LOCUS       NM_010611               8301 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily Q, member 2
            (Kcnq2), transcript variant 1, mRNA.
ACCESSION   NM_010611
VERSION     NM_010611.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8301)
  AUTHORS   Abreo,T.J., Thompson,E.C., Madabushi,A., Soh,H., Varghese,N.,
            Vanoye,C.G., Springer,K., Park,K.L., Johnson,J., Sims,S., Ji,Z.,
            Chavez,A.G., Jankovic,M.J., Habte,B., Zuberi,A.R., Lutz,C.,
            Wang,Z., Krishnan,V., Dudler,L., Einsele-Scholz,S., Noebels,J.L.,
            George,A.L. Jr., Maheshwari,A., Tzingounis,A.V. and Cooper,E.C.
  TITLE     Plural molecular and cellular mechanisms of pore domain KCNQ2
            encephalopathy
  JOURNAL   bioRxiv (2024)
   PUBMED   38260608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8301)
  AUTHORS   Zhan,D., Zhang,J., Su,S., Ren,X., Zhao,S., Zang,W. and Cao,J.
  TITLE     TET1 Participates in Complete Freund's Adjuvant-induced Trigeminal
            Inflammatory Pain by Regulating Kv7.2 in a Mouse Model
  JOURNAL   Neurosci Bull 40 (6), 707-718 (2024)
   PUBMED   37973721
  REMARK    GeneRIF: TET1 Participates in Complete Freund's Adjuvant-induced
            Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model.
REFERENCE   3  (bases 1 to 8301)
  AUTHORS   Soto-Perez,J., Cleary,C.M., Sobrinho,C.R., Mulkey,S.B.,
            Carroll,J.L., Tzingounis,A.V. and Mulkey,D.K.
  TITLE     Phox2b-expressing neurons contribute to breathing problems in Kcnq2
            loss- and gain-of-function encephalopathy models
  JOURNAL   Nat Commun 14 (1), 8059 (2023)
   PUBMED   38052789
  REMARK    GeneRIF: Phox2b-expressing neurons contribute to breathing problems
            in Kcnq2 loss- and gain-of-function encephalopathy models.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8301)
  AUTHORS   Alhassen,L., Alhassen,W., Wong,C., Sun,Y., Xia,Z., Civelli,O. and
            Hoshi,N.
  TITLE     Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel
            Modulator That Reduces Kv7/M-Current Suppression and Inflammatory
            Pain
  JOURNAL   J Neurosci 43 (43), 7073-7083 (2023)
   PUBMED   37648450
REFERENCE   5  (bases 1 to 8301)
  AUTHORS   Han,S., Zhuang,D., Wang,J. and Ju,C.
  TITLE     Inhibition of neuronal Kv7 channels ameliorates MK-801-induced
            cognitive dysfunction in mice via up-regulating NAMPT expression
  JOURNAL   Neurosci Lett 814, 137471 (2023)
   PUBMED   37673371
REFERENCE   6  (bases 1 to 8301)
  AUTHORS   Yang,Y., Beyer,B.J., Otto,J.F., O'Brien,T.P., Letts,V.A.,
            White,H.S. and Frankel,W.N.
  TITLE     Spontaneous deletion of epilepsy gene orthologs in a mutant mouse
            with a low electroconvulsive threshold
  JOURNAL   Hum Mol Genet 12 (9), 975-984 (2003)
   PUBMED   12700166
REFERENCE   7  (bases 1 to 8301)
  AUTHORS   Wen,H. and Levitan,I.B.
  TITLE     Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels
  JOURNAL   J Neurosci 22 (18), 7991-8001 (2002)
   PUBMED   12223552
REFERENCE   8  (bases 1 to 8301)
  AUTHORS   Watanabe,H., Nagata,E., Kosakai,A., Nakamura,M., Yokoyama,M.,
            Tanaka,K. and Sasai,H.
  TITLE     Disruption of the epilepsy KCNQ2 gene results in neural
            hyperexcitability
  JOURNAL   J Neurochem 75 (1), 28-33 (2000)
   PUBMED   10854243
REFERENCE   9  (bases 1 to 8301)
  AUTHORS   McCormack,T., Rudy,B. and Seldin,M.F.
  TITLE     Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3
            in mouse
  JOURNAL   Genomics 56 (3), 360-361 (1999)
   PUBMED   10087209
REFERENCE   10 (bases 1 to 8301)
  AUTHORS   Nakamura,M., Watanabe,H., Kubo,Y., Yokoyama,M., Matsumoto,T.,
            Sasai,H. and Nishi,Y.
  TITLE     KQT2, a new putative potassium channel family produced by
            alternative splicing. Isolation, genomic structure, and alternative
            splicing of the putative potassium channels
  JOURNAL   Recept Channels 5 (5), 255-271 (1998)
   PUBMED   9666519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ121810.1, CJ119072.1, AK139411.1, AK135059.1, CJ125938.1,
            AL450341.10 and CJ263767.1.
            
            On Nov 25, 2014 this sequence version replaced NM_010611.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF490773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CJ121810.1         3-6
            5-367               CJ119072.1         6-368
            368-1141            AK139411.1         2-775
            1142-1368           AK135059.1         603-829
            1369-1851           CJ125938.1         1-483
            1852-3360           AK139411.1         1429-2937
            3361-7937           AL450341.10        75063-79639         c
            7938-8301           CJ263767.1         99-462
FEATURES             Location/Qualifiers
     source          1..8301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.57 cM"
     gene            1..8301
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /note="potassium voltage-gated channel, subfamily Q,
                     member 2"
                     /db_xref="GeneID:16536"
                     /db_xref="MGI:MGI:1309503"
     exon            1..493
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2810
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily KQT member 2;
                     KQT-like 2; potassium channel subunit alpha KvLQT2;
                     voltage-gated potassium channel subunit Kv7.2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 2 isoform 1"
                     /protein_id="NP_034741.2"
                     /db_xref="CCDS:CCDS17198.1"
                     /db_xref="GeneID:16536"
                     /db_xref="MGI:MGI:1309503"
                     /translation="MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAG
                     SEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLL
                     VFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGR
                     LKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW
                     KLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLT
                     TIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRN
                     PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLE
                     LLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGCLCGCCPGHSSQKVSLKDRVFSSPRGM
                     AAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSE
                     EASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVM
                     DVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRL
                     GKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHAD
                     KHGCIIKIVRSTSSTGQRNYAAPPAIPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVRI
                     PPPPAHERSLSAYGGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELER
                     SFSGFSISQSKENLDALGSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATG
                     EGPFGDVAWAGPRK"
     exon            494..584
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            585..711
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            712..887
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1013
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1124
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1220
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1315
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1345
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1414
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1444
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1498
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1722
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1831
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1963
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2087
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..8284
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8258..8263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /note="hexamer: AGTAAA"
     polyA_site      8284
                     /gene="Kcnq2"
                     /gene_synonym="HNSPC; KQT2; Nmf134"
                     /note="major polyA site"
ORIGIN      
        1 ggaagccggc caggcaccga ggcgcgcgcg gagccgggtg gccgcagcgt ccccgcgcgc
       61 ggccgggcca ggtaggaacg cagagccgca gccgcctcgc catgcggctg ccggaccgga
      121 ggcctgggct ggggcccgcg ccaccccccg cgcgccgccc ccgctgagcc cgcgcccgat
      181 agggcgccgc aggcaccatg gtgcagaagt cgcgcaacgg tggcgtgtac cccggcacca
      241 gcggggaaaa gaagctcaag gtgggcttcg tggggctgga ccccggcgcg cccgactcca
      301 cacgcgacgg cgcgctactc atcgcgggct ccgaggcccc caagcgcggc agcgttttga
      361 gcaagccgcg gacgggcggc gcgggagccg ggaagccccc gaagcgcaac gccttctacc
      421 gcaagctgca gaatttcctc tacaacgtgc tagagcggcc ccgcggctgg gcgttcatct
      481 accacgccta cgtgttcctt ttagtcttct cctgccttgt gctttctgtg ttttccacca
      541 tcaaggagta cgagaagagc tctgaggggg ccctctacat cttggaaatc gtgactatcg
      601 tggtattcgg tgttgagtac tttgtgagga tctgggctgc aggctgctgt tgccggtatc
      661 gaggctggag gggcaggctc aagtttgcca ggaagccgtt ctgtgtgatt gatatcatgg
      721 tgctgattgc ctccattgct gtgctggctg ctggttccca gggcaatgtc tttgccacat
      781 ctgcgcttcg gagcttgcgg ttcttgcaaa tcttgcggat gatccgtatg gaccggaggg
      841 gtggcacctg gaagctcttg ggatcggtag tctacgctca cagcaaggag ctggtgactg
      901 cctggtacat tggcttcctc tgcctcatcc tggcctcatt tctggtgtac ttggcagaaa
      961 agggtgagaa tgaccacttt gacacctacg cagatgcact ctggtggggt ctgatcaccc
     1021 tgacgaccat tggctacggg gacaagtacc ctcagacctg gaacgggagg ctgctggcag
     1081 cgacctttac cctcattggt gtctcgttct ttgctcttcc tgctggcatt ttgggatccg
     1141 gctttgccct gaaagtccaa gagcagcatc ggcaaaaaca ctttgagaaa cggcggaacc
     1201 ctgcggcagg tctgatccag tctgcctgga gattctatgc tactaacctc tcacgcaccg
     1261 acctgcactc cacgtggcag tactacgagc ggacagtcac tgtccccatg tacagctcac
     1321 aaactcaaac ctatggggcc tccagactca tcccacctct gaaccagctg gagctgctga
     1381 ggaatctcaa gagcaaatct ggactcacct tcaggaagga gccacagcca gagccatcac
     1441 caagtaaagg cagaccgtgc cgagggtgcc tgtgtggatg ctgccccgga cactctagtc
     1501 agaaggtcag tttgaaagat cgtgtcttct ccagcccccg aggcatggct gccaagggaa
     1561 aggggtctcc ccaggcccag acggtccggc ggtcccccag tgcggatcag agtcttgatg
     1621 acagcccgag caaggtgccc aagagctgga gctttggtga ccgcagccgc acacgccagg
     1681 ctttccgcat caagggtgct gcatcccggc agaattcaga agaagcaagc ctccctgggg
     1741 aggacatcgt agaggacaac aagagctgta actgcgagtt tgtgactgaa gatcttaccc
     1801 ctggcctcaa agttagcatc agagctgtgt gtgttatgcg gttcttggta tctaagcgaa
     1861 agttcaaaga gagtctgcgc ccatatgatg tgatggacgt catcgaacag tactcggctg
     1921 gacacttgga tatgttgtcc cgcatcaaga gcctgcagtc cagagtggac cagattgtgg
     1981 ggcggggccc aacaataacg gataaggacc gcaccaaagg cccagcggaa acggagctgc
     2041 ccgaagaccc cagcatgatg ggacggcttg ggaaggtgga gaaacaggtc ttgtccatgg
     2101 aaaagaagct cgacttcttg gtgagcatct atacacagag aatgggcatc ccaccagcag
     2161 agacagaggc ctattttggg gccaaggagc ctgagccggc accaccctac cacagcccag
     2221 aggacagccg tgaccatgca gacaagcatg gctgtatcat taagatcgtc cgctccacca
     2281 gctctacggg ccagaggaac tacgcagcac ccccagccat cccccctgcc cagtgtcctc
     2341 cctccacctc gtggcagcag agccaccagc gccatggcac ctcccctgtg ggagaccatg
     2401 gctcactggt acgcatccca ccaccccctg cacacgagcg gtcgctgtct gcctacggtg
     2461 ggggcaacag agccagtacc gagttcttga ggctggaggg caccccagcc tgcaggccct
     2521 ctgaggctgc cctgcgggat agcgacacgt ccatctccat cccttcggtg gaccatgagg
     2581 agctggagcg ctccttcagc ggcttcagta tctcccagtc caaggagaac ctggatgccc
     2641 tgggcagctg ttatgcagct gtggcaccat gcgccaaggt caggccctac attgcagagg
     2701 gagagtctga cacagactca gacctctgca caccatgtgg gcctccccca cgctctgcca
     2761 ctggtgaggg cccctttgga gatgtggctt gggcagggcc caggaaatga gtctgggctg
     2821 ggctgctggc cccatgccac acccactctt gttcggtttt agaactggag ttccagggcc
     2881 tttcttaaag tgacagagtg acatagagta gtgtgggttg tgaggatgct catgggatct
     2941 ggctctcagg gttcatgtgg agtggggatg aggcagggct ccttagcaca cacagtaaca
     3001 ttttatagaa gttcttttcc aaccaggaga gggaggttga ggccgggccc tgggggcctt
     3061 gggagctacc tatggcagca aagctagccc tacctagtct tcttgggtga catattgccc
     3121 tgtgagtgag gaaggacagc atgatggtta gcacctgtga gttggggtgt ggctgggagc
     3181 aagtacacgg gacgtagtgg cgaaacaggc atgtctcctg ctgatggcca gtcctggagc
     3241 ttgtgggtct ctcaatttag gctggaagtt cagaggtata gtaggttgct ggaaatggcc
     3301 cactctcaca cctgactgct tatccctcta tccctgactg ccccagtaaa gcattaccag
     3361 gctcactgtt tgcgtgtggt tgggtaatgc ccctcatctg tgagtaccta gctagagagc
     3421 tgccaacatc ttcctccctc ttccaggtta tgtggatctt tccatgggag ccatccttag
     3481 gtcagaaccc ctttcctgga gctgaggaag gggtgaggcc ttagggacca atctggagct
     3541 tagaattgac ccttagactc tcctgacttc cacctcttag gggaagactc aactcacagc
     3601 cttttctgaa aaggtttctt cagcaggttc tggctggctc atccctggca ctgtagccca
     3661 gaaggtatga gttgacactt catggcctct gctttttcct ggtgtggcac tggcctccag
     3721 gctgtggcca gcacttcaag agaaccacca gataagcagg ccagcattgt ccttagccag
     3781 gacacctcct tgcctgctgc ccacttggct ctacagattc aggcagggct aaatgatgtc
     3841 ttcaaactgc cagctctttc tacacgagag cgtggccttt gagcctggtc aaggatcctt
     3901 cccacagaag ctggccatcc agtcatttat ccactaatag gtccctggtc tgtggcccct
     3961 gtgtttgagg aattaggaca ccttgtcctc tactccggtg aggagtaatc tctgtccatc
     4021 atgtgagtgg gcatcttgga ccatctagca ttcagcttta gagagagaca aggtagaata
     4081 gagccctcag ttgtggcccc ataatatctg gcccagaggt gcccggcatt gaatgataac
     4141 attttggggt ggggccccca gacttacttg ctctcagctt tcctggtcac tgagggcaag
     4201 tggtatagag cttgtgcctg ggcagagctc tatctatttc tttcaccctt ttgaaaagtg
     4261 tattctggca agggtaaagg cagtgggagg agggctatgc tcagcaggag gtaccccatc
     4321 cctgaggaga gctggagtca tgtctctgcc agggacctgg gtatttggag agctatgtct
     4381 gttgtctgct gtaaccttca tgtcctccct gttagggcta ctaggatctc acctcagggt
     4441 gcctctgcta gaatccaagt gtggagcctg tctgtttgtt ccaatatgta cacattggtt
     4501 ctctaaggca gtgctatagt caagaacttc ttggtatgag agatgtatac aggaagaata
     4561 gctatacact caagagtctt ctcttggtga gttgagcctg ggtctgcgct cctccatctc
     4621 tgtgtcagga caggaagagt ctagagcaga gggacaaaca catctgcctg gacaaaccaa
     4681 cagccagagc actccttcct tagacctggg cagaccgtag ctatctcagc ctcaggggat
     4741 gtgggaaaga ggttttatct cccctacatg ctccatacag catgtcttgc ctcatacata
     4801 gctccaagtc ctgtccccag agctgccaca gataccagag cctggtgtgc cctgagctgg
     4861 ggttttgtgg gatgaagtag gtgaacagac acccccttcc cagaaaccct ggacacatag
     4921 aatttatcag aagtccttcc ttacagcaag aatgagatga ggaggcatga cttctctgca
     4981 aatgaggaac actggtcaag tctgccatgt tggctacaca gaggaaggga gtctatctca
     5041 aggggtgaca tagaagctct gatgtgagag atgatggagc cctttcttag ggacagatcc
     5101 atgcttaaac aacacaaatg tccactgcct tggcatcccc accggcaaag aagcaagaca
     5161 ggatggaggc tgaaggctcc tacaagaaat ctgtgcactt tcttgggtgc acatgtgacc
     5221 aagtatggct gaaggccaat ggctgcccca tggcaaaatt ttcctcagaa aacatttgtc
     5281 ctaacacatt ccatcacatg cccaccaaca catgcccata cactagacac aaatgtatat
     5341 tctcataagt gcacaccaaa atttaccaca ttttcatatg cacacacaag aatacataca
     5401 acaggtgtac tttcaaacat gtatttctta ttatacgtgc aagctcacac acagtttgtc
     5461 agaccacaca taacaggtat acatacacac atgaacacaa tacaaacata taggcttata
     5521 ggctacatcc tattccacat ttacacatac agcaggtacc cacttttata cctgaatatt
     5581 tacatatatg aacacatatg tatgagtaac ctgtatgtat aatgcacaca cacatgtagg
     5641 ctgtctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt gtgtgtgtgt
     5701 gtgtgtgtgt gtctacacac acaccacttt ttctcttgtg tcttcctgat ggaagctgcc
     5761 taggcagggt gcacaagaat taatggtgaa tgttctaaaa tggtgaacac tgactggggt
     5821 cagagtcctg gttatctagg acttctgagc aacagtggta gagagtccac ctagagacca
     5881 ttgagttccc acactgccct ctccctggac taagtggtgg ctggctgcag gtactgaggg
     5941 tgtggctagg tcagggtgag ggtagttcta gttcgtactg aggtccagac cagtctttgc
     6001 cttgggttaa tcttggtatt ggccatttcc cagtgtccgc ctgtacacat gcccgccttg
     6061 ttgtgccagg ctgtgattgg catttcctgg cttgagttcc tgtccctttt gattgtggcc
     6121 tctggaaagt gcactcttgt ctaacagggc caaaatacct gggctgagag cccatctgct
     6181 gtcttacctg tggtcttggc agatcaagtg gccatttgag gtcataaatt agctcctggt
     6241 tatgctctca cgtttagggc cctcactgga aagccccatg tagaagctgg ggagtcacta
     6301 gacactacat gggcctcctc ggaggagaca ctctgaactg tagtcatcct cagatcctag
     6361 acacaggaga tatacatcca ggaccaccgt ccacctttaa ttcactggtt taaggttttc
     6421 tcccctcgag ctggtagctc aagattcaga atgtggaaga gggggccacc ctgccttctg
     6481 cctcccctac tggatttatc ctatatcagg ggcactgtga agaacaccct tgctttttgt
     6541 aaaaagagtt gatcccagag aggtcttcag actttccccc agatgtaaga ctctgggatg
     6601 gggatgctgt tctgacacac agcatcttgt gtctttcagc tgtaagcagt gcacagagta
     6661 gaggctaatt cacttgtcca cggctcacac cccaacatct gaaggacaac atttaggcct
     6721 ttccctgagg gagaacacac cctcttgaaa taaacatgaa aaatgttgtt tgaacagtgg
     6781 ggcccactgt atgggggggc tcagaggtgt ctggcacacc ttttatccca acagggtaga
     6841 tcagagttaa gagtagataa tctatctata cagggtaccc ctgaagtcca ggctcacatg
     6901 gctgtaatca gatactgatg tggcatctgc tgccctggag cagagaggtc agccctctcc
     6961 cctgagacct ccaagggcac aggatgtagg gtttggggaa agaagtccag gaaatgtctg
     7021 caggcaagtc tgtcaggctg tcctaggctc ctgctgtgtc ccagctgagc taagggggta
     7081 agagcttctc agaggaggtg ttaagatggc aatgaagatt tctagaggag acccaggtgc
     7141 ctcttccttc tgaggaatct tcatgtgtgc tcagcacatg ccctggagcc tagggggccc
     7201 agtgtccctg gaagtgaaca aatttgggcc acagttggct gaattttgct tgtctgtgag
     7261 gtagtgccgg caatatgcct tgggaggggc accaggaaat ggggtagaga aaaagggtta
     7321 gaccctagga aggaggccca ccaaacatcc agagatgcct gggttttatg ttcgttcaga
     7381 actctgtctg tgatgctggc gttggtgccc tagctgacaa aggaatctgg gtctgtccca
     7441 cgacccatcc tgaagttccc ctggtgtcga accctctgtc agagaaggga tagtctctag
     7501 actgtgtttc tgggactctc aggcaggagt gcacatcgct agtaccgcac atccaactgg
     7561 gaccggcttt tacagagttg ttgccttaat gtatgttgag ggccattcac caaggtcacc
     7621 cctgcctctg cctgatacag acactggact ccatctccag gtcctgcgac tggagaggag
     7681 tgctggcatg atgagctgtc actagtagtc ccacgtggag gggctcaaag ctgtgacccc
     7741 cttgacgtca tctacctgcc tgggacggct ccatagacag tgcagcgcac cctgcgcttc
     7801 cagtccacac ctgcccattg cagtcctgta ccccggccgc agctgcggcc gcagcttccc
     7861 catctgcgct gttgcctttg gctgtctttg cacttttgtt catgctccaa agaatatttc
     7921 ataatgcctt catactgatg tgcaccctag ccattttgta cgtgcccttg ggccacagcg
     7981 actggcctcc tcctttgggc cagcgtgccg ccatctgcac acgacgctgt cttctaggga
     8041 tagatgccca gggaatgaac tctagttttc taacggacta gctgagatgc taacttactc
     8101 aacgtgaaca ggatgatatg tgtgctgtgt gggcgggcca acgtgtgctc gcagggaact
     8161 ttggggcaga atcctgcagc agggatgcat gcagatggtt ctggaaagct ttgctgccgc
     8221 agggctaagt tcagatgccc agtggacctg ggcacttagt aaaacacagt gattcaacct
     8281 ggaaaaaaaa aaaaaaaaaa a
//
