agcaccaccg cgcagcacca
      121 ggctcaaggc cctctgcaag gcgcaccggc tcggttcccg cccccgctcc acgggcgcct
      181 gcggcgtggg ctcctgcctc tcgtggtggg tgaggggcgc gcagatcgga agaggggggc
      241 tccacgagcg tcggggccac gcagccacct gtgagcctct cgcggatgtg ggcggtggtg
      301 tgtgcggccg gagactgaag gaggcgcacg gtggaccccg cctgcccggt ggcggggcac
      361 acagacaagc actcacatct acatcctcgc acccgcgcgc actcgcgcag ccagccaacg
      421 gcgtccaccg cggtgatgct tgccagcagg tcggggaagt ttcccgccgg cctctgccgc
      481 gggctcccgt gcacccaggt gtagcgcccc cgcgcggcgc gggcgcctgg gcatctccag
      541 catgacccgc cagagcctgt gggatgtgtc cgataccgac gtcgaggatg gagagatccg
      601 catcaatgtg ggtggcttca agagacggct gcgttcccat acgctgctgc gcttccctga
      661 gacacgcctg ggccgtctgc tcctctgcca ctcgcgagag gccattctgg aactctgcga
      721 tgactacgat gacgttcagc gtgagttcta cttcgaccgt aaccccgagc tcttccccta
      781 tgtgttgcat ttctaccaca ccggcaagct tcacgtcatg gctgagctgt gcgtcttctc
      841 cttcagccag gagatcgagt actggggtat caatgagttc ttcatcgact cttgctgcag
      901 ctatagctat cacggccgca aagtggaacc tgagcaggag aaatgggacg agcagagtga
      961 ccaggaaagc accacttcct ccttcgatga gatcttggcc ttctataatg atgcttccaa
     1021 gttcgatggg caacccctgg gcaacttccg caggcagctg tggctggcgt tggacaaccc
     1081 aggctactca gtcctaagca gggtcttcag tgtcctttcc atcttggtgg tgttgggctc
     1141 catcatcacc atgtgcctca atagcctgcc agacttccaa atccctgata gccagggtaa
     1201 ccccggtgaa gaccccaggt tcgaaattgt ggagcacttt ggcattgctt ggttcacatt
     1261 tgagttggtg gccaggtttg ctgtggcccc tgactttctt aagttcttca agaatgctct
     1321 aaaccttatt gatctcatgt ccattgtccc attttacata actctagtgg tgaacctggt
     1381 ggtggagagt tctcctacct tggctaactt gggcagggtg gctcaagtcc tgaggctaat
     1441 gaggatcttc cgaattctca agctggccag acactccact ggcctccgct ccttgggagc
     1501 caccctgaag tacagctaca aggaagtggg gttgctcttg ctctacctct cagtggggat
     1561 ttccatcttc tctgtggtgg cctacaccat tgaaaaggag gagaacgaag gcctggccac
     1621 catccctgcc tgctggtggt gggccactgt cagtatgacc acagttgggt acggagatgt
     1681 ggtcccaggg acaacagctg ggaagttgac tgcctctgcc tgcatcttgg caggcatcct
     1741 ggtggtggtc ttgcccatca ctttgatctt caataagttc tcccatttct atcggcgcca
     1801 aaagcaactt gagagtgcta tgcgcagctg tgactttgga gatggaatga aagaggtccc
     1861 ttcggtcaat ttaagggact actatgctca taaagttaag tccctcatgg caagtctgac
     1921 aaacatgagt aggagttcac ctagtgaact gagtttagat gattctctac attagctgga
     1981 ccccgactta cattgctgat ctgctgcttg tggttctagc acaatcaggg caattttagg
     2041 gctgtggcat aagaaatcat ccctgcccta gagggagagc tgcatgggac ataagcccta
     2101 gattgctttt gcaatgttta gagaggtttc ttttttcttt tgaggatggt gtgtctaata
     2161 acatgccttt gcacctctca gtgaagtgac actcactggt gtttgcatca tggcaaaaaa
     2221 aaaaatgttc acctttctgc cagatgagta tctagaatgc caatttctct gtccactgtg
     2281 tacagtattc taatgctcat atcccagcat tacctgtgag tggaattgtc tgtgctccta
     2341 tttccgaggc tgctgtatgg gttccagtga caacacatct gtctatgagg tcagcaagga
     2401 tatcgtgaga tttggatcac aaccatgtga aaataatctc aattatgtat cccttgcttt
     2461 catttacctt taataccaaa acagagagat cgcaaagcta agcacacttg accaatgcaa
     2521 atcttcgagt tgtctttcta cttggtcctg tccttgtgat gtgcatgaat gcaccagtca
     2581 ttttaaagaa agatatgtat tgatgtatat ctcctaagtg tcagtgtaaa gagaatgtta
     2641 cttagtcgat atgtagtaaa gactgaatgt ttttcctcca aacagttaaa tttagggaca
     2701 gcgactttag ctaaacatgg accaaacccc aggagttcat gtaggctaag cccttttact
     2761 gatggtcagg cctcttttca tttatttctg gctgagatgc tcaatccagg ccattttgac
     2821 caaagtttgc tgtgtcttgg tattagcatg tttttcaagc atctcttttt taagatgttt
     2881 aggaataagg ccgtgctgtc tttctcctcc actggaagaa gtttgtgttt tgttgtcttt
     2941 gtgaggtaag cactgtcagg ttgctggcaa gggcaatagc ttaaatattt tcttgcctgc
     3001 tctaaaagcc cataaaatga atgttctttt gtttctgagc agagtttcct ttaggtagtt
     3061 ttgcttctag gacacaggat agtgtatgta tagtgtttga ttgccttgag ttcctgcctt
     3121 ggcatggaaa cctggtagtg cagagcatat tcaagatgca gacatgcatg aaggcaggtg
     3181 gcttacccag ggtggaaaca ctgtagcttt tatttccatt gcaattgcaa tggggtttgg
     3241 gggacagggg tagaagtcaa aagaaaagag ttataaagcc aaaaactact ttataagata
     3301 taaataactg tgagcttctt taaaagctta aaactagtaa aatagaaaac aaaaacaaca
     3361 aacaaccctt tcaaccatta agctgtgttg aagggttacc tctatttcct tttccaacac
     3421 actgttcagt taacacaaaa cattatgaag gggcacctgg gcccccttta agaaaattct
     3481 ttcccatcat tgtctaagta atctgatggt tttccagtgg ctttcattat tgttgagtct
     3541 ttggcaaggc tatagaatcc agggatccaa atacggagat aaacaggctt ttaatccaaa
     3601 gtttgggcct actcttaatt ggtccatttt gtgttttagt cagttaagga caatccacac
     3661 ttcacagggg tgtggaatgg atcttctcag agggctctgt gtactagtgg ttgccatggt
     3721 gactacagtg tgggcgattt gttggatgaa tgcactgacc atttaatgcc cttgagcctc
     3781 cagttcagat ctttcatcag actggagact gatgaggggc agaaggtggc aacctcctag
     3841 tgcctacgtg cagacacatc tatgtctatt attccaaagc agcaggaatg tgaggttgac
     3901 ttcaaggaac cccgcctgtg aatcagaaga caggagttgg ttttgggagt ttgcatatgg
     3961 aactcttgtt gttggctggt atcttcagca ctagaagacc aaggatgtat aaaactgttc
     4021 ccagttgcac tgaaggcagg ggacagccta acctgtgagg actgtttggt ttgctgaggc
     4081 tgatggtata ccataactgg gcatgaattg catggtcact gaccatgaag ctgatggaaa
     4141 gaagaaaaga ggagatgcag agtaacttag ccactctcct aaggattttt ctaaatgaac
     4201 atgtttaaca ccaaaaagga gatacctgca aggatatgaa agctggaaaa cttgactttt
     4261 cttttttggt gatgacttgt tttatctggt gcctttcatt gggggaatcc caaagtgctt
     4321 tagagactgt ctttttaaca tttcttgtag atatatgtat aattgtaaaa gaatattcct
     4381 ttgcccacca agacttttag tcgcttctga gcatgaaaag gtcccaggag cattaagttc
     4441 ccccaagcag tagtttcata gaccttgagg gagggccatc cagatggctg ggctctgcag
     4501 tgatctccat agaccataaa gaatggtgta aaggccctgg gaacctttcc cttatcactg
     4561 aactacacgg aggtatgaag ttcacaagtc ctggatcaga cacaaagcct ctgactagtc
     4621 aagtcagata atgtctccca tggtagtttc tcctccagga gagagcagat tcattttctg
     4681 ccgtgttctt gggagtaaag gctaccaaga tgaagtggac tcatagatga tcaaggtagc
     4741 ctgtacaatc ctttcttggg gaacacagta gatgcaggct cattcatacc cagctggtag
     4801 ctaaagagca actccactct tggcatttga cctgttcagt attactgggt caaatacatg
     4861 ggccaagctt tgtcatagca tgcagggtgg gcatttggaa ctgacacacg tttatggcac
     4921 agatacatta gtctggggct gtgtttccca tccaagttct gcatttccca ggttggctgc
     4981 tgaggagggg cgtgtagaat gctgagccta tgcctagctc atcaggtagt aattgatgtt
     5041 taatatttgg gtttgttatt gctacttact gtagctctca aagcactgag cgacctgtta
     5101 attcctgctt tgtttcaatg gaaatgattt gttctgcact ttgggatatc ggcggtagag
     5161 accacaggca gtgtggtctc tacttgaaag cttaactggt atttcttgta tgttttaaca
     5221 gcatgacttg ttccagggtt gtaattttaa acatcgagaa tactgtattt gcgatgtcag
     5281 ttttaacact cattaacaca ctactgtgcc agcgtcctgg cggctcctgc gccattacat
     5341 cgctgctgtg cttgagtttc ttgtgcctcg actccagaat gaggcacatg actgacatac
     5401 tcaggatgcc agccttgcaa atatgcagat taaacagaag ataattattt cacttcaaaa
     5461 aaaaaaaaaa aaa
//
