LOCUS       NM_008434               3043 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus potassium voltage-gated channel, subfamily Q, member 1
            (Kcnq1), transcript variant 1, mRNA.
ACCESSION   NM_008434 XM_290074
VERSION     NM_008434.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Kiper,A.K., Wegner,S., Kadala,A., Rinne,S., Schutte,S., Winter,Z.,
            Bertoune,M.A.R., Touska,F., Matschke,V., Wrobel,E., Streit,A.K.,
            Lang,F., Schmidt,C., Schulze-Bahr,E., Schafer,M.K., Voelkl,J.,
            Seebohm,G., Zimmermann,K. and Decher,N.
  TITLE     KCNQ1 is an essential mediator of the sex-dependent perception of
            moderate cold temperatures
  JOURNAL   Proc Natl Acad Sci U S A 121 (25), e2322475121 (2024)
   PUBMED   38857404
  REMARK    GeneRIF: KCNQ1 is an essential mediator of the sex-dependent
            perception of moderate cold temperatures.
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Aubin Vega,M., Girault,A., Meunier,E., Chebli,J., Prive,A.,
            Robichaud,A., Adam,D. and Brochiero,E.
  TITLE     Function of KvLQT1 potassium channels in a mouse model of
            bleomycin-induced acute lung injury
  JOURNAL   Front Physiol 15, 1345488 (2024)
   PUBMED   38444763
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Udagawa,T., Takahashi,E., Tatsumi,N., Mutai,H., Saijo,H., Kondo,Y.,
            Atkinson,P.J., Matsunaga,T., Yoshikawa,M., Kojima,H., Okabe,M. and
            Cheng,A.G.
  TITLE     Loss of Pax3 causes reduction of melanocytes in the developing
            mouse cochlea
  JOURNAL   Sci Rep 14 (1), 2210 (2024)
   PUBMED   38278860
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Rose,K.P., Manilla,G., Milon,B., Zalzman,O., Song,Y., Coate,T.M.
            and Hertzano,R.
  TITLE     Spatially distinct otic mesenchyme cells show molecular and
            functional heterogeneity patterns before hearing onset
  JOURNAL   iScience 26 (10), 107769 (2023)
   PUBMED   37720106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Lewis,A., Green,K., Dawson,C., Redrup,L., Huynh,K.D., Lee,J.T.,
            Hemberger,M. and Reik,W.
  TITLE     Epigenetic dynamics of the Kcnq1 imprinted domain in the early
            embryo
  JOURNAL   Development 133 (21), 4203-4210 (2006)
   PUBMED   17021040
  REMARK    GeneRIF: Repression of the paternal allele of several imprinted
            genes (including Kcnq1) on distal chromosome 7 is regulated by a
            non-coding antisense transcript, Kcnq1ot1, which is paternally
            expressed.
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Caspary,T., Cleary,M.A., Baker,C.C., Guan,X.J. and Tilghman,S.M.
  TITLE     Multiple mechanisms regulate imprinting of the mouse distal
            chromosome 7 gene cluster
  JOURNAL   Mol Cell Biol 18 (6), 3466-3474 (1998)
   PUBMED   9584186
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Gould,T.D. and Pfeifer,K.
  TITLE     Imprinting of mouse Kvlqt1 is developmentally regulated
  JOURNAL   Hum Mol Genet 7 (3), 483-487 (1998)
   PUBMED   9467008
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Barhanin,J., Lesage,F., Guillemare,E., Fink,M., Lazdunski,M. and
            Romey,G.
  TITLE     K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks)
            cardiac potassium current
  JOURNAL   Nature 384 (6604), 78-80 (1996)
   PUBMED   8900282
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015800.13, AC012540.12 and AC023248.20.
            
            On Oct 12, 2022 this sequence version replaced NM_008434.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045142.1, AK154244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17021040
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AC015800.13        169436-169935
            501-591             AC012540.12        44298-44388
            592-718             AC012540.12        77530-77656
            719-797             AC012540.12        77897-77975
            798-894             AC012540.12        78427-78523
            895-1035            AC012540.12        79202-79342
            1036-1146           AC012540.12        86220-86330
            1147-1242           AC012540.12        87376-87471
            1243-1365           AC012540.12        89022-89144
            1366-1507           AC012540.12        90063-90204
            1508-1628           AC012540.12        156056-156176
            1629-1704           AC023248.20        166964-167039       c
            1705-1799           AC023248.20        163063-163157       c
            1800-1846           AC023248.20        162473-162519       c
            1847-1908           AC023248.20        162055-162116       c
            1909-3043           AC023248.20        98705-99839         c
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.12 cM"
     gene            1..3043
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /note="potassium voltage-gated channel, subfamily Q,
                     member 1"
                     /db_xref="GeneID:16535"
                     /db_xref="MGI:MGI:108083"
     exon            1..500
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..591
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..718
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..797
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..894
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1035
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1146
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1242
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1365
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1507
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1628
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1704
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1799
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1846
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1908
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..3043
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /note="hexamer: AATAAA"
     polyA_site      3043
                     /gene="Kcnq1"
                     /gene_synonym="Kcna9; KVLQT1"
                     /note="major polyA site"
ORIGIN      
        1 agacagcggc cccccgtggc tgggctggca gcagtggcta cccgcgctgc gccctgcgct
       61 ctgcgctgcc ttcacctcag ctccgaggag cagcggggtc aggggtcctg tctggccatg
      121 gacacggcct cgtccccgcc cagtgctgaa aggaagcgcg cgggttggag ccgcctgcta
      181 ggcgcccggc ggggcagcgc ggtggtcaag aagtgtccct tctcactgga gctggccgaa
      241 ggtggccctg agggcagcac ggtctatgcg cccatcgcgc caaccggagc ccccgggctc
      301 gcgcccccca tgtcgacccc agtgtcgccc gccccggccc ctgcagacct cggcccacgt
      361 ccgcgggtga gccttgaccc gcgggtctcc atctacagtg cgcgccgccc gctgctggcg
      421 cgcacccaca tccagggccg agtctacaac ttcctcgagc gccccacggg ttggaagtgt
      481 ttcgtgtacc acttcaccgt cttcctcatt gttctggtct gcctcatctt cagtgtcctg
      541 tccactattg agcagtatgc cgctctggcc accgggaccc tcttctggat ggagattgtc
      601 cttgtggtgt tctttgggac agaatatgtg gtccgcctct ggtctgcagg ctgccgcagc
      661 aagtacgtgg gcatctgggg ccggctacgt tttgcccgga agcccatttc catcattgac
      721 ctcatcgtgg ttgtagcctc tatggttgtc ctctgcgtgg gttccaaagg acaagtgttc
      781 gccacatcag ctatcagggg tatccgcttc cttcagatcc tgcggatgct gcatgtcgat
      841 cgccaggggg gtacctggag gctcctgggc tctgtagtct tcattcaccg ccaggagctg
      901 atcaccaccc tgtacattgg ctttctgggc cttatcttct cctcctactt tgtctacttg
      961 gctgagaaag atgcggtgaa cgagtccggc cgcatcgagt ttggcagcta cgcagatgct
     1021 ctgtggtggg gggtggtcac agtcactacc attggctacg gggataaggt acctcagacg
     1081 tgggttggga agaccatcgc ctcctgtttc tctgtcttcg ccatatcctt ctttgcactc
     1141 ccagcgggga tacttggctc tgggttcgcg ctgaaggtcc agcagaagca gaggcagaag
     1201 cacttcaacc ggcagatccc agctgcagcc tcactcatcc agactgcatg gaggtgctat
     1261 gccgctgaga accctgactc agccacttgg aagatctatg tccggaagcc tgctcggagt
     1321 cacacgcttc tgtcccccag ccccaaacct aaaaagtctg tcatggtaaa gaagaagaag
     1381 ttcaagctgg ataaggataa tgggatgagt cctggagaga agatgttcaa tgttcctcac
     1441 atcacttatg atcccccaga ggataggagg ccagaccatt tctccattga tggctatgac
     1501 agctcagtaa ggaagagccc tacactgctg gaagtaagca caccccattt cttgagaaca
     1561 aacagctttg cagaggacct ggacctggaa ggggagacac tgctgacccc catcacccat
     1621 gtgtcacagc tgcgggatca ccatcgggcc accatcaagg tcatcaggcg catgcagtac
     1681 tttgtagcca agaagaaatt ccagcaagca cggaagccct acgacgtgcg agatgtcatc
     1741 gagcagtact cccagggcca cctgaacctt atggtgcgca ttaaagaact acagagaagg
     1801 ctggatcagt ccattgggaa gccatctttg ttcatcccca tctcagaaaa gagcaaagac
     1861 cgtggcagta acaccatcgg tgcccgtctg aacagggtgg aagacaaggt gacacaactg
     1921 gaccagagac tggtgatcat cacagacatg ctccaccagc tgctgtccat gcaacaaggt
     1981 ggtccaacct gcaacagcag gtcacaagtt gtagccagca atgaaggtgg ctccatcaac
     2041 cctgagctct tcctacccag caacagcctg cccacctacg aacaactgac tgtgccccag
     2101 acaggccctg atgagggttc ctgaaggagc tcagaaggga ggtccagggt aaacccccca
     2161 caggtctgcc ccacctccct ctcaacaggg gcacacccac ctggttctca cccccttgaa
     2221 ggcctgatat gacagcctag ctccctaagg ccccgaaacc catgggccaa gccactggcc
     2281 tggatctgga tatcaccaac acccctctgc ccagccagtg ggaactagaa cttgtctggg
     2341 catggggttc ctctcaggcc cctatcaaga tgttgatgct gctcttctga tggctggaac
     2401 atagggatgg ggagtatatg tgtaaagcag gatgcagctc aggcagaggg aagcccatcc
     2461 aggtatgcca agtggcttcc taaagggaaa caggaagagt ctggggtttc caccctcagc
     2521 cctgaatcca gagaccatca gggaacgtgc agggcaagac aggcccggcc cacactaact
     2581 gcaggctgta gcccagtggg agctcagcag gctagagcct gactccttca ttctctagtg
     2641 atgttgacca caacaagata ctagcgggat tttcacaccc cccccaaagg atatcccaag
     2701 caagggattg tccactgtcc accctagcca ggtatggact gacaacttct cccctaaagt
     2761 gaaaagcagg gccctcaagc cctatgagcc ccacatgtgc agcctgcctc cttcttgctg
     2821 gtcagaggtg ctggaccaat gctcagactc cagcctcttt cacgccacat tgaagttagg
     2881 ggcatcaccg attcttccag gattggttcc ttgggcttgg gcaccacgcc tcacagaaat
     2941 caagataatt tctggtgatt cagactcttg tgttttaatg aatttcgtag tatgatcttg
     3001 attgagagac ttttccaaat aaagttggga cgtcccaggt tga
//
