LOCUS       NM_021452               1371 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus potassium large conductance calcium-activated channel,
            subfamily M, beta member 4 (Kcnmb4), transcript variant 1, mRNA.
ACCESSION   NM_021452 XM_916312
VERSION     NM_021452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Sartoretti,M.M., Campetella,C.A. and Lanuza,G.M.
  TITLE     Dbx1 controls the development of astrocytes of the intermediate
            spinal cord by modulating Notch signaling
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35815610
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Wang,B., Wang-France,J., Li,H. and Sansom,S.C.
  TITLE     Furosemide reduces BK-alphabeta4-mediated K+ secretion in mice on
            an alkaline high-K+ diet
  JOURNAL   Am J Physiol Renal Physiol 316 (2), F341-F350 (2019)
   PUBMED   30484346
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Pratt,C.P., Kuljis,D.A., Homanics,G.E., He,J., Kolodieznyi,D.,
            Dudem,S., Hollywood,M.A., Barth,A.L. and Bruchez,M.P.
  TITLE     Tagging of Endogenous BK Channels with a Fluorogen-Activating
            Peptide Reveals beta4-Mediated Control of Channel Clustering in
            Cerebellum
  JOURNAL   Front Cell Neurosci 11, 337 (2017)
   PUBMED   29163049
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Pyott,S.J., Meredith,A.L., Fodor,A.A., Vazquez,A.E., Yamoah,E.N.
            and Aldrich,R.W.
  TITLE     Cochlear function in mice lacking the BK channel alpha, beta1, or
            beta4 subunits
  JOURNAL   J Biol Chem 282 (5), 3312-3324 (2007)
   PUBMED   17135251
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Brenner,R., Chen,Q.H., Vilaythong,A., Toney,G.M., Noebels,J.L. and
            Aldrich,R.W.
  TITLE     BK channel beta4 subunit reduces dentate gyrus excitability and
            protects against temporal lobe seizures
  JOURNAL   Nat Neurosci 8 (12), 1752-1759 (2005)
   PUBMED   16261134
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Nehrke,K., Quinn,C.C. and Begenisich,T.
  TITLE     Molecular identification of Ca2+-activated K+ channels in parotid
            acinar cells
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C535-C546 (2003)
   PUBMED   12388098
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Weiger,T.M., Holmqvist,M.H., Levitan,I.B., Clark,F.T., Sprague,S.,
            Huang,W.J., Ge,P., Wang,C., Lawson,D., Jurman,M.E.,
            Glucksmann,M.A., Silos-Santiago,I., DiStefano,P.S. and Curtis,R.
  TITLE     A novel nervous system beta subunit that downregulates human large
            conductance calcium-dependent potassium channels
  JOURNAL   J Neurosci 20 (10), 3563-3570 (2000)
   PUBMED   10804197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139376.3 and AC135862.4.
            
            On Mar 10, 2023 this sequence version replaced NM_021452.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013647.1, BC048471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               AC139376.3         52021-52717         c
            698-825             AC135862.4         23772-23899
            826-1371            AC135862.4         51820-52365
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 64.73 cM"
     gene            1..1371
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /note="potassium large conductance calcium-activated
                     channel, subfamily M, beta member 4"
                     /db_xref="GeneID:58802"
                     /db_xref="MGI:MGI:1913272"
     exon            1..697
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..994
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /note="isoform 1 is encoded by transcript variant 1; large
                     conductance calcium-dependent potassium ion channel beta 4
                     subunit; calcium-activated potassium channel subunit
                     beta-4; BK channel subunit beta-4; maxi K channel subunit
                     beta-4; charybdotoxin receptor subunit beta-4;
                     calcium-activated potassium channel, subfamily M subunit
                     beta-4; Slowpoke beta 4"
                     /codon_start=1
                     /product="calcium-activated potassium channel subunit
                     beta-4 isoform 1"
                     /protein_id="NP_067427.1"
                     /db_xref="CCDS:CCDS24184.1"
                     /db_xref="GeneID:58802"
                     /db_xref="MGI:MGI:1913272"
                     /translation="MAKLRVSYEYTEAEDKSIRLGLFLIVSGILSLFIFGFCWLSPAL
                     QDLQATAANCTVLSVQQIGEVFECTFTCGTDCRGTSQYPCVQVYVNNSESNSRALLHS
                     DQHQLLTNPKCSYIPPCKRENQKNSESVMNWQQYWKDEIGSQPFTCYFNQHQRPEDVL
                     LQRTHDEIALLHCFLWPVVAFVVGVLIVVLTICAKSLAVKAEAMKKRKFS"
     exon            698..825
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1371
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /note="hexamer: ATTAAA"
     polyA_site      1371
                     /gene="Kcnmb4"
                     /gene_synonym="1700058G18Rik; 2900045G12Rik; BKbeta4;
                     k(VCA)beta-4; slo-beta-4"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctccc agcgtcgggg cgccgggcgc tcggccgcgg cgatggcagg cgggcggcgc
       61 gcgcggggag gcgggcgcgg ggcgcggagc gcgcgggggc gggggcgggc tcggggagcc
      121 ccggggtgcc ggacgctgtg aggcggcggt ggcacccggg agcccggcct cgggcagcgc
      181 cgtcgccgcc gccgggggcg tcgccggcct cggccccttt gttctcgcgc gcgccccctc
      241 gccgcccact cccctgctgt cgcgcggcgg cggcggcggc tcctcccgcc cgaggcggtt
      301 gagctcggcg ccgggggcgg gagggggcgg ggagcgcgcc agccgtggag agtggggggc
      361 gatggcgaag ctcagggtgt cttacgagta cacggaagcc gaagacaaga gcatccggct
      421 cggcttgttc ctcatcgtct ccggcatcct gtcgctcttc atcttcggct tctgctggct
      481 cagtcccgcc ttgcaggatc tgcaagccac ggcggccaac tgcaccgtgc tgtcggtgca
      541 gcagatcggc gaggtgttcg agtgcacctt cacctgtggc accgactgca ggggcacctc
      601 gcagtatccc tgcgtccagg tgtacgtgaa caactccgag tccaactcca gggcgctgct
      661 acacagcgac cagcaccagc tcctgaccaa ccccaagtgc tcctatatcc cgccctgtaa
      721 gagagaaaac cagaagaact cggagagcgt catgaactgg cagcagtatt ggaaagatga
      781 gatcggttcc cagccattca cttgctattt taatcagcat cagagaccag aggacgttct
      841 cctacagcgc acacacgacg agattgctct cctgcactgc ttcctctggc cggtggtggc
      901 gtttgtggtg ggtgttctca tcgtggtcct gaccatctgt gccaagagcc tggcggtcaa
      961 ggcggaagcc atgaagaaac gcaagttctc ttaacgggga ggaggaggat tgtgggaagc
     1021 cgagaccaga ggttgcctcg tcggcactcg cctgccctgc agagcccaca tttggtggcg
     1081 caggagatgg aaggggccgc aagaggcccc cgagaggccc ctccctcgtc ggcagcagaa
     1141 acaggcacag ttggaagact ggggggactt aactgcctgt attccatgtg ctgtagcaac
     1201 ggctaaaggg tcaagctctt agctctatgg agtgactaac tgtttgggaa accctcaaag
     1261 aagtcggttt tctttggaaa gtaacagtct atcatttgta tagtgtagta tacaaaccat
     1321 tatgatttat gctcctcaca aatattaaaa gacagtgctc tgtgctctct a
//
