LOCUS       NM_001312905            3692 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus potassium intermediate/small conductance
            calcium-activated channel, subfamily N, member 2 (Kcnn2),
            transcript variant 1, mRNA.
ACCESSION   NM_001312905 XM_006525638
VERSION     NM_001312905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Lin,T.F., Busch,S.E. and Hansel,C.
  TITLE     Intrinsic and synaptic determinants of receptive field plasticity
            in Purkinje cells of the mouse cerebellum
  JOURNAL   Nat Commun 15 (1), 4645 (2024)
   PUBMED   38821918
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   Xu,J., Zhang,D., Ma,Y., Du,H., Wang,Y., Luo,W., Wang,R. and Yi,F.
  TITLE     ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through
            the NF-kappaB signaling pathway
  JOURNAL   J Biol Chem 300 (3), 105735 (2024)
   PUBMED   38336298
  REMARK    GeneRIF: ROS in diabetic atria regulate SK2 degradation by
            Atrogin-1 through the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Peng,X., Chen,P., Zhang,Y., Wu,K., Ji,N., Gao,J., Wang,H.,
            Zhang,Y.M., Xu,T. and Hua,R.
  TITLE     MPP2 interacts with SK2 to rescue the excitability of glutamatergic
            neurons in the BLA and facilitate the extinction of conditioned
            fear in mice
  JOURNAL   CNS Neurosci Ther 30 (1), e14362 (2024)
   PUBMED   37469037
  REMARK    GeneRIF: MPP2 interacts with SK2 to rescue the excitability of
            glutamatergic neurons in the BLA and facilitate the extinction of
            conditioned fear in mice.
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Chen,H., Xia,F., Chen,X., Cai,Y. and Jin,Z.
  TITLE     Ablation of small conductance calcium-activated potassium type-2
            channel (SK2) delays occurrence of bupivacaine-induced
            cardiotoxicity in isolated mouse hearts
  JOURNAL   Hum Exp Toxicol 40 (3), 464-471 (2021)
   PUBMED   32909839
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Wu,K., Gao,J.H., Hua,R., Peng,X.H., Wang,H. and Zhang,Y.M.
  TITLE     Predisposition of Neonatal Maternal Separation to Visceral
            Hypersensitivity via Downregulation of Small-Conductance
            Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice
  JOURNAL   Neural Plast 2020, 8876230 (2020)
   PUBMED   33029124
  REMARK    GeneRIF: Predisposition of Neonatal Maternal Separation to Visceral
            Hypersensitivity via Downregulation of Small-Conductance
            Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   Callizot,N., Guenet,J.L., Baillet,C., Warter,J.M. and Poindron,P.
  TITLE     The frissonnant mutant mouse, a model of dopamino-sensitive,
            inherited motor syndrome
  JOURNAL   Neurobiol Dis 8 (3), 447-458 (2001)
   PUBMED   11442353
REFERENCE   7  (bases 1 to 3692)
  AUTHORS   Bond,C.T., Sprengel,R., Bissonnette,J.M., Kaufmann,W.A.,
            Pribnow,D., Neelands,T., Storck,T., Baetscher,M., Jerecic,J.,
            Maylie,J., Knaus,H.G., Seeburg,P.H. and Adelman,J.P.
  TITLE     Respiration and parturition affected by conditional overexpression
            of the Ca2+-activated K+ channel subunit, SK3
  JOURNAL   Science 289 (5486), 1942-1946 (2000)
   PUBMED   10988076
REFERENCE   8  (bases 1 to 3692)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   9  (bases 1 to 3692)
  AUTHORS   Davisson,M.T., Cook,S.A., Johnson,K.R. and Eicher,E.M.
  TITLE     Balding: a new mutation on mouse chromosome 18 causing hair loss
            and immunological defects
  JOURNAL   J Hered 85 (2), 134-136 (1994)
   PUBMED   8182278
REFERENCE   10 (bases 1 to 3692)
  AUTHORS   Lane,P.W., Searle,A.G., Beechey,C.V. and Eicher,E.
  TITLE     Chromosome 18 of the house mouse
  JOURNAL   J Hered 72 (6), 409-412 (1981)
   PUBMED   6949984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099590.16, AC122852.2, AC121957.2 and AC101593.16.
            
            On Mar 1, 2019 this sequence version replaced NM_001312905.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (SK2-L).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033158.1, SRR10662772.2393600.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AC099590.16        153232-153789
            559-644             AC122852.2         70537-70622         c
            645-843             AC121957.2         62786-62984         c
            844-2117            AC121957.2         60650-61923         c
            2118-2213           AC121957.2         59958-60053         c
            2214-2632           AC121957.2         28850-29268         c
            2633-2774           AC101593.16        148155-148296       c
            2775-2885           AC101593.16        133166-133276       c
            2886-3013           AC101593.16        126430-126557       c
            3014-3083           AC101593.16        120354-120423       c
            3084-3692           AC101593.16        117611-118219       c
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.34 cM"
     gene            1..3692
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /note="potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 2"
                     /db_xref="GeneID:140492"
                     /db_xref="MGI:MGI:2153182"
     exon            1..558
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..644
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..843
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             822..3371
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /note="isoform SK2-L is encoded by transcript variant 1;
                     small conductance calcium-activated potassium channel
                     protein 2; small conductance calcium-activated potassium
                     channel subfamily N member 2"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 2 isoform SK2-L"
                     /protein_id="NP_001299834.1"
                     /db_xref="GeneID:140492"
                     /db_xref="MGI:MGI:2153182"
                     /translation="MFGRTCKCDVMPIVLVRPTNRTRRLDSTGAGMGPSSHQQQESPL
                     PTITHCAGCTTAWSPCSFNSSDMETPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDK
                     PCAPFAPLPHPHHHPHLAHQQPGSGGSSPCLRCNSCASSGAPAAGAGAGDNLSLLLRT
                     SSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQLNVSELTPSSHASALRQQYAQQPASAS
                     QYHQCHSLQPATSPTGSLGSLGSGPPLSHHHHHPHPAHHQHHQPQARRESNPFTEIAM
                     SSCRYNGGVMRPLSNLSSSRRNLQEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSS
                     APEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGSGHGSSSGTKSSKKKNQNIGYKLG
                     HRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII
                     LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWT
                     ARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINF
                     NTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISI
                     TFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMD
                     TQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQR
                     KLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLI
                     SQTIRQQQRDFIETQMENYDKHVSYNAERSRSSSRRRRSSSTAPPTSSESS"
     exon            844..2117
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2213
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2632
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2774
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2885
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3013
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3083
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3692
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3667..3672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /note="hexamer: AATAAA"
     polyA_site      3692
                     /gene="Kcnn2"
                     /gene_synonym="bc; fri; KCa2.2; SK2; SKCA2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcgca cccgcgttta tttttggcgc acgcacaccc ctcggtagcc tcaaggtcag
       61 cgacaaccct gatcagtcgg gggtcccccc gcccgtccac cagtgctctc ccgcctgcca
      121 aggacgtggg aaggaggaag tcccccagtg gtggcggggc atcttgggga gccctgcagt
      181 ttcagcactg tcgtactgga gcggggacaa acagaagcct gtccccaaag gtgtggactt
      241 gcaccttcac cagtgggcag ccggggcctg gctggtccca gccgcgcccg ggctcgctgc
      301 ccacctccag gggctccttg cagccccttg gctctgtccg ccagctgtca cggaatttgg
      361 ctctgagaag cagctggtcc tggtcaggat ccctggtcca tctcaaatgg aaacagttcc
      421 tcccgaggaa tcggctggga atctcagtgg aaatgcactg gggctgggcc ccccctggcg
      481 tgtttaacca aggccaagct taccactttg aggcaaggga tgtttcaaat ggagcgggat
      541 tcctggttac agactgagac tcttgtagag agaattacaa aaggatggga tccagcgaga
      601 ggccagggga gcccaaggaa tggagcaggc tataagcagt agtggtctgg aggaagagga
      661 aaaacagaga agccggcagt ctgcgctggc taagcagccc ccagaccctg gaacaagcct
      721 cgtctacacc gctaaagtag ccctcggacc tacccactca ggctgctgga ccgcctgagc
      781 gtcagagccc cggacctggc ggccaggggc gccagcccct catgttcggg agaacgtgca
      841 aatgtgatgt catgcccatt gttttggtgc gcccaaccaa tcggactcgc cgcctggatt
      901 ctaccggagc cggcatgggc ccttcctcgc accagcagca ggagtccccg ctcccgacca
      961 taacgcattg cgcagggtgc accaccgcct ggtctccctg cagctttaac agctctgaca
     1021 tggaaacccc attgcagttc cagcgcggct tcttcccaga gcagccgccg ccaccgccgc
     1081 gctcctcaca cctgcattgc cagcagcagc aacagagcca ggacaagccg tgcgcgccct
     1141 tcgcgcccct cccgcaccct caccaccacc cgcacctcgc gcaccagcag ccgggcagcg
     1201 gtggcagcag cccatgcctc cggtgcaaca gctgcgcctc ctccggtgcc ccggcagcgg
     1261 gggcgggggc gggggataac ctgtccctgc tgctccgcac ctcatcgccc ggcggcgcct
     1321 tccggacccg cacctcctcg ccactgtcgg gctcttcgtg ctgttgctgc tgctcgtcgc
     1381 gccggggcag ccagctcaat gtgagcgagc tgacgccgtc cagccatgcc agtgcgctcc
     1441 ggcagcagta cgcgcagcag cccgcgtccg cctcccagta ccaccagtgc cacagcctgc
     1501 agcccgccac cagccccaca ggcagcctgg gcagcctggg ctccgggccc ccgctctcgc
     1561 accaccacca ccacccgcac ccggcgcacc accagcatca ccaaccccag gcgcgccgcg
     1621 agagcaaccc cttcaccgaa atagccatga gcagctgcag gtacaacggg ggcgtcatgc
     1681 gtccgctcag caacttgagc tcgtcccgcc ggaacctgca ggagatggac tccgaggctc
     1741 agcccctgca gccccccgcg tccgtcgtag gaggaggtgg tggtgcgtcc tccccgtctg
     1801 ctgccgccgc cgcctcatcc tcagccccgg agatcgtggt gtctaagccg gagcacaaca
     1861 attctaacaa cctggcgctc tacgggactg gcggcggagg cagcaccgga ggcggcggcg
     1921 gcggcagcgg gcatggcagc agcagcggca ccaagtccag caaaaagaag aaccagaaca
     1981 tcggctacaa gctgggccat cggcgcgccc tgtttgagaa gcgcaagcgg ctcagcgact
     2041 atgcgcttat cttcggcatg ttcggcatcg tggttatggt cattgagacc gagctgtctt
     2101 ggggcgccta cgacaaggcg tcgctgtatt ctttagctct gaaatgcctt atcagtctct
     2161 ccacgatcat cctgcttggt ctgatcatcg tgtaccacgc cagggaaata cagttattca
     2221 tggtggacaa tggagcagat gactggagaa tagccatgac ttatgagcgt attttcttca
     2281 tctgcttgga aatactggtg tgtgctatcc atcccatacc tgggaattat acgttcacat
     2341 ggacagcccg gcttgccttc tcctatgccc cctccacaac caccgcagat gtggatatta
     2401 ttttatctat accaatgttc ttaaggctct atctgattgc cagagtcatg ctattacata
     2461 gcaaactttt caccgatgcc tcgtctagaa gcattggggc acttaataag ataaacttca
     2521 atacgcgttt tgttatgaag actttaatga ctatctgccc aggaactgtg ctcttggttt
     2581 ttagtatctc attatggata attgccgcat ggactgtccg agcttgtgaa aggtaccatg
     2641 atcaacagga tgtcactagc aacttccttg gagcaatgtg gttgatatca ataacttttc
     2701 tctccattgg ttatggtgac atggtaccca acacatactg tgggaaagga gtctgcttgc
     2761 ttactggaat catgggtgca ggttgcacag ccctggtggt agccgtagtg gcaagaaagc
     2821 tagaacttac caaagcagaa aagcatgtgc acaatttcat gatggatact cagctgacca
     2881 aaagagtgaa aaacgcagcc gccaatgtac tcagggaaac gtggttaatc tacaaaaaca
     2941 caaagctagt gaaaaagatc gaccacgcaa aagtaagaaa gcatcaacgg aaattcttgc
     3001 aagctattca tcaattaaga agtgtgaaga tggaacagag gaaactgaat gaccaagcaa
     3061 ataccctagt ggatctggca aagacccaga atatcatgta tgacatgatt tccgacttga
     3121 atgaaaggag tgaagacttt gagaaaagga tcgtcaccct ggaaacaaaa ctagagactt
     3181 tgattggtag cattcatgcc ctccctgggc taatcagcca gaccatcaga cagcagcaaa
     3241 gggacttcat tgagacacag atggagaact acgacaagca tgtctcctac aatgctgagc
     3301 gctcccggtc ctcgtccagg aggcggcggt cctcctccac agcgccacca acttcatcag
     3361 agagtagcta gaagagaata agttaaccac aaaataagac tttttgccat catatggtca
     3421 atattttagc ttttattgta aagcccctat ggttctaatc agcgttatcc gggttctgat
     3481 gtcagaatct tgggaacctg aacactaagt tttaggccaa aatatgagtg aaaactcttt
     3541 ttttttttct ttcagatgca cagggaatgc accaattatt gctatataga ttgttcctcc
     3601 tgtaatttca ctaacttttt attcatgcac ttcaaacaaa ctttactact acattatatg
     3661 atatataata aaaaaaaaag ttaatttctg ca
//
