LOCUS       NM_008435               2727 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus K+ voltage-gated channel, subfamily S, 1 (Kcns1),
            mRNA.
ACCESSION   NM_008435
VERSION     NM_008435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2727)
  AUTHORS   Tsantoulas,C., Denk,F., Signore,M., Nassar,M.A., Futai,K. and
            McMahon,S.B.
  TITLE     Mice lacking Kcns1 in peripheral neurons show increased basal and
            neuropathic pain sensitivity
  JOURNAL   Pain 159 (8), 1641-1651 (2018)
   PUBMED   29697531
  REMARK    GeneRIF: After neuropathic injury, Kcns1 KO mice exhibited
            exaggerated mechanical pain responses and hypersensitivity to both
            noxious and innocuous cold, consistent with increased A-fiber
            activity. Interestingly, Kcns1 deletion also improved locomotor
            performance in the rotarod test, indicative of augmented
            proprioceptive signalling.
REFERENCE   3  (bases 1 to 2727)
  AUTHORS   Hirst,C.S., Foong,J.P., Stamp,L.A., Fegan,E., Dent,S., Cooper,E.C.,
            Lomax,A.E., Anderson,C.R., Bornstein,J.C., Young,H.M. and
            McKeown,S.J.
  TITLE     Ion channel expression in the developing enteric nervous system
  JOURNAL   PLoS One 10 (3), e0123436 (2015)
   PUBMED   25798587
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2727)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   5  (bases 1 to 2727)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127291.1, AF008573.1, AK158889.1, AL591512.11 and AW047812.1.
            
            On Aug 22, 2006 this sequence version replaced NM_008435.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008573.1, SRR7974084.16204.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               BY127291.1         2-166
            166-1607            AF008573.1         143-1584
            1608-2114           AK158889.1         1161-1667
            2115-2668           AL591512.11        94188-94741         c
            2669-2727           AW047812.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..2727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.6 cM"
     gene            1..2727
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="K+ voltage-gated channel, subfamily S, 1"
                     /db_xref="GeneID:16538"
                     /db_xref="MGI:MGI:1197019"
     exon            1..87
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..269
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..1315
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1783
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="potassium voltage-gated channel subfamily S member
                     1; voltage-gated potassium channel subunit Kv9.1;
                     delayed-rectifier K(+) channel alpha subunit 1;
                     delayed-rectifier potassium channel subunit Kv9.1;
                     potassium voltage-gated channel modifier subfamily S
                     member 1"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS1"
                     /protein_id="NP_032461.2"
                     /db_xref="CCDS:CCDS17022.1"
                     /db_xref="GeneID:16538"
                     /db_xref="MGI:MGI:1197019"
                     /translation="MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTR
                     LGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFA
                     FGQEADYWGLGENALATCCRARYLERRVARPRAWDEDSDAPSSVDPCPDEISDVQREL
                     ARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQARE
                     AAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNL
                     IDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGL
                     RSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEENEGFHTIPACWWWGTVSMTT
                     VGYGDVVPETVGGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQ
                     REFEDLLSSVDGVSDVSLETSRDTSQEGRSTDLETQAPREPAKSHSY"
     exon            1316..2712
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2692..2697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="hexamer: AATAAA"
     polyA_site      2712
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgcagc ggggcctcgg gacagaaaac agtccagggc ggcgacttga gggacaagcg
       61 cgctggaatc cctggagacc aatacagttg taggtaataa gccttaacta ttcccatcta
      121 cggcggagga tactgaggat cagaagagcc accgtggaca tttggcttcc caaatccaag
      181 cttgtccagg aaaaagagag atgtcccata caaatcccta gtagatgcca ggccatccca
      241 ccatcccatc actccaatag ccctgcaagg gaggcacact gtcgtagcca tggtgagcga
      301 gtttccgggt ccaggctctc gggtcccctg gcggcctaga gacgaggcgc tgcgcgtgaa
      361 cgtgggcgga gtgcggcggc tgctgagcgc gcgcgccctt gcgcgcttcc cgggcacgcg
      421 cctgggccgc ctacaggcgg cggcgtccga ggagcaggcg cggcgcctgt gcgacgacta
      481 cgacgcagcg gcgcacgagt tctactttga tcggcatccg ggcttctttc tcggcctcct
      541 acacttctac cgcaccgggc acctgcacgt cctagacgag ctgtgcgtct tcgccttcgg
      601 ccaggaggct gactactggg gcctgggcga gaacgcgctg gccacgtgct gccgcgcgcg
      661 gtatctggag cggcgtgtgg cgcggcctcg cgcctgggac gaggacagcg acgcgccgag
      721 cagcgtggac ccgtgtcccg acgagatctc ggacgtgcag cgggagctgg cgcgctatgg
      781 tgcggctcgc tgtggccgcc tgcgccgtcg tctctggctc accatggaga atccaggcta
      841 ctcgctgccc agcaagctct tcagctgcgt atccatcggc gtggtgctcg cctccatcgc
      901 tgccatgtgc atccacagcc tgccggagta ccaagctcgg gaggcggcgg cggcggtggc
      961 tgcagtggcc gcgggtcgca gcgcagagga ggtgcgcgac gacccggtgc tgcgccgcct
     1021 ggagtacttc tgcatcgctt ggttcagctt cgaggtgtcg tcgcgcctgc tgctggctcc
     1081 cagcacgcgc aacttcttct gccacccgct caacctcatt gacatcgtgt cggtgctgcc
     1141 cttctatctc acactgctgg ctggcgcagc gcttggtgac cagcgcggag ccagcgggga
     1201 ggagctcggg gacctgggca aggtagtgca agtgttccgc ctcatgcgca tcttccgcgt
     1261 gctcaagctg gcgcgccact ccacggggct gcgttcgctg ggcgccacgc tcaagcacag
     1321 ctaccgtgag gtgggcatct tactgctgta cctggccgtg ggtgtgtcag tgttctccgg
     1381 cgtggcctac acagccgaag aagaaaacga gggctttcac acaatccctg cctgctggtg
     1441 gtggggcaca gtgagcatga ccacagtggg ctatggggat gtggtgccag agactgtggg
     1501 tggcaagctg gcggcctcgg gctgcatcct cgggggcatc ctggtggtcg ccctccccat
     1561 caccatcatc ttcaacaagt tttcccactt ctaccggcgc cagaaggcac tggaggcggc
     1621 cgtgcggagc agcggtcagc gcgagtttga ggacttgctg agtagcgttg acggggtatc
     1681 ggatgtgtct ctggaaacat cccgggacac ttctcaggag ggacgctcta cagacctgga
     1741 gacccaagct ccccgggagc ctgcaaaatc tcacagttat taaaaccagg gctctgtgtt
     1801 ccctccccac agcctgggaa tcagctaaca cagagcagag tcctcccctg cttggggtct
     1861 gcatgggcgc catccacctg agccgtcaga cataggggcc acagatcttt cttgaaaagc
     1921 tcaggcagga tagcacagcc ctacattcta tgagcaccga gaggaggaag agggcggcct
     1981 ccataggagc ctttttagcc tggcagatga ttatccccat ttcacagatg agggcactga
     2041 ggcccagctg aatgccacag agaaatcact aagcctttgt cactaagtcc ctggaaggag
     2101 ctgggggggg ggggggctgg gtttttggaa tctgtaggat ccatagcaca atcatctacc
     2161 acacacctac ttcctaggga tgacttacag agaaagcctg aatagaccct tctgggaccc
     2221 agacccagct ctagacctgc cacaggaaag gtggccaagg cctgtcccca gaactagagt
     2281 ctagccaatc cgtcacagca tgtgacccag agaggaggtt actgagaagg cccagctcat
     2341 ctctgaactg ttggtggcag aggggtgcag ttgcatgcac ctgacctgac acaagctaaa
     2401 gttacctggg aggaggagcc tccactgagg ggacatctcc atcagattgc ttgcaggcaa
     2461 gcccggtgag acattagctt gattaatgat tcaatatggg agggcccagc ccactgtggg
     2521 cagtaccact ccctctcggg tatataagaa agtagactga actggccacg ggagcgagtc
     2581 agtaagcagt gttcctccat ggcctctgct tcagttcctg cttgcaggct cctgccttat
     2641 gctcctgcct tggcatccct cagtgaacta tgacctggga tatgtaagcc aaataaaccc
     2701 tttcctctcc aaaaaaaaaa aaaaaaa
//
