LOCUS       NM_031169               4188 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus potassium large conductance calcium-activated channel,
            subfamily M, beta member 1 (Kcnmb1), mRNA.
ACCESSION   NM_031169
VERSION     NM_031169.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   North,K.C., Shaw,A.A., Bukiya,A.N. and Dopico,A.M.
  TITLE     Progesterone activation of beta1-containing BK channels involves
            two binding sites
  JOURNAL   Nat Commun 14 (1), 7248 (2023)
   PUBMED   37945687
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Mysiewicz,S., North,K.C., Moreira,L. Jr., Odum,S.J., Bukiya,A.N.
            and Dopico,A.M.
  TITLE     Interspecies and regional variability of alcohol action on large
            cerebral arteries: regulation by KCNMB1 proteins
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 324 (4), R480-R496 (2023)
   PUBMED   36717168
  REMARK    GeneRIF: Interspecies and regional variability of alcohol action on
            large cerebral arteries: regulation by KCNMB1 proteins.
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Zhu,Y.R., Jiang,X.X., Ye,P., Wang,Z.M., Zheng,Y., Liu,Z., Chen,S.L.
            and Zhang,D.M.
  TITLE     Knockout of AKAP150 improves impaired BK channel-mediated vascular
            dysfunction through the Akt/GSK3beta signalling pathway in diabetes
            mellitus
  JOURNAL   J Cell Mol Med 24 (8), 4716-4725 (2020)
   PUBMED   32163656
  REMARK    GeneRIF: Knockout of AKAP150 improves impaired BK channel-mediated
            vascular dysfunction through the Akt/GSK3beta signalling pathway in
            diabetes mellitus.
REFERENCE   4  (bases 1 to 4188)
  AUTHORS   Barnes,E.A., Lee,L., Barnes,S.L., Brenner,R., Alvira,C.M. and
            Cornfield,D.N.
  TITLE     beta1-Subunit of the calcium-sensitive potassium channel modulates
            the pulmonary vascular smooth muscle cell response to hypoxia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 315 (2), L265-L275 (2018)
   PUBMED   29644895
  REMARK    GeneRIF: Compromised PASMC beta1 function may contribute to the
            heightened microvascular vasoconstriction that characterizes
            pulmonary hypertension.
REFERENCE   5  (bases 1 to 4188)
  AUTHORS   Liu,B., Liu,Y., Shi,R., Feng,X., Li,X., Zhang,W., Wu,J., Li,N.,
            Zhou,X., Sun,M. and Xu,Z.
  TITLE     Chronic Prenatal Hypoxia Down-Regulated BK Channel Beta1 Subunits
            in Mesenteric Artery Smooth Muscle Cells of the Offspring
  JOURNAL   Cell Physiol Biochem 45 (4), 1603-1616 (2018)
   PUBMED   29486465
  REMARK    GeneRIF: Whole-cell currents density of BK channels and amplitude
            of spontaneous transient outward currents were significantly
            reduced in hypoxia vascular myocytes.
REFERENCE   6  (bases 1 to 4188)
  AUTHORS   Petkov,G.V., Bonev,A.D., Heppner,T.J., Brenner,R., Aldrich,R.W. and
            Nelson,M.T.
  TITLE     Beta1-subunit of the Ca2+-activated K+ channel regulates
            contractile activity of mouse urinary bladder smooth muscle
  JOURNAL   J Physiol 537 (Pt 2), 443-452 (2001)
   PUBMED   11731577
REFERENCE   7  (bases 1 to 4188)
  AUTHORS   Dick,G.M. and Sanders,K.M.
  TITLE     (Xeno)estrogen sensitivity of smooth muscle BK channels conferred
            by the regulatory beta1 subunit: a study of beta1 knockout mice
  JOURNAL   J Biol Chem 276 (48), 44835-44840 (2001)
   PUBMED   11590153
REFERENCE   8  (bases 1 to 4188)
  AUTHORS   Pluger,S., Faulhaber,J., Furstenau,M., Lohn,M., Waldschutz,R.,
            Gollasch,M., Haller,H., Luft,F.C., Ehmke,H. and Pongs,O.
  TITLE     Mice with disrupted BK channel beta1 subunit gene feature abnormal
            Ca(2+) spark/STOC coupling and elevated blood pressure
  JOURNAL   Circ Res 87 (11), E53-E60 (2000)
   PUBMED   11090555
REFERENCE   9  (bases 1 to 4188)
  AUTHORS   Brenner,R., Perez,G.J., Bonev,A.D., Eckman,D.M., Kosek,J.C.,
            Wiler,S.W., Patterson,A.J., Nelson,M.T. and Aldrich,R.W.
  TITLE     Vasoregulation by the beta1 subunit of the calcium-activated
            potassium channel
  JOURNAL   Nature 407 (6806), 870-876 (2000)
   PUBMED   11057658
REFERENCE   10 (bases 1 to 4188)
  AUTHORS   Jiang,Z., Wallner,M., Meera,P. and Toro,L.
  TITLE     Human and rodent MaxiK channel beta-subunit genes: cloning and
            characterization
  JOURNAL   Genomics 55 (1), 57-67 (1999)
   PUBMED   9888999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF020711.1, AL731867.27, AK038987.1, AU043056.1, AK039715.1 and
            BB196456.2.
            
            On Apr 16, 2009 this sequence version replaced NM_031169.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020711.1, AK038987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AF020711.1         1-203
            204-205             AL731867.27        135264-135265
            206-273             AF020711.1         206-273
            274-1626            AK038987.1         2-1354
            1627-1825           AU043056.1         1-199               c
            1826-4053           AK039715.1         168-2395
            4054-4055           BB196456.2         493-494
            4056-4188           AK039715.1         2396-2528
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.32 cM"
     gene            1..4188
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="potassium large conductance calcium-activated
                     channel, subfamily M, beta member 1"
                     /db_xref="GeneID:16533"
                     /db_xref="MGI:MGI:1334203"
     exon            1..314
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..472
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..644
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..4188
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="hexamer: CATAAA"
     polyA_site      1298
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="major polyA site"
     regulatory      1526..1531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="hexamer: TATAAA"
     polyA_site      1554
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="major polyA site"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="hexamer: AATACA"
     polyA_site      1827
                     /gene="Kcnmb1"
                     /gene_synonym="BKbeta1"
                     /note="major polyA site"
ORIGIN      
        1 taatggcttt tgctgtttga catctgtttc ccaggagact ctgggaaatg caggggcaga
       61 gtccccaaca gcagctgagg gctgtgaggc taggtacctg cttgtggagt ttttatcccg
      121 gggcaagctg tgtgctcaga cttgaccatg tttgggcatg gaggctcgac ccagatggga
      181 ctgagactgc ttccctggag accagctggg agaccaaact tcctgctaga gctcccaggc
      241 ctgacttggg gtgggggtgg gggtggggcg agtggagaga aaccatctgc cagccagcgg
      301 agacccagag aactaaatga ctgttgcctc cagtggccat ggggaagaag ctggtgatgg
      361 cccagaagcg cggagagaca cgagccctct gcctgggagt ggcaatggta gtgtgtgctg
      421 ccatcaccta ctacgtcctg ggtacaactg tgctgcccct ctaccagaaa agtgtgtgga
      481 cccaggaatc catatgtcac ttgattgaaa ctaatatcaa ggaccaggaa gagctggagg
      541 gcaagaaggt gccccagtac ccatgccttt gggtcaatgt atcagctgtg ggcagatggg
      601 ccatgctgta tcacacggaa gacactcggg atcaaaacca acagtgctcc tatatcccca
      661 ggaacctgga caactaccag acagccttgg cagatgtgaa gaaggtcaga gccaatttct
      721 ataagcacca tgaattctat tgcctttctg cacctcaagt caacgagacc agcgtcgtgt
      781 accagcgcct ctacgggccc caagtcctcc tcttctcctt cttctggccc accttcctgc
      841 tgaccggggg tcttattctt attgccatgg tgaagctcaa caggtcccta tccatcttgg
      901 cggctcagaa gtaggccagt cccctctgca ccacagcaga gactcaccaa ggaactgcag
      961 agtccctagc aggctaccca tcactctctt cctttgtctc ctatttcatt tgttcaacat
     1021 ctttggaaag ctgtttcttg ctcaagaatg cgtatccgat tcccagtgac tttggaggac
     1081 caagaagctc ccagttacag cttcccatcc ctgacttcag ttggttcata tctgttacct
     1141 gcaatgacgc tgtctgctac caggatgatg aatattgtca cctctatccc tacgtgctct
     1201 ctcttagctc cccaaatacc cacccatcac attcaggatg ttgtccttgg ccaaattcag
     1261 cttctttgaa ttgtcataaa aacaataatt cccattgaca gggcaactga atgtactgct
     1321 ttttgttaag gacattaagt ctctctctct ctctctctct ctctctctct ctctctgtgt
     1381 gtgtgtgtgt gtgtgtctgt ctctctctct ctgtctctct ctctgtctct cacacacaca
     1441 cacctctaaa atttaaaaat actgctatcc ttcagtatcc acagggacca gttctgcgac
     1501 ttgctcagat gtcacaaatc ccttctataa agtgatgcag tctcggttgc ggaagctctg
     1561 tccacctttc tccatgctgc agtgtctcca gatgactagt aaacacccac tacagcgtca
     1621 gtgctgaaaa tgatttcatt ctagggacca atgatgggga agggtccgtc catgctcaca
     1681 gcagatgcaa ttattaccca aatactttca atctgccctt gattgaatcc aatggggcag
     1741 aacctgccga tacagatcca agcatataca tacacacagg aaaaaaaagt ctacgaggaa
     1801 ataaatacaa atgcctcaaa atattaacca tggcatggtg gttaatttta attttcttcc
     1861 ttaaccccgc tccattttct tttgttattt tcattcttca ataataggaa gatcatacag
     1921 tgttttgttt tgttttaatc agaaaagtaa tacatagctg ttattttgga aaatattgaa
     1981 agggacagcc tttagggaga tgaggatggg cttcgagagg ctgtttctcc catcagagac
     2041 aagctgggaa gacacagttg ttaggccccc tggatggaag gaaggcgctt acttagttga
     2101 gcatttgtag cttcctgttg ctgatgcttt caccatgtcc cctataaaca caggtgttgg
     2161 gcatttgaca cagttaatgt tcacagcatt cagatgcaat cggggttaga atgatgcccc
     2221 taagatggca ccgttggctt tacaggcaca gtaagagaga aagaggcaag acctgaggta
     2281 acaggttgtg ctgccgtgcc ttttggtgtt ctctccacat gcagatgatg tcaccacact
     2341 ggatttgaca cttctctcca ggcagccctg atgtcgcctg tggccctcca gtttcttatc
     2401 cgtggcccct cctctcaagg aaaaatagct catcattccc caaggcatct ccctccaagg
     2461 tcaggaaagc catattctga cattatggta gagtttgcaa gatgctacca ccggggagat
     2521 tcacatgtgg ctagcagggc tctttcttac aactaccata taaatctata attatctccc
     2581 aaatttgaat tcaacttaaa aagagaaacc aaaggttcca aaagggagtc tggctttaag
     2641 gggttgcttt atgaaggttt ccaggtccct gcgtttgggg ctgaaagaca gaaaaactca
     2701 gaatatccaa acagcaggag aaaaggacac acccttctag aagaatcagt gtgcagggat
     2761 gcccagctcc cttgccccat gcattagtca tgacgacctt cgtttccttt gggaaaattt
     2821 ttgccgtcct gtcaacaagg actggcctac ttccatcaaa agccacaccc atccgtggtc
     2881 acagaactgc atgggcagcg tgagtgtgaa actgtgggca tttgagcgtg atggacttag
     2941 aggtgggaga aagatgatct tggcagcaat ggctgcctgg gaacagagag gcctcccctg
     3001 tcctgaatag gtcactgcta atgagtgtca ggtgctttct gtattcttgc attgattctt
     3061 ataggccatg actcatgtct gcaaaggagt acccggtcca tttctcaggt gtcctttttt
     3121 cctaaatcgg cctccacatg gggatcagag tcatcaggac ccctgggctt ctgatctaat
     3181 gtagaaagga tccctgtgag atgctctaat aatgccaggc ctcacacagc tccagctctt
     3241 cagccaaggc tgtgactcaa ttcatgactt gaagaaagcc ggcctcttcc atgtgtgaat
     3301 gttacaaggg aaaagcttgt tctgtgctct ctaatggctg aagcctggaa gggccaggga
     3361 tatgagtcag gtgtatggat gccttcaagg agctgtctat tttcctgctc tgcccccaac
     3421 cccatcaccg tcactgtggt cgcttcttcg tggtaaagaa ccagattgca tttaaaatca
     3481 tgtaatataa aaatcttaat ttttgtgatt caccaaaatg attccaagtt cctcattaaa
     3541 acagtaattc tcaatctgta ggttgcgacc cctccaggta ttgaataacc cttttcacag
     3601 gagtcaccta agactattgg aaagcacaga tatttacatt acaattcata acagtagccc
     3661 ttgggtaagg atactgagat ggaaatctca tcttttctta actgttctcg taaaaatatg
     3721 ttgtcagaca ttccagatca aggcagcatg atatacatat catagctgat caaatatgga
     3781 acactgattg gagtccagct gcttggttaa ctagacatta aatatatttt caaaaattat
     3841 acaacagagg caggagagat gcctcagtgg ctaagggtgt gtgtgtggct cttgcagatg
     3901 acctgggtct gattctcagc gcctacatca ggtagctcac agctgtctgt aactccagct
     3961 gcagggaggt tgatacctct cggttccatg ggcacctgca ctcaagtgca cacacatgtg
     4021 tacacacaca cacacacaca cacacacaca cacacttaaa aataaaaata aatcttttaa
     4081 aatgcaaaac gataagcttt ctcttggttg gaaggtaaaa ttatttttca taaaatattt
     4141 ttgtaacatg tgataggttt attactttga aataaagcaa gtgaaatg
//
