LOCUS       NM_001081142            4070 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily Q, member 4
            (Kcnq4), transcript variant 1, mRNA.
ACCESSION   NM_001081142 XM_143960
VERSION     NM_001081142.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Hong,H., Koo,E.J., Park,Y., Song,G., Joo,S.Y., Kim,J.A., Gee,H.Y.,
            Jung,J., Park,K., Han,G.C., Choie,J.Y. and Kim,S.H.
  TITLE     Vestibular hair cells are more prone to damage by excessive
            acceleration insult in the mouse with KCNQ4 dysfunction
  JOURNAL   Sci Rep 14 (1), 15260 (2024)
   PUBMED   38956136
  REMARK    GeneRIF: Vestibular hair cells are more prone to damage by
            excessive acceleration insult in the mouse with KCNQ4 dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Zhang,X., Shi,T., Li,J., Wu,X., Wu,K., Li,D., Wang,D., Guan,J. and
            Wang,H.
  TITLE     Natural History of KCNQ4 p.G285S Related Hearing Loss, Construction
            of iPSC and Mouse Model
  JOURNAL   Laryngoscope 134 (5), 2356-2363 (2024)
   PUBMED   37962101
  REMARK    GeneRIF: Natural History of KCNQ4 p.G285S Related Hearing Loss,
            Construction of iPSC and Mouse Model.
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Maamrah,B., Pocsai,K., Bayasgalan,T., Csemer,A. and Pal,B.
  TITLE     KCNQ4 potassium channel subunit deletion leads to exaggerated
            acoustic startle reflex in mice
  JOURNAL   Neuroreport 34 (4), 232-237 (2023)
   PUBMED   36789839
  REMARK    GeneRIF: KCNQ4 potassium channel subunit deletion leads to
            exaggerated acoustic startle reflex in mice.
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Kaiser,M., Ludtke,T.H., Deuper,L., Rudat,C., Christoffels,V.M.,
            Kispert,A. and Trowe,M.O.
  TITLE     TBX2 specifies and maintains inner hair and supporting cell fate in
            the Organ of Corti
  JOURNAL   Nat Commun 13 (1), 7628 (2022)
   PUBMED   36494345
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4070)
  AUTHORS   Zhang,H., Li,H., Lu,M., Wang,S., Ma,X., Wang,F., Liu,J., Li,X.,
            Yang,H., Zhang,F., Shen,H., Buckley,N.J., Gamper,N., Yamoah,E.N.
            and Lv,P.
  TITLE     Repressor element 1-silencing transcription factor deficiency
            yields profound hearing loss through Kv7.4 channel upsurge in
            auditory neurons and hair cells
  JOURNAL   Elife 11, e76754 (2022)
   PUBMED   36125121
  REMARK    GeneRIF: Repressor element 1-silencing transcription factor
            deficiency yields profound hearing loss through Kv7.4 channel
            upsurge in auditory neurons and hair cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4070)
  AUTHORS   Beisel,K.W., Rocha-Sanchez,S.M., Morris,K.A., Nie,L., Feng,F.,
            Kachar,B., Yamoah,E.N. and Fritzsch,B.
  TITLE     Differential expression of KCNQ4 in inner hair cells and sensory
            neurons is the basis of progressive high-frequency hearing loss
  JOURNAL   J Neurosci 25 (40), 9285-9293 (2005)
   PUBMED   16207888
  REMARK    GeneRIF: primary defect leading to high-frequency loss in DFNA2
            patients may be attributable to high levels of the dysfunctional
            Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the
            basal hook region
REFERENCE   7  (bases 1 to 4070)
  AUTHORS   Oliver,D., Knipper,M., Derst,C. and Fakler,B.
  TITLE     Resting potential and submembrane calcium concentration of inner
            hair cells in the isolated mouse cochlea are set by KCNQ-type
            potassium channels
  JOURNAL   J Neurosci 23 (6), 2141-2149 (2003)
   PUBMED   12657673
  REMARK    GeneRIF: KCNQ channels set the resting membrane potential of inner
            hair cells in the isolated organ of Corti and maintain [Ca2+]i at
            low levels
REFERENCE   8  (bases 1 to 4070)
  AUTHORS   Yahata,T., Takedatsu,H., Dunwoodie,S.L., Braganca,J., Swingler,T.,
            Withington,S.L., Hur,J., Coser,K.R., Isselbacher,K.J.,
            Bhattacharya,S. and Shioda,T.
  TITLE     Cloning of mouse Cited4, a member of the CITED family
            p300/CBP-binding transcriptional coactivators: induced expression
            in mammary epithelial cells
  JOURNAL   Genomics 80 (6), 601-613 (2002)
   PUBMED   12504852
REFERENCE   9  (bases 1 to 4070)
  AUTHORS   Beisel,K.W., Nelson,N.C., Delimont,D.C. and Fritzsch,B.
  TITLE     Longitudinal gradients of KCNQ4 expression in spiral ganglion and
            cochlear hair cells correlate with progressive hearing loss in
            DFNA2
  JOURNAL   Brain Res Mol Brain Res 82 (1-2), 137-149 (2000)
   PUBMED   11042367
REFERENCE   10 (bases 1 to 4070)
  AUTHORS   Kharkovets,T., Hardelin,J.P., Safieddine,S., Schweizer,M.,
            El-Amraoui,A., Petit,C. and Jentsch,T.J.
  TITLE     KCNQ4, a K+ channel mutated in a form of dominant deafness, is
            expressed in the inner ear and the central auditory pathway
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4333-4338 (2000)
   PUBMED   10760300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606924.14.
            
            On Jun 18, 2019 this sequence version replaced NM_001081142.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1036034.1,
                                           SRR17784646.577124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               AL606924.14        163929-164468       c
            541-631             AL606924.14        134527-134617       c
            632-758             AL606924.14        133994-134120       c
            759-934             AL606924.14        133621-133796       c
            935-1060            AL606924.14        132835-132960       c
            1061-1171           AL606924.14        132320-132430       c
            1172-1267           AL606924.14        132054-132149       c
            1268-1356           AL606924.14        130081-130169       c
            1357-1518           AL606924.14        128292-128453       c
            1519-1739           AL606924.14        121424-121644       c
            1740-1839           AL606924.14        119455-119554       c
            1840-1971           AL606924.14        116961-117092       c
            1972-2101           AL606924.14        115568-115697       c
            2102-4070           AL606924.14        113207-115175       c
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.52 cM"
     gene            1..4070
                     /gene="Kcnq4"
                     /note="potassium voltage-gated channel, subfamily Q,
                     member 4"
                     /db_xref="GeneID:60613"
                     /db_xref="MGI:MGI:1926803"
     exon            1..540
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..631
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..758
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            759..934
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1060
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1171
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1267
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1356
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1518
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1739
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1839
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1971
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2101
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..4070
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq4"
                     /note="hexamer: ATTAAA"
     polyA_site      4070
                     /gene="Kcnq4"
                     /note="major polyA site"
ORIGIN      
        1 cccagtcgcc ggggaagcgg gcggtcagta cgggctcccg cggccccgag gctccgagcg
       61 accgcctccg gaccccgcac ggacccggcc tggtccctag cccccgccgc ctgcgtgcgc
      121 gcccagggtc gcctcgccgg cccggggttc gagccatgcg actctgagcc gcccgagcgc
      181 gcccccgccc cgcaacgccc cggtcccccg tccggcgccg cccatggccg aggccccccc
      241 gcgccgcctc ggcctgggcc ccccgcccgg ggacgccccc cgcgcggagt tggtggcgct
      301 cacggccgtg cagagtgaac agggcgaggc gggcgggggc ggctctccgc gtcgcctcgg
      361 ccttctgggc agccccctgc cgccgggcgc gcccctccct gggccgggct ccggctcggg
      421 ctccgcctgc ggcggccagc gctcctccgc cgcgcagaag cgctaccgcc gcctgcagaa
      481 ctgggtctac aacgtgctgg agcggccccg cgggtgggcc ttcgtctacc acgtcttcat
      541 atttttgcta gtcttcagct gcctggtgct gtctgtactg tccaccatcc aggagcacca
      601 ggaacttgcc aacgagtgtc tccttatctt ggaattcgtg atgattgtgg tctttggctt
      661 ggagtatata atccgtgtct ggtcggccgg atgctgttgt cgctacagag gatggcaggg
      721 acgctttcgc ttcgccagga aacccttctg tgtcatcgac ttcatcgtgt tcgtggcctc
      781 ggtggcagtg atagctgcgg gcacacaagg caacatcttt gctacgtccg cgttgcgcag
      841 tatgcgcttc ctacagatcc tgcgcatggt gcgtatggat cgccgcggtg gcacctggaa
      901 gctgttggga tccgtggtct atgcgcacag taaggagctg atcaccgcct ggtacatcgg
      961 gttcctggtg ctcatctttg cctctttcct ggtctacctg gctgagaagg atgccaactc
     1021 tgacttctcc tcctatgccg actcgctctg gtgggggacg atcacactga cgaccattgg
     1081 ctatggtgac aagacgccac atacatggct gggcagggtt ctggctgccg gcttcgcctt
     1141 actgggcatc tccttctttg ccctgcctgc cggcatcctg ggctctggct ttgccctgaa
     1201 ggtccaggag cagcacaggc agaagcactt tgagaagcgc aggatgccag cagctaatct
     1261 catccaggct gcgtggcgcc tgtactccac ggacacaagc cgggcctatt tgacagccac
     1321 ctggtattac tatgacagca ttctcccatc tttcagagag ctggccctct tgtttgagca
     1381 catacaacgg gcccgcaatg ggggcttacg gcccctggag gtgaggcggg cgccagtacc
     1441 tgatggagcg ccctctcgct acccgcccgt tgccacctgc caccggccag gcagtgcctc
     1501 cttctgccct ggggaaagca gccggatggg catcaaagac cgaatccgca taagcagctc
     1561 ccagaagcgg acaggcccct ccaagcagca tctggcccct ccgccgattc ccacctcgcc
     1621 aagcagtgag caggtgggcg aggcatccag ccccagcaag gtgcagaaaa gctggagctt
     1681 caatgaccgc acccgcttcc gggcctctct aagactcaag cctcgctgct ctgctgagga
     1741 gggcccctca gaggaagtgg ccgaggagaa gagctaccag tgtgagctta cggtggatga
     1801 tgtcatgcct gctgtgaaga cggtcatccg ttctgtcagg attctgaagt tcctggtagc
     1861 caaaaggaaa ttcaaggaga cgctgcggcc atatgatgtg aaggatgtca ttgagcagta
     1921 ttcagcagga cacctggaca tgctgggacg aatcaagagc ctgcaagccc gggtggacca
     1981 aattgtgggt cggggccctg gggaccgcaa gactcgggag aagggcgata agggtccttc
     2041 agacacggag gcagtggatg aaatcagcat gatggggcgc gtagtcaagg tggaaaagca
     2101 ggtgcagtcc atcgaacata agttggatct gctgctgggc ttctactcgc gctgcctccg
     2161 ctctggcacc tcggccagcc tgggcactgt gcaagtgccg ctcttcgacc ccgacatcac
     2221 ctcggactac cacagccctg tagaccacga ggacatctct gtctccgcac agacgctcag
     2281 catctctcgc tcagtcagca ccaacatgga ctgaagggct tctcaggggc ggggcagcct
     2341 tcggattgcc cctcggattc accccggggc ctctggactc ctctcttact tgaactcgct
     2401 ccctggcagg gagagaggcc atacgcagta ttgagctgtc tgggtgggcg agatacccaa
     2461 tgccagccag gtaccagcgc cccaggagca tgaaatgcca ggccacagca atggctgacc
     2521 ggaggccact gggcgctccc agaccctgtc cgctccatca aggctcaatg tggcccgcct
     2581 ggcaggggct ctgccctggg aatgggagca gagcactggg gccctggtcc ctgacccagc
     2641 ttctagctat gcaaggtgag gtctccaggc ccgcccttcc aggtagagca gggaagtcct
     2701 cctgccaagc ccggccccac ccggggatgg gcccaaggtg cccccacagg tgcccataaa
     2761 gcacaggact ctgccataag gtagatgggc atcatatatg caaactatgt taaatatgca
     2821 actttaggga cccccatggg gttcctctgc ccctccctta ctgggagatg ggccccagca
     2881 gtagctggtc tcaggctgct tggccatact ccacctccat tctttggctt aacatccatc
     2941 ctcacccagc atggggccta aacctctctg tcctctccaa agggcaagac ctgggccttt
     3001 ctgtcccttt gtaggtgtca ccccaggggc tcgctcttac tgctggatat ccattcccat
     3061 tggccctcca acagttttga cagcacaagt tcctgtattt cccctaaacc taccagacag
     3121 tggcccacca ccaggaacca caagcatggt ccttttattt ctccagcaga atgccgcaca
     3181 caccgatgca cacgatgcca cacacttgaa ggcgtgagca caaagccact ggatctttcc
     3241 tgggcaggag aggagggttt agagcatcca cgtgtctccc caggccccac ctcagagttt
     3301 gacttgctcc cctcctcaca aaaggtccaa tagtcctctg gttgccctaa ggactatgtt
     3361 ggtgtcccca tagtgtaact caggcctagg ccttggggcc ttgcacacct ggagagaatc
     3421 caggcacatc ctcttcctag tctcagcgag gacacgtgta tccagtgcta tagcaactgc
     3481 acctggctct caccggcacc ggtctctgcc ccactttctc acttcaattg gcagcgctgc
     3541 atattggcac aaacacccaa acactgcggg ccccatcctc agttttagag ccctacccct
     3601 ttgctccttt cctgctaagc taatgcaggt ggcaagagag tgaggggtgg ggttccaacg
     3661 acaatactcc gggggagact tgggaacaag gggctgaggc cgaactgtct gcatctcata
     3721 ctgggacctg catgtaccag tgccagggct tgggttgaat cctgctcagc cctatggtgc
     3781 ccaatctctg tcctaccatc tgcatgtacc atcaggccct ggatggagcc catcctggct
     3841 cacttcactt gcattgtatt gccccctggt gagccactcc accccctcag agatggagct
     3901 gtacagaggg tctggagact aagattatcc tgtgaccaaa ggagacatgg gaagaggccc
     3961 tccctccttc cacgattgag gttcccccac caacccggtt ctcagatatg caagtacctc
     4021 actttgttaa cttattaact tattggtttc attaaagttt tcagtaggaa
//
