LOCUS       NM_010609               1137 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus potassium channel, subfamily K, member 7 (Kcnk7),
            mRNA.
ACCESSION   NM_010609
VERSION     NM_010609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1137)
  AUTHORS   Yost CS, Oh I, Eger EI 2nd and Sonner JM.
  TITLE     Knockout of the gene encoding the K(2P) channel KCNK7 does not
            alter volatile anesthetic sensitivity
  JOURNAL   Behav Brain Res 193 (2), 192-196 (2008)
   PUBMED   18572259
  REMARK    GeneRIF: Data show that knockout mice (KCNK7-/-) display no
            difference in the minimum alveolar concentration (MAC) for the
            three volatile anesthetics compared to heterozygous (+/-) or
            wild-type (+/+). littermates.
REFERENCE   2  (bases 1 to 1137)
  AUTHORS   Harrell MD, Harbi S, Hoffman JF, Zavadil J and Coetzee WA.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   3  (bases 1 to 1137)
  AUTHORS   Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X
            and Hunter KW.
  TITLE     Sipa1 is a candidate for underlying the metastasis efficiency
            modifier locus Mtes1
  JOURNAL   Nat Genet 37 (10), 1055-1062 (2005)
   PUBMED   16142231
REFERENCE   4  (bases 1 to 1137)
  AUTHORS   Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SA and Gallagher
            PG.
  TITLE     Genomic organization and chromosomal localization of the murine 2 P
            domain potassium channel gene Kcnk8: conservation of gene structure
            in 2 P domain potassium channels
  JOURNAL   Gene 261 (2), 365-372 (2000)
   PUBMED   11167025
REFERENCE   5  (bases 1 to 1137)
  AUTHORS   Saridaki A, Ferraz C, Demaille J, Scherer G and Roux AF.
  TITLE     Genomic sequencing reveals the structure of the Kcnk6 and map3k11
            genes and their close vicinity to the sipa1 gene on mouse
            chromosome 19
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 85-88 (2000)
   PUBMED   10894943
REFERENCE   6  (bases 1 to 1137)
  AUTHORS   Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G and
            Lazdunski M.
  TITLE     Cloning of a new mouse two-P domain channel subunit and a human
            homologue with a unique pore structure
  JOURNAL   J Biol Chem 274 (17), 11751-11760 (1999)
   PUBMED   10206991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160180.1 and AF012324.2.
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NM_010609.4.
            
            On Dec 30, 2016 this sequence version replaced NM_010609.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110521.1, AK160180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AK160180.1         2-100
            100-1121            AK160180.1         102-1123
            1122-1137           AF012324.2         1025-1040
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1137
                     /gene="Kcnk7"
                     /gene_synonym="2310014G03Rik; Kcnk6; Kcnk8; Knot; Mlk3"
                     /note="potassium channel, subfamily K, member 7"
                     /db_xref="GeneID:16530"
                     /db_xref="MGI:MGI:1341841"
     exon            1..324
                     /gene="Kcnk7"
                     /gene_synonym="2310014G03Rik; Kcnk6; Kcnk8; Knot; Mlk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1037
                     /gene="Kcnk7"
                     /gene_synonym="2310014G03Rik; Kcnk6; Kcnk8; Knot; Mlk3"
                     /note="double-pore K(+) channel 3; putative potassium
                     channel DP3; neuromuscular two p domain potassium channel"
                     /codon_start=1
                     /product="potassium channel subfamily K member 7
                     precursor"
                     /protein_id="NP_034739.2"
                     /db_xref="CCDS:CCDS29477.1"
                     /db_xref="GeneID:16530"
                     /db_xref="MGI:MGI:1341841"
                     /translation="MGSLKPWARYLLLLMAHLLAMGLGAVVLQALEGPPARHLQAQVQ
                     AELASFQAEHRACLPPEALEELLGAVLRAQAHGVSSLGNSSETSNWDLPSALLFTASI
                     LTTTGYGHMAPLSSGGKAFCVVYAALGLPASLALVAALRHCLLPVFSRPGDWVAIRWQ
                     LAPAQAALLQAAGLGLLVACVFMLLPALVLWGVQGDCSLLEAIYFCFGSLSTIGLGDL
                     LPAHGRGLHPAIYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGPSGSRT
                     DEDQDGILGQDELALSTVLPDAPVLGPTTPASVSEHQNRPQPADPSQATGSQLDRVGG
                     PEREAPRSA"
     exon            325..723
                     /gene="Kcnk7"
                     /gene_synonym="2310014G03Rik; Kcnk6; Kcnk8; Knot; Mlk3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1122
                     /gene="Kcnk7"
                     /gene_synonym="2310014G03Rik; Kcnk6; Kcnk8; Knot; Mlk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctatggg gagtctgaaa ccatgggccc gatacctgct cctgcttatg gcccacctgc
       61 tggccatggg ccttggggct gtggtgcttc aggccctgga gggccctcca gctcgccacc
      121 tccaggccca ggtccaggct gaactggcta gcttccaggc agagcacagg gcctgcttgc
      181 cacctgaggc cctggaggag ctgctaggtg cggtcctgag agcacaggcc catggagttt
      241 ccagcctggg caacagctca gagacaagca actgggatct gccctcagct ctgctgttca
      301 ctgccagcat cctcaccacc accggttatg gccacatggc cccactctcc tcaggtggaa
      361 aggccttctg tgtggtctat gcagcccttg ggctgccagc ctctctagca cttgtggctg
      421 ccctgcgcca ctgcttgctg cctgtgttca gtcgcccagg tgactgggta gccattcgct
      481 ggcagctggc accagctcag gctgctctgc tacaggcagc aggactgggc ctcctggtgg
      541 cctgtgtctt catgctgctg ccagcactgg tgctgtgggg tgtacagggt gactgcagcc
      601 tgctagaagc catctacttc tgtttcggct cactcagcac gatcggccta ggagacttgc
      661 tgcctgccca tggacgtggc ctgcacccag ccatttacca ccttgggcag tttgcacttc
      721 ttggttactt gctcctgggg ctcctggcca tgttgttagc agtagagacc ttctcagagc
      781 tgcctcaggt ccgtgccatg gtgaaattct ttgggcccag tggctctaga accgatgaag
      841 atcaagatgg catcctaggc caagatgagc tggctctgag cactgtgctg cctgacgccc
      901 cagtcttggg accaaccacc ccagcctcag tatcagaaca tcagaacaga ccccagcctg
      961 ctgaccccag tcaggcgaca ggaagtcagc tcgatcgtgt tgggggacct gagcgggagg
     1021 caccaaggag tgcttgaaga acatagcagg aaggggttat gggaatgaat atgtcatggg
     1081 ataatgttaa ttttaaaaat taaatgggct gcttagcatg caaaaaaaaa aaaaaaa
//
