LOCUS       NM_080466               7617 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus potassium intermediate/small conductance
            calcium-activated channel, subfamily N, member 3 (Kcnn3), mRNA.
ACCESSION   NM_080466 XM_001005677
VERSION     NM_080466.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7617)
  AUTHORS   Ye,H., Yang,X., Feng,B., Luo,P., Torres Irizarry,V.C.,
            Carrillo-Saenz,L., Yu,M., Yang,Y., Eappen,B.P., Munoz,M.D.,
            Patel,N., Schaul,S., Ibrahimi,L., Lai,P., Qi,X., Zhou,Y., Kota,M.,
            Dixit,D., Mun,M., Liew,C.W., Jiang,Y., Wang,C., He,Y. and Xu,P.
  TITLE     27-Hydroxycholesterol acts on estrogen receptor alpha expressed by
            POMC neurons in the arcuate nucleus to modulate feeding behavior
  JOURNAL   Sci Adv 10 (28), eadi4746 (2024)
   PUBMED   38996023
REFERENCE   2  (bases 1 to 7617)
  AUTHORS   Mulholland,P.J., Padula,A.E., Wilhelm,L.J., Park,B., Grant,K.A.,
            Ferguson,B.M. and Cervera-Juanes,R.
  TITLE     Cross-species epigenetic regulation of nucleus accumbens KCNN3
            transcripts by excessive ethanol drinking
  JOURNAL   Transl Psychiatry 13 (1), 364 (2023)
   PUBMED   38012158
  REMARK    GeneRIF: Cross-species epigenetic regulation of nucleus accumbens
            KCNN3 transcripts by excessive ethanol drinking.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7617)
  AUTHORS   Li,J.J., Zhao,X.Y., Wang,Y., Xu,R., Di,X.H., Zhang,Y., Yang,H.,
            Han,M.Z., Bai,R.Y., Xie,L., Pang,Z.D., Zhang,X., Zhang,J., Du,X.J.,
            Deng,X.L., Zhang,Y. and Xie,W.
  TITLE     Endothelial KCa3.1 and KCa2.3 Mediate S1P
            (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure
            Homeostasis
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (5), 726-738 (2023)
   PUBMED   36951065
  REMARK    GeneRIF: Endothelial KCa3.1 and KCa2.3 Mediate S1P
            (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure
            Homeostasis.
REFERENCE   4  (bases 1 to 7617)
  AUTHORS   Feng,B., Liu,H., Mishra,I., Duerrschmid,C., Gao,P., Xu,P., Wang,C.
            and He,Y.
  TITLE     Asprosin promotes feeding through SK channel-dependent activation
            of AgRP neurons
  JOURNAL   Sci Adv 9 (8), eabq6718 (2023)
   PUBMED   36812308
REFERENCE   5  (bases 1 to 7617)
  AUTHORS   Comerma-Steffensen,S., Prat-Duran,J., Mogensen,S., Fais,R.,
            Pinilla,E. and Simonsen,U.
  TITLE     Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3
            Channels in the Penile Tissue of Type-2 Diabetic db/db Mice
  JOURNAL   J Sex Med 19 (5), 697-710 (2022)
   PUBMED   35321830
  REMARK    GeneRIF: Erectile Dysfunction and Altered Contribution of KCa1.1
            and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db
            Mice.
REFERENCE   6  (bases 1 to 7617)
  AUTHORS   Herrera,G.M., Pozo,M.J., Zvara,P., Petkov,G.V., Bond,C.T.,
            Adelman,J.P. and Nelson,M.T.
  TITLE     Urinary bladder instability induced by selective suppression of the
            murine small conductance calcium-activated potassium (SK3) channel
  JOURNAL   J Physiol 551 (Pt 3), 893-903 (2003)
   PUBMED   12813145
  REMARK    GeneRIF: these channels have a significant role in the control of
            non-voiding contractions of the urinary bladder in vivo
REFERENCE   7  (bases 1 to 7617)
  AUTHORS   Tamarina,N.A., Wang,Y., Mariotto,L., Kuznetsov,A., Bond,C.,
            Adelman,J. and Philipson,L.H.
  TITLE     Small-conductance calcium-activated K+ channels are expressed in
            pancreatic islets and regulate glucose responses
  JOURNAL   Diabetes 52 (8), 2000-2006 (2003)
   PUBMED   12882916
  REMARK    GeneRIF: SK1, -2, -3, and IK1 (SK4) are expressed in islet cells
            and insulin-secreting cells and are able to influence
            glucose-induced calcium responses, thereby regulating insulin
            secretion.
REFERENCE   8  (bases 1 to 7617)
  AUTHORS   Taylor,M.S., Bonev,A.D., Gross,T.P., Eckman,D.M., Brayden,J.E.,
            Bond,C.T., Adelman,J.P. and Nelson,M.T.
  TITLE     Altered expression of small-conductance Ca2+-activated K+ (SK3)
            channels modulates arterial tone and blood pressure
  JOURNAL   Circ Res 93 (2), 124-131 (2003)
   PUBMED   12805243
  REMARK    GeneRIF: Endothelial SK3 channels exert a profound, tonic,
            hyperpolarizing influence in resistance arteries and suggest that
            the level of SK3 channel expression in endothelial cells is a
            fundamental determinant of vascular tone and blood pressure
REFERENCE   9  (bases 1 to 7617)
  AUTHORS   Ro,S., Hatton,W.J., Koh,S.D. and Horowitz,B.
  TITLE     Molecular properties of small-conductance Ca2+-activated K+
            channels expressed in murine colonic smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G964-G973 (2001)
   PUBMED   11557517
REFERENCE   10 (bases 1 to 7617)
  AUTHORS   Bond,C.T., Sprengel,R., Bissonnette,J.M., Kaufmann,W.A.,
            Pribnow,D., Neelands,T., Storck,T., Baetscher,M., Jerecic,J.,
            Maylie,J., Knaus,H.G., Seeburg,P.H. and Adelman,J.P.
  TITLE     Respiration and parturition affected by conditional overexpression
            of the Ca2+-activated K+ channel subunit, SK3
  JOURNAL   Science 289 (5486), 1942-1946 (2000)
   PUBMED   10988076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137738.1 and AC166364.2.
            
            On Oct 30, 2007 this sequence version replaced NM_080466.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137738.1, BC106769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2527              AK137738.1         2-2528
            2528-7617           AC166364.2         72664-77753         c
FEATURES             Location/Qualifiers
     source          1..7617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.16 cM"
     gene            1..7617
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3"
                     /db_xref="GeneID:140493"
                     /db_xref="MGI:MGI:2153183"
     exon            1..1241
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2504
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="SKCa 3; small conductance calcium-activated
                     potassium channel 3"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 3"
                     /protein_id="NP_536714.2"
                     /db_xref="CCDS:CCDS38495.1"
                     /db_xref="GeneID:140493"
                     /db_xref="MGI:MGI:2153183"
                     /translation="MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPPAPPA
                     VPQQPPGPLLQPQPPQPQQQQSQQQQQQQSQQQQQQAPLHPLPQLAQLQSQLVHPGLL
                     HSSPTAFRAPTSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQAS
                     PLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPP
                     EIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRA
                     LFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTVILLGL
                     IIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLA
                     FSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF
                     VMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLS
                     IGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLT
                     KRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSD
                     QANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTL
                     RQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC"
     exon            1242..1337
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1756
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1898
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2009
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2137
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2207
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..7617
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="hexamer: AATAAA"
     polyA_site      2549
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="major polyA site"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="hexamer: AATAAA"
     polyA_site      3081
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="major polyA site"
     regulatory      5674..5679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="hexamer: AATAAA"
     polyA_site      5694
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
     regulatory      7590..7595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="hexamer: TATAAA"
     regulatory      7595..7600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
                     /note="hexamer: AATATA"
     polyA_site      7614
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
     polyA_site      7617
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3; SKCA3"
ORIGIN      
        1 attgagccag cgaggagtga agctgagtct gcttcataca ctcctagagg accgccttca
       61 gaatagagtt cttttcgccc cttcctcctt cccccggctc ctctcctggc ttttctaccc
      121 gcccaataca atgcatactc gagtggcagc cccagagaac tgaagcaaac caaagagaga
      181 ggactggagc caagacactt ctggtgggga atcttggatg cctggctttc tttgaggtca
      241 tctttggaac gagggtggct ttggggtgga gggtcgtgct gcagggaact cagccaggcc
      301 ccaagatgga cacttctggg cacttccatg actcgggggt gggggacctg gatgaagacc
      361 ccaagtgtcc ctgtccatct tctggggacg agcaacagca gcagcagcaa ccgccaccac
      421 cgccagcgcc accagcagtc ccccagcagc ctccgggacc cttgctgcag cctcagcctc
      481 cgcagcctca gcagcaacag tcgcagcagc agcagcagca gcagtcgcag cagcagcagc
      541 agcaggctcc actgcacccc ctgcctcagc ttgcccaact ccagagccag cttgtccatc
      601 ctggtctgtt gcactcttct cccacggcgt tcagggcccc cacttcagcc aactctaccg
      661 ccatcctcca cccttcctcc aggcaaggca gccagctaaa tctcaatgac cacttgcttg
      721 gccactctcc aagttccaca gccacaagtg ggcccggtgg aggcagccgg caccggcagg
      781 ccagccccct ggtgcaccgg cgggacagca atcccttcac ggagatagct atgagctcct
      841 gcaaatacag cggtggggtc atgaagcccc tcagccgcct cagcgcctct cggagaaacc
      901 ttatcgaggc tgagcctgag ggccaacccc tccagctctt cagtcccagc aaccccccag
      961 agattatcat ctcctccagg gaggataacc atgcccacca gactctgctc catcacccca
     1021 acgctaccca caaccaccag catgccggca ccacggccgg cagcaccacc ttccccaaag
     1081 ccaacaagcg gaaaaaccaa aacattggct ataagctggg acacaggagg gccctgtttg
     1141 aaaagagaaa gcgactgagt gactatgctc tgatttttgg gatgtttgga attgttgtta
     1201 tggtgataga gaccgaactg tcttggggtt tgtactcaaa ggattccatg ttttcgttgg
     1261 ccctgaaatg ccttatcagt ttatccaccg tcatcctgct tggtttgatc atcgcctatc
     1321 acacaaggga agtacagctc tttgtgatcg acaatggtgc agatgactgg cggatagcca
     1381 tgacctacga gcgtatcctc tacatcagcc tggagatgct ggtgtgcgcc atccacccca
     1441 tccctggaga gtacaagttc ttctggactg cacgcctggc cttctcctat accccatctc
     1501 gggcagaggc tgacgtggac attattctgt ccatccccat gttcctgcgc ctgtacctga
     1561 tcgcccgggt catgctgctc catagcaaac tcttcactga tgcctcctcc cgaagcatcg
     1621 gggccctcaa caagatcaac ttcaacaccc gattcgtcat gaagacgctc atgaccatct
     1681 gccctggcac ggtgctgctg gtgttcagca tctctctgtg gatcatcgct gcctggactg
     1741 tgcgagtctg tgaaaggtac catgatcagc aggatgtaac tagtaacttt ctgggtgcca
     1801 tgtggctcat ctccatcacg ttcctttcca ttggctatgg ggacatggtg ccccacacat
     1861 actgtgggaa aggtgtctgt cttctcaccg gcatcatggg tgcaggctgc actgcccttg
     1921 tggtagctgt ggttgcccga aagctcgaac tcaccaaagc agagaagcat gtgcacaact
     1981 tcatgatgga cactcagctc accaaacgga tcaagaatgc cgccgccaat gtcctccggg
     2041 aaacgtggct aatctataaa catacaaagc tgctaaagaa gattgaccat gccaaagtca
     2101 ggaaacacca gaggaagttc ctccaagcta tccaccaact gcggggtgtc aagatggaac
     2161 aaaggaagct gagtgaccaa gccaacaccc tggtggacct ttccaagatg cagaacgtca
     2221 tgtatgactt aatcacggag ctcaatgacc ggagtgaaga tctagaaaag cagattggca
     2281 gcctggagtc caagctggag cacctcacag ccagtttcaa ttccctgccc ctgctcatcg
     2341 cagataccct gcgccagcag cagcagcagc tgctcactgc cttcgtggag gcccggggca
     2401 tcagtgtggc cgtgggaact agccacgccc ctccctctga cagccctatc gggatcagct
     2461 ccacctcttt cccaacccca tacacaagtt caagcagttg ctaaataaaa ctccccactc
     2521 cagaagcatt acccataggt cttaagatgc aaatcaactc tctcctggtc gctttgctgt
     2581 caaggaagtt gcagaccagg gaacagaacg aagagagatg gaacggatga gctgactcat
     2641 gtcctttcag cgtgctttgt tcgatatgcc ttgaaaccag aaatctaatc tctgtttagg
     2701 tgcctctact tgggagctgg aagacgaggt gacgggaagc aacgcctctg tcagggccct
     2761 tgctgcagag ttggcggaga acagaaatcc ctgctcaatc tcaggttttc acagggaggt
     2821 ggggaggggc agccactctg aagcagctga gagggaagcc agccaaagtg gggtgtgctg
     2881 agcaagggtg gtattaggtt tggggagtgg gttcctggct gccttgggac ctcagctcac
     2941 ctgtcctgtc cttttgtcta aggaagcctc tgggtggtaa aaaataaaag agagccgccc
     3001 agaattttcc aaaacggaca tacccaaatt agacttgggg agggtggtga cgtagacaaa
     3061 taaaaagcca gattttccat ccaataatac tatccatcat atacacacac agatgttcaa
     3121 tccaggtcat tttctgtttg agttgagccc aaatgaaagg gacctggtac ctccccctgc
     3181 acacagtaat tctgcattga gatgatgcat ggggtgtgtt tagttgagga cgttagaggg
     3241 tattggccac attttgacct tcattgaaga tgcaggtccc tccttcacag tgccctggac
     3301 atgcatgtgg cctgatttaa atgtatgcca actccacact ggagagataa acgtcctttt
     3361 aaaaacaaca gcttttgaag aggtttcatc cagccaaata agctgtgtgc tgatggaacc
     3421 catgttccca ggtgtctgtg tgtgtggggg agcggggggg ggggggggag gaggagacaa
     3481 gcgtgcccag tgccaccata gtgaatgcaa ctattgtctg gggccgaagc atcttcagcc
     3541 agcagcaggt tccagccgga gatgtaggag tgtggaagga tcagtgccta acactgctag
     3601 gttgggagga gaaaggtaga gagtggctcc tgtggtccct tctaccttac ctgacatcat
     3661 ctcaaaatga aacactgtga gaacacaaga agccctaggg gcatgtgtgt aaagtgagag
     3721 gacacatttg ttggaggctt gttcctattg tgccacgctc atcttggggc aaaacctact
     3781 ccactgaacc caagagactc tagaaacaag cagatctggg atagacatgg gcgcttgctt
     3841 ttatccccat tgctctgtga cctgaccgta cacacagctg tggtgggaaa gctattgagt
     3901 tttatcactt ctcccatctg gaggtcttcg atttctgctt ataagaaatt atacgtggaa
     3961 tatttcatcc atcttttggt agggcaaaag gatgttatct gtgtatagtt gctgtcttga
     4021 gagtagcccc gtgtgaggct atcacaggtc cctggaggca tcgtcttact atgtgcattt
     4081 ttcttgtgca atgctggggc tggtcctctc aggacaggga attgctggac agtgaggtgg
     4141 gcaactgtgg cacggaagac atgccttggt tttttgtttg tttgtttcta agcctcttgt
     4201 ttgtctttct gtcttgatgc tgctgtctcg tgtcttgtgt ctgcagtgct ggagatcaga
     4261 cttgcagctt catgcgtttt aaacaagtgc tgttccactc agccacaccc cagcctgctg
     4321 ctgttgtctt aatggcctat cttcttaatg gtctatcttg atcgccccct cgagcatttt
     4381 cattagctgt tttgcacacc agagaggcca catttgttgt tagcatttaa ttctttttac
     4441 ttgttctttt aattattaat tattggaaag attattttta tcctgagaat ggtattcctg
     4501 ttttcagttt agccatacct acaggcagat atacacacag atgaaatagc cattgtacct
     4561 tctctgtagc attggttgca tttcacaaaa ggaaggctgc tgatgggcct acttcctggt
     4621 catgtgctct atggccctca gctgttttcc ctgccctctg ttgcgtcttg ctgtgatcct
     4681 gtgctgtgtg gtcataagca tggcacatct aggatttagt tcccattttc acacaaatga
     4741 catgcaagat cccacgcttc tcctgccgtg tatccatctt ggtctggaca tagtctacaa
     4801 tctgtctttt tattgatatt cttgctaagt aaaccctgaa ggccaagcta gcgacgctag
     4861 tttagaggat ggctagagct gtttcaggag ggcaccacta gcattagaga gagacgtggg
     4921 aatttgtagg gtggcctggt ccgttggtat tgcaataggt ctgtgtggtc ttatctctag
     4981 cagaagaata tacctcgaga aacatgacag gatcagaagg ttggctctgt gatggcaaat
     5041 gagctactgc ttctctgtcc tgatattgca acttcatgag ggaagtaata attctcttgc
     5101 aaatacaatc gacccttgat gacctaggta atgaggatcc tggttagctc acccagacgt
     5161 atctctgcat cttttagatg atcccacatc acctaagtat cccagttgag tgggaaagga
     5221 ggctagtgga ttctaaggcc atgtggtagt ggaaagggtc tgagtctcaa gagtgggctg
     5281 caatttaaaa ctatgaatta ctgtaatttt gccctagccc tgaactggtc caatttcact
     5341 cactcctaga aggctgaccg atggcagagg ccttcctagc atctttccag gaatgcagta
     5401 gcagacagaa gcactccaat atttccccaa atatctggac acttgaatta aaaatataga
     5461 gccaccctgt cattgcttaa gccatataat tgcttcatgt actgtgaagt cagggatgta
     5521 ctgtgatact ccaagaccac tgagctcagt gggatttcag gatatagcct cagttggtaa
     5581 tttacacccg actagaagct cattccttct tagattgaca tccaaataag aatctgcacc
     5641 tttggctcaa aggtcgcatg tgtgattatc atcaataaat cattatgaag tgtctgtgag
     5701 ccattcttac cacctccata atgtataact ccatgacatc atgtctcaaa atatgaccca
     5761 aatgaatgag aggggctata gccatgcatc accagtgact gtgaccccaa cagggtcggt
     5821 cctgtgctgc aacaacaacc ttgtaaatta gaagacgtag aaactgtatg tgaaatctag
     5881 ccctcaaaca ccacagcatt gacaaataat gatttcaatg tatctggaga gtttccccta
     5941 acaaagaagt catggaaaga agaaaactag tgatacaaaa tcagaatagg taaaagtctg
     6001 agactcctgc caatagctct cggtttgtgt gtatttaaaa gtgaagatga attgagttca
     6061 aagtattcag tagaagacaa aatgagatcc ctatcgctag cgcagcagcc ttgactgact
     6121 agctaaccca cacttagatg ttacatttga atgtagtgat agttaccaaa aagtaattac
     6181 tgcacattgg ataggtagtg atttgcaggg agaaagacag agtttgtgca gagttcagga
     6241 agcccccatc ctccagagga tgacaaacaa tgtattccaa atagagagtc agtgttccat
     6301 ctcaaaacag acaccctagc cactgctaga gaaacccggc tgagacactg tgacactacc
     6361 agcaggttac gactttctaa actactgctt ttaaatgctc aaataggttc ccacctcatc
     6421 cagtcactct acttccccca aagctactag aagaagatta aggatccatt agtggtcatt
     6481 ctgctgtccc tgttgacttc ttggtttggt ttcagtccct tagatggcta tctggaggct
     6541 tcctggcaga cacgaacagt tcattctctc ccctgtagcc agctggcttg ttcatgcctt
     6601 gggcagtatc tcttccttct ccacctctgc caaagcaaac atttggggaa tgggattaaa
     6661 gctagcccta agacggtggg gcgttgtggg tggggaggac ggagggtggt gatagtgtct
     6721 gcctgtggta acaggaagct tgtgtcaggc tgcgtgaata gtaagctcct gccggacaag
     6781 gaatatgtag acttgtgttg aactaggcca cagcttagga acacatgttc tgtgcagtgg
     6841 tctataggca gccacagaag gggatgtaat tgtgatcctt ttgtcttacg ccattactgg
     6901 aaacgcccac acacgaactg gagttccctc ggaacaacat tgtcaaatct tcaacagacg
     6961 acctccgaac caggtgccac gagccctgca cagctgttta cacactgaga catgtattct
     7021 ggaagctgcg agcaacctcg ggcctggact gacaagagac cttgtgacca atcaagctgg
     7081 tggaggaaaa gcacaaaatt ccataccaac ctctagttaa gatcccaaag agatgctgac
     7141 atttctagca aaaataacaa tgataatact aaataataaa taaataggaa cagtgacaaa
     7201 taaaaaaaaa tgaatctgat tggaacagcc gacatccagc ttcccagagg gaggacgggg
     7261 ctaagtgaca ttctccagct gtgtcacttc tcggatccca accagagctg acccaccttc
     7321 atcatatatg gtgtttaatg gcgcaacaga gtgatcgatt tagtcccagt ctcttcattc
     7381 tttgctggcc acaagagaac aacaaacgcg agtgatagga tgttgatgga ggaaccattt
     7441 tcatagcaaa ctcagaaatg gaggtgttta tattccaaac cagatgggct tcagtatgaa
     7501 tttgcatctt gcctctgtac tgcttgctat tttttaatga taggagaaag cataacagtt
     7561 tattttaaat atgaaatata ttgctatatt ataaaatata ttgtaacttt cgattaa
//
