LOCUS       NM_023872               6935 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily Q, member 5
            (Kcnq5), transcript variant 2, mRNA.
ACCESSION   NM_023872 XM_129704
VERSION     NM_023872.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6935)
  AUTHORS   Tsvetkov,D., Schleifenbaum,J., Wang,Y., Kassmann,M.,
            Polovitskaya,M.M., Ali,M., Schutze,S., Rothe,M., Luft,F.C.,
            Jentsch,T.J. and Gollasch,M.
  TITLE     KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation
  JOURNAL   Hypertension 81 (3), 561-571 (2024)
   PUBMED   38354270
  REMARK    GeneRIF: KCNQ5 Controls Perivascular Adipose Tissue-Mediated
            Vasodilation.
REFERENCE   3  (bases 1 to 6935)
  AUTHORS   Wei,A.D., Wakenight,P., Zwingman,T.A., Bard,A.M., Sahai,N.,
            Willemsen,M.H., Schelhaas,H.J., Stegmann,A.P.A., Verhoeven,J.S., de
            Man,S.A., Wessels,M.W., Kleefstra,T., Shinde,D.N., Helbig,K.L.,
            Basinger,A., Wagner,V.F., Rodriguez-Buritica,D., Bryant,E.,
            Millichap,J.J., Millen,K.J., Dobyns,W.B., Ramirez,J.M. and
            Kalume,F.K.
  TITLE     Human KCNQ5 de novo mutations underlie epilepsy and intellectual
            disability
  JOURNAL   J Neurophysiol 128 (1), 40-61 (2022)
   PUBMED   35583973
REFERENCE   4  (bases 1 to 6935)
  AUTHORS   Soh,H., Springer,K., Doci,K., Balsbaugh,J.L. and Tzingounis,A.V.
  TITLE     KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
  JOURNAL   Proc Natl Acad Sci U S A 119 (13), e2117640119 (2022)
   PUBMED   35320039
  REMARK    GeneRIF: KCNQ2 and KCNQ5 form heteromeric channels independent of
            KCNQ3.
REFERENCE   5  (bases 1 to 6935)
  AUTHORS   Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
            Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
            Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   6  (bases 1 to 6935)
  AUTHORS   Yeung,S., Schwake,M., Pucovsky,V. and Greenwood,Ia.
  TITLE     Bimodal effects of the Kv7 channel activator retigabine on vascular
            K+ currents
  JOURNAL   Br J Pharmacol 155 (1), 62-72 (2008)
   PUBMED   18536747
  REMARK    GeneRIF: Results provide support for KCNQ4- or KCNQ5-encoded
            channels having an important functional impact in the vasculature.
REFERENCE   7  (bases 1 to 6935)
  AUTHORS   Yeung,S.Y., Lange,W., Schwake,M. and Greenwood,I.A.
  TITLE     Expression profile and characterisation of a truncated KCNQ5 splice
            variant
  JOURNAL   Biochem Biophys Res Commun 371 (4), 741-746 (2008)
   PUBMED   18457656
  REMARK    GeneRIF: These data represent an exhaustive characterisation of a
            truncated KCNQ5 splice variant that may contribute to the native
            XE991-sensitive channel in murine vasculature.
REFERENCE   8  (bases 1 to 6935)
  AUTHORS   Yeung,S.Y., Pucovsky,V., Moffatt,J.D., Saldanha,L., Schwake,M.,
            Ohya,S. and Greenwood,I.A.
  TITLE     Molecular expression and pharmacological identification of a role
            for K(v)7 channels in murine vascular reactivity
  JOURNAL   Br J Pharmacol 151 (6), 758-770 (2007)
   PUBMED   17519950
  REMARK    GeneRIF: Murine blood vessels exhibit a distinctive expression
            profile of KCNQ1, KCNQ4, and KCNQ5, with 'neuronal' KCNQ4
            dominating
REFERENCE   9  (bases 1 to 6935)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   10 (bases 1 to 6935)
  AUTHORS   Jensen,H.S., Callo,K., Jespersen,T., Jensen,B.S. and Olesen,S.P.
  TITLE     The KCNQ5 potassium channel from mouse: a broadly expressed
            M-current like potassium channel modulated by zinc, pH, and volume
            changes
  JOURNAL   Brain Res Mol Brain Res 139 (1), 52-62 (2005)
   PUBMED   15963599
  REMARK    GeneRIF: Data show that murine KCNQ5 channels are tightly regulated
            by changes in extracellular Zn2+, pH, and tonicity, thus adding to
            the complex regulation of these channels.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147264.1, BE648243.1, AY679158.1, CX239866.1 and AW493240.1.
            
            On May 13, 2009 this sequence version replaced NM_023872.2.
            
            Transcript Variant: This variant (2) omits an in-frame coding exon,
            compared to variant 1, resulting in a shorter protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY679158.1, AF263836.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AK147264.1         4-384
            382-382             BE648243.1         302-302
            383-574             AK147264.1         386-577
            575-1305            AY679158.1         214-944
            1306-1306           AK147264.1         1309-1309
            1307-2820           AY679158.1         946-2459
            2821-5191           AK147264.1         2881-5251
            5192-5193           CX239866.1         561-562
            5194-6918           AK147264.1         5252-6976
            6919-6935           AW493240.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..6935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.67 cM"
     gene            1..6935
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="potassium voltage-gated channel, subfamily Q,
                     member 5"
                     /db_xref="GeneID:226922"
                     /db_xref="MGI:MGI:1924937"
     exon            1..762
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..3163
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     potassium voltage-gated channel subfamily KQT member 5;
                     voltage-gated potassium channel type Kv7.5; KQT-like 5;
                     potassium channel subunit alpha KvLQT5; voltage-gated
                     potassium channel subunit Kv7.5"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 5 isoform 2"
                     /protein_id="NP_076361.1"
                     /db_xref="CCDS:CCDS35525.1"
                     /db_xref="GeneID:226922"
                     /db_xref="MGI:MGI:1924937"
                     /translation="MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGGRPGSGMKDVESGR
                     GRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQS
                     CRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSC
                     LLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVV
                     SAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL
                     VLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFAL
                     LGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIA
                     TWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPS
                     TDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGIDDVYDEKGCQC
                     DVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIK
                     SLQTRVDQILGKGQMTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKLDCL
                     LDIYQQVLRKGSASALTLASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSAS
                     ANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPMSQNDGSSVVATNNIANQISAA
                     PKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPTGLQESISDVTTCLVASKESVQFAQSN
                     LTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSR
                     GSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQN
                     ICKTGDSTDALSLPHVKLN"
     exon            763..853
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..980
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1156
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1282
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1393
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1489
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1584
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1611
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1832
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1941
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2073
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2200
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..6923
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3617..3622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="hexamer: AGTAAA"
     polyA_site      3640
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="major polyA site"
     regulatory      6902..6907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="hexamer: ATTAAA"
     polyA_site      6923
                     /gene="Kcnq5"
                     /gene_synonym="7730402H11; 9230107O05Rik; D1Mgi1"
                     /note="major polyA site"
ORIGIN      
        1 tgggtgtgca cgcgtgcgag cgtgcctccg ggcatcccgc acaccctcag tcccgtgtgc
       61 cgacactcct cggggaggag ggagtggcag ccaccagact aaaggaaagc gagggacacc
      121 tcacaaagtg acgcccccaa caggtccgga tttggaattg gaagcggcag aaatccggac
      181 ctccccgggc ctgctccgca caccccgccg cccccgcccg gagccccgac tctaggctag
      241 tccgcccccc cggggcgccc cgtcggctgc gggtttcctc ctgcagacct gcccgcgcac
      301 atgaagccgc tgcccccgcc gcaggcgcca gcgcccccct cgcggtgccc gtggtgatgc
      361 catgccccgc caccacgcgg gaggagagga gggcggtgcc gccgggctct gggtgaggag
      421 cggcgcggcg gcggcggcag gcgcgggtgg ggggcgcccg ggcagcggca tgaaggatgt
      481 ggagtccggc cgcggcaggg tgctgctgaa ctcggcggcc gccaggggcg acggcctgct
      541 gttgctcggc acccgcgcgg cggcgctcgg cggaggcggc ggcggcttga gagagagccg
      601 ccggggcaag cagggggccc gaatgagcct gctggggaag ccgctctcct acaccagcag
      661 ccagagctgt cggcgcaacg tcaagtaccg gcgggtgcag aactatctgt acaacgtgct
      721 ggagcgaccc cgcggctggg cgttcgtcta ccacgcgttc gtttttctcc ttgtgtttgg
      781 ttgcttgatt ttgtcagtgt tttctaccat ccctgagcat acaaaattgg cttcaagttg
      841 cctcttaatt ctggagttcg tgatgatcgt tgtctttggc ttggagttca tcattcgaat
      901 ctggtctgca ggttgctgtt gtcgttatag aggatggcaa ggaagactga ggtttgctcg
      961 aaaaccattc tgtgtaatag ataccattgt tctcatcgct tcaatagcag ttgtctctgc
     1021 aaaaactcag ggtaatattt tcgccacgtc agcgctcaga agtctccggt tcctacagat
     1081 cctgcgtatg gtgcgcatgg acagaagggg agggacctgg aagctgctcg gctctgtggt
     1141 ttatgctcac agcaaggaat taatcacagc ctggtacatt ggatttctgg ttcttatttt
     1201 ttcatccttc cttgtctatc ttgtggaaaa ggatgccaat aaagagtttt cgacatatgc
     1261 ggatgctctc tggtggggca caatcacact gacaaccatt ggctatggag acaaaacacc
     1321 cctaacgtgg ctgggaagac tgctctctgc aggcttcgca ctccttggca tttctttctt
     1381 tgcacttcct gctggcattc ttggctcagg ttttgcatta aaagtacagg agcagcaccg
     1441 ccagaagcat tttgagaaaa gaaggaaccc agctgccaac ctcatccagt gtgtctggcg
     1501 tagttatgca gctgatgaaa aatctgtttc cattgcaacc tggaagccac atctgaaggc
     1561 cttgcacacc tgcagcccta ccaagaaaga acaaggggag gcatcaagca gtcagaagct
     1621 gagctttaag gagcgagtgc gcatggctag cccaaggggc cagagcatta agagcagaca
     1681 agcatcagta ggtgacagga gatccccgag cactgacatc actgccgagg gcagccccac
     1741 caaagtccag aagagttgga gcttcaacga ccgaacccgc ttcaggccct cactacggct
     1801 caagagttcc cagccaaagc cagtgataga cgccgacaca gcccttggca ttgatgatgt
     1861 gtatgatgag aaaggatgcc agtgtgacgt ctctgtggag gacctcaccc caccacttaa
     1921 aaccgtcatc cgagcaatca gaattatgaa gtttcatgtt gcaaagcgga agtttaagga
     1981 aacattacgc ccatatgatg taaaagatgt cattgaacaa tactctgctg gtcacctgga
     2041 catgctttgt agaataaaaa gccttcagac acgcgttgat caaattcttg gaaaaggaca
     2101 aatgacgtca gataagaaga gccgagagaa aataacagca gaacacgaga caacagatga
     2161 ccccagcatg ctcgcccggg ttgtgaaggt tgagaaacag gtccagtcca tcgaatccaa
     2221 gctggactgc ctgctggata tctatcaaca ggtcctccgg aaaggctctg cctccgccct
     2281 cactctggca tcctttcaga tcccgccttt tgaatgtgaa cagacctctg actatcaaag
     2341 tcctgtggat agcaaagacc tgtctggctc agcacaaaac agcggctgtt taacgaggtc
     2401 agccagtgcc aacatctcaa gaggcctgca gttcatccta acaccaaatg agttcagtgc
     2461 tcagactttc tatgcgctta gccctactat gcacagccaa gctacccagg tacccatgag
     2521 tcaaaatgac ggctcctccg tggtagccac caataacatt gcaaaccaaa taagcgccgc
     2581 acccaagcca gcagccccaa caactttaca gatccctcct cctctctcgg ccatcaagca
     2641 cttgtccagg ccagaacctc tgctctcaaa ccccaccggc ttacaagaga gtatttctga
     2701 tgtcaccacc tgccttgttg cctccaagga aagtgttcag tttgcacagt caaacctgac
     2761 caaggaccgt tccctgagga aaagtttcga catgggagga gaaactctgt tgtctgtccg
     2821 ccccatggtg cccaaggatt tgggcaaatc tctgtctgta caaaacctga tcaggtcgac
     2881 agaagaactg aacttacagt tttcaggcag cgagtcaagc ggctctcgag gcagtcaaga
     2941 tttttatccc aagtggagag aatccaaatt gtttataact gatgaggagg tcggtgccga
     3001 agagacagaa acagatactt ttgacggcac cccaccgcct gcgggggagg ctgctttctc
     3061 atcagactct ctaaggactg gaaggtcacg gtcatctcag aacatttgta agacaggaga
     3121 cagtacagac gccctcagtt tgcctcacgt caaactgaac taagttcttt gtttcctttc
     3181 taagcatagc tgttctttta gccatacata tcactgcatg aagtactctg gaagcccgtc
     3241 tatagagttg aaatcgcaca agagtcagga agaacgcgaa aggccattta taagcctgtt
     3301 atcttttaat tgcatgaaaa tgcatgttta ggggtggcag aaattccaag gtacatcgac
     3361 attaatccat gcatttaata acgtaccttg agtctaaaat cccaagccaa cagtcgctgc
     3421 tgatgctatg gggtgtgtga agatgccggg atattagttc aattgcaaga gttgacgctg
     3481 tgttttgaaa ttgtgaaagt aaacaccttc aaatttcagg catttctgct ttatgactag
     3541 ataccaagta cattttcaaa attaggccat aatgtatgtt tagacacaat ggctatcaac
     3601 agctgctaat aacaaaagta aagcagaatt tgggatataa ccgaaatggc tgcttatttc
     3661 aagaaacctt tgccagcccg tttctcctaa gtcatttcat caatgtgatt tgaatgtcaa
     3721 tctgtgtgct tctggtgact tagcgctgtg gcaagcagtt tcgcacattg ttttcatgtt
     3781 gtcctttacg ctgcgaatgt tttccaatta gaatatggcc agataatgtt attgagggcc
     3841 agtgggggag gagacctccc cttcctacgg catcttccac ttcatgacaa catagtctct
     3901 aatggaggag tcaaccctga aaatggtcaa cctctctaca agcatatgaa gtactggtgg
     3961 atttaacagc ctgtgcaacg gggctggtct ctctgtgagg atacaaccac aggtttgccc
     4021 atcctgtccc ctcaaatggc cagggtgact aacaattccc atttagtgga catagaggta
     4081 tagggcctgg ggaaggggtt tcctacttga ggttggggga aaacaacttg gaaagactcc
     4141 acagttacca caggtgggtg acattaaagg aagtacatct ccatcccccc ccccccgcac
     4201 cccatgggca aggaggagag gagcccaaaa tttgaaataa ataactagat tttcttagaa
     4261 aaataaatat tgctaggaaa tccaactacc taaacaccca cttattcttg tatagcagag
     4321 aattttgcaa gctatttatt tttaatatgc cctgagtgtc ttttgctatt aagtagcaca
     4381 ttttgcatat gaaaggctaa aatgaaactt cctttacttt tatactatag tgaacatttt
     4441 tctattcttc ccaacaaagt tatcccacat aagaaactac cggctcagtt tccagattat
     4501 gaacatttat aactgcaaac cagatagcac tggatgggtc tgcagatcaa aactccttag
     4561 tcatgtatta tgatggaaaa gaaacaaata aaaaagtgta tttattaaaa atgcatttcc
     4621 caaaaggcaa gcaatactgg ctgcttgtta gaattcaacc ccatacctgt aatcatggag
     4681 acggggaacc gaagatagag gatcatgagt tcaatgctag cctggctcat acagcaagac
     4741 tgtgtaaaga gagtgggggg ggcgggctgc taaagaaaga tctataactg ccatttaaat
     4801 tatataagct ttaactaaaa gattcctgaa agaagatgtt tttctttttg tgctgggtgg
     4861 tctgggttgg gagagttggg ggccttttca acctttttag catccaagcc aaatgagcag
     4921 aatctctagg gatgtcaagt ggttgatgga agcaaggaag gctctcaacc caccagcctc
     4981 tcccccagca gaacgctgtc cctgaacaat cgcccttact tttctttccc ctaactggta
     5041 actctacacc acaattttgc tttaaaactt caccaggttt cagccagcct ccaccctcaa
     5101 gcaaaccaat tctctcttcc tctgtttctt cccaaccttt aagtaacttt gtcatttaaa
     5161 gtcttccccc ccaccccttt ctctctctct ctcacccctc aaggacacat gcagggtgtg
     5221 gtcgcacacc tctaatccca ggatttgaga ggcaaagttg ggtggatctt tgtgtgttca
     5281 aggccagtct ggtctacaag gtgtgttcca ggccagccag ggtgacagag agaccctgtc
     5341 tcaaaaaaaa aggaaggggg ggggggggag tgtgtctgaa aaaaagacaa acaaaaactt
     5401 tcttggactc ttaatacggt ctcttagagt gtagcattca ggatcttctg acctatgaga
     5461 acatctttaa agtctaaatt ctacactcca ttgaaattgg aatgctcctc aagcctttcg
     5521 agctattctt ctcattttgc aaacagactg ctactcaatt attatatgat gttttattta
     5581 cctatgtctc caaccaacct gaatgatgta ccctccaacg gacattacac acatgtgtgt
     5641 atacccacaa cacatccctc accattgagc aaaagccaga gaaacctgcc tggcactgaa
     5701 caaggctcac tccaaatacg ggctgaggaa gaggagggag ctgacagctt ccagacagca
     5761 ctgatactgt ctcaggttga accccactgg cagcaagaat tgtgaatgta tcagggaccc
     5821 cttcttctta ggcatcctcg ggcctcaagc acagtacagt tcatctaaca tagctgaaag
     5881 ctgaagattc agagacaaag cctaaacgtg tccctacggt cttaagcaca gcaaaaatgt
     5941 gaagaatggc attgagaacg atgtctgcac attgaagcca tgaccacttt gtgtctgctt
     6001 tattctagca caaaaccacc tggatgttgg taggttttgg gtgtgtacat ttcagaggta
     6061 tgtctattat gtcatgctct gggggaacag aggaggggtc tcccatttac acttagcaga
     6121 gacccattgc tccaccccaa agagtggcag gggtgacgga aggggagcac aggttagccg
     6181 agcacactga ataaccctgt gctttctcag cccaaaccca tctgccctcc gcaaaccaca
     6241 gggttggtgg agctcatata gaacagcaat catcccatgc aggaagttac ctaaaacatg
     6301 tttgccacgt ctaatctaaa tgtttgcatc attacaatgt acaaacatta caatgtttgt
     6361 tgagccaaat taatatctgt agatggcaaa ttcatttaat ttaagagctt tattgggttt
     6421 tctaagtact taatttgggt tcttaggtgc ctttctgacc tgctattggc tcagcctttt
     6481 ggtattttgt ttttttctgg aaggttctta atatgaaaat caaaaaagcc taatagagga
     6541 gttgaggcac acactaggta tatatcatac ctatttccag agcaaaacta taaagaatga
     6601 tgaaacccag gcaaacagat catccagtca gatgctatca cagatgctaa ttccccagaa
     6661 cccaatttat ttatttattt tttttgcctt aaatgacatg gttgtgtttt tgtaaggaaa
     6721 atttaattta atataattat gtgcatttaa ctgagcagtt ccaaaagtca tgtacgaaaa
     6781 caatgcaatt gtctgtttcc tgaaaaacaa ctaaatcagg aatagcacac ccatttcaag
     6841 ctatcattaa aatgtaattt cctttgctct tttaccaaga tgatatgttt taaactaaaa
     6901 cattaaaaag atgtctataa acaaaaaaaa aaaaa
//
