LOCUS       NM_008433               1888 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus potassium intermediate/small conductance
            calcium-activated channel, subfamily N, member 4 (Kcnn4),
            transcript variant 1, mRNA.
ACCESSION   NM_008433
VERSION     NM_008433.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Chen,H., Liu,H., Liu,D., Fu,Y., Yao,Y., Cao,Z., Peng,Z., Yang,M.
            and Zhao,Q.
  TITLE     M2 macrophage-derived exosomes alleviate KCa3.1 channel expression
            in rapidly paced HL-1 myocytes via the NF-kappaB (p65)/STAT3
            signaling pathway
  JOURNAL   Mol Med Rep 29 (4) (2024)
   PUBMED   38334149
  REMARK    GeneRIF: M2 macrophage-derived exosomes alleviate KCa3.1 channel
            expression in rapidly paced HL-1 myocytes via the NF-kappaB
            (p65)/STAT3 signaling pathway.
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Ran,L., Ye,T., Erbs,E., Ehl,S., Spassky,N., Sumara,I., Zhang,Z. and
            Ricci,R.
  TITLE     KCNN4 links PIEZO-dependent mechanotransduction to NLRP3
            inflammasome activation
  JOURNAL   Sci Immunol 8 (90), eadf4699 (2023)
   PUBMED   38134241
  REMARK    GeneRIF: KCNN4 links PIEZO-dependent mechanotransduction to NLRP3
            inflammasome activation.
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Li,J.J., Zhao,X.Y., Wang,Y., Xu,R., Di,X.H., Zhang,Y., Yang,H.,
            Han,M.Z., Bai,R.Y., Xie,L., Pang,Z.D., Zhang,X., Zhang,J., Du,X.J.,
            Deng,X.L., Zhang,Y. and Xie,W.
  TITLE     Endothelial KCa3.1 and KCa2.3 Mediate S1P
            (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure
            Homeostasis
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (5), 726-738 (2023)
   PUBMED   36951065
  REMARK    GeneRIF: Endothelial KCa3.1 and KCa2.3 Mediate S1P
            (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure
            Homeostasis.
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Saxena,S., Nuyens,V., Rodts,C., Jamar,K., Albert,A., Seidel,L.,
            Cherkaoui-Malki,M., Boogaerts,J.G., Wulff,H., Maze,M., Kruys,V. and
            Vamecq,J.
  TITLE     Involvement of KCa3.1 channel activity in immediate perioperative
            cognitive and neuroinflammatory outcomes
  JOURNAL   BMC Anesthesiol 23 (1), 80 (2023)
   PUBMED   36927341
  REMARK    GeneRIF: Involvement of KCa3.1 channel activity in immediate
            perioperative cognitive and neuroinflammatory outcomes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Tamarina,N.A., Wang,Y., Mariotto,L., Kuznetsov,A., Bond,C.,
            Adelman,J. and Philipson,L.H.
  TITLE     Small-conductance calcium-activated K+ channels are expressed in
            pancreatic islets and regulate glucose responses
  JOURNAL   Diabetes 52 (8), 2000-2006 (2003)
   PUBMED   12882916
  REMARK    GeneRIF: SK1, -2, -3, and IK1 (SK4) are expressed in islet cells
            and insulin-secreting cells and are able to influence
            glucose-induced calcium responses, thereby regulating insulin
            secretion.
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Nehrke,K., Quinn,C.C. and Begenisich,T.
  TITLE     Molecular identification of Ca2+-activated K+ channels in parotid
            acinar cells
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C535-C546 (2003)
   PUBMED   12388098
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Ayabe,T., Wulff,H., Darmoul,D., Cahalan,M.D., Chandy,K.G. and
            Ouellette,A.J.
  TITLE     Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1,
            a Ca2+-activated, intermediate conductance potassium channel
  JOURNAL   J Biol Chem 277 (5), 3793-3800 (2002)
   PUBMED   11724775
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Warth,R., Hamm,K., Bleich,M., Kunzelmann,K., von Hahn,T.,
            Schreiber,R., Ullrich,E., Mengel,M., Trautmann,N., Kindle,P.,
            Schwab,A. and Greger,R.
  TITLE     Molecular and functional characterization of the small
            Ca(2+)-regulated K+ channel (rSK4) of colonic crypts
  JOURNAL   Pflugers Arch 438 (4), 437-444 (1999)
   PUBMED   10519135
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Vandorpe,D.H., Shmukler,B.E., Jiang,L., Lim,B., Maylie,J.,
            Adelman,J.P., de Franceschi,L., Cappellini,M.D., Brugnara,C. and
            Alper,S.L.
  TITLE     cDNA cloning and functional characterization of the mouse
            Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease
            and erythroid differentiation
  JOURNAL   J Biol Chem 273 (34), 21542-21553 (1998)
   PUBMED   9705284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159140.10.
            
            On Oct 12, 2022 this sequence version replaced NM_008433.4.
            
            Transcript Variant: This variant (1) differs in the 3' UTR compared
            to variant 2. Variants 1-3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010943.1, BC010274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC159140.10        69647-69917         c
            272-367             AC159140.10        65475-65570         c
            368-789             AC159140.10        62538-62959         c
            790-925             AC159140.10        60973-61108         c
            926-1036            AC159140.10        58480-58590         c
            1037-1155           AC159140.10        57962-58080         c
            1156-1225           AC159140.10        57701-57770         c
            1226-1399           AC159140.10        56060-56233         c
            1400-1888           AC159140.10        55032-55520         c
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.37 cM"
     gene            1..1888
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /note="potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 4"
                     /db_xref="GeneID:16534"
                     /db_xref="MGI:MGI:1277957"
     exon            1..271
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1390
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /note="isoform a is encoded by transcript variant 1;
                     intermediate conductance calcium-activated potassium
                     channel protein 4; SKCa4; SKCa 4"
                     /codon_start=1
                     /product="intermediate conductance calcium-activated
                     potassium channel protein 4 isoform a"
                     /protein_id="NP_032459.3"
                     /db_xref="CCDS:CCDS20948.1"
                     /db_xref="GeneID:16534"
                     /db_xref="MGI:MGI:1277957"
                     /translation="MGGELVTGLGALRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHA
                     EMLWFLGCKWVLYLLLVKCLITLSTAFLLCLIVVFHAKEVQLFMTDNGLRDWRVALTR
                     RQVAQILLELLVCGVHPVPLRSPHCALAGEATDAQPWPGFLGEGEALLSLAMLLRLYL
                     VPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTA
                     WVLSVAERQAVNATGHLTDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCT
                     ALLVAVVARKLEFNKAEKHVHNFMMDIHYAKEMKESAARLLQEAWMYYKHTRRKDSRA
                     ARRHQRKMLAAIHTFRQVRLKHRKLREQVNSMVDISKMHMILCDLQLGLSSSHRALEK
                     RIDGLAGKLDALTELLGTALQQQQLPEPSQEAT"
     exon            272..367
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            368..789
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            790..925
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1036
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1155
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1225
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1399
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1888
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /note="hexamer: AATAAA"
     polyA_site      1888
                     /gene="Kcnn4"
                     /gene_synonym="IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1;
                     mKCa4; SK4; SKCas"
                     /note="major polyA site"
ORIGIN      
        1 agagtgagca gaacaggccg ctggcctgga agccaagctg gctgccattt gcgtactgag
       61 aggtggggga ccctgggcag gaagctggct gagccccaag acctcagggg ccatgggcgg
      121 ggagctggtg actggcctgg gggccctgag acggagaaag cgcctgctgg agcaggagaa
      181 gagggtggcc ggctgggcgt tggtgctggc gggaactggc atcggactca tggttctgca
      241 cgctgagatg ttgtggttcc tgggctgcaa gtgggtgctg tacctgctcc tggttaagtg
      301 tttgatcacc ctgtccactg ccttcctcct ttgtcttatt gtggtcttcc atgccaagga
      361 ggtccagctg ttcatgactg acaacgggct ccgggactgg cgcgtggcgc tgacccggcg
      421 gcaggtggcg cagatcctgc tggagctgtt ggtgtgcggg gtgcacccgg tgcccctacg
      481 gagcccgcac tgcgccctgg cgggggaggc caccgacgcg cagccctggc cgggtttcct
      541 gggcgaaggc gaggcgttgc tgtccctggc catgctcctg cgtctctacc tggtgccccg
      601 cgcggtgctg ctgcgcagcg gggtcctgct caacgcgtcc taccgcagca tcggggcgct
      661 caaccaagtc cgcttccgcc actggttcgt ggccaagctg tacatgaaca cgcacccggg
      721 tcgcctgctg ctgggcctca cgctgggtct ctggctcacc acagcttggg tgctgtctgt
      781 ggctgagagg caggctgtca atgccacggg gcacctcaca gacacactgt ggctgattcc
      841 gatcacattc ctgaccattg gctatgggga cgtggtacct ggcaccatgt ggggcaagat
      901 tgtctgcctg tgcaccggag tcatgggggt ctgctgcaca gctctcctgg tggctgtggt
      961 ggctcggaag ctggagttca acaaggcgga gaaacacgtg cacaacttca tgatggacat
     1021 ccattatgcc aaagagatga aggagtcagc ggcgcggctg ctgcaggaag cctggatgta
     1081 ctacaagcac actcgaagga aggactcccg ggctgcccgc agacatcagc gcaagatgct
     1141 ggccgccatc cacacgttcc gccaggtacg gctgaaacac cggaagctcc gggaacaagt
     1201 gaattccatg gtggacatct ccaagatgca catgatcctg tgcgacctgc agctgggtct
     1261 cagctcctcg caccgtgccc tggagaagag aatcgacggt ctggcaggaa agctggatgc
     1321 cctgacagag ctgctcggca ctgctctgca gcaacagcag ctaccagaac ccagtcagga
     1381 ggccacatag ctccacatga actcacagaa gaaccaggct aagtacccaa ggaccgagct
     1441 caaggacatg ctccctgcca attccgacca agccccacga taaatcacct caagatgcca
     1501 ggacccaagt ggatccacgt tgaggtgcat ggactctggt ggtggcagcc atgagtggac
     1561 actgaattgg acctcccacg tcaatgggaa catggccacc actacacata tgccctcatc
     1621 agaagccctt tctgctgtgc tgctgttcag gaccccttaa tctctgttgg aggaggaggt
     1681 gcctggggtc taggatgcta ggaagcttca gttaaccgcg ggcgggtctc gctgaaggaa
     1741 ccaggtccga gcgacgggag gtgctgcccc ctggtggaca cctgggaaga tgccgtttcc
     1801 tcctgattgc agagactgtg ccagaagagg gtacagggtg ctgctcacca atccaccctc
     1861 atactttgta ataaatggta aacgaaga
//
