LOCUS       NM_001363407            3773 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus potassium intermediate/small conductance
            calcium-activated channel, subfamily N, member 1 (Kcnn1),
            transcript variant 1, mRNA.
ACCESSION   NM_001363407 XM_006509807
VERSION     NM_001363407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Wang,H., Zuo,W., Feng,X., Huo,X., Liang,Y., Wang,B., Sharma,D.,
            Li,X., Yasin,B., Ye,J.H., Hu,H. and Tao,Y.X.
  TITLE     ESRRG-controlled downregulation of KCNN1 in primary sensory neurons
            is required for neuropathic pain
  JOURNAL   JCI Insight 9 (12), e180085 (2024)
   PUBMED   38912580
  REMARK    GeneRIF: ESRRG-controlled downregulation of KCNN1 in primary
            sensory neurons is required for neuropathic pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Baskin,K.K., Makarewich,C.A., DeLeon,S.M., Ye,W., Chen,B.,
            Beetz,N., Schrewe,H., Bassel-Duby,R. and Olson,E.N.
  TITLE     MED12 regulates a transcriptional network of calcium-handling genes
            in the heart
  JOURNAL   JCI Insight 2 (14), 91920 (2017)
   PUBMED   28724790
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Li,Y., Hu,H., Tian,J.B., Zhu,M.X. and O'Neil,R.G.
  TITLE     Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+
            channels plays a critical role in regulating the K+-secretory BK
            channel in kidney collecting duct cells
  JOURNAL   Am J Physiol Renal Physiol 312 (6), F1081-F1089 (2017)
   PUBMED   28274924
  REMARK    GeneRIF: Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3
            and IK1 K(+) channels plays a critical role in regulating the
            K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Hirst,C.S., Foong,J.P., Stamp,L.A., Fegan,E., Dent,S., Cooper,E.C.,
            Lomax,A.E., Anderson,C.R., Bornstein,J.C., Young,H.M. and
            McKeown,S.J.
  TITLE     Ion channel expression in the developing enteric nervous system
  JOURNAL   PLoS One 10 (3), e0123436 (2015)
   PUBMED   25798587
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Schilling,T., Stock,C., Schwab,A. and Eder,C.
  TITLE     Functional importance of Ca2+-activated K+ channels for
            lysophosphatidic acid-induced microglial migration
  JOURNAL   Eur J Neurosci 19 (6), 1469-1474 (2004)
   PUBMED   15066143
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Nariyama,M., Shimizu,K., Uematsu,T. and Maeda,T.
  TITLE     Identification of chromosomes associated with dental caries
            susceptibility using quantitative trait locus analysis in mice
  JOURNAL   Caries Res 38 (2), 79-84 (2004)
   PUBMED   14767162
REFERENCE   8  (bases 1 to 3773)
  AUTHORS   Tamarina,N.A., Wang,Y., Mariotto,L., Kuznetsov,A., Bond,C.,
            Adelman,J. and Philipson,L.H.
  TITLE     Small-conductance calcium-activated K+ channels are expressed in
            pancreatic islets and regulate glucose responses
  JOURNAL   Diabetes 52 (8), 2000-2006 (2003)
   PUBMED   12882916
  REMARK    GeneRIF: SK1, -2, -3, and IK1 (SK4) are expressed in islet cells
            and insulin-secreting cells and are able to influence
            glucose-induced calcium responses, thereby regulating insulin
            secretion.
REFERENCE   9  (bases 1 to 3773)
  AUTHORS   Ro,S., Hatton,W.J., Koh,S.D. and Horowitz,B.
  TITLE     Molecular properties of small-conductance Ca2+-activated K+
            channels expressed in murine colonic smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G964-G973 (2001)
   PUBMED   11557517
REFERENCE   10 (bases 1 to 3773)
  AUTHORS   Shmukler,B.E., Bond,C.T., Wilhelm,S., Bruening-Wright,A.,
            Maylie,J., Adelman,J.P. and Alper,S.L.
  TITLE     Structure and complex transcription pattern of the mouse SK1 K(Ca)
            channel gene, KCNN1
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 36-46 (2001)
   PUBMED   11267657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019302.14 and AC162446.2.
            
            On Aug 29, 2022 this sequence version replaced NM_001363407.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               AC019302.14        185845-186657
            814-922             AC019302.14        187832-187940
            923-1399            AC019302.14        194128-194604
            1400-1495           AC019302.14        194883-194978
            1496-1914           AC019302.14        196533-196951
            1915-2056           AC019302.14        198864-199005
            2057-2167           AC019302.14        200717-200827
            2168-2295           AC019302.14        201303-201430
            2296-2304           AC019302.14        202833-202841
            2305-2374           AC019302.14        203041-203110
            2375-3773           AC162446.2         195375-196773       c
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.27 cM"
     gene            1..3773
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 1"
                     /db_xref="GeneID:84036"
                     /db_xref="MGI:MGI:1933993"
     exon            1..813
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..922
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1399
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1004..2620
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="isoform a is encoded by transcript variant 1; small
                     conductance calcium-activated potassium channel protein 1"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 1 isoform a"
                     /protein_id="NP_001350336.1"
                     /db_xref="CCDS:CCDS52578.1"
                     /db_xref="GeneID:84036"
                     /db_xref="MGI:MGI:1933993"
                     /translation="MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQM
                     VAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRK
                     RLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHA
                     REIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPS
                     AAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLM
                     TICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDM
                     VPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNA
                     AANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQAN
                     TLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPL
                     PPPWPGPGHLATATQSPQSHWLPTMGSDCG"
     exon            1400..1495
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1914
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2056
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2167
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2295
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2304
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2374
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..3773
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3753..3758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="hexamer: AATAAA"
     polyA_site      3773
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="major polyA site"
ORIGIN      
        1 acttagagga caaagcagga cagagccagc agcccacaaa ttcagttttg gagagccacc
       61 tcagaatgga ctggagaaac tgagtcttgg gtctagccaa gatcaccaca agggtctcgg
      121 accctctcca gacccaggct ctgctttccc gctccttgag cactccagac cccaggaggc
      181 tcattgttct ggctgggtat tttgaccttc acggtcccgc cacccctgca tccgccgtta
      241 ggggcgcagg ggggactcca gctgcgtgag cggcaccttc cagccagaca cagggacaga
      301 gaagttttct cttcctgcct ctctggtcac cccacccctc gcccccaaac caggaccttc
      361 cagcctgggc cgcgtcatca gctgctggag tctcccggcg tctctccctc tcgacccttc
      421 cctgccccag gctcagcttc tcgctggagt gcatttccct gtgggaggcg acagctgctg
      481 cacctgactg ggttgaagga caaggatccc tggtctttgt cgcagcctca gtttccccgt
      541 ctgaaaactg cgcgcgtaaa gccagcggac accaaggatc gccccagccc ttggcgtgtc
      601 ctcggtcact gtcctcggcc tcggcgggga gcgcgctggg tgccgccgcg gaggggacac
      661 ctgaccgtcc ccagcgggcc gcgcgggtgg ggggtccgcg ctgcagcggc gcgcgcacct
      721 ctgttcccac gcccttgccc gtctgcttac tcacttggtt ttgctctcgg gccgggacgc
      781 agggactcca gcagctgcgg ctggagacta ctggtgtgga gaagagccaa gggcagggcc
      841 atcccacgtc tgagggcaac ttcaagacac ggaagagcag cggcctcagg ttggtggttt
      901 ccagagcccc ttggacccca gggtccattc agaagctctg ctgcggaacc atgctgggcc
      961 ccaaagggcc tgctgcacgc ccagcccacg gaggcaggtg gccatgagta gccacagcca
     1021 caatggcagc gtggggcagc ctctgggcag cgggcctgga ttcctgggct gggagcctgt
     1081 ggaccctgag gcaggccgcc ccctgcagcc cacccaaggc ccaggcctgc agatggtggc
     1141 caagggtcag cctgtcaggc tgtcacccgg tggttccagg ggccaccccc aggagcagga
     1201 ggaggaagag gaagaggagg aggaggagga ggacaagaca ggctcaggga agcccccaac
     1261 agtcagccac cgcctgggac accgcagggc cctctttgaa aagcgtaaac ggctcagtga
     1321 ctatgcgctc atctttggca tgtttgggat tgtcgtcatg gtgacagaaa cagagctgtc
     1381 ctggggtgta tacaccaagg agtcactctg ctcttttgct ctgaaatgcc tcatcagcct
     1441 gtccactgtc atcttgcttg gccttgtcat cctgtaccac gcccgagaga tccagctgtt
     1501 cttggtggac aatggtgccg acgactggcg tatcgccatg acgtgggagc gcgtgtccct
     1561 gatctcgctg gagttggtcg tgtgtgccat ccacccggtg cccggccact atcgcttcac
     1621 gtggacggca cgactggcct tctctctggt gccgtcggca gccgaggcag acctggatgt
     1681 gctgctgtcc atccccatgt tcctgcgcct ctacctgctg gctcgggtca tgctcctgca
     1741 cagccgcatc ttcaccgatg catccagccg cagcatcggg gcccttaacc gcgtcacctt
     1801 caacacacgc ttcgtcacca agacgctcat gaccatctgc cccggcactg tgttgttggt
     1861 cttcagcgtc tcctcctgga tcgttgctgc gtggacagtg cgcgtgtgtg agaggtacca
     1921 cgataagcag gaagtgacca gcaacttcct gggagccatg tggctcatct ccatcacctt
     1981 cttgtccatt ggctatggag acatggtgcc gcatacctac tgtgggaagg gtgtgtgtct
     2041 gctcactggc atcatgggag caggctgcac tgcactcgtg gtggccgtcg tggctcggaa
     2101 gttggaactc accaaggctg agaaacacgt gcacaacttc atgatggaca cacagctcac
     2161 caagcgggtc aaaaatgctg ctgcaaacgt tctcagggag acatggctca tctacaaaca
     2221 caccaggctg gtgaagaagc cagaccaagg ccgggttcgg aaacaccagc gtaagttcct
     2281 tcaggccatc catcaggctc agaagctccg aagtgtgaag attgaacaag ggaaggtgaa
     2341 cgatcaggcc aacacgctgg ctgagctggc caaggcacag agcatcgcat atgaggtggt
     2401 gtcagagctg caggcccagc aggaggagtt ggaggcacgc ctagccgcct tggagagccg
     2461 actggatgtc ctgggtgcct ccctgcaggc tctaccaggc cttatagccc aagccatatg
     2521 ccctctacca ccaccctggc ctgggcctgg tcacctggcc acagccaccc agagcccaca
     2581 aagccactgg ctgcccacca tgggatcaga ctgtgggtga tggctgctga ccgctagact
     2641 gctccatctc agccatcgtg tggccacagc tagctccttg ccgttttgga cctccggact
     2701 actgcattta gaagcttggg tgaactgagc cgactggact ggcactcatc cttctgaggc
     2761 tgggccacag gatccaggtc cccttagctg tcccaggccc caggagggca aggagtagta
     2821 gcaggggcct caacatttct aagtaaatca ggagcttcca gcccgctttc tgttgacatg
     2881 cagggggctg caaacatctc cccagaggag gtagatgacc ccacctgggg attccttaat
     2941 ggacggggac agacgtggaa agtcactgca catgcattga gtatctactg tatacaggga
     3001 ctgaaacaat ggcttttctt caggatctat ctaactggag taagatacaa acaaatgaga
     3061 attcagagag gtgaggccac ttgcctgtag ccacacagca atggtctgag gcaaacacac
     3121 ttgttaaaca gcataagcgg atagattcta cttggggatc ctgatgtcaa agtaaggaca
     3181 cacgggaggg tgagaggcca gggttacaga cgagcagagt caccacggtc acttcagacc
     3241 ttaggcttca gactttgggt acttggggaa cactgagaca cctcacaggc atgggcggct
     3301 tatcaagagc agcctaagtc acagtgtcct ctgatcagac tttcagccac ctgtcttggg
     3361 agatagtgga cctgtgtggg aacccagagg cccagtttgg attctataag tttgtggggt
     3421 ggagctctgg ggtggacctg ggcaggcttt attcccctgc tgctgtggga aacaggccta
     3481 acccaacccc cacacgggtc agacagtagg tgctcaataa ataccccctc cttcctaaga
     3541 ctgcccatga gggcttggga aacatggacc catcctgccc cttctgagcc cagtattagc
     3601 tcctgtccat caggaagggg actgagatca aaacaggtcc agaagaaata aacaaggcag
     3661 gtcaatgtga cacatgcctt tattcctaac acctaggagg caaaggcagg tgggttgcag
     3721 tgtatacagt gtaagacgtg gggtggcaca gaaataaaca aggctgtagg tga
//
