LOCUS       NM_152923              11824 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily Q, member 3
            (Kcnq3), mRNA.
ACCESSION   NM_152923
VERSION     NM_152923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11824)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11824)
  AUTHORS   Varghese,N., Moscoso,B., Chavez,A., Springer,K., Ortiz,E., Soh,H.,
            Santaniello,S., Maheshwari,A. and Tzingounis,A.V.
  TITLE     KCNQ2/3 Gain-of-Function Variants and Cell Excitability:
            Differential Effects in CA1 versus L2/3 Pyramidal Neurons
  JOURNAL   J Neurosci 43 (38), 6479-6494 (2023)
   PUBMED   37607817
  REMARK    GeneRIF: KCNQ2/3 Gain-of-Function Variants and Cell Excitability:
            Differential Effects in CA1 versus L2/3 Pyramidal Neurons.
REFERENCE   3  (bases 1 to 11824)
  AUTHORS   Oh,H., Lee,S., Oh,Y., Kim,S., Kim,Y.S., Yang,Y., Choi,W., Yoo,Y.E.,
            Cho,H., Lee,S., Yang,E., Koh,W., Won,W., Kim,R., Lee,C.J., Kim,H.,
            Kang,H., Kim,J.Y., Ku,T., Paik,S.B. and Kim,E.
  TITLE     Kv7/KCNQ potassium channels in cortical hyperexcitability and
            juvenile seizure-related death in Ank2-mutant mice
  JOURNAL   Nat Commun 14 (1), 3547 (2023)
   PUBMED   37321992
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11824)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11824)
  AUTHORS   Gamal El-Din,T.M., Lantin,T., Tschumi,C.W., Juarez,B., Quinlan,M.,
            Hayano,J.H., Li,J., Zweifel,L.S. and Catterall,W.A.
  TITLE     Autism-associated mutations in KV7 channels induce gating pore
            current
  JOURNAL   Proc Natl Acad Sci U S A 118 (45) (2021)
   PUBMED   34728568
  REMARK    GeneRIF: Autism-associated mutations in KV7 channels induce gating
            pore current.
REFERENCE   6  (bases 1 to 11824)
  AUTHORS   Ballif,B.A., Arnaud,L., Arthur,W.T., Guris,D., Imamoto,A. and
            Cooper,J.A.
  TITLE     Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated
            neurons
  JOURNAL   Curr Biol 14 (7), 606-610 (2004)
   PUBMED   15062102
  REMARK    Erratum:[Curr Biol. 2004 Apr 20;14(8):742]
REFERENCE   7  (bases 1 to 11824)
  AUTHORS   Devaux,J.J., Kleopa,K.A., Cooper,E.C. and Scherer,S.S.
  TITLE     KCNQ2 is a nodal K+ channel
  JOURNAL   J Neurosci 24 (5), 1236-1244 (2004)
   PUBMED   14762142
REFERENCE   8  (bases 1 to 11824)
  AUTHORS   Wen,H. and Levitan,I.B.
  TITLE     Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels
  JOURNAL   J Neurosci 22 (18), 7991-8001 (2002)
   PUBMED   12223552
REFERENCE   9  (bases 1 to 11824)
  AUTHORS   Watanabe,H., Nagata,E., Kosakai,A., Nakamura,M., Yokoyama,M.,
            Tanaka,K. and Sasai,H.
  TITLE     Disruption of the epilepsy KCNQ2 gene results in neural
            hyperexcitability
  JOURNAL   J Neurochem 75 (1), 28-33 (2000)
   PUBMED   10854243
REFERENCE   10 (bases 1 to 11824)
  AUTHORS   McCormack,T., Rudy,B. and Seldin,M.F.
  TITLE     Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3
            in mouse
  JOURNAL   Genomics 56 (3), 360-361 (1999)
   PUBMED   10087209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110897.11, AC102633.8 and AC091276.7.
            
            On Jun 24, 2019 this sequence version replaced NM_152923.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY118171.1, BC116306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-794               AC110897.11        12116-12909
            795-885             AC102633.8         146572-146662       c
            886-1012            AC102633.8         145711-145837       c
            1013-1185           AC102633.8         143817-143989       c
            1186-1341           AC102633.8         140306-140461       c
            1342-1452           AC102633.8         138839-138949       c
            1453-1548           AC102633.8         136933-137028       c
            1549-1643           AC102633.8         135479-135573       c
            1644-1670           AC102633.8         131641-131667       c
            1671-1873           AC091276.7         252095-252297       c
            1874-1976           AC091276.7         251045-251147       c
            1977-2108           AC091276.7         248518-248649       c
            2109-2207           AC091276.7         246340-246438       c
            2208-2292           AC091276.7         244024-244108       c
            2293-11824          AC091276.7         232697-242228       c
FEATURES             Location/Qualifiers
     source          1..11824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.16 cM"
     gene            1..11824
                     /gene="Kcnq3"
                     /note="potassium voltage-gated channel, subfamily Q,
                     member 3"
                     /db_xref="GeneID:110862"
                     /db_xref="MGI:MGI:1336181"
     exon            1..794
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..3027
                     /gene="Kcnq3"
                     /note="KQT-like 3; potassium channel subunit alpha KvLQT3;
                     voltage-gated potassium channel subunit Kv7.3"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 3"
                     /protein_id="NP_690887.2"
                     /db_xref="CCDS:CCDS49619.1"
                     /db_xref="GeneID:110862"
                     /db_xref="MGI:MGI:1336181"
                     /translation="MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKV
                     GLAPGDVEQVTLALGAGADKDGTLLLEGGGREEGQRRTPQGIGLLAKTPLSRPVKRNN
                     AKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLL
                     ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGN
                     QGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS
                     SFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIA
                     ATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPN
                     RLDLVATWRFYESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLN
                     VDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFL
                     IEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
                     TRIDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPRNEPYVARAATSETEDQSMMGKFV
                     KVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGEKKEDNRYSDLK
                     TIICNYSETGPPDPPYSFHQVPIDRVGPYGFFAHDPVKLTRGGPSSTKAQANLPSSGS
                     TYAERPTVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSITRDSDTPLSLMSVNH
                     EELERSPSGFSISQDRDDYVFGPSGGSSWMREKRYLAEGETDTDTDPFTPSGSMPMSS
                     TGDGISDSIWTPSNKPT"
     exon            795..885
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1012
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1185
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1341
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1452
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1548
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1643
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1670
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1873
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1976
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2108
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2207
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2292
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..11824
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11769..11774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq3"
                     /note="hexamer: AATAAA"
     regulatory      11791..11796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq3"
                     /note="hexamer: AATAAA"
     polyA_site      11796
                     /gene="Kcnq3"
                     /note="major polyA site"
     polyA_site      11824
                     /gene="Kcnq3"
                     /note="major polyA site"
ORIGIN      
        1 aaactgcgat gctgtctcgg gctcgccggc ccgggtgccg ccgtcgccgc cgcctccctg
       61 gagcttcggt gccaggctcc cgccgtcgcg cgccctagcg ccaccgcgcc agcctcgcgc
      121 gccctcaacg ggctccccgt ggaccccggc ttcctgcgcc cctccgggtc ccacagagga
      181 cccgctcggg atgtgacccc ttgactcccc acccgacctc ctctggcccc cgggaggccc
      241 gcctttgcct gcttttgggg gggtgggcgg ggaggggcgc gcggatcatg gcattggagt
      301 tcccgggctt gcagccgccg ccgccgcctc gtccacgtac cccaagtgct cctacttccc
      361 ggagcagcag cggagaaggc gaagcgcccg gtgggggcga ggcagatggg tctcaaggct
      421 cgcagggcgg cgggggcggc tggcgggggc ggcggcgaag ggggcggcgg cggcggcggg
      481 gccgctaacc ctgctggagg ggactcggcg gtggccggcg acgaggagcg gaaagtgggg
      541 ctggcgccag gagacgtgga gcaagtcacc ttggcgctag gggccggagc cgacaaagac
      601 gggaccctgc tgctggaggg cggtggccgc gaagaggggc agaggaggac cccgcagggc
      661 atcgggctcc tggcaaagac ccccctgagc cgcccagtca agaggaacaa cgccaagtac
      721 aggcgcatcc aaactttgat ctatgacgcc ctggagagac cgcggggctg ggcgctgctc
      781 taccacgcgc ttgtgttcct gattgtcctg ggatgcttga ttctggccgt gctcaccacc
      841 ttcaaggaat atgagactgt gtctggagac tggcttttgc tgctggaaac ctttgctatt
      901 ttcatctttg gagctgagtt tgctttgagg atctgggctg caggatgttg ctgtcgatac
      961 aaaggctggc gtggacggct aaagtttgcc aggaagcccc tgtgcatgtt ggacatcttc
     1021 gtactgattg cctctgtgcc agtggttgcc gtgggaaacc agggcaatgt cttggccacc
     1081 tccctgcgaa gccttcgctt cctgcagatc ctgcgcatgc ttcgaatgga taggaggggt
     1141 ggcacctgga agctcctggg ctcggctatc tgtgcccaca gcaaagaact catcactgcc
     1201 tggtacatag gcttcctgac actcatcctt tcttcatttc ttgtctacct ggtggagaag
     1261 gatgtgccag agatggatgc ccaaggagag gaaatgaagg aggagtttga gacctatgca
     1321 gatgctctgt ggtggggcct gatcacactg gccaccattg gttatggaga caagacacct
     1381 aaaacctggg aaggacgtct gattgctgcc accttttctt taatcggcgt ctcctttttt
     1441 gcccttccgg caggcatcct tggctcagga ctggcactga aggttcagga gcagcaccgt
     1501 cagaagcact ttgagaagag aaggaagcca gctgcggaac tcatccaggc tgcctggaga
     1561 tattatgcta ccaaccccaa caggttggat ctggtggcaa cctggagatt ttatgaatca
     1621 gttgtctctt tcccattctt caggaaagaa caactggaag cagcagccag ccaaaagctg
     1681 ggtctcttgg atcgggttcg cctttctaat cctcgtggta gcaatactaa aggaaagcta
     1741 tttacccctc tgaatgtaga tgccatagaa gaaagccctt ccaaagagcc aaagcctgtt
     1801 ggcttaaaca ataaagagcg tttccgcacc gccttccgca tgaaagccta cgctttctgg
     1861 cagagttctg aagatgctgg gacaggcgac cccatggcag aagacagggg ctatgggaat
     1921 gacttcctca ttgaagacat gatccctacc ctaaaggctg ccatccgagc tgtcagaatt
     1981 ctacagttcc gtctatataa aaaaaagttc aaggagacgt tgaggcctta tgatgtgaaa
     2041 gatgtgattg agcagtattc ggccggacat cttgacatgc tttccaggat aaagtaccta
     2101 cagacaagaa tagatatgat tttcacccct ggacctccat ccactccaaa acataagaag
     2161 tctcagaaag ggtcagcatt tacctaccca tcccagcagt ctccaaggaa tgaaccatat
     2221 gtagccaggg cagccacatc agaaactgaa gaccaaagca tgatggggaa gtttgtaaaa
     2281 gttgaaagac aggttcatga catggggaag aaactggact tcctcgtgga catgcatatg
     2341 cagcatatgg aacgcttaca ggtacatgtc actgagtact acccaactaa gggggcctcc
     2401 tccccagccg aaggggagaa gaaagaagac aacaggtact ctgatttgaa aaccatcatc
     2461 tgcaactact cagagacagg gccccctgac cctccttaca gcttccacca ggtgcccatc
     2521 gacagagttg gcccttacgg gttttttgca catgatcctg tgaaactgac ccgaggggga
     2581 cccagttcta caaaggctca agctaacctt ccctcctcgg gaagtacata tgcagagagg
     2641 cccacagtcc tgcccatctt gactcttctg gactcatgtg tgagctacca ctcccagaca
     2701 gaactgcaag gtccctattc ggaccacatc tcgccccgcc agagacgcag catcactagg
     2761 gacagtgata cacctctgtc cctcatgtcc gtcaatcacg aggaactgga gcggtctcca
     2821 agtggcttca gcatctcaca agacagagat gattatgtat ttggccccag tgggggatcg
     2881 agctggatga gggaaaagcg gtacctggct gaaggagaaa cggacacgga cacagacccc
     2941 ttcacaccca gtggttccat gcctatgtca tccactgggg atggtatttc agattccata
     3001 tggacccctt ccaacaagcc cacttaaaag gggtcactgg ctgactcctg gtactgtaga
     3061 cagactttgt acagctcact tactctcaca actagcgctt acaatgggga ctccactggc
     3121 tgtgtcaagc gcatgcatgt gcgctgtggc ccccctgcaa gcaggggctt ctcgcggcct
     3181 tcttcctccc ccatctcact gcaacagaat cgcttccttt tcagcatggt ttgcatgact
     3241 tgacactata taaaaggcac tgttagtctc ttctagatac acatttatct gcacttcttc
     3301 ctttaatcac gattgaacaa gtacagggag acttattgat gagctgtgtt atttgtttgg
     3361 ttggctggtt tgggttttga ttcagataaa ctgagagcat agtttaaatt atttctaggc
     3421 tcatttcccc cttgtgtaaa tgctccagta aatttactgt tttctaaagc aaggaaataa
     3481 ttttctcaac caaaacatcc tgcatcacaa tgaggctatc ctctgagcaa acagaatagg
     3541 aacaagatag tcattcaacc ccaaagccaa gatttaaaac aattatctct ctaaaggaag
     3601 gctggcaaaa ttatttaaaa gctctcaggg agacttggtc tacccgttgt tcagtacggt
     3661 gcctcagttt atttaaccat aagatgttgg tgattcaaaa tataacatca catgtgttat
     3721 ggactggtga agagaaatct tgcacacacg ccacaaacat aaaaaaatag ttcccaattt
     3781 ctgtagccaa agataataaa atttaccaga agtggggtgg tcttctaggc aggagctaaa
     3841 tttggtgttt taaaatgaaa ttccaacacc ttcttctgca ttacctgaac ctgaatccaa
     3901 aacggagatt tgaatcaaga gcaatcatct taccgtgtcc tctatttcaa aatgatatgt
     3961 tttggatgta aggcaaatga catgtcttga gacacttggt tgtcctgtgg agagtaagga
     4021 ctcaaaacct ccacctgagg actcacccct taccacagtc tcccctcacg ctatcccatt
     4081 tgcataccgg aatccaggaa tcgtaccaag acgccagcac tctttaacca tgggatgtaa
     4141 tcttcagtct ttactcaaag ggagaatgat gtctgctttg actgcaaagc atgcttactt
     4201 gatgctttat aagtgggatc caggatgggg aatgcaaatt agttataaat atacaaatag
     4261 gaagaattcc cagaatcacc cacttttact tctccagatt ttctcaatga aaatactaga
     4321 accacataaa atcaaaagag ctcctgatgt gacaaccaag agcctggaaa tccctgccct
     4381 gctgcagaaa gatggatgtt aagcacaagc cactatgtgg cctattggga gatattgcta
     4441 cttgctgaaa acctctgatg gaaaaggtta aactggctac tctttgtgga tcaccacagt
     4501 attagtgtct cagtcatttc atgcctttaa atatggtttt aaatggttgc catgatgacc
     4561 atcaagatga tgaaaatacc cttatttagt gtttgaatat gactctcacc agtgctgttg
     4621 ctgtgttgcc aagagccata aatatcatag cagacaccta ctttatgttt tcatcaattc
     4681 ccagtgctag tattctgccc tgtgttgggg aaagagtctt cagagatcag tttcttacaa
     4741 cttacatgct gattggcctg tataaagagc tgagaataca gtgataatga aagtttgtcc
     4801 ccttgatgag aggaccttaa accaaagcag ttccaagaat gatggcaagg actgtgagtt
     4861 ggtagaggaa tagcaacatg gagagtctca tgaatggata tatgaatagt gacatttaag
     4921 tccaaggcag gcaatatatt aatacagtta cacacactag aggtaaagct tttcttatag
     4981 atttcaattg atttttctgg caatctgaaa gacaaaggct gtgtacctgt tccctcaaat
     5041 ctttcaatat gacttcagtg gtgccagttt gactataatc taagaaaact tacacctctt
     5101 cctagggatt tggttcttga atctgctctt cctatatttt tttcaccaga aataactgcc
     5161 ctacctagca cctaacatat actatccctt tttatgtcca tgagttatcg gaaacaaaaa
     5221 tgatgatgag taatatatgc cacatggttt ttcctaacat taacattctt tcacaacctt
     5281 ctagcattgg tatgttacat taggatgcac tttttaaaat aagtcatgtt ttattttatt
     5341 ctttgggttt ttatttattt tatttttaca ctccagattt tattcctctc tcccagtcca
     5401 ccctccaact gttccacatc ccatacctcc tccctacccc atgttttcat gaggatgtcc
     5461 ttcccctcca cccactccac cagacctcta aacttcccgg agcctccaat ctcttcaggg
     5521 ttaggtgcat catctctggc tgaacccaga cccagcaatc ctcttctgta tgtgttgggg
     5581 gcctcatatc agctggggtc tggtgtctgg ttggtggccc agtgtttgag agatctcagg
     5641 gctccagatt aattgatagt gctggtcatt ctaccaggtt gccctcctcc tcacttcttc
     5701 caggctttct ctaattcaac caaaggggtc agttacttct atccatcggt taggtacaaa
     5761 taactgcatc tgactctttc agctgctttt tgggtcttcc agagtgtggt catgataggt
     5821 ccctttttgt gagtgttcca tagcctcagt aatagtgtca ggccttggga cctccccttg
     5881 aactgaatcc cactttgggc ctgtcactgg accttctttt cctcaggctc ctctccattt
     5941 ccatccctgc agttttttca gacaggaaga aatatgggtc agaattttgg ctgtgggata
     6001 gcaacccctt ccttcacttg atgccctgtc ttcctgctgg aggtgagcta tgtaagttcc
     6061 ctcttcccac tgtctgggca tttcatgtat ggccccctcc ttacctcccc ggtctctggt
     6121 gcatgtattt tcaggagttc aaatggggat cttggccaag aattctttga actggaattt
     6181 gcattatttt ccaaacaaga tctaagttta tagtcttgct tccctggtga ttcaaaatca
     6241 gagtggcagg aattagtttt gtgttgtttg ccaagctggt atatgtctag tcagttgtct
     6301 gtatcagcca aatgcaggac gaatactaag ggccctaaga gctgcttgtt tgcatctaag
     6361 aaacaaacag aagaaagata agataatctg aaatccttct attgaactat cctttttaaa
     6421 aaagatgtct aaaccagcca accaaatgta ttcaactgaa catgtcaata cattgcatgg
     6481 tcgtcatggc tggtgttctg atcctcagtt gaaatgtcaa tgtgagttct ataacgatcc
     6541 tttgtaacac aaaagaatct caggacagaa taattcaaga taatatgtat cggaaagcac
     6601 atcagtagct ctgcagcttg cctaggaagt cataacactt ttaacagaaa cccagaaaga
     6661 ctgagaaatt aattccatca caaaaaacag gaatggtttt atcaggataa aggatcgtct
     6721 tatatgtatt tggctgccat gttttaaaat atatttaaac tttacaattt ttaagaaatg
     6781 ggaatgaaag tataattcag tggtagagta cttgtatacc atacattaaa ttctggcttt
     6841 gatccctagt attgcacgac acattgtgtg tgtgtacgcg cgcgcgcgcg cacacacaca
     6901 cacacacaca cacacacaca cacacacaca cattagtcgg acatatttta gcaagaaaaa
     6961 atgaaaagaa tgaattttta aatgctaaat aaagataatt ctatcaggct gaagaaaagt
     7021 gaaattgtta cattttaaga gatatttaaa tatttccata taagcagata ctgaaaactt
     7081 aagaaaaagt gaaattgtag aaagaagggg gaaaaaaacc cactgaattg agaaagtcct
     7141 tttcaattac tgtctgtttt taaaacttag aattcagact tactagatat gacactaatg
     7201 ttctaaaatt ttatttttat gaagaaataa ttagaaaata ccaaagtgta taggtaaaac
     7261 caaattaatt aaccaacact tatgcatcct atatctattc tgtacaaagc catttctaag
     7321 cattgtagct caaaagtaaa cacccttaga aatgatagca tcacagaatc tactcagttt
     7381 gccaaaatta ttctcataat ttcatgctac tctgagagtg taacaacgaa atattcattt
     7441 agcaagatgt tctagatatc actgaatacc aagaattatg caacaaacat tcaaagacca
     7501 gaaagctagt ctctgctgta agaaaactca tgacctcagc tgttgatatt tgtcttagac
     7561 tcatcatact tgatttcatg gctgtggaca actgtctacc aatatgaata ttcccccact
     7621 gggaacattg aatggggatt ttgcatttga gttcaccatt ctggactctg taacatccaa
     7681 taattgatgt aagcacttgg gctctgaaaa cagctttttt ctctatatcc tgtcatggtg
     7741 gagggcagac aagtagccgt ggcatctgtt tcaccatatt gaccaaaaat ggcctagcac
     7801 aggccatggc acaacatcta tttgaaaaag aaggaactca ttctgcccat gggaagttga
     7861 agattggagt atacggaaga aagagaagaa atgttctcag aagtcaacta gacttttgac
     7921 aaggctgcca gatcgacccc aattctcact ccattgctgc ctagaataga tactctttgg
     7981 ttctcatgag catgcgcgcc caagaaatcc aggaccacag aggtgttctt ggtttaaatt
     8041 ttgtagtcag ttgtcttcaa aagcatgcta tttccaccat gtactttaac ctacatttgc
     8101 tttctgtatc aaaaaatatt caaaatgaca tactgttctt acatgcctca aaactgagct
     8161 atctttaccc taaacagggc agcagaatat agtttagtgg tacccagcta tagaaataaa
     8221 tcttaggggt cagagtacct atgtagcttt cagaggtttg gaaaccatgg tgtgaagcta
     8281 atgttgaaca aacaaaaatg ggatagagat gacttgtatt aaaaatttga gtcttggaac
     8341 actcagaact atttcagtct atttaaaatt tcaagtgaga caatcaacta tgtataaagt
     8401 ccttagtgca gtgactggtc catgccaaaa ctgttaataa ttatttgtat ctgtttttat
     8461 agtatgtata gactccatta catcagttag tgatatcact tacagactct aagtttacac
     8521 cagaaaatat ttttttaggg aaaaaaaaaa agctggtgga gatataattc aaattattgc
     8581 atgataaaac taggattttt tttagtcgtt ctttaactat gtacctgtct gcaactgaac
     8641 atgattattt ttcccatcaa aatgtgcaag ataaggaata ctggaaggag cattaagaat
     8701 gtggttctca gttgctagct ggtgaaagtc ctattggaga aaaagtgcca gatgtagcag
     8761 tgttctctaa aacatgactt ataggagata tagacaaaaa aaaaacctaa ttaaatatga
     8821 acagaaagcc aactgtggca tgatgactac cagggagcac ccttgccatg aataggacct
     8881 cttcaagaag aaggtcaaaa cttgttcaaa ttcttccttg taactatggt ctcagccttc
     8941 agcagcctca atgtcagtat ccttctagaa tcaatcatag ctcaacggaa ttgaggagat
     9001 gtaattttgc atgttctaaa atattcagag gaagaaaatg atcacccata ttttttagga
     9061 caggacacag atgctcagac atcagggatt ctgagtctca ttgtgagtaa aataaagatc
     9121 cggtagcaga gtggtcctag gtctcaggtg ccctgactcc tggtccagat gttagagatg
     9181 ggagtatttc tggtgacgct ggaagataaa ttgtctgact cccttgagaa acagctgaac
     9241 cagaaatggt ttttgagact tcactctatc tctagactag gactgattct cccatgtcac
     9301 aaagatgtcc catctgaatg tttcatcttc aaagggctca gagaaacctc ctgccaatga
     9361 gcacacctag ggagatactg aagaacaacc ttttaaccat gtgtataact tctctccacc
     9421 cttctgacta ttactgcttt gtctctcata tgctgcaaag attggacagg tttacctgtt
     9481 tggttcatcc cctggactca ttaagagcca ttcacagatc cttgggttgc accctcagat
     9541 actggcccac tgcatgagac ttctctatag gtttaaggtt ctgatttctt tgggaatctg
     9601 acttgccgca aacttccagt tcaaccatag gtgactgtgt actggaatat ctggggtttg
     9661 tctgagtatg tctagttcct ctcacttgac cctaggggat cctaatcctt gccatttcat
     9721 agatatttca aagagtacat actctttgcc aaaagctgca ttggatctgt ccttcttaaa
     9781 acatatcacg tctgtgtaat tgtggcaaca ctttagggaa aaatttggta tctcatgatt
     9841 cacatgcaga aatctagagt ttccacttga gctgtgctta catttgccag aatttaacag
     9901 tgctcccaca gaaatctgta ttaaacccat tggtaagata ggatgtctta gtgatcctga
     9961 ttgggctgtt ccaaaaactt ctgaaagatt caaagagaaa agtgacacat tatggtatgg
    10021 ctttggttta ctggattatt ttaaagactg tcattctgcc tgaatccccc ctcctcccaa
    10081 tggcactcct tcaagattga agtaagtgtc aggaaagaat agtaatcttt tgacatatta
    10141 aaaattcaga gatctgtgca acccgataat ggcttaaaat taaccaagcc tagcctagta
    10201 ctttggaata taccaaactc caattggaaa cttaagattt atgaaaaaga agagacagtt
    10261 tgatttcagt gctcctttct tcaactctgc ctgcaaaact gaggtctggg ataggagaag
    10321 agctccccct gcgttctcct taagtgttgc atgcatgaga gtgatgcagt tctctgatgc
    10381 ctgcatgctg cacccttagt gtaaacccac ccgaaggctg tcactggctg cacagacatc
    10441 aaaagctgaa agaaaaagag ctgcctagat gtcacatagt acgagagaaa gaactgagat
    10501 tttacactaa gccatggatc tcaaaagttt ttcctatccc ctggcactac cccccccccc
    10561 aagtgtcaca tggcagtaga aatgctcccc agtcaggccc tgtggtccct aagaagacga
    10621 ttccctcctc tgcagtcagc gttccaatga aatgatcaca gacccaccca tgccctggag
    10681 agtagaagaa agactgtccg cggctccttt gactattcag caagttcttt gaatgttttc
    10741 accatccagc tgtcggaggc agaaagcgat gccgcataaa ttattcacac agttcacatt
    10801 ggagtccatt agcccttaga gtttggtggc cacagatatt cccacaaaca ccctttgttc
    10861 tcggtcccca cagatcctct gtcaccatat ttacctgaac aagttcaaaa gtatcccagg
    10921 ctcagctgac tctcatcttc tttctctaga ctgtatcttt atttcagggc tttgaaattt
    10981 tgcagacaca aacaggcctt taaaaaaaaa aagttctctg agaggccaaa agtgcagatc
    11041 aattattact ccatctttca atattaagag aacaagaatc tgcacggaca ccaaatggat
    11101 ctcctaactg ggccatgctt tacccttctg aatccatttc cagggaacga gagatcaggt
    11161 ccaccctcca accctccctg agggctaaat ggaggatttg gatagccctt cagtcaaatt
    11221 gcagacccaa gctgttagag agagaacctg tgcccaattc tgaaaagcta acctaggatg
    11281 gatgcacatt atcagttctg ccagtccttc ccatttaaaa aaaaaaaaaa aaaagaatct
    11341 ctccatctct ccctcttgcc taagatgggc tgtgactacc cccctctccc tggtcctgat
    11401 atagtactga tggaagacac cgactgtgga agaacaagtt gaggtttgca atgacatgag
    11461 tcactgtatt tgattttagg ttgattttat ttcacccctt tttacggcat agaattctgg
    11521 tgccttgctc cctggatttg tctccgtgct ctgagtaggc tctccacatt ctggcttaca
    11581 cgggaacaca actattccac aagtgccctt tagtgctctt tataatatgg tttcctgtaa
    11641 tttttaaact gtatgtgtaa tttatattct ggctctgtcc gatatttgac aactttaata
    11701 ggttgatttc catatatata ttatgcaaac aattcttacc tgattttttt atgttctatc
    11761 tcaaaatcaa taaagattgc accacttatt aataaatgga tgattcaatg attctgtgaa
    11821 aaaa
//
